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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(R)-(+)-1,2-Dithiolane-3-pentanoic acid

Cas:1200-22-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality R(+) Alpha Lipoic Acid supplier in China

Cas:1200-22-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

Our company`s advantages : 1) Specialized in pharmaceutical industrial for 35 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms :LC and T.T 30-60 days. 4) We have warehouse in USA for quickly shipment . 5) We

High quality supplements antioxidant R-alpha lipoic acid powder CAS 1200-22-2

Cas:1200-22-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Kono Chem Co.,Ltd

Product Name: R (+) alpha Lipoic acid Appearance : Pale yellow powder Cas:

CAS:1200-22-2 R-(+)-alpha-Lipoic acid factory sales

Cas:1200-22-2

Min.Order:1 Kilogram

Negotiable

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for R-(+)-Alpha Lipoic Acid Cas 1200-22-2 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Yellow crystalline powder Storage:-20°C Freezer Package:1kg/bag with

High purity R-(+)-Alpha Lipoic Acid Cas 1200-22-2 with factory price

Cas:1200-22-2

Min.Order:1 Kilogram

FOB Price: $300.0 / 500.0

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

99% D-lipoic acid / R alpha Lipoic acid powder CAS:1200-22-2

Cas:1200-22-2

Min.Order:1 Kilogram

FOB Price: $259.0 / 299.0

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:White

(R)-(+)-1,2-Dithiolane-3-pentanoic acid

Cas:1200-22-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply R(+) Alpha Lipoic Acid

Cas:1200-22-2

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% R-(+)-alpha-Lipoic acid 1200-22-2 GMP manufacturer

Cas:1200-22-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing

R)-(+)-α-Lipoic acid I

Cas:1200-22-2

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

R-alpha-Lipoic Acid CAS: 1200-22-2 Molecular Formula: C8H14O2S2 Home Product Category Organic raw materials Organic acid 1200-22-2 1200-22-2 - Names and Identifiers Name R-alpha-Lipoic Acid Synonyms D-lipoic acid

factory supply R-α-Lipoic Acid/(R)-(+)-1,2-Dithiolane-3-pentanoic acid

Cas:1200-22-2

Min.Order:1 Kilogram

FOB Price: $200.0 / 300.0

Type:Trading Company

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

R-Alpha Lipoic Acid

Cas:1200-22-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

(R)-(+)-1,2-Dithiolane-3-pentanoic acid CAS NO.1200-22-2

Cas:1200-22-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(R)-(+)-α-Lipoic acid

Cas:1200-22-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:(R)-(+)-Lipoic acid CAS NO:1200-22-2 Grade:Medical scientific research and export Molecular formula:C8H14O2S2 Molecular weight:206.33 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability

(R)-(+)-Lipoic acid/ CAS:1200-22-2/raw material/ high-quality

Cas:1200-22-2

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing

(R)-(+)-1,2-Dithiolane-3-pentanoic acid CAS:1200-22-2

Cas:1200-22-2

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 1200-22-2 with best quality

Cas:1200-22-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

(R)-(+)-1,2-Dithiolane-3-pentanoic acid

Cas:1200-22-2

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product name R Alpha Lipoic Acid Product alias (R)-Thioctic Acid CAS no 1200-22-2 Molecular formula C8H14O2S2 Molecular weight 206.32600

R-Alpha Lipoic Acid CAS: 1200-22-2

Cas:1200-22-2

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Yellow Powder Storage:Store in sealed containers at cool &

Hangzhou Sartort Biopharma Co., Ltd

Appearance:yellow crystalline solid Storage:-20°C,Keep container tightly closed in a dry and well-ventilated place Package:25kg / drum Application:APIs;Intermediates Transportation:Express/Sea/Air Port:Any port in China

Factory supply R-alpha-Lipoic Acid

Cas:1200-22-2

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

R-(+)-alpha-Lipoic acid 1200-22-2

Cas:1200-22-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

ShangHai Soyoung Biotechnology Inc

Shanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye

L-Lysine thioctate CAS 20902-53-8 R-(+)-ALA-L-Lysine

Cas:1200-22-2

Min.Order:25 Kilogram

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: High quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:light yellow powder Storage:Room temperature Pa

