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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryOur company`s advantages : 1) Specialized in pharmaceutical industrial for 35 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms :LC and T.T 30-60 days. 4) We have warehouse in USA for quickly shipment . 5) We
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inquiryProduct Name: R (+) alpha Lipoic acid Appearance : Pale yellow powder Cas:
Cas:1200-22-2
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inquiryUnique advantages for R-(+)-Alpha Lipoic Acid Cas 1200-22-2 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Yellow crystalline powder Storage:-20°C Freezer Package:1kg/bag with
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inquiryXi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
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inquiryT he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:White
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing
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inquiryR-alpha-Lipoic Acid CAS: 1200-22-2 Molecular Formula: C8H14O2S2 Home Product Category Organic raw materials Organic acid 1200-22-2 1200-22-2 - Names and Identifiers Name R-alpha-Lipoic Acid Synonyms D-lipoic acid
Cas:1200-22-2
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inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
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Cas:1200-22-2
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inquiryName:(R)-(+)-Lipoic acid CAS NO:1200-22-2 Grade:Medical scientific research and export Molecular formula:C8H14O2S2 Molecular weight:206.33 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability
Cas:1200-22-2
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:1200-22-2
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inquiryProduct name R Alpha Lipoic Acid Product alias (R)-Thioctic Acid CAS no 1200-22-2 Molecular formula C8H14O2S2 Molecular weight 206.32600
Cas:1200-22-2
Min.Order:5 Metric Ton
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Yellow Powder Storage:Store in sealed containers at cool &
Cas:1200-22-2
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inquiryAppearance:yellow crystalline solid Storage:-20°C,Keep container tightly closed in a dry and well-ventilated place Package:25kg / drum Application:APIs;Intermediates Transportation:Express/Sea/Air Port:Any port in China
Cas:1200-22-2
Min.Order:25 Kilogram
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inquiryShanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye
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inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:light yellow powder Storage:Room temperature Pa
Cas:1200-22-2
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Cas:1200-22-2
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inquiry(R)-(+)-1,2-Dithiolane-3-pentanoic acid CAS:1200-22-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qu
Cas:1200-22-2
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:1200-22-2
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Cas:1200-22-2
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiry(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Stage #1: (S)-6,8-dichlorooctanoic acid ethylester With sodium sulfide; sulfur In water at 80℃; for 2h; Stage #2: With water; sodium hydroxide at 80℃; for 8h; Temperature; | 99.8% |
With sodium sulfide; sulfur | |
Stage #1: (S)-6,8-dichlorooctanoic acid ethylester With sodium sulfide; sulfur In water at 82℃; for 4.5h; Stage #2: With water; sodium hydroxide In toluene at 92℃; for 8h; pH=1; Solvent; Temperature; | n/a |
(+)-isopropyl lipoate
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With water; potassium carbonate In methanol at 22℃; for 40h; | 96% |
