For integers k,r>0, a (k,r)-coloring of a graph G is a proper coloring on the vertices of G with k colors such that every vertex v of degree d(v) is adjacent to vertices with at least min{d(v),r} different colors. The r-hued chromatic number, denoted by χr(G), is the smallest integer k for whic...

SummaryIn the present study, the compatibility between bisoprolol fumarate and selected excipients (ascorbic acid, citric acid anhydrous, butylated hydroxyanisole, polyvinylpyrrolidone, glycerol, mannitol and sorbitol) in mixtures (1:10 ratio of drug and excipient) was investigated by subjecting...

HPLC analysis of drug products containing bisoprolol fumarate and lactose revealed the presence of N-formylbisoprolol, which is a final product of the Maillard reaction. Formulations containing secondary amines and reducing carbohydrates are prone to the condensation of amine and carbonyl functi...

ObjectivesThe purpose of the study was to develop sustained release tablets containing bisoprolol fumarate and an innovative combination of Precirol ATO5 and hydroxypropyl methylcellulose, in order to conclude upon: properties of pharmaceutical tablet formulations, drug-excipients interactions, ...

2,6-Dideoxy-7-O-(β-d-glucopyranosyl) 2,6-imino-d-glycero-l-gulo-heptitol (7-O-β-d-glucopyranosyl-α-homonojirimycin, 1) was isolated from the 50% methanol extract of the whole plant of Lobelia sessilifolia (Campanulaceae), which was found to potently inhibit rice α-glucosidase. Adenophorae ra...

1.1. In isolated rat aortic rings, leminoprazole (2-[2-N-methyl-N-(2-methylpropyl)amino] benzylsulfinyl benzimidazole) (10−6-10−4 M) inhibited contractile responses to phenylephrine (PE), KCl and Ca2+ in KCl-depolarized tissues in a Ca2+ free medium. Leminoprazole also relaxed the aorta contract...

Metal binding has been suggested to be relevant in the antifungal and antibacterial mechanism of histatin 5, a human salivary protein. Proton nuclear magnetic resonance (NMR) spectra were obtained to investigate the specificity of metal binding to the seven histidyl, one aspartyl and one glutamy...

Histatin 5 is a cationic salivary peptide with strong candidacidal and bactericidal activity at physiological concentration. In this paper we demonstrate by optical spectroscopy and ESI-IT-MS experiments that a synthetic peptide related to the N-terminus of histatin 5 specifically binds copper i...

Histatins are small histidine-rich salivary polypeptides which exhibit antimicrobial activity against Candida albicans. This antimicrobial activity has been ascribed in part to a high content of basic amino acids. However, unlike most other antimicrobial proteins histatins have a high content of...

Histatin 5 is a low molecular weight salivary protein which is known to exhibit inhibitory activity against several proteinases, including the cysteine proteinases gingipains. The purpose of this study was to characterize the effect of salivary histatin on the proteolytic activity of the cystein...

SummaryHistatins are human salivary antifungal proteins that are prone to extensive enzymatic degradation upon their release into the oral cavity. Histatin proteolysis, leading to the disappearance of the intact protein can be expected to have functional consequences. Histatin 5, comprising 24 r...

Histatin-5 is a peptide secreted in the human saliva, which possesses powerful antifungal activity. Previous studies have shown that this peptide exerts its candidacidal activity, through the inhibition of both mitochondrial respiration and the formation of reactive oxygen species. The purpose o...

Histatins are a family of human salivary antimicrobial peptides. Histatin-5 (Hst-5, DSHAKRHHGYKRKFHEKHHSHRGY), a prominent member of this family contains an albumin-like, N-terminal Asp-Ser-His sequence, known to bind a Ni(II) ion in a square-planar geometry. Nickel is a strong allergen, and ora...

HypothesisThe adsorption of histatin 5 to hydrophilic silica surfaces is governed by electrostatic attractive forces between the positive protein and the negative surface. Hence pH and ionic strength control the adsorbed amount, which can be described by coarse-grained Monte Carlo simulations ac...

SummaryBackgroundCandidiasis is a major opportunistic fungal infection in humans. The low number of antifungal drugs available to treat Candida infections and the increasing incidence of multidrug resistant (MDR) strains point to an urgent need of identifying new therapeutic options. The role of...

ObjectiveTo study the ultrastructural alterations induced in Streptococcus mutans (ATCC 25175) incubated with saliva, saliva plus histatin 5 and histatin 5.

(−)-(1S,2R,3R,4S)-1,2-Epoxy-1-methyl-4-(1-methylethyl)-cyclohex-3-yl acetate has previously been identified as the active compound of Minthostachys tomentosa responsible for the insecticidal activity against Oncopeltus fasciatus. Its structure was initially assigned on the basis of spectral data...

Two new silicon-based prosthetic groups, derived from 3-[ethoxybis(1-methylethyl)silyl]propanamine, have been prepared in good yields. These silicon groups bearing an acid or an azide group were coupled to a model tripeptide (Leu-Gly-Gly) either through a classical amide bond formation or throug...

Efficient preparations both of 2,3:5,6:3′,4′-tri-O-isopropylidenelactose dimethyl acetal (5, 95% yield) and its 6′-O-(1-methoxy-1-methylethyl) derivative (65% yield), useful intermediates for the conversion of lactose into biologically relevant oligosaccharides, by ‘one-pot’ acetonation pro...

The multiple-effect distillation (MED) technology is nowadays the most promising desalination process to be coupled with variable heat sources, thus leading to a more sustainable way to produce water. In order to prove the potential of this, it is of major interest to develop powerful modelling ...