Acetaldehyde (1–20 mM) was metabolized at high rates and in a dose-dependent manner in isolated human and baboon kidney-cortex tubules. Acetaldehyde removal was accompanied by a large accumulation of acetate in both human and baboon tubules. By contrast, a large synthesis of ethanol was observe...

High-resolution neutron powder diffraction is particularly suited for structure solution and refinement of low-melting point organic crystals of moderate complexity. Here we present the ab initio structure solution and refinement of stable-phase and metastable-phase perdeuterated acetaldehyde (m...

The phosphorescence spectrum of CD3CDO(3A″) has been obtained by collisional sensitization with triplet state sensitizers. The energy of CD3CDO(3A″) has been assigned at 27 400 ± 200 cm−1.

Spectra of vibronic bands 1501, 14011501 of S1 (n, π*)–S0 of d4-acetaldehyde in a supersonic jet are recorded and analyzed. The fitted rotational parameters A, B and C of vibrational levels 151 and 141151 are 1.040(4), 0.280(5) and 0.249(5) cm−1 and 1.038(5), 0.282(5) and 0.250(5) cm−1, respec...

Four new salts with low melting points of the general formula (EMIm)[NiBr3(L)] (EMIm = 1-ethyl-3-methyl-imidazolium) with L = N-methylimidazole (NMIm), N-methylbenzimidazole (NMBIm), quinoline (quin), and triphenylphosphane (PPh3) were prepared and characterized by means of elemental analysis, I...

Five palladium(II) complexes (1–5) with benzimidazole and 2-methylbenzimidazole were prepared and characterized by thermal analysis and, IR and NMR spectroscopy. The crystal structures of two of them, trans-[Pd(benzimidazole)2Br2]·2DMSO (1) and trans-[Pd(2-methylbenzimidazole)2I2] (5) were det...

Oxidation of seven 1-methylbenzimidazole (MBI) derivatives (with pKa's ranging from 1.6 to 6.0) was carried out with m-chloroperoxybenzoic acid and structures of the products formed were identified. (Condensed benzene moiety-hydroxylated)-2-(m-chlorobenzyloxy)-MBIs and 2-oxo-MBIs were obtai...

A series of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives have been synthesized. The structures of these compounds were established by IR, 1H NMR, 13C NMR, Mass spectral data and elemental analyses. Compounds were evaluated for their anti-inflammatory and analgesic act...

Synthesis of two new 1-(2-methylpropenyl)-2-methylbenzimidazoles by reaction of 2-methylbenzimidazole with 3-chloro-2-methylpropene using a strong base as a catalyst is described. Gas chromatography–mass spectrometry (GC–MS) allowed the characterization of the structural isomers: the slightly ...

In this paper are reported the synthesis and antiprotozoal activity in vitro of 24 1-methylbenzimidazole derivatives (13–36) substituted at position 2 with aminocarbonyl, N-methylaminocarbonyl, N,N-dimethylaminocarbonyl, ethoxycarbonyl, 1-hydroxyethyl and acetyl groups, some of them with chlori...

2-Seleno-1-methylbenzimidazole, H(sebenzimMe), can be synthesized from 1-methylbenzimidazole by sequential treatment with (i) BunLi, (ii) elemental selenium and (iii) HCl(aq). This method is also applicable to the synthesis of 2-seleno-1-t-butylbenzimidazole, H(sebenzimBut). Single crystal X-ray...

In this work, we report a combined experimental and theoretical study on the molecular structure and vibrational spectra of 1-(2-pyridinylmethyl)-2-methylbenzimidazole. The structure of the target compound has been proposed by elemental analysis and spectroscopic data, i.e., IR, Raman, UV, MS, 1...

3-Methylpyridazine (3-Mepydz) reacts with halogenotrimethylplatinum(IV), [PtXMe3)4], to afford complexes of type fac-[PtXMe3(3-Mepydz)2] (X = Cl, Br or I). In solution these complexes undergo 1,2-metallotropic shifts between the contiguous nitrogen donors producing different linkage isomers. Sol...

In this work the Raman spectrum of 3-methylpyridazine is reported for the first time and the infrared spectrum has been remeasured. On the basis of the experimental data a general assignment is proposed which is consistent with a Cs symmetry. The molecular structure as well as the potential ener...

Six new two-dimensional heteropolynuclear complexes, [M(3-mpdz)2M′(μ-CN)4]n (M = Zn(II) or Cd(II); M′ = Ni(II), Pd(II) or Pt(II); 3-mpdz = 3-methylpyridazine) were synthesized and characterized by FT-IR, Raman spectroscopy, single crystal X-ray diffraction, thermal and elemental analyses tech...

Two organic materials incited by electron deficiency of a pyridazine moiety were designed for application as bipolar host materials of phosphorescent organic light-emitting diodes. Modification of the pyridazine moiety with carbazole and pyrrolocarbazole hole transport units provided 3,6-bis(2-(...

Geranyl pyrophosphate:(−)-endo-fenchol cyclase catalyzes the conversion of geranyl pyrophosphate to (−)-endo-fenchol by a process thought to involve the initial isomerization of the substrate to the tertiary allylic isomer, linalyl pyrophosphate, and the subsequent cyclization of this bound inte...

Several stereoselective routes to both ethyl α- and β- fenchols 1α and 1β are discussed. Direct addition of ethyllithium to fenchone was the best route to 1α whereas obtention of 1β was achieved through the highly stereoselective retroethynylation of a mixture of ethynyl α- and β-fenchol...

Biotransformation of (+)-(1R,2S)-fenchol by the larvae of Spodoptera litura was carried out. Substrate was converted to three new terpenoids, (+)-(1R,2S)-10-hydroxyfenchol, (+)-(1R,2R,3S)-8-hydroxyfenchol and (−)-(1S,2S,6S)-6-exo-hydroxyfenchol, and one known terpenoid, (−)-(1R,2R,3R)-9-hydroxyf...

A series of reduced lipophilic N-benzylic imidazo[1,2-a]pyridine carboxamides (IPAs) with various side chains were designed and synthesized as new anti-TB agents in this work. Five derivatives A2, A3, A4, B1 and B9 exhibit excellent in vitro activity (MIC: