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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Octanoic acid,6,8-dimercapto- Manufacturer/High quality/Best price/In stock

Cas:462-20-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 6,8-disulfanyloctanoic acid

Cas:462-20-4

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6,8-Dimercaptooctanoic acid

Cas:462-20-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 462-20-4 with competitive price

Cas:462-20-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Octanoic acid,6,8-dimercapto- 462-20-4

Cas:462-20-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Octanoic acid,6,8-dimercapto-

Cas:462-20-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

DIHYDROLIPOIC ACID

Cas:462-20-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Octanoic acid,6,8-dimercapto-

Cas:462-20-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: DIHYDROLIPOIC ACID Synonyms: DHLA;(+/-)-DIHYDROLIPOIC ACID;DIHYDROLIPOIC ACID;DL-ALPHA-LIPOIC ACID REDUCED FORM;DL-ALPHA-LIPOIC ACID, DIHYDRO-;DL-6,8-THIOCTIC ACID, REDUCED;DL-6,8-THIOCTIC ACID REDUCED FORM;DL-1,2-

TIANFUCHEM--High purity 462-20-4 DIHYDROLIPOIC ACID

Cas:462-20-4

Min.Order:1 Metric Ton

FOB Price: $20.0

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

DIHYDROLIPOIC ACID

Cas:462-20-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

462-20-4 CAS NO.462-20-4

Cas:462-20-4

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Dihydrolipoic acid

Cas:462-20-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Dihydrolipoic Acid 100mg

Cas:462-20-4

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

DIHYDROLIPOIC ACID

Cas:462-20-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Nanjing HuaNuo Bio-Pharmacuetical Co.,Ltd

Independent research and development of impurities, familiar with the market and impurity characteristics; We can ship out on the same day if the products are in stock; Focus on impurity development of new products in the market; Expert in customizi

Thioctic Acid Impurity 7

Cas:462-20-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Octanoic acid,6,8-dimercapto-

Cas:462-20-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

best seller Application:API

DIHYDROLIPOIC ACID

Cas:462-20-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

462-20-4

Cas:462-20-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Octanoic acid,6,8-dimercapto- cas 462-20-4Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Octanoic acid,6,8-dimercapto- cas 462-20-4

Cas:462-20-4

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

DIHYDROLIPOIC ACID

Cas:462-20-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:200mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any po

γ-Lipoic Acid

Cas:462-20-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

The factory supplies Application:manufacturing supplies

Octanoicacid,6,8-dimercapto-

Cas:462-20-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

462-20-4

Cas:462-20-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

AstaTech ( Chengdu) BioPharmaceutical Corp.

Quality assurance, stable process and affordable priceAppearance:detailed see specifications Storage:enquiry Package:according to the clients requirement Application:Pharmaceutical intermediates Transportation:Normal Port:chengdu

dihydrolipoic acid

Cas:462-20-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Muhuang Technology Co., Ltd

best seller Application:API

DIHYDROLIPOIC ACID

Cas:462-20-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

DIHYDROLIPOIC ACID

Cas:462-20-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

DIHYDROLIPOIC ACID

Cas:462-20-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

(6R)-6,8-dimercaptooctanoate

Cas:462-20-4

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Changzhou Extraordinary Pharmatech co.,LTD

Changzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa

Dihydrolipoic acid

Cas:462-20-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

462-20-4 CAS NO.462-20-4

Cas:462-20-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

Thioctic acid
1077-28-7, 62-46-4

Thioctic acid

dihydrolipoic acid
462-20-4

dihydrolipoic acid

Conditions
ConditionsYield
With sodium tetrahydroborate; sodium hydrogencarbonate In water at 20℃; for 3h;100%
Stage #1: Thioctic acid With sodium hydrogencarbonate In water
Stage #2: With sodium tetrahydroborate In water at 0 - 20℃; for 1.33333h;
Stage #3: With hydrogenchloride In water at 0℃; pH=1;
100%
With sodium tetrahydroborate; sodium hydrogencarbonate at 0℃; for 3h;99.5%
(R)-1,2-dithiolane-3-pentanoic acid
1200-22-2