1200-22-2 cas 99% (R)-(+)-1,2-Dithiolane-3-pentanoic acid CAS NO.1200-22-2

Cas:1200-22-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

2-Chloro-3-pyridinamine Clopyridine

Cas:1200-22-2

Min.Order:1 Kilogram

FOB Price: $450.0 / 500.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(R)-(+)-1,2-Dithiolane-3-pentanoic acid CAS:1200-22-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qu

(R)-(+)-1,2-Dithiolane-3-pentanoic acid CAS:1200-22-2

Cas:1200-22-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(R)-alpha-Lipoic acid

Cas:1200-22-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Antioxidant Health Products Alpha Lipoic Acid Powder, High Quality Thioctic Acid, CAS 1200-22-2

Cas:1200-22-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(S)-6,8-dichlorooctanoic acid ethylester

(S)-6,8-dichlorooctanoic acid ethylester

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
Stage #1: (S)-6,8-dichlorooctanoic acid ethylester With sodium sulfide; sulfur In water at 80℃; for 2h;
Stage #2: With water; sodium hydroxide at 80℃; for 8h; Temperature;
99.8%
With sodium sulfide; sulfur
Stage #1: (S)-6,8-dichlorooctanoic acid ethylester With sodium sulfide; sulfur In water at 82℃; for 4.5h;
Stage #2: With water; sodium hydroxide In toluene at 92℃; for 8h; pH=1; Solvent; Temperature;
n/a
(+)-isopropyl lipoate
97961-65-4

(+)-isopropyl lipoate

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With water; potassium carbonate In methanol at 22℃; for 40h;96%
(R)-6,8-dichloroctanoic acid
188412-21-7

(R)-6,8-dichloroctanoic acid

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With sodium sulfide; N-benzyl-N,N,N-triethylammonium chloride; sulfur In water at 85℃; Reagent/catalyst; Temperature;92.1%
C8H14O2S2*C7H9NO

C8H14O2S2*C7H9NO

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With citric acid In methanol; toluene at 35 - 40℃; for 3h; Temperature; Darkness; Industrial scale;83.1%
[ethyl (5R)-5-(1,2-dithiolan-3yl)pentanoate]
104726-74-1

[ethyl (5R)-5-(1,2-dithiolan-3yl)pentanoate]

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide In ethanol for 24h; Ambient temperature;75%
With potassium hydroxide In ethanol at 20℃; for 24h;75%
With potassium hydroxide In ethanol at 20℃; for 24h;75%
hydrolysis;
With sodium hydroxide
(+)-6,8-dichlorooctanoic acid

(+)-6,8-dichlorooctanoic acid

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
Product distribution / selectivity;72%
(R)-5-[1,2-dithiolan-3-yl]pentanoic acid methyl ester
99427-00-6

(R)-5-[1,2-dithiolan-3-yl]pentanoic acid methyl ester

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With potassium hydroxide In methanol for 3h; Ambient temperature;70%
With potassium hydroxide; water for 24h;54%
Stage #1: (R)-5-[1,2-dithiolan-3-yl]pentanoic acid methyl ester With potassium hydroxide In methanol; water at 50℃; for 2h;
Stage #2: With phosphoric acid In methanol; water; toluene at 30℃;
45%
With potassium carbonate In methanol; water
Potassium; (S)-6,8-bis-methanesulfonyloxy-octanoate

Potassium; (S)-6,8-bis-methanesulfonyloxy-octanoate

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
52%
C8H11N*C8H14O2S2

C8H11N*C8H14O2S2

A

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With sulfuric acid In acetone at 15 - 60℃; for 2h; Temperature; Solvent;A 47.5%
B n/a
C8H11N*C8H14O2S2

C8H11N*C8H14O2S2

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With sulfuric acid In acetone at 15 - 40℃; for 24h; Solvent;46%
(S)-6,8-dimethylsulfonyloxyoctane-1-carboxylic acid
107554-84-7

(S)-6,8-dimethylsulfonyloxyoctane-1-carboxylic acid

A

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium sulfide; potassium hydroxide In water; N,N-dimethyl-formamide at 80℃; for 28h; Title compound not separated from byproducts;A n/a
B 45%
6,8-dichlorooctanoic acid ethyl ester
1070-64-0

6,8-dichlorooctanoic acid ethyl ester

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With ammonium hydrogen sulfite; sodium sulfide nonahydrate; sulfur In propan-1-ol; water; isopropyl alcohol at 70℃; for 3.5h; Temperature; Solvent; Reagent/catalyst; Inert atmosphere; Darkness;30.6%
Thioctic acid
1077-28-7, 62-46-4

