Add time:09/29/2019 Source:infona.pl
A series of small molecules derived from MK-0677, a potent synthetic GHS, mimicking the N-terminal Gly-Ser-O-(n-octanoyl)-l-Ser-Phe segment of ghrelin was synthesized and tested in a binding and in a functional assay measuring intracellular calcium elevation in HEK-293 cells expressing hGHSR1a. Replacement of Phe in this tetrapeptide with a spiro(indoline-3,4′-piperidine) group, Gly-Ser with 2-aminoisobutyric acid, and O-(n-octanoyl)-l-Ser with O-benzyl-d-Ser provided synthetic GHS agonists with similar functional potency as ghrelin.
We also recommend Trading Suppliers and Manufacturers of SPIRO[INDOLINE-3,4'-PIPERIDINE] (cas 171-75-5). Pls Click Website Link as below: cas 171-75-5 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View