(R)-1,2-dithiolane-3-pentanoic acid

dihydrolipoic acid
462-20-4

dihydrolipoic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium borohydrid; sodium hydrogencarbonate In water100%
With sodium tetrahydroborate; sodium hydrogencarbonate In water at 5 - 20℃; for 1.25h;96.8 mg
(+/-)-8-hydroxy-6-mercapto-octanoic acid
101567-87-7

(+/-)-8-hydroxy-6-mercapto-octanoic acid

thiourea
17356-08-0

thiourea

dihydrolipoic acid
462-20-4

dihydrolipoic acid

Conditions
ConditionsYield
With hydrogen bromide anschliessend mit wss. Natronlauge;
2-(2-Benzoyloxyethyl)cyclohexanone
82725-55-1

2-(2-Benzoyloxyethyl)cyclohexanone

dihydrolipoic acid
462-20-4

dihydrolipoic acid

Conditions
ConditionsYield
(i) AcOOH, (ii) thiourea, aq. HI, (iii) aq. KOH; Multistep reaction;
1,4-dithio-D,L-threitol
27565-41-9

1,4-dithio-D,L-threitol

Thioctic acid
1077-28-7, 62-46-4

Thioctic acid

A

dihydrolipoic acid
462-20-4

dihydrolipoic acid

Conditions
ConditionsYield
In water-d2 for 48h; Equilibrium constant; phosphate buffer (pD 7.0); also in CD3OD/D2O;
N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine
131760-67-3

N,N'-dimethyl-N,N'-bis(mercaptoacetyl)hydrazine

Thioctic acid
1077-28-7, 62-46-4

Thioctic acid

A

dihydrolipoic acid
462-20-4

dihydrolipoic acid

B

1,2-dimethyl-3,8-dioxo-1,2,5,6-diazadithiocane
131760-68-4

1,2-dimethyl-3,8-dioxo-1,2,5,6-diazadithiocane

Conditions
ConditionsYield
With buffer (pH 7.0, 2 mM EDTA, 0.1 M phosphate) Equilibrium constant;
2-hydroxyethanethiol
60-24-2

2-hydroxyethanethiol

Thioctic acid
1077-28-7, 62-46-4

Thioctic acid

A

dihydrolipoic acid
462-20-4

dihydrolipoic acid

B

bis(2-hydroxyethyl) disulfide
1892-29-1

bis(2-hydroxyethyl) disulfide

Conditions
ConditionsYield
In water-d2 for 48h; Equilibrium constant; phosphate buffer (pD 7.0); also in CD3OD/D2O;
6,8-bis-carbamimidoylsulfanyl-octanoic acid; compound with GENERIC INORGANIC NEUTRAL COMPONENT

6,8-bis-carbamimidoylsulfanyl-octanoic acid; compound with GENERIC INORGANIC NEUTRAL COMPONENT

A

dihydrolipoic acid
462-20-4

dihydrolipoic acid

B

Thioctic acid
1077-28-7, 62-46-4

Thioctic acid

C

5,8-Dimercaptooctanoic acid

5,8-Dimercaptooctanoic acid

Conditions
ConditionsYield
With potassium hydroxide; water for 3h; Hydrolysis; Rearrangement; Cyclization; Heating; Title compound not separated from byproducts;
(+-)-6,8-bis-benzylsulfanyl-octanoic acid

(+-)-6,8-bis-benzylsulfanyl-octanoic acid

dihydrolipoic acid
462-20-4

dihydrolipoic acid

Conditions
ConditionsYield
With phosphoric acid
With ammonia; sodium; toluene
(+-)-8-acetylsulfanyl-6-hydroxy-octanoic acid ethyl ester

