Crystal structure of the new ternary antimonide Y3Ni6Sb5 was investigated using X-ray single crystal data: own type of structure, space group P21/m, a = 1.06358(6) nm, b = 0.42030(3) nm, c = 1.26520(9), β = 113.326(3)°, Z = 2, RF = 0.055, wRF = 0.063 for 1341 independent reflections and 98 var...

Fast proton transport materials are of high interest for their application in diverse fields and devices like electrochemical sensors, fuel cells, capacitors, electrochromic devices and electrochemical reactors. This work shows inorganic solid proton conducting composites prepared with phosphotu...

Transformation of renewable biomass into chemicals has attracted much attention recently. Efficient catalytic dehydration of biomass-derived sorbitol into isosorbide over solid acid catalysts under moderate reaction conditions is still a technical challenge. A series of silver-exchanged phosphot...

Novel polyelectrolytes complex (PEC)/11-phosphotungstic acid hydrate (PW11) hybrid membranes (PEC/PW11) were prepared by blending sodium alginate (SA) and gelatin (GE), followed by incorporating with PW11, and then crosslinking by γ-Glycidoxypropyltrimethoxysilane (GPTEOS). Structures of the me...

Phosphotungstic acid (HPW) was immobilized on a sulphonic-acid-functionalized SBA-15 mesoporous molecular sieve through a one-step hydrothermal synthesis method, using non-ionic surfactant pluronic P123 as a structure-directing agent in acidic media, tetraethoxysilane (TEOS) as a silicon source ...

The selective condensation of 2-methylfuran and furfural to C15 compounds is performed using supported phosphotungstic acid catalysts in a continuous-flow fixed-bed reactor. The formation of unwanted viscous tetramers (C20) is suppressed when the continuous-flow reaction system is used. Stronger...

The dehydration of fructose to 5-hydroxymethylfurfural (HMF) is a way to produce a very versatile intermediate of the green chemistry. Heteropolyacid compounds are acid catalysts with singular properties (strong acidity and well-defined structure). This paper aims to analyze the activity of phos...

Combination therapy with the use of fixed-dose combinations (FDCs) is evincing increasing interest of prescribers, manufacturers and even regulators, evidently due to the primary benefit of improved patient compliance. However, owing to potential of drug-drug interaction, FDCs require closer scr...

ObjectiveSublingual tablets of Losartan Potassium were prepared to improve its bioavailability, to avoid pre-systemic metabolism in the gastrointestinal tract and hepatic first pass elimination.

The purpose of this study was to investigate the effect of polymer and surfactant concentration on drug loading and in vitro drug release of micro particulate drug delivery system of Losartan potassium (LST). Microparticles were prepared by O/O solvent emulsification method. A 32 full factorial ...

This paper describes an environmentally friendly procedure for the determination of losartan potassium (Los-K) in pharmaceuticals. The photometric method was based on the light scattering effect due to particles suspension, which were formed by the reaction of Los-K with Cu (II) ions. The method...

The work was aimed at investigating the influence of diffusion of basis functions on the geometry optimization of molecule of losartan in acidic and salt form. Spectroscopic properties of losartan potassium were also calculated and compared with experiment. Density functional theory method with ...

ABSTRACTEstimation of metabolite data as a supportive evidence of comparable therapeutic outcome is recommended by various guidance documents. However, a consensus on using it solely to establish bioequivalence (BE) is lacking as parent drug is believed to detect pharmacokinetic differences betw...

The project was aimed to achieve biphasic pulsed drug release of losartan potassium by fabricating ‘Tabs in cap’ system wherein drug loaded tablets sandwiched the erodible guar gum time spacer tablet. The system was capsulated in non biodegradable body capped with water soluble cap. The system...

BackgroundThe main objective of the present investigation is to design controlled release microcapsules of losartan potassium using Eudragit S100 as a release rate retarding polymer.

PurposeThe goal of this study was to compare the efficacy and safety of fixed-dose combinations of amlodipine/losartan potassium/chlorthalidone (A/L/C) and A/L in Korean patients with stage 2 hypertension inadequately controlled by A/L.

Losartan potassium is an antihypertensive drug in the angiotensin II receptor antagonist (ARA) class. Some studies claim that, in addition to regulating blood pressure, this class of drug has anticancer properties. The objective of this study was to evaluate the genotoxic and antigenotoxic poten...

Production of zinc borate from boric acid was investigated in aqueous media. Zinc oxide and zinc borate are used as seed crystal to convert all the zinc oxide and to get a high reaction rate. The effect of some parameters such as temperature, stirring speed, H3BO3-to-ZnO ratio, % seed crystal/(H...

Two pure zinc borates with microporous structure 3ZnO·3B2O3·3.5H2O and 6ZnO·5B2O3·3H2O have been synthesized and characterized by XRD, FT-IR, TG techniques and chemical analysis. The molar enthalpies of solution of 3ZnO·3B2O3·3.5H2O(s) and 6ZnO·5B2O3·3H2O(s) in 1 mol · dm−3 HCl(aq) were...

Boric acid and kieserite were prepared from low-grade ascharite by sulfuric acid method. This method results in the recovery of 71.06% and 45.03% for boric acid and kieserite, respectively. Meanwhile, the boric acid was precipitated from the filtrate at low temperature and the solution was recyc...