Thioctic acid

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With cinchonidine salt
(R)-6,8-dimercaptooctanoic acid
119365-69-4

(R)-6,8-dimercaptooctanoic acid

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With iron(III) chloride; potassium carbonate
With chloroform; iodine; potassium iodide
With mushroom tyrosinase
(S)-6,8-dimethylsulfonyloxyoctane-1-carboxylic acid
107554-84-7

(S)-6,8-dimethylsulfonyloxyoctane-1-carboxylic acid

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With sodium sulfide; potassium hydroxide; sulfur 1.) 5 min, 2.) DMF, 80 deg C, 24h; Yield given. Multistep reaction;
(7R,10S)-7-Isopropyl-10-methyl-1,5-dithia-spiro[5.5]undecane
114529-48-5

(7R,10S)-7-Isopropyl-10-methyl-1,5-dithia-spiro[5.5]undecane

A

l-menthone
3391-87-5

l-menthone

B

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
Multistep reaction;
(3S)-6-bromo-1,3-isopropylidendioxyhexane
139685-60-2

(3S)-6-bromo-1,3-isopropylidendioxyhexane

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

1,2-dithiolane-3-pentanoic acid methyl ester
46236-19-5

1,2-dithiolane-3-pentanoic acid methyl ester

A

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With potassium hydroxide In methanol Yield given. Title compound not separated from byproducts;
sodium-salt of/the/ (+)-6,8-dichloro-octanoic acid

sodium-salt of/the/ (+)-6,8-dichloro-octanoic acid

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
With ethanol; sodium disulfide
(6S)-(-)-methyl 6,8-dihydroxyoctanoate
116349-04-3

(6S)-(-)-methyl 6,8-dihydroxyoctanoate

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Et3N / CH2Cl2
2: Na2S; sulphur / dimethylformamide / 24 h / 90 °C
3: K2CO3 / methanol; H2O
View Scheme
Multi-step reaction with 4 steps
1: Et3N / CH2Cl2 / 1 h / 0 °C
2: dimethylformamide; cyclohexane / 4 h / 50 °C
3: H2O; KOH / 6 h / 20 °C
4: FeCl3; air; NaOH / H2O / 3 h / pH 9
View Scheme
Multi-step reaction with 3 steps
1: 92 percent / Et3N / CH2Cl2 / 0.5 h / 0 °C
2: 83 percent / Na2S*9H2O, sulfur / dimethylformamide / 2.42 h / 80 °C
3: 70 percent / aq. KOH / methanol / 3 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1: 98 percent / Et3N
2: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h
3: 54 percent / 0.1M KOH, H2O / 24 h
View Scheme
(S)-6,8-diphenylmethoxyoctanoic acid
116315-78-7

(S)-6,8-diphenylmethoxyoctanoic acid

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.75 g / diethyl ether
2: 87 percent / H2 / Pd/C / ethanol / 5 h / 2585.81 Torr
3: Et3N / CH2Cl2
4: Na2S; sulphur / dimethylformamide / 24 h / 90 °C
5: K2CO3 / methanol; H2O
View Scheme
Multi-step reaction with 5 steps
1: 3percent HCl
2: 95 percent / H2 / 5percent palladium on charcoal / methanol / 1551.4 Torr
3: 98 percent / Et3N
4: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h
5: 54 percent / 0.1M KOH, H2O / 24 h
View Scheme
(6S)-(+)-methyl 6,8-bis(methylsulfonyloxy)octanoate
116349-05-4

(6S)-(+)-methyl 6,8-bis(methylsulfonyloxy)octanoate

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Na2S; sulphur / dimethylformamide / 24 h / 90 °C
2: K2CO3 / methanol; H2O
View Scheme
Multi-step reaction with 3 steps
1: dimethylformamide; cyclohexane / 4 h / 50 °C
2: H2O; KOH / 6 h / 20 °C
3: FeCl3; air; NaOH / H2O / 3 h / pH 9
View Scheme
Multi-step reaction with 2 steps
1: 83 percent / Na2S*9H2O, sulfur / dimethylformamide / 2.42 h / 80 °C
2: 70 percent / aq. KOH / methanol / 3 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h
2: 54 percent / 0.1M KOH, H2O / 24 h
View Scheme
(S)-1-phenylmethoxyoct-7-en-3-ol
116315-75-4