(+-)-8-acetylsulfanyl-6-hydroxy-octanoic acid ethyl ester

dihydrolipoic acid
462-20-4

dihydrolipoic acid

Conditions
ConditionsYield
With sodium hydroxide beim Erhitzen des Reaktionsprodukts mit Thioharnstoff und wss. Jodwasserstoffsaeure und anschliessend Erhitzen mit wss. Natronlauge;
With sodium hydroxide beim Erhitzen des Reaktionsprodukts mit Thioharnstoff und wss. Jodwasserstoffsaeure und anschliessend Erhitzen mit wss. Natronlauge;
thiourea
17356-08-0

thiourea

(+-)-6,8-dihydroxy-octanoic acid methyl ester

(+-)-6,8-dihydroxy-octanoic acid methyl ester

dihydrolipoic acid
462-20-4

dihydrolipoic acid

Conditions
ConditionsYield
With hydrogen iodide beim Erhitzen des Reaktiosgemisches mit wss. Kalilauge unter Stickstoff;
thiourea
17356-08-0

thiourea

(+-)-8-acetoxy-6-hydroxy-octanoic acid lactone

(+-)-8-acetoxy-6-hydroxy-octanoic acid lactone

dihydrolipoic acid
462-20-4

dihydrolipoic acid

Conditions
ConditionsYield
With hydrogen iodide beim Erhitzen des Reaktiosgemisches mit wss. Kalilauge unter Stickstoff;
8-Ethoxy-6-formyloxyoctanoic acid
156594-99-9

8-Ethoxy-6-formyloxyoctanoic acid

A

dihydrolipoic acid
462-20-4

dihydrolipoic acid

B

(PhAsO)n

(PhAsO)n

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HBr; H2O / 20 h / 116 °C
2: KOH; H2O / 3 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: HBr; H2O / 20 h / 116 °C
2: KOH; H2O / 3 h / Heating
3: NaBH4; NaHCO3 / H2O / 0.5 h / 5 °C
View Scheme
Multi-step reaction with 3 steps
1.1: HBr; H2O / 20 h / 116 °C
2.1: KOH; H2O / 3 h / Heating
2.2: FeCl3; air / H2O / 2.5 h / pH 8.8 - 11.5
3.1: NaBH4; NaHCO3 / H2O / 0.5 h / 5 °C
View Scheme
6,8-bis-carbamimidoylsulfanyl-octanoic acid; compound with GENERIC INORGANIC NEUTRAL COMPONENT

6,8-bis-carbamimidoylsulfanyl-octanoic acid; compound with GENERIC INORGANIC NEUTRAL COMPONENT

A

dihydrolipoic acid
462-20-4

dihydrolipoic acid

B

(PhAsO)n

(PhAsO)n

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: KOH; H2O / 3 h / Heating
2: NaBH4; NaHCO3 / H2O / 0.5 h / 5 °C
View Scheme
Multi-step reaction with 2 steps
1.1: KOH; H2O / 3 h / Heating
1.2: FeCl3; air / H2O / 2.5 h / pH 8.8 - 11.5
2.1: NaBH4; NaHCO3 / H2O / 0.5 h / 5 °C
View Scheme
(+/-)-3-acetylsulfanyl-octanedioic acid-8-ethyl ester-1-chloride
104665-85-2

(+/-)-3-acetylsulfanyl-octanedioic acid-8-ethyl ester-1-chloride

dihydrolipoic acid
462-20-4

dihydrolipoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium borate; dioxane / beim Erwaermen des Reaktionsprodukts mit wss.-methanol. Natronlauge und wenig Zink-Pulver
2: aqueous hydrobromic acid / anschliessend mit wss. Natronlauge
View Scheme
Thioctic acid
1077-28-7, 62-46-4

Thioctic acid

6-[N-(4-Aminobutyl)-N-ethylamino]-2,3-dihydrophthalazine-1,4-dione
66612-29-1

6-[N-(4-Aminobutyl)-N-ethylamino]-2,3-dihydrophthalazine-1,4-dione

A

dihydrolipoic acid
462-20-4

dihydrolipoic acid

B

C14H20N2O4

C14H20N2O4

Conditions
ConditionsYield
With sodium hydroxide In ethanol
6,8-dichlorooctanoic acid ethyl ester
1070-64-0