(R)-6,8-dichloroctanoic acid
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With sodium sulfide; N-benzyl-N,N,N-triethylammonium chloride; sulfur In water at 85℃; Reagent/catalyst; Temperature; | 92.1% |
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With citric acid In methanol; toluene at 35 - 40℃; for 3h; Temperature; Darkness; Industrial scale; | 83.1% |
[ethyl (5R)-5-(1,2-dithiolan-3yl)pentanoate]
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With hydrogenchloride; potassium hydroxide In ethanol for 24h; Ambient temperature; | 75% |
With potassium hydroxide In ethanol at 20℃; for 24h; | 75% |
With potassium hydroxide In ethanol at 20℃; for 24h; | 75% |
hydrolysis; | |
With sodium hydroxide |
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Product distribution / selectivity; | 72% |
(R)-5-[1,2-dithiolan-3-yl]pentanoic acid methyl ester
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol for 3h; Ambient temperature; | 70% |
With potassium hydroxide; water for 24h; | 54% |
Stage #1: (R)-5-[1,2-dithiolan-3-yl]pentanoic acid methyl ester With potassium hydroxide In methanol; water at 50℃; for 2h; Stage #2: With phosphoric acid In methanol; water; toluene at 30℃; | 45% |
With potassium carbonate In methanol; water |
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
52% |
A
(R)-1,2-dithiolane-3-pentanoic acid
B
(S)-lipoic acid
Conditions | Yield |
---|---|
With sulfuric acid In acetone at 15 - 60℃; for 2h; Temperature; Solvent; | A 47.5% B n/a |
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With sulfuric acid In acetone at 15 - 40℃; for 24h; Solvent; | 46% |
(S)-6,8-dimethylsulfonyloxyoctane-1-carboxylic acid
A
(R)-1,2-dithiolane-3-pentanoic acid
B
(S)-lipoic acid
Conditions | Yield |
---|---|
With hydrogenchloride; sodium sulfide; potassium hydroxide In water; N,N-dimethyl-formamide at 80℃; for 28h; Title compound not separated from byproducts; | A n/a B 45% |
Conditions | Yield |
---|---|
With ammonium hydrogen sulfite; sodium sulfide nonahydrate; sulfur In propan-1-ol; water; isopropyl alcohol at 70℃; for 3.5h; Temperature; Solvent; Reagent/catalyst; Inert atmosphere; Darkness; | 30.6% |
Thioctic acid
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With cinchonidine salt |
(R)-6,8-dimercaptooctanoic acid
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With iron(III) chloride; potassium carbonate | |
With chloroform; iodine; potassium iodide | |
With mushroom tyrosinase |
(S)-6,8-dimethylsulfonyloxyoctane-1-carboxylic acid
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With sodium sulfide; potassium hydroxide; sulfur 1.) 5 min, 2.) DMF, 80 deg C, 24h; Yield given. Multistep reaction; |
(7R,10S)-7-Isopropyl-10-methyl-1,5-dithia-spiro[5.5]undecane
A
l-menthone
B
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Multistep reaction; |
(3S)-6-bromo-1,3-isopropylidendioxyhexane
(R)-1,2-dithiolane-3-pentanoic acid
1,2-dithiolane-3-pentanoic acid methyl ester
A
(R)-1,2-dithiolane-3-pentanoic acid
B
(S)-lipoic acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol Yield given. Title compound not separated from byproducts; |
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With ethanol; sodium disulfide |
(6S)-(-)-methyl 6,8-dihydroxyoctanoate
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Et3N / CH2Cl2 2: Na2S; sulphur / dimethylformamide / 24 h / 90 °C 3: K2CO3 / methanol; H2O View Scheme | |
Multi-step reaction with 4 steps 1: Et3N / CH2Cl2 / 1 h / 0 °C 2: dimethylformamide; cyclohexane / 4 h / 50 °C 3: H2O; KOH / 6 h / 20 °C 4: FeCl3; air; NaOH / H2O / 3 h / pH 9 View Scheme | |
Multi-step reaction with 3 steps 1: 92 percent / Et3N / CH2Cl2 / 0.5 h / 0 °C 2: 83 percent / Na2S*9H2O, sulfur / dimethylformamide / 2.42 h / 80 °C 3: 70 percent / aq. KOH / methanol / 3 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1: 98 percent / Et3N 2: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h 3: 54 percent / 0.1M KOH, H2O / 24 h View Scheme |
