Add time:07/23/2019         Source:sciencedirect.com

Nicotine has ameliorating effects on sensorimotor gating deficits in schizophrenia. We have shown that nicotine ameliorated disruption of prepulse inhibition (PPI) via the α7 nicotinic acetylcholine receptor (nAChR) in Wistar rats. The 5-HT3 receptor antagonist tropisetron was recently found to be an α7 nAChR partial agonist. We initially investigated the effects of tropisetron on disruption of PPI induced by phencyclidine (PCP) (2 mg/kg) or apomorphine (1 mg/kg). Tropisetron had no effect on the disruption of PPI induced by PCP, but ameliorated the disruption by apomorphine. The ameliorating effect of tropisetron was antagonized by methyllycaconitine (2 or 5 mg/kg), a partially selective α7 nAChR antagonist. Next, to find the action site of tropisetron, we examined c-Fos protein expression in the nucleus accumbens (NAc), dorsolateral striatum (DLst) and ventral tegmental area (VTA). Tropisetron alone did not change the number of c-Fos-positive cells, whereas apomorphine increased the number of positive cells in the NAc and DLst. Tropisetron administration followed by apomorphine administration decreased the number of positive cells in the VTA compared with the apomorphine-alone group. These results suggest that tropisetron has an ameliorating effect on the sensorimotor gating deficits via the α7 nAChR, and that one possible site of its action is the VTA.

► Tropisetron ameliorates PPI disruption by apomorphine via α7nAChR. ► The probable site of action of tropisetron is ventral tegmental area. ► Tropisetron suppresses the mesolimbic dopaminergic pathway.

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