Use of a directing group in C–H functionalizations, often referred to as chelation assistance, is one of the most reliable methods for achieving highly efficient and highly site-selective reactions. Although a variety of transition metals can be used in directed C–H functionalization reactions...

The functionalization of primary C–H bonds has been a longstanding challenge in catalysis. Our group has developed a series of silylations of primary C–H bonds that occur with site selectivity and diastereoselectivity resulting from an approach to run the reactions as intramolecular processes....

The synthesis, characterization, calculation, photophysical and thermal properties of 2, 9, 16, 23-tetrakis (7-coumarinoxy-4-methyl)-phthalocyanine are reported in this paper. The ground state absorbance suggests that an intramolecular color matching is formed between phthalocyanine and coumarin...

The electronic absorption and fluorescence spectra of coumarin derivative, (S)-(1-((7-hydroxy-2-oxo-2H-chromen-4-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl2-(((9H-fluoren-9-yl)methoxy)cabonylamino)-3-phenylpropanoate have been studied in solvents of different polarities, and the data were used to s...

Photolysis of 9-methyl-10-nitroanthracene in chloroform or methanol produces mainly two products 9-methyl-9-nitrosoanthracen-10-one and 9,10-anthraquinone in about 4:1 ratio under ambient air. The formation of 9-methyl-9-nitrosoanthracen-10-one confirms the proposed excited state rearrangement r...

Imidazo[1,2-b]pyridazine, which has been prepared for the first time, and several of its analogs were submitted to electrophilic substitution, such as halogenation, nitration and sulphonation. NMR data for several imidazo[1,2-b]pyridazines are included and from these conclusive evidence is obtai...

Publisher SummaryThis chapter covers the chemistry of pyridazine and its benzo derivatives; and a useful background review of the chemistry in this area in the period 1982-95 is available. The hydroformlation reaction can be tuned by a suitable choice of catalyst and reaction conditions, thus al...

Publisher SummaryThis chapter focuses on pharmacologically active pyridazine derivatives. This chapter describes that the cardiovascular diseases occupy first place as causa mortis in civilized countries continues to influence strongly the research in the field of bioactive pyridazine derivative...

Publisher SummaryThis chapter discusses the synthetic methods for the synthesis of pyridazine. Numerous syntheses of pyridazines follow the well-known approaches, but there are some significant developments and new methods, such as syntheses of pyridazines by cycloaddition, which have become pow...

Reactions of 6-chloro-4- and 5-hydrazino-2-phenyl-3(2H)-pyridazinones (1–3) with dimethylformamide/phosphorus oxychloride afforded the pyrazolo[3,4-d]pyridazinones (4–6). Concurrently the formation of acyclic 6-chloro-4- and 5-(N, N-dimethylaminomethylidenehydrazino)-2-phenyl-3(2H)-pyridazinon...

Di-O-isopropylidene- and O-methanesulfonyl-protected 1-C-(6-chloro-1,2,4-triazolo[4,3-b]pyridazin-3-yl)pentitols were prepared in three to four steps from d-galactose, d-glucose, d-mannose, and 2,3:5,6-di-O-isopropylidene-α-d-mannofuranose. Acid-catalysed treatment of (1S)- and (1R)-1-C-(6-chlo...

Novel 3,6-disubstituted pyridazines were synthesized by facile method and screened for their vasorelaxant properties utilizing isolated thoracic rat aortic rings. Compounds 8a and 11a exerted potent vasorelaxant activity (IC50 = 198 and 177 μM, respectively) relative to doxazosin mesylate (used...

The results are given in Table 2. The tabulation is arranged by alphabetical order (Ag, Al, Ar, …). This provides ease of use in quickly locating the data by using the chemical formula. The compound name, CAS number, molecular weight, freezing point, boiling point, density, and state are next p...

Crystallization-induced asymmetric transformation was employed to prepare a labile γ-oxo-α-aminoacid (3) with a new stereogenic center in high diastereomeric and enantiomeric purity. Compound 3 was reduced to a stable compound, (2R,1′S)-2-(1′-benzyl-2′-hydroxyethylamino)-4-phenylbutanoic ac...

The combination of [3-[(2S)-2-[(diphenylphosphanyl)oxy]-3-phenoxypropyl]-1-methyl-1H-imidazol-3-ium chloride] with [Ru(η6-arene)(μ-Cl)Cl]2, Ir(η5-C5Me5)(μ-Cl)Cl]2 or [Rh(μ-Cl)(cod)]2, in the presence of KOH/isoPrOH, has been found to generate catalysts that are capable of enantioselectively...

11-Beta-Hydroxysteroid dehydrogenase-1(11β-HSD1) inhibitors are one of the emerging classes of molecules to fight against diabetic complications. A novel series of 4-(1-substituted-1H-1,2,3-triazol-4-yl)-1,4-dihydropyridine derivatives were synthesized and evaluated for their anti-diabetic acti...

Prenylated phenolic compounds are an important class of bioactive natural products. One major in vivo metabolic pathway of these compounds is hydroxylation at terminal methyl of the isoprenyl group. This study aims to identify the P450 isozyme catalyzing this metabolic reaction. In human liver m...

Effect of intravenous infusion of atriopeptin 3 on immediate renal allograft function. Thirty-eight recipients of nineteen pairs of cadaveric kidneys were entered into a double-blind randomized study in which one recipient received a 12-hour intravenous infusion of Atriopeptin III (AP-3), a synt...

Vasopressin, its 1-deamino analog (dAVP), angiotensin II, and phenylephrine, administered intravenously, increased plasma atriopeptin immunoreactivity in chloral hydrate-anesthetized rats. A continuous one hour infusion of either dAVP or phenylephrine caused a sustained elevation in: a) systemic...

Homeostatic regulation of fluid and electrolyte balance is essential for survival. The kidney plays a primary role in determining the composition and volume of body fluids. Although numerous factors which regulate this homeostatic balance have been analysed, the humoral control of sodium excreti...