Extensive employment of plant resins and propolis, as an antiseptic agents dating from ancient times in numerous cultures indicating that it may have antimicrobial and other biological properties. Resins from deciduous trees from the Populus and Salix genera, several fruit trees from the genus P...

Salt stress is one of the key abiotic stresses threatening future agricultural production and natural ecosystems. This study investigates the salt stress response of two rice seedlings, which were screened from 28 Kenya rice cultivars. A proteomic analysis was carried out and Mapman bin codes em...

The development of a practical and efficient synthesis of a novel PPAR α/γ dual agonist, (S)-2-(((3-fluoro-4-methylphenoxy)carbonyl)(1-(4-((5-methyl-2-phenyloxazol-4-yl)methoxy)phenyl)ethyl) amino)acetic acid (1), is described. Development of a stereoselective synthesis of the (S)-4-(1-aminoet...

Physical features, bioactive compounds and total antioxidant capacity (TAC) of coloured quinoa varieties (Chenopodium quinoa Willd.) from Peruvian Altiplano were studied. Quinoa seeds did not show a pure red colour, but a mixture which corresponded to different fractal colour values (51.0–71.8)...

Two chiral diarylmethylamines with a phenolic hydroxy group at their ortho positions (1c and 1d) were synthesized, and their direct enantioseparation via diastereomeric salt formation was investigated. Crystallographic analyses of the diastereomeric salts involving 1c were conducted: water molec...

New bromotyrosine-derived alkaloids, purealidins B (1) and C (2), have been isolated from the Okinawan marine sponge Psammaplysilla purea and their structures elucidated on the basis of spectroscopic data. Purealidin B (1) showed antibacterial activity, while purealidin C (2) exhibited antifunga...

Purealidin D, a new alkaloid possessing a pyridinium and a bromotyrosine moiety was isolated from the Okinawan marine sponge Psammaplysilla purea and the structure elucidated on the basis of spectroscopic data.

The efficient synthesis of four benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-ω-iodoalkanoates {benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-3-iodopropanoate, benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-4-iodobutanoate, benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-5-iodopentanoate, benzyl 2-(S)-[(tert-buto...

A series of homochiral organometallic NADH mimics incorporating the chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)] at the C-3 carbonyl and a chiral carboxamide at C-5 of a 1,4-dihydronicotinoyl fragment have been prepared. These complexes were shown to stereoselectively reduce ethyl benzoylformate to...

Porcine hemagglutinating encephalomyelitis virus (PHEV) is a typical neurotropic virus that can cause obvious nerve damage. Integrin α5β1 is a transmembrane macromolecular that closely related to neurological function. We recently demonstrated that integrin α5β1 plays a critical role in PHEV...

A series of novel N-phenyl-2-(2-((4-phenyl piperazin-1-yl) methyl)-1H-benzo [d] imidazol-1-yl) acetamides (7a-o) have been synthesized in multiple steps with suitable reaction procedures and well characterized by various analytical techniques. All the synthesized compounds were evaluated for the...

2-(Quinolin-4-yloxy)acetamides have been described as potent and selective in vitro inhibitors of Mycobacterium tuberculosis (Mtb) growth. Herein, a new series of optimized compounds were found to demonstrate highly potent antitubercular activity, with minimum inhibitory concentration (MIC) valu...

Glibenclamide is widely used in the management of non-insulin dependent diabetes mellitus, but numerous risks limit its use in therapy. In the search for novel structures that are safer and more efficient than glibenclamide, we obtained new chemical analogs based on bioisosterism, through the tr...

Described in this paper is the biosynthesis of defensive drimanes in dorid nudibranchs. Two geographically distinct populations of molluscs belonging to the genus Dendrodoris have been studied. The de novo synthesis of 7-deacetoxyolepupuane (2) has been demonstrated by radiolabelled precursors i...

A new series of push–pull azo-dyes containing tricyanodiphenyl electron-withdrowing block, namely (4-N,N-dialkylaminophenyl)azobiphenyl-2,3’,4’-tricarbonitriles, was proposed and synthesized. The azo-dyes possess high temperature stability and are prone to form polymorph modifications. DSC me...

A gravimetric method was used to measure the solubility of the 4-(4-Aminophenyl)-3-morpholinone under atmospheric pressure in 1,4-dioxane, methanol, tetrahydrofuran, ethanol, ethyl acetate, n-propanol as well as in the (1,4-dioxane + ethyl acetate) binary mixtures from T = (278.15 to 333.15) K. ...

Water-soluble CuInS2 ternary quantum dots (QDs) capped by mercaptopropionic acid were directly synthesized in aqueous solution. Consequently, the CuInS2 QDs were covalently linked to 3-aminophenyl boronic acid molecules to form the 3-aminophenyl boronic acid-functionalized CuInS2 QDs (F-CuInS2 Q...

The chalcone compound (2E)-1-(4-aminophenyl)-3-phenyl-prop-2-en-1-one of chemical formula C15H13NO was synthesized and structurally characterized using Nuclear Magnetic Resonance (NMR). The spectroscopy investigation has been carried out by Fourier Transform Raman (FT-Raman), Fourier Transform i...

Density functional calculations were performed on N,N′-bis(3′-carboxy,4′-aminophenyl)-1,4-quinonediimine, a carboxylic acid substituted aniline trimer. Results of the calculations were compared to experimental properties of the herein synthesized trimer, as well as to the properties of the an...

In the present work, we report convenient methods for the synthesis of 3-(4-aminophenyl)-coumarin-7-O-sulfamate derivatives N-acylated with fluorinated analogues of benzoic or phenylacetic acid as steroid sulfatase (STS) inhibitors. The design of these potential STS inhibitors was supported by m...