Claisen condensation and consecutive reduction of 3-methoxyestra-1,3,5(10)-trien-17-one theoretically leads to four diastereomers of 17-hydroxy-16-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene and their further transformations give different compounds with different biological activities. High-p...

Reducing agents are crucial for the management of maladaptive inflammation-induced macrophage death and hematopoietic toxicity of chemotherapy. 2-O-β-d-glucopyranosyl-l-ascorbic acid (AA-2βG), a unique AA (or vitamin C) derivative identified in Lycium barbarum, exhibited enhanced free radical ...

Highly variable synthetic routes were elaborated toward trisubstituted C-glycopyranosyl 1,2,4-triazoles. N-Acyl-thioamide derivatives were obtained by acylation of O-perbenzoylated 2,6-anhydro-d-glycero-d-gulo-heptonothioamide by acid chlorides and of thioamides by O-perbenzoylated 2,6-anhydro-d...

Three new acyl glycosides with rare β-d-apiofuranosyl-(1 → 2)-[β-d-apiofuranosyl-(1 → 6)]-β-d-glucopyranosyl moieties, 2-O-[2,6-O-bis(5-O-syringoyl-β-d-apiofuranosyl)-β-d-glucopyranosyl]-isopropyl alcohol (1), 1-O-[2,6-O-bis(5-O-syringoyl-β-d-apiofuranosyl)-β-d-glucopyranosyl]-isoamyl a...

Annulated C-β-d-glucopyranosyl heterocycles were synthesized and tested as inhibitors of glycogen phosphorylase. 2-(β-d-Glucopyranosyl)-1H-imidazo[4,5-b]pyridine was formed by ring-closure of O-perbenzoylated C-β-d-glucopyranosyl formic acid with 2,3-diaminopyridine in the presence of triphen...

The mass spectra of twenty-four 3-phenylisothiazoles and three 3-(halophenyl)isothiazoles are reported and discussed. Their common features are the prominent molecular ions and the diagnostic fragment ions arising from cleavages of the NS or SC(5) bonds, eliminations of the side chains and f...

Reduction of 1-(2-nitro-4-R-phenyl)-1H-benzimidazoles with tin(II) chloride in an acidic water–alcohol medium is accompanied by unusual recyclization of 1-(2-amino-4-R-phenyl)-1H-benzimidazoles formed at the first stage into isomeric 1-(2-aminophenyl) - 5-R-1H-benzimidazoles.

Synthesis and structural assignment of four trigonal planar copper(I) complexes (1a–4a) having the general formula [Cu(CH3OCONHCSNHR)2Cl] where R = 2-methoxyphenyl (1), 4-methoxyphenyl (2), 2-chloro 4-nitrophenyl (3) and 2-methoxy 4-nitrophenyl (4) have been described. The characterization were...

We initiated our structure-activity relationship (SAR) studies for novel ACC1 inhibitors from 1a as a lead compound. Our initial SAR studies of 1H-Pyrrolo[3,2-b]pyridine-3-carboxamide scaffold revealed the participation of HBD and HBA for ACC1 inhibitory potency and identified 1-methyl-1H-pyrrol...

ResumeLes CMI de 5 antibiotiques du groupe des nitroimidazoles (Métronidazole, Tinidazole, Ornidazole, Nimorazole et Ternidazole) ont été déterminées par une méthode de dilution en milieu liquide vis-à-vis de 16 souches de Clostridium perfringens type A. Les CMB ont été obtenues par rep...

ABSTRACT:The solid-state properties of antiprotozoal ternidazole (3-(2-methyl-5-nitroimidazol-1-yl)-propan-1-ol) have been studied. Crystals are triclinic in the temperature interval between 100 and 333 K (melting point) with two different molecular conformations present in the asymmetric unit (...

The standard (p∘ = 0.1 MPa) molar enthalpies of combustion, ΔcHm∘, for crystalline 2-, 4-, 6-chloroquinoline and 4,7-dichloroquinoline were determined at the temperature 298.15 K using a rotating-bomb combustion calorimeter. The standard molar enthalpies of sublimation, ΔcrgHm∘, at T =  298...

The binary europium complex EuL3 (L=4-tert-butylbenzoate) and ternary europium complexes EuL3TTA0.1 (TTA=2- thenoyltrifluoroacetone), EuL3DBM0.5 (DBM=dibenzoylmethane) and EuL3phen0.5 (phen=1, 10-phenanthroline) were synthesized. The poly(methyl methacrylate) (PMMA) or copolymer of methyl methac...

dl-Thioctic acid (DLTA) coated magnetite (Fe3O4) NP's have been prepared by the co-precipitation of iron oxide in the presence of DLTA. The product identified as magnetite, which has an average crystallite size of 7 ± 2 nm as estimated from X-ray line profile fitting. Particle size was est...

The standard (po=0.1 MPa) molar enthalpies of combustion at 298.15 K were measured by static-bomb calorimetry and the standard molar enthalpies of sublimation at 298.15 K were measured by microcalorimetry for three benzylidene t-butylamine N-oxide derivatives and for 4-nitrobenzylidine t-butylam...

The equilibria and kinetics of the reactions of [UO2]2+ with heptane-2,4,6-trione (H2hto), 1-phenylhexane- 1,3,5-trione (H2phto) and 1,5-diphenylpentane-l,3,5-trione (H2dppto) have been investigated in methanol-water (70:30 vol./vol.) solution at 25 °C and ionic strength 0.5 mol dm−3. A mechani...

The equilibria and kinetics of the reactions of iron(III) with heptane-2,4,6-trione (H2hto), 1-phenylhexane- 1,3,5-trione (H2phto) and 1,5-diphenylpentane-l,3,5-trione (H2dppto) have been investigated in methanol-water (70:30 vol./vol.) solution at 25 °C and ionic strength 0.5 mol dm−3. The hyd...

The kinetics of the reactions of copper(II) with heptane-2,4,6-trione (H2hto), 1-phenylhexane-1,3,5-trione (H2phto) and 1,5-diphenylpentane-1,3,5-trione (H2dppto) in methanol-water (70:30 vol./vol.) solution at 25 °C and ionic strength 0.5 mol dm−3 have been investigated. The equilibrium consta...

In an attempt to convert the carcinogenic benzene which is almost restricted for its use in gasoline, alkylation reaction with olefin 1-hexene has been conducted on various zeolites. Four zeolites having different pore topology and pore size have been applied as solid acid catalysts for effectiv...

Controlled chlorination of trifluoromethoxybenzene produced the mono-, di-, tri-, and tetrachloro derivatives. Two isomers were detected at each level of substitution. Exhaustive chlorination and bromination of 1,3- and 1,4-bis(trifluoromethoxy)-benzene yielded isomeric mixtures of only the disu...