(S)-1-phenylmethoxyoct-7-en-3-ol

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: 85 percent / TBAI; NaH / dimethylformamide / 2 h / 20 °C
2.1: BH3*DMS / tetrahydrofuran / 2 h / 20 °C
2.2: 88 percent / aq. NaOEt; H2O2 / tetrahydrofuran / 2 h / 20 °C
3.1: aq. NaCl2O; NaOCl; TEMPO / acetonitrile; aq. phosphate buffer / 35 °C / pH 6.7
4.1: 1.75 g / diethyl ether
5.1: 87 percent / H2 / Pd/C / ethanol / 5 h / 2585.81 Torr
6.1: Et3N / CH2Cl2
7.1: Na2S; sulphur / dimethylformamide / 24 h / 90 °C
8.1: K2CO3 / methanol; H2O
View Scheme
Multi-step reaction with 8 steps
1: 95 percent
2: 89 percent / diisopentylborane / tetrahydrofuran / 0 °C
3: pyridinium dichromate / dimethylformamide / 0 deg C, then RT, 24 h
4: 3percent HCl
5: 95 percent / H2 / 5percent palladium on charcoal / methanol / 1551.4 Torr
6: 98 percent / Et3N
7: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h
8: 54 percent / 0.1M KOH, H2O / 24 h
View Scheme
(S)-6,8-diphenylmethoxyoct-1-ene
116315-76-5

(S)-6,8-diphenylmethoxyoct-1-ene

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: BH3*DMS / tetrahydrofuran / 2 h / 20 °C
1.2: 88 percent / aq. NaOEt; H2O2 / tetrahydrofuran / 2 h / 20 °C
2.1: aq. NaCl2O; NaOCl; TEMPO / acetonitrile; aq. phosphate buffer / 35 °C / pH 6.7
3.1: 1.75 g / diethyl ether
4.1: 87 percent / H2 / Pd/C / ethanol / 5 h / 2585.81 Torr
5.1: Et3N / CH2Cl2
6.1: Na2S; sulphur / dimethylformamide / 24 h / 90 °C
7.1: K2CO3 / methanol; H2O
View Scheme
Multi-step reaction with 7 steps
1: 89 percent / diisopentylborane / tetrahydrofuran / 0 °C
2: pyridinium dichromate / dimethylformamide / 0 deg C, then RT, 24 h
3: 3percent HCl
4: 95 percent / H2 / 5percent palladium on charcoal / methanol / 1551.4 Torr
5: 98 percent / Et3N
6: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h
7: 54 percent / 0.1M KOH, H2O / 24 h
View Scheme
(S)-6,8-diphenylmethoxyoctan-1-ol
116315-77-6

(S)-6,8-diphenylmethoxyoctan-1-ol

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: aq. NaCl2O; NaOCl; TEMPO / acetonitrile; aq. phosphate buffer / 35 °C / pH 6.7
2: 1.75 g / diethyl ether
3: 87 percent / H2 / Pd/C / ethanol / 5 h / 2585.81 Torr
4: Et3N / CH2Cl2
5: Na2S; sulphur / dimethylformamide / 24 h / 90 °C
6: K2CO3 / methanol; H2O
View Scheme
Multi-step reaction with 6 steps
1: pyridinium dichromate / dimethylformamide / 0 deg C, then RT, 24 h
2: 3percent HCl
3: 95 percent / H2 / 5percent palladium on charcoal / methanol / 1551.4 Torr
4: 98 percent / Et3N
5: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h
6: 54 percent / 0.1M KOH, H2O / 24 h
View Scheme
(S)-methyl 6,8-diphenylmethoxyoctanoate
116315-79-8

(S)-methyl 6,8-diphenylmethoxyoctanoate

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 87 percent / H2 / Pd/C / ethanol / 5 h / 2585.81 Torr
2: Et3N / CH2Cl2
3: Na2S; sulphur / dimethylformamide / 24 h / 90 °C
4: K2CO3 / methanol; H2O
View Scheme
Multi-step reaction with 4 steps
1: 95 percent / H2 / 5percent palladium on charcoal / methanol / 1551.4 Torr
2: 98 percent / Et3N
3: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h
4: 54 percent / 0.1M KOH, H2O / 24 h
View Scheme
ethyl (S)-6,8-dihydroxy octanoate
104726-72-9

