The reactivity of the yttrium trichloride complex [Cl3Y{(μ3-NH)3Ti3(η5-C5Me5)3(μ3-N)}] (2) with a variety of main-group metal cyclopentadienyl reagents [M(C5H3R1R2)] (M = Li, Na, K, Tl) or [Mg(C5H5)2] has been investigated. Treatment of 2 with one equivalent of [Na(C5H5)] or [K(C5H4SiMe3)] gi...

Reduction of ansa-titanocene dichlorides [X(η5-C5H4)2TiCl2] (X = SiMe2 (1) and CMe2 (2)) in tetrahydrofuran (THF) by preactivated magnesium in the presence of bis(trimethylsilyl)acetylene (BTMSA) yielded complexes [X(η5-C5H4)2Ti(η2-BTMSA)] (X = SiMe2 (3) and CMe2 (4)). The prolonged action of...

The He(I) photoelectron spectra have been obtained for a series of bis(η5-cyclopentadienyl)titanium dihalide complexes (C5H5-n(CH3)n)2TiCl2 (n = 0, 1, 3, 4, 5) and (C5H5-n(CH3)n)2(TiBr2 (n = 0, 1, 3). From the progressive displacements of the photoionization bands upon methylation it follows th...

The reactivity pattern of the 16-electron species [M(Cp)2Cl2] (M = Zr, Hf; Cp− = η5-C5H5−) and [Ti(MeCp)2Cl2] (MeCp− = η5-C5H4CH3−) towards the dipicolinate(−2) (dipic2−) ligand under mild (ambient temperature) and convenient (aerobic reactions, aqueous media) conditions have been investigated...

The paramagnetic compounds exo,exo-bis(η5-isodicyclopentadienyl)chlorotitanium(III) (3) and its analogue with trimethylsilyl-substituted isodicyclopentadienide (isodiCp) ligand (4), and the similar pair of diamagnetic exo,exo-bis(isodicyclopentadienyl)[η2-bis(trimethylsilyl)ethyne]titanium(II)...

ObjectiveThe β-cell metabolism of glucose and of some other fuels (e.g. α-ketoisocaproate) generates signals triggering and acutely amplifying insulin secretion. As the pathway coupling metabolism with amplification is largely unknown, we aimed to narrow down the putative amplifying signals.

Oxidation of N-acyl- and N-methanesulfonyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ols (7) with lead tetraacetate in dichloromethane produced quantitatively title compounds (o-QAs) (8). Treatment of N-trifluoroacetyl and N-formyl o-QAs (8a,b) with acetic acid at 30–40°C afforded N-trifluoroa...

A new organic compound 3, 5-diethyl-2, 6-di(4-methoxyphenyl)-4-oxopiperidinium chloride (DMOC) was synthesized and its crystals were grown from an ethanolic solution adopting slow evaporation solution growth technique. The structure of the grown crystal was analyzed by single crystal X-ray diffr...

The diastereoselective hydrogenation of o-toluic acid or o-methoxy benzoic acid covalently bound to different chiral auxiliaries was performed on Rh and Ru supported catalysts. The cis-isomers were formed predominantly, with a diastereoselectivity largely influenced by the structure of the chira...

Oxidation of 2-alkoxy-3,4-dihydro-2H-pyrans 3 with dimethyldioxirane or MTO/urea–H2O2 followed by Jones oxidation leads to rearrangement and stereocontrolled formation of 4,5-cis-disubstituted tetrahydrofuranones. The method is applied to the synthesis of the whisky lactone 9, cognac lactone 10...

Publisher SummaryThis chapter provides an overview of structure, screening, detection, and isolation methods for saframycins and isoquinolines. Mimosamycin is produced by Streptomyces lavendulae and detected by thin layer chromatography (TLC) of the solvent layer of the fermentation beer. Naphth...

The complete relative and absolute configurations of (+)-thiazinotrienomycin E, a potent new ansatrienin cancer cell growth inhibitory agent, have been determined via degradation and chemical correlation.

The effects of oral dipyridamole administration (150 mg) on coronary hemodynamics, myocardial metabolism, and pacing threshold were studied in 10 patients with significant coronary artery disease (CAD). Following dipyridamole through 120 minutes, there was no significant change in resting heart ...

Dipyridamole, in relatively low doses, when used in combination with aspirin was shown to be effective in normalizing reduced platelet survival seen in patients with prosthetic heart valves, whereas either drug, when tested alone, was ineffective. To determine whether this combined drug effect w...

The effects of dipyridamole on the metabolism of adenosine were studied in human whole blood. The half-life for adenosine disappearance and the formation of deamination and phosphorylation products were determined by adding [3H]adenosine to blood incubating at 37°C. The initial adenosine concen...

Publisher SummaryDipyridamole is an adenosine reuptake inhibitor and a phosphodiesterase inhibitor with antiplatelet and vasodilating activity. One of these is through the inhibition of phosphodiesterase enzyme in platelets, resulting in an increase in intraplatelet cyclic AMP and the consequent...

The resolving power of spectrophotometric assisted mathematical techniques were demonstrated for the simultaneous determination of perindopril arginin (PER) and amlodipine besylate (AML) in presence of their degradation products. The conventional univariate methods include the absorptivity facto...

A systematic review identified 86 outcome–based clinical trials involving perindopril, amlodipine, or other antihypertensive drugs. In fixed–effects meta–analyses of 11 clinical trials (90,208 subjects), amlodipine was associated with a significant 24% increase in heart failure, but a signifi...

Approximately 25% of US adults have high blood pressure (BP). Selection of effective and safe antihypertensive therapy for these individuals is an important health-care priority. High BP can be treated with a wide range of antihypertensive agents from a number of different classes. These drugs m...

The molecular structure of the antihypertensive drug perindopril (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2 carboxylic acid), its active metabolite perindoprilat ((2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-carboxybutyl]amino]propanoyl]-2,3,3...