(S)-6,8-diphenylmethoxyoctanoic acid
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1.75 g / diethyl ether 2: 87 percent / H2 / Pd/C / ethanol / 5 h / 2585.81 Torr 3: Et3N / CH2Cl2 4: Na2S; sulphur / dimethylformamide / 24 h / 90 °C 5: K2CO3 / methanol; H2O View Scheme | |
Multi-step reaction with 5 steps 1: 3percent HCl 2: 95 percent / H2 / 5percent palladium on charcoal / methanol / 1551.4 Torr 3: 98 percent / Et3N 4: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h 5: 54 percent / 0.1M KOH, H2O / 24 h View Scheme |
(6S)-(+)-methyl 6,8-bis(methylsulfonyloxy)octanoate
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Na2S; sulphur / dimethylformamide / 24 h / 90 °C 2: K2CO3 / methanol; H2O View Scheme | |
Multi-step reaction with 3 steps 1: dimethylformamide; cyclohexane / 4 h / 50 °C 2: H2O; KOH / 6 h / 20 °C 3: FeCl3; air; NaOH / H2O / 3 h / pH 9 View Scheme | |
Multi-step reaction with 2 steps 1: 83 percent / Na2S*9H2O, sulfur / dimethylformamide / 2.42 h / 80 °C 2: 70 percent / aq. KOH / methanol / 3 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h 2: 54 percent / 0.1M KOH, H2O / 24 h View Scheme |
(S)-1-phenylmethoxyoct-7-en-3-ol
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: 85 percent / TBAI; NaH / dimethylformamide / 2 h / 20 °C 2.1: BH3*DMS / tetrahydrofuran / 2 h / 20 °C 2.2: 88 percent / aq. NaOEt; H2O2 / tetrahydrofuran / 2 h / 20 °C 3.1: aq. NaCl2O; NaOCl; TEMPO / acetonitrile; aq. phosphate buffer / 35 °C / pH 6.7 4.1: 1.75 g / diethyl ether 5.1: 87 percent / H2 / Pd/C / ethanol / 5 h / 2585.81 Torr 6.1: Et3N / CH2Cl2 7.1: Na2S; sulphur / dimethylformamide / 24 h / 90 °C 8.1: K2CO3 / methanol; H2O View Scheme | |
Multi-step reaction with 8 steps 1: 95 percent 2: 89 percent / diisopentylborane / tetrahydrofuran / 0 °C 3: pyridinium dichromate / dimethylformamide / 0 deg C, then RT, 24 h 4: 3percent HCl 5: 95 percent / H2 / 5percent palladium on charcoal / methanol / 1551.4 Torr 6: 98 percent / Et3N 7: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h 8: 54 percent / 0.1M KOH, H2O / 24 h View Scheme |
(S)-6,8-diphenylmethoxyoct-1-ene
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: BH3*DMS / tetrahydrofuran / 2 h / 20 °C 1.2: 88 percent / aq. NaOEt; H2O2 / tetrahydrofuran / 2 h / 20 °C 2.1: aq. NaCl2O; NaOCl; TEMPO / acetonitrile; aq. phosphate buffer / 35 °C / pH 6.7 3.1: 1.75 g / diethyl ether 4.1: 87 percent / H2 / Pd/C / ethanol / 5 h / 2585.81 Torr 5.1: Et3N / CH2Cl2 6.1: Na2S; sulphur / dimethylformamide / 24 h / 90 °C 7.1: K2CO3 / methanol; H2O View Scheme | |
Multi-step reaction with 7 steps 1: 89 percent / diisopentylborane / tetrahydrofuran / 0 °C 2: pyridinium dichromate / dimethylformamide / 0 deg C, then RT, 24 h 3: 3percent HCl 4: 95 percent / H2 / 5percent palladium on charcoal / methanol / 1551.4 Torr 5: 98 percent / Et3N 6: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h 7: 54 percent / 0.1M KOH, H2O / 24 h View Scheme |
(S)-6,8-diphenylmethoxyoctan-1-ol
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: aq. NaCl2O; NaOCl; TEMPO / acetonitrile; aq. phosphate buffer / 35 °C / pH 6.7 2: 1.75 g / diethyl ether 3: 87 percent / H2 / Pd/C / ethanol / 5 h / 2585.81 Torr 4: Et3N / CH2Cl2 5: Na2S; sulphur / dimethylformamide / 24 h / 90 °C 6: K2CO3 / methanol; H2O View Scheme | |
Multi-step reaction with 6 steps 1: pyridinium dichromate / dimethylformamide / 0 deg C, then RT, 24 h 2: 3percent HCl 3: 95 percent / H2 / 5percent palladium on charcoal / methanol / 1551.4 Torr 4: 98 percent / Et3N 5: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h 6: 54 percent / 0.1M KOH, H2O / 24 h View Scheme |