6,8-dichlorooctanoic acid ethyl ester

dihydrolipoic acid
462-20-4

dihydrolipoic acid

Conditions
ConditionsYield
Stage #1: 6,8-dichlorooctanoic acid ethyl ester With sodium sulfide; hydrogen sulfide In ethanol; water under 2625.26 Torr; for 3.41667h; Large scale;
Stage #2: With sodium tetrahydroborate; water; sodium hydroxide In ethanol at 70℃; for 2.5h; Pressure; Temperature; Time; Reagent/catalyst; Large scale;
dihydrolipoic acid
462-20-4

dihydrolipoic acid

ortho-anisaldehyde
135-02-4

ortho-anisaldehyde

5-(2-(2-methoxyphenyl)-1,3-dithian-4-yl)pentanoic acid

5-(2-(2-methoxyphenyl)-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 1h; Inert atmosphere;100%
Stage #1: dihydrolipoic acid; ortho-anisaldehyde In dichloromethane at 20℃; for 1h; Inert atmosphere;
Stage #2: With boron trifluoride diethyl etherate In dichloromethane at -25 - 20℃; Inert atmosphere;
dihydrolipoic acid
462-20-4

dihydrolipoic acid

3-methoxy-benzaldehyde
591-31-1

3-methoxy-benzaldehyde

5-(2-(3-methoxyphenyl)-1,3-dithian-4-yl)pentanoic acid

5-(2-(3-methoxyphenyl)-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 1h; Inert atmosphere;100%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

3-Trifluoromethylbenzaldehyde
454-89-7

3-Trifluoromethylbenzaldehyde

5-(2-(3-(trifluoromethyl)phenyl)-1,3-dithian-4-yl)pentanoic acid

5-(2-(3-(trifluoromethyl)phenyl)-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 1h; Inert atmosphere;99.4%
Stage #1: dihydrolipoic acid; 3-Trifluoromethylbenzaldehyde In dichloromethane at 20℃; for 1h; Inert atmosphere;
Stage #2: With boron trifluoride diethyl etherate In dichloromethane at -25 - 20℃; Inert atmosphere;
dihydrolipoic acid
462-20-4

dihydrolipoic acid

2-Trifluoromethylbenzaldehyde
447-61-0

2-Trifluoromethylbenzaldehyde

5-(2-(2-(trifluoromethyl)phenyl)-1,3-dithian-4-yl)pentanoic acid

5-(2-(2-(trifluoromethyl)phenyl)-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 1h; Inert atmosphere;99.4%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

2-nitro-benzaldehyde
552-89-6

2-nitro-benzaldehyde

5-(2-(2-nitrophenyl)-1,3-dithian-4-yl)pentanoic acid

5-(2-(2-nitrophenyl)-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 1h; Inert atmosphere;97.6%
methanol
67-56-1

methanol

bismuth(III) chloride

bismuth(III) chloride

dihydrolipoic acid
462-20-4

dihydrolipoic acid

methyl 5-(2-chloro-1,3,2-dithiabisman-4-yl)pentanoate
1600506-20-4

methyl 5-(2-chloro-1,3,2-dithiabisman-4-yl)pentanoate

Conditions
ConditionsYield
at 20℃; for 2h; Inert atmosphere; Darkness;96%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

Langlois reagent
2926-29-6

Langlois reagent

C9H15F3O2S2

C9H15F3O2S2

Conditions
ConditionsYield
With iodine pentoxide In dimethyl sulfoxide at 110℃; for 24h; chemoselective reaction;94%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

3-Chlorobenzaldehyde
587-04-2

3-Chlorobenzaldehyde

5-(2-(3-chlorophenyl)-1,3-dithian-4-yl)pentanoic acid

5-(2-(3-chlorophenyl)-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 1h; Inert atmosphere;93.8%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

2-chloro-benzaldehyde
89-98-5

2-chloro-benzaldehyde

C15H19ClO2S2

C15H19ClO2S2

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 1h; Inert atmosphere;93.1%
Stage #1: dihydrolipoic acid; 2-chloro-benzaldehyde In dichloromethane at 20℃; for 1h; Inert atmosphere;
Stage #2: With boron trifluoride diethyl etherate In dichloromethane at -25 - 20℃; Inert atmosphere;
dihydrolipoic acid
462-20-4

dihydrolipoic acid

acetone
67-64-1

acetone

5-(2,2-dimethyl-1,3-dithian-4-yl)pentanoic acid
2036-55-7

5-(2,2-dimethyl-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With yttrium(III) trifluoromethanesulfonate In acetonitrile93%
With boron trifluoride diethyl etherate at 60℃;75%
With boron trifluoride diethyl etherate at 60℃;75%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