ethyl (S)-6,8-dihydroxy octanoate

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / Et3N / CH2Cl2 / 4 h / 0 °C
2: 72 percent / Na2S; S / dimethylformamide / 24 h / 90 °C
3: 75 percent / KOH / ethanol / 24 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: Et3N / CH2Cl2 / 4 h / 0 °C
2: 70 percent / sodium sulfide nonahydrate, sulfur / dimethylformamide / 24 h / 90 °C
3: 75 percent / 1.) 0.1M potassium hydroxide, 2.) 5M HCl / ethanol / 24 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
2: Na2S - S / dimethylformamide / 90 °C
3: hydrolysis
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 4 h / 0 °C
2: sodiumsulfide nonahydrate; sulfur / N,N-dimethyl-formamide / 24 h / 85 - 90 °C
3: potassium hydroxide / ethanol / 24 h / 20 °C
View Scheme
(S)-Ethyl 6,8-Bis(methylsulphonyloxy)octanoate
104726-73-0

(S)-Ethyl 6,8-Bis(methylsulphonyloxy)octanoate

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 72 percent / Na2S; S / dimethylformamide / 24 h / 90 °C
2: 75 percent / KOH / ethanol / 24 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 70 percent / sodium sulfide nonahydrate, sulfur / dimethylformamide / 24 h / 90 °C
2: 75 percent / 1.) 0.1M potassium hydroxide, 2.) 5M HCl / ethanol / 24 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: Na2S - S / dimethylformamide / 90 °C
2: hydrolysis
View Scheme
Multi-step reaction with 2 steps
1: sodiumsulfide nonahydrate; sulfur / N,N-dimethyl-formamide / 24 h / 85 - 90 °C
2: potassium hydroxide / ethanol / 24 h / 20 °C
View Scheme
(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

(R)-6,8-dimercaptooctanoic acid
119365-69-4

(R)-6,8-dimercaptooctanoic acid

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 20℃; for 1h;100%
With 1,4-dihydronicotinamide adenine dinucleotide; porcine heart dihydrolipoamide dehydrogenase at 35℃; Enzyme kinetics;
With sodium borohydrid In water; toluene
dimethylbiguanide
657-24-9

dimethylbiguanide

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

N,N-dimethylimidodicarbonimidic diamide R-(+)-lipoate
959986-37-9

N,N-dimethylimidodicarbonimidic diamide R-(+)-lipoate

Conditions
ConditionsYield
In methanol for 2h; Product distribution / selectivity;100%
In acetonitrile for 0.166667h; Product distribution / selectivity;95%
In acetone for 0.166667 - 0.5h; Product distribution / selectivity;95%
In methanol; acetone for 0.333333h; Product distribution / selectivity;
pyridoxamine
85-87-0

pyridoxamine

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

(3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methanaminium (R)-5-( 1,2-dithiolan-3-yl)pentanoate

(3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methanaminium (R)-5-( 1,2-dithiolan-3-yl)pentanoate

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 2h;100%
In ethanol at 20 - 50℃; for 0.5h;68%
(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

dihydrolipoic acid
462-20-4

dihydrolipoic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium borohydrid; sodium hydrogencarbonate In water100%
With sodium tetrahydroborate; sodium hydrogencarbonate In water at 5 - 20℃; for 1.25h;96.8 mg
(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

(S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-aminium (R)-5-(1,2-dithiolan-3-yl)pentanoate

(S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-aminium (R)-5-(1,2-dithiolan-3-yl)pentanoate

Conditions
ConditionsYield
In tetrahydrofuran for 2h;100%
tropicamide
1508-75-4

tropicamide

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

(R)-5-(1,2-dithiolan-3-yl)pentanoic acid N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide

(R)-5-(1,2-dithiolan-3-yl)pentanoic acid N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide

Conditions
ConditionsYield
In dichloromethane at 20℃; for 4h;100%
tetrahydrozoline
84-22-0

tetrahydrozoline

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

(R)-5-(1,2-dithiolan-3-yl)pentanoate 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazol-1-ium

(R)-5-(1,2-dithiolan-3-yl)pentanoate 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazol-1-ium

Conditions
ConditionsYield
In dichloromethane at 20℃; for 4h;100%
2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