(S)-methyl 6,8-diphenylmethoxyoctanoate
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 87 percent / H2 / Pd/C / ethanol / 5 h / 2585.81 Torr 2: Et3N / CH2Cl2 3: Na2S; sulphur / dimethylformamide / 24 h / 90 °C 4: K2CO3 / methanol; H2O View Scheme | |
Multi-step reaction with 4 steps 1: 95 percent / H2 / 5percent palladium on charcoal / methanol / 1551.4 Torr 2: 98 percent / Et3N 3: 1.) sodium sulphide nonahydrate, sulphur / 1.) DMF, 80 deg C, 1 h, 2.)DMF, 80 deg C, 67 h, then RT, 17 h 4: 54 percent / 0.1M KOH, H2O / 24 h View Scheme |
ethyl (S)-6,8-dihydroxy octanoate
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 92 percent / Et3N / CH2Cl2 / 4 h / 0 °C 2: 72 percent / Na2S; S / dimethylformamide / 24 h / 90 °C 3: 75 percent / KOH / ethanol / 24 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: Et3N / CH2Cl2 / 4 h / 0 °C 2: 70 percent / sodium sulfide nonahydrate, sulfur / dimethylformamide / 24 h / 90 °C 3: 75 percent / 1.) 0.1M potassium hydroxide, 2.) 5M HCl / ethanol / 24 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 2: Na2S - S / dimethylformamide / 90 °C 3: hydrolysis View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 4 h / 0 °C 2: sodiumsulfide nonahydrate; sulfur / N,N-dimethyl-formamide / 24 h / 85 - 90 °C 3: potassium hydroxide / ethanol / 24 h / 20 °C View Scheme |
(S)-Ethyl 6,8-Bis(methylsulphonyloxy)octanoate
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 72 percent / Na2S; S / dimethylformamide / 24 h / 90 °C 2: 75 percent / KOH / ethanol / 24 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 70 percent / sodium sulfide nonahydrate, sulfur / dimethylformamide / 24 h / 90 °C 2: 75 percent / 1.) 0.1M potassium hydroxide, 2.) 5M HCl / ethanol / 24 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: Na2S - S / dimethylformamide / 90 °C 2: hydrolysis View Scheme | |
Multi-step reaction with 2 steps 1: sodiumsulfide nonahydrate; sulfur / N,N-dimethyl-formamide / 24 h / 85 - 90 °C 2: potassium hydroxide / ethanol / 24 h / 20 °C View Scheme |
(R)-1,2-dithiolane-3-pentanoic acid
(R)-6,8-dimercaptooctanoic acid
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol at 20℃; for 1h; | 100% |
With 1,4-dihydronicotinamide adenine dinucleotide; porcine heart dihydrolipoamide dehydrogenase at 35℃; Enzyme kinetics; | |
With sodium borohydrid In water; toluene |
dimethylbiguanide
(R)-1,2-dithiolane-3-pentanoic acid
N,N-dimethylimidodicarbonimidic diamide R-(+)-lipoate
Conditions | Yield |
---|---|
In methanol for 2h; Product distribution / selectivity; | 100% |
In acetonitrile for 0.166667h; Product distribution / selectivity; | 95% |
In acetone for 0.166667 - 0.5h; Product distribution / selectivity; | 95% |
In methanol; acetone for 0.333333h; Product distribution / selectivity; |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 2h; | 100% |
In ethanol at 20 - 50℃; for 0.5h; | 68% |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium borohydrid; sodium hydrogencarbonate In water | 100% |
With sodium tetrahydroborate; sodium hydrogencarbonate In water at 5 - 20℃; for 1.25h; | 96.8 mg |
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
In tetrahydrofuran for 2h; | 100% |
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 4h; | 100% |
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 4h; | 100% |
Conditions | Yield |
---|---|
With ethyl acetate at 40℃; for 4h; | 99.64% |
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With dihydro-(+)-lipoic acid; magnesium methanolate In isopropyl alcohol at 15 - 20℃; for 0.35h; Product distribution / selectivity; | 98.7% |
With magnesium hydroxide In ethanol | 85% |
With magnesium methanolate In methanol; isopropyl alcohol Inert atmosphere; |
Conditions | Yield |
---|---|
Stage #1: bethanechol chloride With sodium hydrogencarbonate In methanol at 20℃; for 0.0833333h; Stage #2: (R)-1,2-dithiolane-3-pentanoic acid In methanol at 20℃; for 16h; | 97.6% |
3β-hydroxyoleanane-12-en-28-oic acid(6-bromohexyl) ester
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 24h; | 96% |
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol | 95% |
2-(N,N-dimethylamino)ethanol
(R)-1,2-dithiolane-3-pentanoic acid
R-(+)-LA dimethylethanolamine salt
Conditions | Yield |
---|---|
In ethanol | 95% |
methanol
(R)-1,2-dithiolane-3-pentanoic acid
(R)-5-[1,2-dithiolan-3-yl]pentanoic acid methyl ester
Conditions | Yield |
---|---|
With sulfuric acid at 78.3℃; for 1h; Dean-Stark; | 95% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 5h; | |
With thionyl chloride at 0 - 20℃; for 1h; | |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Cooling with ice; |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25℃; for 19h; | 95% |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide In dichloromethane at 20℃; | 94% |
With dicyclohexyl-carbodiimide In 1,4-dioxane at 0 - 20℃; |
(R)-1,2-dithiolane-3-pentanoic acid
N-[(R)-1,2-dithiolane-3-pentanoyl]taurine
Conditions | Yield |
---|---|
Stage #1: (R)-1,2-dithiolane-3-pentanoic acid With di(succinimido) carbonate; N-ethyl-N,N-diisopropylamine In acetone at 20℃; for 2h; Darkness; Stage #2: Taurine With water; N-ethyl-N,N-diisopropylamine In acetone | 95% |
Conditions | Yield |
---|---|
With 2,6-dimethylpyridine; 1,1'-carbonyldiimidazole In 1,2-dichloro-ethane at 20℃; for 24h; Cooling with ice; Green chemistry; | 95% |
With 2,6-dimethylpyridine; 1,1'-carbonyldiimidazole In chloroform at 20℃; for 24h; Solvent; Reagent/catalyst; Temperature; | 85% |
(2S,4R)-1-(6-aminohexanoyl)-4-hydroxy-2-(4,4′-dimethoxytrityloxymethyl)pyrrolidine
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Stage #1: (R)-1,2-dithiolane-3-pentanoic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.166667h; Stage #2: (2S,4R)-1-(6-aminohexanoyl)-4-hydroxy-2-(4,4′-dimethoxytrityloxymethyl)pyrrolidine In N,N-dimethyl-formamide at 25℃; for 1h; | 95% |
Conditions | Yield |
---|---|
In acetone at 20℃; for 4h; Product distribution / selectivity; Reflux; | 94.5% |
In acetone at 0 - 15℃; for 3h; | 92.3% |
In acetone at 0 - 15℃; for 3h; | 92.3% |
In acetone at 0 - 15℃; for 3h; | 92.3% |
1-hydroxy-pyrrolidine-2,5-dione
(R)-1,2-dithiolane-3-pentanoic acid
2,5-dioxopyrrolidin-1-yl 5-(1,2-dithiolan-3-yl)pentanoate
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; | 94% |
With dicyclohexyl-carbodiimide In tetrahydrofuran; dichloromethane at 4 - 20℃; for 5h; | 75.8% |
With dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 16h; | 66% |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Inert atmosphere; |
bromohexyl-3β-hydroxy-urs-12-en-28-oate
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 24h; Solvent; Reagent/catalyst; | 94% |
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 24h; | 94% |
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 24h; | 94% |
Conditions | Yield |
---|---|
In ethanol at 0 - 60℃; Product distribution / selectivity; | 93.1% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In toluene at 35℃; for 18h; Cooling with ice; Green chemistry; | 93% |
With dmap; dicyclohexyl-carbodiimide In chloroform at 35℃; for 18h; Solvent; Reagent/catalyst; Temperature; | 89% |
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 30℃; for 10h; | 92.1% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 35℃; for 18h; Cooling with ice; | 92% |
L-Lysine hydrochloride
(R)-1,2-dithiolane-3-pentanoic acid
Conditions | Yield |
---|---|
Stage #1: (R)-1,2-dithiolane-3-pentanoic acid With sodium ethanolate In ethanol at 20℃; Stage #2: L-Lysine hydrochloride In acetone at 55 - 60℃; for 2h; Concentration; Temperature; | 92% |
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