Add time:09/28/2019 Source:infona.pl
As a better alternative to radical cyclization, 5-(2-bromo-6-methoxyphenoxy)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline (2) and its 1-oxo analog 3 underwent Pd-catalyzed intramolecular cyclization to give the tetracyclic (ACNO) morphine fragments 5 and 6 respectively. 4-[(2 -Iodo-6 -methoxyphenoxy)methyl]-1-ethoxycarbonyl-1,2,5,6,-tetrahydro pyridine (11) reacted similarly to provide the tricyclic ANO fragment 12 in 70% yield and 45% e.e. when a Pd-(S)-BINAP complex was used as the catalyst.
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