R-lipoic acid tromethamine salt

R-lipoic acid tromethamine salt

Conditions
ConditionsYield
With ethyl acetate at 40℃; for 4h;99.64%
(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

magnesium R-(+)-α-lipoate

magnesium R-(+)-α-lipoate

Conditions
ConditionsYield
With dihydro-(+)-lipoic acid; magnesium methanolate In isopropyl alcohol at 15 - 20℃; for 0.35h; Product distribution / selectivity;98.7%
With magnesium hydroxide In ethanol85%
With magnesium methanolate In methanol; isopropyl alcohol Inert atmosphere;
bethanechol chloride
590-63-6

bethanechol chloride

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

2-(carbamoyloxy)-N,N,N-trimethylpropan-1-aminium (R)-5-(1,2-dithiolan-3-yl)pentanoate

2-(carbamoyloxy)-N,N,N-trimethylpropan-1-aminium (R)-5-(1,2-dithiolan-3-yl)pentanoate

Conditions
ConditionsYield
Stage #1: bethanechol chloride With sodium hydrogencarbonate In methanol at 20℃; for 0.0833333h;
Stage #2: (R)-1,2-dithiolane-3-pentanoic acid In methanol at 20℃; for 16h;
97.6%
3β-hydroxyoleanane-12-en-28-oic acid(6-bromohexyl) ester
1161826-45-4

3β-hydroxyoleanane-12-en-28-oic acid(6-bromohexyl) ester

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

[((5-((R)-1,2-dithiolan-3-yl)pentanoyl)oxy)hexyl]-3β-hydroxyolean-12-en-28-oate

[((5-((R)-1,2-dithiolan-3-yl)pentanoyl)oxy)hexyl]-3β-hydroxyolean-12-en-28-oate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 24h;96%
(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

sodium lipoic acid

sodium lipoic acid

Conditions
ConditionsYield
With sodium ethanolate In ethanol95%
2-(N,N-dimethylamino)ethanol
108-01-0

2-(N,N-dimethylamino)ethanol

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

R-(+)-LA dimethylethanolamine salt
919507-94-1

R-(+)-LA dimethylethanolamine salt

Conditions
ConditionsYield
In ethanol95%
methanol
67-56-1

methanol

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

(R)-5-[1,2-dithiolan-3-yl]pentanoic acid methyl ester
99427-00-6

(R)-5-[1,2-dithiolan-3-yl]pentanoic acid methyl ester

Conditions
ConditionsYield
With sulfuric acid at 78.3℃; for 1h; Dean-Stark;95%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 5h;
With thionyl chloride at 0 - 20℃; for 1h;
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Cooling with ice;
2,3,4,5,6-pentafluorophenol
771-61-9

2,3,4,5,6-pentafluorophenol

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

(R)-perfluorophenyl 5-(1,2-dithiolan-3-yl)pentanoate

(R)-perfluorophenyl 5-(1,2-dithiolan-3-yl)pentanoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25℃; for 19h;95%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide In dichloromethane at 20℃;94%
With dicyclohexyl-carbodiimide In 1,4-dioxane at 0 - 20℃;
Taurine

Taurine

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

N-[(R)-1,2-dithiolane-3-pentanoyl]taurine
874111-37-2

N-[(R)-1,2-dithiolane-3-pentanoyl]taurine

Conditions
ConditionsYield
Stage #1: (R)-1,2-dithiolane-3-pentanoic acid With di(succinimido) carbonate; N-ethyl-N,N-diisopropylamine In acetone at 20℃; for 2h; Darkness;
Stage #2: Taurine With water; N-ethyl-N,N-diisopropylamine In acetone
95%
choline bromide
1927-06-6

choline bromide

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

R-lipoic acid choline ester bromide

R-lipoic acid choline ester bromide

Conditions
ConditionsYield
With 2,6-dimethylpyridine; 1,1'-carbonyldiimidazole In 1,2-dichloro-ethane at 20℃; for 24h; Cooling with ice; Green chemistry;95%
With 2,6-dimethylpyridine; 1,1'-carbonyldiimidazole In chloroform at 20℃; for 24h; Solvent; Reagent/catalyst; Temperature;85%
(2S,4R)-1-(6-aminohexanoyl)-4-hydroxy-2-(4,4′-dimethoxytrityloxymethyl)pyrrolidine
851912-61-3

(2S,4R)-1-(6-aminohexanoyl)-4-hydroxy-2-(4,4′-dimethoxytrityloxymethyl)pyrrolidine

