Add time:09/30/2019         Source:infona.pl

An improved procedure for the preparation of benzo[4, 5]imidazo[2,1-a]isoquinolines using PdCl2–PPh3 as catalyst was developed, featuring simple, sequential workup, good selectivity, and compatibility with a wide range of functional groups. Various (Z)-2-bromovinylimidazoles and 2-chlorophenylboronic acids containing either electron-withdrawing or electron-donating groups were shown to smoothly undergo this sequence of reactions to generate the respective benzo[4, 5]imidazo[2,1-a]isoquinolines in 62–77% yields.

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