A resolution method using enantiopure 2-methoxy-2-(1-naphthyl)propionic (MαNP) acid 1 has been successfully applied to various racemic alcohols for preparing enantiopure (100% ee) alcohols and also for determining their absolute configurations by 1H NMR diamagnetic anisotropy and/or by X-ray cr...

Chiral 2-arylcarboxylic acid esters are important intermediates in preparation of enantioenriched 2-arylpropionic acids type Non-steroidal anti-inflammatory drugs (NSAIDs). Enantiomer separation of 2-arylcarboxylic acid esters is crucial for evaluation of the asymmetric synthesis efficiency and ...

Molecular hybridization is a ligand based drug design approach is well known recent medicinal chemistry to design anti-parasitic agents. In the present study, we have designed a series of (1-phenyl-9H-pyrido [3,4-b]indol-3-yl) (4-phenylpiperazin-1-yl)methanone derivatives using molecular hybridi...

Effect-directed isolation of free radical scavengers from the methanol extract of the freeze-dried fruiting bodies of the cultivated basidiomycetous mushroom, black poplar (Cyclocybe cylindracea), yielded a β-carboline alkaloid. Its structure was determined based on ESI-TOF-MS/MS, NMR and circu...

A convenient and efficient metal free, atom economical flexible synthesis of β-carbolines involving a domino Pictet-Spengler reaction and aromatization in oxygen atmosphere in N-methyl-2-pyrollidone (NMP) is described. Variety of aryl, heteroaryl and aliphatic aldehydes were found to be good su...

The extensive researches about the thermodynamic and intrinsic kinetic of disproportionation reaction of methyl phenyl carbonate to diphenyl carbonate were investigated independently with dibutyltin oxide as a catalyst, at a temperature range of 433.15–473.15 K and different catalyst concentrat...

An ascorbate peroxidase from a new source Musa paradisiaca leaf juice has been purified to homogeneity using a simple procedure involving concentration by ultra filtration and anion exchange chromatography on diethyl amino ethyl [DEAE] cellulose column. Sodium dodecyl sulphate-polyacrylamide gel...

The present study summarizes the conductivity of the drop-cast film for various amine complexes of the novel self-doped polyanilines bearing phosphonic acid, poly(2-methoxyaniline-5-phosphonic acid) (PMAP) and poly(2-methoxyaniline-5-phosphonic acid monoethyl ester) (PMAPE). The conductivity was...

Ionically crosslinked acid/base blend membranes of PBI-OO and a sulfonated polysulfone can be covalently crosslinked through aromatic sulfone groups, which form in a thermally induced Friedel-Crafts reaction. Here we systematically compare a series of blend membranes before and after curing. Eve...

A new N-sulfonic acid based on the polymer-support as a solid acid catalyst is prepared by the reaction of the modified poly(styrene-alt-maleic anhydride) with neat chlorosulfonic acid. 4H-Pyrimido[2,1-b]benzothiazole derivatives, tetrasubstituted imidazoles and benzoxanthenones as selected solv...

The use of two biphenyl sulfonic acid ligands for the catalytic C-N cross coupling of aryl halides with anilines, 3-aminopyridine, and secondary amines is reported. Our results represent a significant improvement compared to state of the art methods especially with regards to the removal of pall...

A water soluble chitosan-caffeic acid conjugate (C-CAC) was prepared by chemical modification of chitosan using activated caffeoyl with dimethyl aminopyridine as a catalyst. The C-CAC was characterized using UV–visible spectrometry, Fourier transform infrared, nuclear magnetic resonance spectro...

A newly-synthesized derivative of prazosin, prazosinamine hydrochloride, was examined for its ability to antagonize the interaction of the α1-adrenergic agonist phenylephrine with liver cells. Using a Ca2−-selective electrode to measure changes in perfusate Ca2+ concentration, prazosinamine was...

Two new copper(II)–prazosin (Prz) complex compounds, the binuclear green complex Cu2Prz2Cl2(CH3O)2 (1) and the complex salt prazosinium tetrachlorocuprate(II) [HPrz]2[CuCl4] (2), have been synthesized and characterized by chemical analysis, electronic spectra, IR and EPR spectroscopy, magnetoch...

ObjectiveTo investigate whether maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 were altered in pregnancies complicated by later preeclampsia (PE).

ObjectiveTo investigate human placental growth hormone (hGH-V) in ectopic pregnancy (EP): detection in maternal blood, correlation with immunohistochemistry and possible role as a marker for the course of EP.

Niridazole, a nitro heterocyclic antischistosomal drug, is extensively metabolized to unknown metabolites by Schistosoma mansoni. We report that 1-thiocarbamoyl-2-imidazolidinone was isolated by high pressure liquid chromatography and identified by high resolution electron impact mass spectrosco...

Organic salt 2-chloro-4-nitrobenzoate (CNBA−) 3-ammonium-phenol (AP+) exhibits fluorescence at 338 nm in solution and frontier molecular orbitals generated from TDDFT calculations indicate that the ground state and the excited state are physically separated on AP+ and CNBA−. The crystal structur...

The synthesis, spectral, thermal, magnetic properties, and structural features of four new one-dimensional (1-D) polymers having formula [M(4-npa)2(μ2-H2O)(H2O)2]·2H2O where (M = Mn 1; M = Co 2; M = Zn 3; M = Ni 4; 4-npa = 4-nitrophenylacetate) are investigated and compared with corresponding ...

Evaluation of a several fluorine-containing stationary phases for the chromatographic separation of fluorine-containing pharmaceuticals from their corresponding desfluoro analogs revealed a number of perfluoroaryl and perfluoroalky stationary phases that afford good separations. These fluorous s...