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

(2S,4R)-4-hydroxy-2-(4,4'-dimethoxytrityloxymethyl)-1-(6-(N-(5-((R)-1,2-dithiolan-3-yl)pentanoylamino)hexanoyl))pyrrolidine

(2S,4R)-4-hydroxy-2-(4,4'-dimethoxytrityloxymethyl)-1-(6-(N-(5-((R)-1,2-dithiolan-3-yl)pentanoylamino)hexanoyl))pyrrolidine

Conditions
ConditionsYield
Stage #1: (R)-1,2-dithiolane-3-pentanoic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.166667h;
Stage #2: (2S,4R)-1-(6-aminohexanoyl)-4-hydroxy-2-(4,4′-dimethoxytrityloxymethyl)pyrrolidine In N,N-dimethyl-formamide at 25℃; for 1h;
95%
piperazine
110-85-0

piperazine

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

piperazine di-(R)-α-lipoate

piperazine di-(R)-α-lipoate

Conditions
ConditionsYield
In acetone at 20℃; for 4h; Product distribution / selectivity; Reflux;94.5%
In acetone at 0 - 15℃; for 3h;92.3%
In acetone at 0 - 15℃; for 3h;92.3%
In acetone at 0 - 15℃; for 3h;92.3%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

2,5-dioxopyrrolidin-1-yl 5-(1,2-dithiolan-3-yl)pentanoate
1115175-97-7

2,5-dioxopyrrolidin-1-yl 5-(1,2-dithiolan-3-yl)pentanoate

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;94%
With dicyclohexyl-carbodiimide In tetrahydrofuran; dichloromethane at 4 - 20℃; for 5h;75.8%
With dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 16h;66%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Inert atmosphere;
bromohexyl-3β-hydroxy-urs-12-en-28-oate
1383539-92-1

bromohexyl-3β-hydroxy-urs-12-en-28-oate

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

[((5-((R)-1,2-dithiolan-3-yl)pentanoyl)oxy)hexyl]-3β-hydroxyurs-12-en-28-oate

[((5-((R)-1,2-dithiolan-3-yl)pentanoyl)oxy)hexyl]-3β-hydroxyurs-12-en-28-oate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 24h; Solvent; Reagent/catalyst;94%
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 24h;94%
3β-hydroxyoleanane-12-en-28-oicacid(4-bromobutyl) ester

3β-hydroxyoleanane-12-en-28-oicacid(4-bromobutyl) ester

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

[((5-((R)-1,2-dithiolan-3-yl)pentanoyl)oxy)butyl]-3β-hydroxyolean-12-en-28-oate

[((5-((R)-1,2-dithiolan-3-yl)pentanoyl)oxy)butyl]-3β-hydroxyolean-12-en-28-oate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 24h;94%
2,2,2-tris(hydroxymethyl)ethylamine
7332-39-0

2,2,2-tris(hydroxymethyl)ethylamine

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

trometamol (R)-α-lipoate

trometamol (R)-α-lipoate

Conditions
ConditionsYield
In ethanol at 0 - 60℃; Product distribution / selectivity;93.1%
choline chloride
67-48-1

choline chloride

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

R-lipoic acid choline ester chloride

R-lipoic acid choline ester chloride

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In toluene at 35℃; for 18h; Cooling with ice; Green chemistry;93%
With dmap; dicyclohexyl-carbodiimide In chloroform at 35℃; for 18h; Solvent; Reagent/catalyst; Temperature;89%
(E)-15,19-dimethyl-3,6,9,12-tetraoxaicosa-14,18-dien-1-ol

(E)-15,19-dimethyl-3,6,9,12-tetraoxaicosa-14,18-dien-1-ol

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

C26H46O6S2

C26H46O6S2

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 30℃; for 10h;92.1%
(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

2-chloro-ethanol
107-07-3

2-chloro-ethanol

(R)-lipoic acid 2-chloroethyl ester

(R)-lipoic acid 2-chloroethyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 35℃; for 18h; Cooling with ice;92%
L-Lysine hydrochloride
657-27-2, 10098-89-2

L-Lysine hydrochloride

(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

R(+)-lipoic acid L-lysine salt

R(+)-lipoic acid L-lysine salt

Conditions
ConditionsYield
Stage #1: (R)-1,2-dithiolane-3-pentanoic acid With sodium ethanolate In ethanol at 20℃;
Stage #2: L-Lysine hydrochloride In acetone at 55 - 60℃; for 2h; Concentration; Temperature;
92%

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