The third-order nonlinear optical response of fullerene C84 (isomeric mixture as obtained from fullerenic soot) and its isomer C84–D2d (II) dissolved in toluene were studied using nanosecond and picosecond laser pulses employing the Z-scan and the Optical-Kerr-effect techniques. The nonlinear a...

The cyclic water-trimer encapsulations into D2(22)-C84 fullerene are evaluated. The encapsulation energy is computed at the M06-2X/6-31++G∗∗ level and it is found that the trimer storage in C84 yields the potential-energy gain of 10.4 kcal/mol. The encapsulated trimer can have two different form...

An isomer of C84 fullerene, D3d-C84(24)(CF3)12, has been isolated by the HPLC method from the products of trifluoromethylation of C84 fullerene mixture. Its molecular structure has been determined by a single crystal X-ray diffraction using synchrotron radiation. In the addition pattern, 12 CF3 ...

The synthesis and characterization of novel homochiral oligomacrocycle species composed of enantiomerically-pure tetraphenylene were described. Structural studies showed that the macrocyclic molecule possessed a helical chiral cavity, which exhibited unique and efficient recognition affinity tow...

The trifluoromethylation of a higher fullerene mixture followed by the HPLC separation of CF3 derivatives resulted in the isolation of C76(CF3)14, C76(CF3)16 and C76(CF3)18 (two isomers), the crystal and molecular structures of which were determined by X-ray diffraction with the use of synchrotr...

Very recently, two novel monometallic cluster fullerenes [email protected]s(6)–C82 and [email protected]2(5)–C82 are prepared and characterized, respectively. Inspired by these findings, the possibility of encapsulating MCN (M = Sc, Y) cluster in the C76 fullerene has been performed using dens...

A novel capillary zone electrophoresis (CZE) assay method was developed to evaluate the systemic disposition of [d-pen2,5]enkephalin (DPDPE) in rats. DPDPE was recovered from serum samples (200 μl) by solid-phase extraction. Complete resolution of DPDPE and the internal standard ([d-ser2]leucin...

Capillary zone electrophoresis (CZE) has been applied to qualitative and quantitative analysis and separation of synthetic analogues and fragments of enkephalins ([Leu5]enkephalin, H-Tyr-Gly-Gly-Phe-Leu-OH, [Met5]enkephalin, H-Tyr-Gly-Gly-Phe-Met-OH), and dalargin (H-Tyr-d-Ala-Gly-Phe-Leu-Arg-OH...

Tetrahydroisoquinolines (TIQs) are endogenous alkaloid compounds deriving from the non-enzymatic Pictet–Spengler condensation of catecholamines with aldehydes. These compounds are able to unsettle catecholamines uptake and release from synaptosomes and have been detected in urine and in post-mo...

Four novel Schiff bases 4-(2,4-dinitrobenzylideneamino)-5-m-tolyl-2H-1,2,4-triazole-3(4H)-thione) (F1), 4-(2,4-dinitrobenzylideneamino)-5-(2-methoxyphenyl)-2H-1,2,4-triazole-3(4H)-thione) (F2), 4-(2,4-dinitrobenzylideneamino)-5-(3-methoxyphenyl)-2H-1,2,4-triazole-3(4H)-thione) (F3) and 4-(2,4-di...

The selenic hydrogen bonded salt Bis(5-amino-3-carboxy-1H-1,2,4-triazol-4-ium) selenate dihydrate (BACTSe) has been synthesized and characterized by XRD, FT-IR and FT-Raman techniques. It crystallizes in the C2/c space group and displays a three-dimensional framework stabilized mainly via interm...

In vitro anti-mycobacterial activities of novel 4-amino-5-alkynylpyrimidine-2(1H)-ones were investigated. 4-Amino-5-heptynylpyrimidine-2(1H)-one (3) and 4-amino-5-(2-phenylethynyl)pyrimidine-2(1H)-one (7) displayed potent in vitro activity against Mycobacterium bovis and Mycobacterium tuberculos...

This work described a novel and efficient synthesis of 3-amino-4-cyano-5-phenyl-1H-pyrrole-2-carboxamides. The synthesis was carried out via a simple three-component reaction between arylidenmalononitrile, malononitrile and hydroxylamine hydrochloride in solvent-free conditions. Short reaction t...

Analysis of the 1H and 13C NMR spectra of the labeled hemiacetal [3a,8a-13C2]1 showed that this compound exists in solution in equilibrium with the benzopyran derivative 2. This equilibrium was exploited for an alternative preparation of the furo[2,3-b]benzofuran fragment present in aflatoxins.

Lophirone A, isolated as a new type of biflavonoid-related inhibitor of Epstein-Barr virus (EBV) activation, was tested for further inhibitory properties against tumor promotion by short-term systems. Lophirone A (200 μg) significantly inhibited inflammation of mouse ear (inhibitory effect (IE)...

In order to discovery autotaxin (ATX) and EGFR dual inhibitors with potential therapeutic effect on IPF-LC, a series of novel tetrahydropyrido[4,3-d]pyrimidine derivatives possessing semicarbazones moiety were designed and synthesized. The preliminary investigation at the cellular level indicate...

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease with a dismal prognosis and a largely unknown etiology. Autotaxin (ATX) is a secreted lysophospholipase D, largely responsible for extracellular production of lysophosphatidic acid (LPA), a bioactive phospholipid. LPA has nu...

Autotaxin (ATX) is a potential target for the treatment of various cancers. A new series of ATX inhibitors was rationally designed and synthesized based on our previous study. Biological evaluation and structure-activity relationship (SAR) of this series are discussed. Among fourteen synthesized...

During a survey of mushroom-beds in Apulia and Basilicata (southern Italy), several bacterial strains belonging to the fluorescent pseudomonads group have been isolated from the basidiomata of Pleurotus eryngii on account of symptoms of yellowing. On the basis of LOPAT tests, 95% of the recovere...

SummaryA sharply defined white line in vitro forms between the pathogenic form of Pseudomonas tolaasii and another Pseudomonas bacterium, referred to as “reactans”. This interaction has been considered as highly specific. However, results presented in this study rise doubt about the strict spe...