Pentafluorobenzyl (PFB) derivatives of chlorinated acetic and propionic acids were prepared adapting previously published methods to prepare PFB derivatives of non-chlorinated acids. Reaction of monochloro- and dichloroacetic acids and 2-chloro-, 2,2-dichloro- and 2,3-dichloropropionic acids wit...

Nowadays, diabetes and its associated inflammatory complications are important public health problems worldwide. Market limitations of drugs with dual actions as anti-inflammatory (AI) and anti-diabetic have been led to a temptation for focusing on the discovery and development of new compounds ...

The enantiomers R- and S-3-hydroxyeicosatetraenoic acid 11a, 11b were synthesized from coupling of a chiral aldehyde 7 with a Wittig salt 4, which were derived from 2-deoxy-D-ribose and arachidonic acid, respectively.

A number of novel and synthetically important pyridyl/naphthyl/(diphenyl)methylseleno substituted alkanoic acids (20–25) have been synthesized using an efficient and operationally simple strategy. Starting substrates, ethyl pyridyl/naphthyl/(diphenyl)methylseleno substituted alkanoates (8–13) ...

A simple method for the synthesis of inaccessible gem-dinitro derivatives of pyridine is described. A wide range of 2-halogencycloalka[b]pyridine-3,4-dicarbonitriles are produced by the three-component reaction (ketone, TCNE, hydrohalic acid), side-chain nitration of latter with 60% nitric acid ...

The reactions of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile (14) with a range of primary and secondary amines are investigated. Treatment with n-BuNH2 and BnNH2 gave 1,3-di-n-butyl- and 1,3-dibenzyl-2-(3,5-dicyano-6-ethoxy-4-phenylpyrid-2-yl)guani...

A planar chiral secondary phosphine oxide based on [2.2]paracyclophane was synthesized and its chemistry investigated; it was shown to be a competent pre-ligand in palladium(0)-mediated reactions, and displayed promising activity in gold(I)-catalysed cyclisations. The secondary phosphine oxide c...

4,12-di-(2-ferrocenylvinyl)-[2.2]-paracyclophane 2 has been prepared and investigated with respect to its electrochemical and UV/Vis/NIR spectroelectrochemical properties. Cyclic and square wave voltammetric measurements show two consecutive one-electron oxidations with a moderate redox splittin...

In this study, the synthesis and the characterization of new deoxyribonucleic acid (DNA) based compounds containing [2.2]paracyclophane moiety are reported. The DNA molecule was functionalized with hexadecyltrimethylammonium chloride (CTMA), [2.2]paracyclophane-4-methoxy-5-formyl [A] and [2.2]pa...

The animation of bromanil with 2,5-diaminobenzenesulphonic acid at 60°C, unlike that of chloranil, leads to the total loss of halogen. Reaction at 0°C, however, results in the formation of 2,5-bis-(4-amino-3-sulphoanilino)-3,6-dibromo-1,4-benzoquinone. This dianilide, unlike the corresponding ...

The incorporation of amino-substituted benzoquinoid bridging ligands into extended solids may provide a route to access light-weight metal-organic solids with high-temperature magnetic behavior and electronic conductivity. Reaction of Zn(NO3)2·6H2O with 2,5-diamino-3,6-dibromo-1,4-benzoquinone ...

Consumption of chlorinated drinking water has shown somewhat consistent association with increased risk of bladder cancer in a series of epidemiological studies, but plausible causative agents have not been identified. Halobenzoquinones (HBQs) have been recently predicted as putative disinfectio...

The photochemistry of 2,5-dibromo-3-methyl-6-isopropyl-1,4-benzoquinone (Br2TQ) in solution was studied by UV–vis spectroscopy using 20 ns laser pulses at 308 nm. The first transient with a lifetime of 0.06–0.2 μs is assigned to a triplet state. This triplet is converted into a short-lived zw...

The gas phase kinetics of the first stage of acetaldehyde oxidation were studied from 1030°K to 1115°K in a turbulent flow reactor which permits accurate determination of the spatial distribution of stable species. Experiments were performed in nitrogen at atmospheric pressure containing 0.1–...

Cells with electron-microscopic characteristics of myofibroblasts were isolated from baboon liver biopsy specimens by collagenase digestion and Percoll density gradient centrifugation and then cultured. The cultures consisted of only one cell type. By immunofluorescence, these cells synthesized ...

Acetaldehyde was found to form adducts with rat serum lipoproteins. The binding of [14C] acetaldehyde to lipoproteins was studied at low concentrations which are known to exist during ethanol oxidation. The amount of lipoprotein adducts was a linear function of acetaldehyde concentration up to 2...

Incubation of histone H1 with pharmacologically relevant concentrations of acetaldehyde resulted in the formation of spontaneously stable acetaldehyde-protein linkages. The reaction of acetaldehyde and H1 purified from rat liver either by a DNA recognition site affinity chromatography or by perc...

Hepatic fibrosis is an important morphological feature of alcohol-induced liver injury. We previously reported that acetaldehyde, but not ethanol can stimulate type I collagen and fibronectin synthesis in cultures of rat fat-storing cells (FSC) by increasing transcription of the specific genes. ...

Expired ethanol and acetaldehyde were measured after an oral injection of ethanol in C57BL/6J and DBA/2J mouse strains by a combination of several techniques in a sequence involving a method for trapping expired radioactive compounds, separation of compounds by gas chromatography, isolation of r...

Incubation of neutral salt soluble type III pN-collagen with [14C]acetaldehyde in, vitro resulted in the formation of spontaneously stable acetaldehyde-protein adducts. This reaction occurred primarily at lysine residues and it was not affected by 0.2 – 2 mM concentrations of ascorbate but addi...