2-methylphenyl aldehyde
529-20-4

2-methylphenyl aldehyde

5-(2-(o-tolyl)-1,3-dithian-4-yl)pentanoic acid

5-(2-(o-tolyl)-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane at 45℃; for 12h; Inert atmosphere;91%
Stage #1: dihydrolipoic acid; 2-methylphenyl aldehyde In dichloromethane at 20℃; for 1h; Inert atmosphere;
Stage #2: With boron trifluoride diethyl etherate In dichloromethane at -25 - 20℃; Inert atmosphere;
dihydrolipoic acid
462-20-4

dihydrolipoic acid

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

5-(2-(4-nitrophenyl)-1,3-dithian-4-yl)pentanoic acid

5-(2-(4-nitrophenyl)-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 1h; Inert atmosphere;90.9%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

trimethylsilyl 6-mercapto-8-(trimethylsilylthio)octanoate
1333319-11-1

trimethylsilyl 6-mercapto-8-(trimethylsilylthio)octanoate

Conditions
ConditionsYield
With 1H-imidazole at 100℃; for 24h; Inert atmosphere;90%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

bismuth(III) oxide
1304-76-3

bismuth(III) oxide

8,6-bis[[4-(4-carboxybutyl)-1,3,2-dithiabisman-2-yl]thio]octanoic acid
1600506-19-1

8,6-bis[[4-(4-carboxybutyl)-1,3,2-dithiabisman-2-yl]thio]octanoic acid

Conditions
ConditionsYield
In methanol at 20℃; for 48h; Darkness;89%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

antimony(III) chloride
10025-91-9

antimony(III) chloride

5-(2-chloro-1,3,2-dithiastibinan-4-yl)pentanoic acid
1600506-15-7

5-(2-chloro-1,3,2-dithiastibinan-4-yl)pentanoic acid

Conditions
ConditionsYield
In acetonitrile at 20℃; for 5h;86%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

5-(2-(3-nitrophenyl)-1,3-dithian-4-yl)pentanoic acid

5-(2-(3-nitrophenyl)-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 1h; Inert atmosphere;83.9%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

5-(2-(benzo[d][1,3]dioxol-5-yl)-1,3-dithian-4-yl)pentanoic acid

5-(2-(benzo[d][1,3]dioxol-5-yl)-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane at 20℃; for 1h; Inert atmosphere;83.1%
methanol
67-56-1

methanol

bismuth (III) nitrate pentahydrate

bismuth (III) nitrate pentahydrate

dihydrolipoic acid
462-20-4

dihydrolipoic acid

A

1,2-dithiolane-3-pentanoic acid methyl ester
46236-19-5

1,2-dithiolane-3-pentanoic acid methyl ester

B

methyl 8,6-bis[[4-(5-methoxy-5-oxopentyl)-1,3,2-dithiabisman-2-yl]thio]octanoate
1600506-22-6

methyl 8,6-bis[[4-(5-methoxy-5-oxopentyl)-1,3,2-dithiabisman-2-yl]thio]octanoate

Conditions
ConditionsYield
at 20℃; for 5h; Inert atmosphere; Darkness; Overall yield = 175 mg;A 7 %Spectr.
B 81%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

m-tolyl aldehyde
620-23-5

m-tolyl aldehyde

5-(2-(m-tolyl)-1,3-dithian-4-yl)pentanoic acid

5-(2-(m-tolyl)-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 1h; Inert atmosphere;80.1%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

2-nitrophenyl-[76As]-arsonic acid

2-nitrophenyl-[76As]-arsonic acid

5-[2-(2-nitrophenyl)-1,3,2-dithi-[76As]-arsinan-4-yl]pentanoic acid

5-[2-(2-nitrophenyl)-1,3,2-dithi-[76As]-arsinan-4-yl]pentanoic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In methanol; water at 40℃; for 1h; Cyclization;80%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

