Advances, during the period 1995–2012, in the chemistry of oxiranes (epoxides) and oxirenes fused to other ring systems are presented. Particular emphasis is placed on advances in the asymmetric synthesis of ring-fused oxiranes (metallosalen catalyzed, chiral dioxirane, or iminium salt mediated...

A series of novel, non-basic 3-(6-chloronaphth-2-ylsulfonyl)aminopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating an alanylamide P4 group, was designed and synthesised. Within this series, the N-2-(morpholin-4-yl)-2-oxoethyl derivative 24 was shown to be a potent, selective fXa i...

The benzoylamino group was identified as a useful radical cyclization auxiliary that can be smoothly removed on hydro-de-halogenation of chlorinated N-substituted-pyrrolidin-2-ones with Raney-Ni. This methodology was successfully implemented in a new and appealing route to the anti-epileptic dru...

A series of new 1-[3-(4-arylpiperazinyl-1-yl)-2-(N-alkylcarbamoyloxy)propyl]-pyrrolidin-2-one derivatives (4a–12a) were synthesised and tested for their electrocardiographic, antiarrhythmic and antihypertensive activity, as well as for the α1- and α2-adrenoceptor binding affinities. Of the ne...

Different solid state forms of the research chemical fasoracetam, which counters the effects of Alzheimer’s disease, have been subjected to a thermal and structural analysis. Single crystals were obtained from solution evaporation and from the melt. Single-crystal X-ray analyses of the crystals...

The catalytic activity of the [PdCl2(dppp)] complex in the 1-olefin/ethene (E)/CO terpolymerisation has been studied in MeOH (containing 1000 ppm of H2O) as a solvent. The 1-olefins tested were propene (P), 1-hexene (Hex), 1-decene (D) and styrene (S). At 90 °C and 45 atm (E/CO = 1/1), the syst...

The synthesis and characterization of ruthenium compounds of the type [RuCl2(NO)(dppp)(L)]PF6 [dppp = 1,3-bis(diphenylphosphino)propane; L = pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described. The complexes were characterized by elemental analysis, UV/Vis and infr...

Polyketones are obtained by the copolymerization of carbon monoxide and ethylene in the presence of a palladium catalyst formed in situ from Pd(OAc)2, dppp and formic acid in methanol which acted as a solvent. The productivity (g polymer/g Pd* h) is significantly influenced by the concentration ...

The organometallic compound [Pd(C-bzan)(SCN)(dppp)] {bzan = N-benzylideneaniline, dppp = 1,3-bis(diphenylphosphino)propane} was synthesized and characterized by elemental analyses, infrared and 1H and 31P{1H} NMR spectroscopies. The crystal and molecular structures of the title complex were dete...

The reactions of 1,3-bis(diphenylphosphino)propane (dppp) and 1,10-phenanthroline derivative with Ag salts in the mixed solvent of methanol and dichloromethane generate the corresponding complexes, {[Ag2(dppp)2(phen)2](BF4)2(H2O)2}n (1) (dppp = 1,3-bis(diphenylphosphino)propane), {[Ag2(dppp)2(dm...

The Pd-catalyzed oxidative esterification of benzaldehyde with methanol using organic halides as oxidant agents is reported. Our results demonstrate the crucial role of the ligand in the choice of the oxidant for this reaction. Phenyl bromide can be used as oxidants by using dppp as ligand. On t...

Reactions of [Pt(SeC5H4N)2(P∩P)] with M(OAc)2.2H2O/MX2 (P∩P = dppm, dppp; M = Zn, Cd, Hg, Cu; X = Cl) resulted various products depend upon the nature of the phosphine. In case of dppm, reaction between [Pt(SeC5H4N)2(dppm)] and M(OAc)2.2H2O/MX2 (M = Zn, Cd, Hg) afforded an exchange product of ...

Reductive carbonylation of methanol is a potential process for ethanol production, but the reaction temperature is always higher than 190 °C and reaction pressure higher than 19 MPa. Due to the corrosions of the catalytic system, the reaction conditions, especially the pressure limited commerci...

Density functional theory (DFT) was used to account and evaluate Co(dppp)-catalyzed regioselective intermolecular hydroacylation of 1,3-dienes and benzaldehydes. All species were entirely optimized at the B3LYP/6-31G(d,p) level (LANL2DZ(f) for Co). The calculations suggested this hydroacylation ...

The synthesis of heteroleptic monomeric cationic Rh(I) bis-diphosphine complex [Rh(dppe)(dppp)]Cl (dppe = 1,2-bis-(diphenylphosphino)ethane and dppp = 1,3-bis-(diphenylphosphino)propane) was achieved by reaction between the neutral dimeric complex [Rh2(dppe)2(μ2-Cl)2] and the dppp ligand. The c...

Adrenomedullin 2/intermedin (AM2/IMD) is a member of calcitonin related gene peptide family and an important nitric oxide mediated vasorelaxant in various vascular beds. However, the mechanism of post receptor-interaction is not clear and may differ depending on tissue type and species. In this ...

We have reported previously that calcitonin gene-related peptide (CGRP) exerts hypertrophic effects, defined in the broadest sense as increased mass of protein per cell, in adult rat ventricular cardiomyocytes in vitro. The aim of the present investigation was to determine whether the peptide al...

We found an increase in calcitonin gene-related peptide (CGRP)-like immunoreactivity in motoneurons of rat spinal cord after peripheral axotomy. By means of in situ hybridization histochemistry and Northern blotting, we further demonstrated that this increase was the result of increased levels o...

We examined the expression of α-calcitonin gene-related peptide (α-CGRP) and β-CGRP mRNAs in the rat dorsal root ganglion (DRG) using in situ hybridization histochemistry with oligonucleotide probes. Analysis of autoradiograms showed that α-CGRP mRNA labeled 36.4% of all DRG neurons and β-C...

Expression of the calcitonin gene-related peptide, α-calcitonin gene-related peptide (CGRP), and the homologous β-CGRP were compared in sensory and enteric nerves of the rat. Anatysis of CGRP-like immunoreactivity by cation exchange chromatography and radioimmunoassay showed that in the dorsal...