(3-bromopropyl)phosphine

(3-bromopropyl)phosphine

6,8-bis-(3-phosphanyl-propylsulfanyl)-octanoic acid
244007-29-2

6,8-bis-(3-phosphanyl-propylsulfanyl)-octanoic acid

Conditions
ConditionsYield
Stage #1: dihydrolipoic acid With sodium hydride In tetrahydrofuran at 0℃; for 0.333333h; Metallation;
Stage #2: (3-bromopropyl)phosphine In tetrahydrofuran for 12h; Alkylation; Heating;
80%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

5-(2-(p-tolyl)-1,3-dithian-4-yl)pentanoic acid

5-(2-(p-tolyl)-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 1h; Inert atmosphere;79%
Stage #1: dihydrolipoic acid; 4-methyl-benzaldehyde In dichloromethane at 20℃; for 1h; Inert atmosphere;
Stage #2: With boron trifluoride diethyl etherate In dichloromethane at -25 - 20℃; Inert atmosphere;
dihydrolipoic acid
462-20-4

dihydrolipoic acid

benzaldehyde
100-52-7

benzaldehyde

5-(2-phenyl-1,3-dithian-4-yl)pentanoic acid
107275-54-7

5-(2-phenyl-1,3-dithian-4-yl)pentanoic acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 1h; Inert atmosphere;78%
With polyphosphoric acid trimethylsilyl ester In dichloromethane at 20℃; for 2h;60%
With hydrogenchloride; zinc(II) chloride
methanol
67-56-1

methanol

bismuth (III) nitrate pentahydrate

bismuth (III) nitrate pentahydrate

dihydrolipoic acid
462-20-4

dihydrolipoic acid

methyl 5-[2-(nitrooxy)-1,3,2-dithiabisman-4-yl]pentanoate

methyl 5-[2-(nitrooxy)-1,3,2-dithiabisman-4-yl]pentanoate

Conditions
ConditionsYield
for 5h; Inert atmosphere; Darkness;77%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

diphenylmercury(II)
587-85-9

diphenylmercury(II)

Hg(C6H5Hg)2(SCH2CH2CH(S)(CH2)4C(O)OH)2*C4H8O

Hg(C6H5Hg)2(SCH2CH2CH(S)(CH2)4C(O)OH)2*C4H8O

Conditions
ConditionsYield
In tetrahydrofuran (N2), stirred at room temp. for 48 h; concd. (vac), ppt. washed (THF), dried briefly (vac.); elem. anal.;76%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

trityl chloride
76-83-5

trityl chloride

C46H44O2S2
1161852-24-9

C46H44O2S2

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 3h;76%
dihydrolipoic acid
462-20-4

dihydrolipoic acid

bismuth(III) oxide
1304-76-3

bismuth(III) oxide

5,5'-[oxybis(1,3,2-dithiabismane-2,4-diyl)]dipentanoic acid
1600506-17-9

5,5'-[oxybis(1,3,2-dithiabismane-2,4-diyl)]dipentanoic acid

Conditions
ConditionsYield
In methanol at 20℃; for 48h; Darkness;76%
methanol
67-56-1

methanol

dihydrolipoic acid
462-20-4

dihydrolipoic acid

methyl 5-[2-(nitrooxy)-1,3,2-dithiabisman-4-yl]pentanoate

methyl 5-[2-(nitrooxy)-1,3,2-dithiabisman-4-yl]pentanoate

A

1,2-dithiolane-3-pentanoic acid methyl ester
46236-19-5

1,2-dithiolane-3-pentanoic acid methyl ester

B

methyl 8,6-bis[[4-(5-methoxy-5-oxopentyl)-1,3,2-dithiabisman-2-yl]thio]octanoate
1600506-22-6

methyl 8,6-bis[[4-(5-methoxy-5-oxopentyl)-1,3,2-dithiabisman-2-yl]thio]octanoate

Conditions
ConditionsYield
at 20℃; for 24h; Darkness; Overall yield = 149 mg;A 8 %Spectr.
B 72%

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