New substituted 3-((1H-1,2,3-triazol-1-yl)methyl)-5-arylisoxazoles (aryl = Ph, p-Tol) and 2-(5-phenylisoxazol-3-yl)-5-(2-(1-((5-(p-tolyl)isoxazol-3-yl)methyl)-1H-1,2,3-triazol-4-yl)ethyl)-1,3,4-oxadiazole were synthesized by means of click-chemistry procedures. The obtained compounds were used a...
The palladium-catalyzed, copper-promoted cross-dehydrogenative-coupling (CDC) of electron-deficient thiazoles with azine N-oxides through dual C–H activations was developed. It was found that copper(II) pivalate was an efficient dual-function reagent for the oxidative cross-coupling reactions, ...
Bis-paddlewheel heterobimetallic complexes in which palladium(II) is connected to the rare-earth metals(III) [Pd(μ-OOCMe)4Ln(OH2)(μ,η2-OOCMe)]2 × 2HOOCMe (Ln = Nd, Sm, Eu, Yb and Tm) by four acetate bridges were synthesised by the reaction of Pd3(μ-OOCMe)6 with the LnIII acetates. The tetra...
Polychlorinated diphenyl ethers (PCDEs) are a focus of current environmental concern. The formation of PCDEs was investigated using laboratory-scale flow reactors under air and under nitrogen at 350 °C. The results show the amount of PCDEs formed from the condensation of pentachlorophenol (PCP)...
Environmental levels and detailed congener profiles (31 congeners and 3 coeluting congener groups) of polybrominated diphenyl ethers (PBDEs) were assessed in a number of biota samples taken over a large geographic range covering harbours and industrial sites on Canada's West Coast. Addition...
Polychlorinated diphenyl ethers (PCDEs) are industrial byproducts found in many ecosystems at low levels. PCDEs are not markedly toxic to adult rodents, but their developmental toxicity has not previously been examined. We evaluated the maternal and perinatal toxicity of nine PCDE congeners to o...
Cellulose gels regenerated from aqueous alkali–urea solvent were found to have different surface polarity depending on coagulant species. Gels coagulated by alcohols adsorbed Congo red about twice as much as those coagulated by aqueous coagulants. The difference was also noted in the iodine rea...
High levels of extracellular polymeric substances (EPS) and bound water in sludge negatively impact sludge dewaterability. This study applied a novel sludge conditioning process involving calcium hypochlorite (Ca(ClO)2) oxidation, ferric coagulant re-flocculation, and walnut shell (WS) skeleton ...
Solution studies by 1H- and 13C-NMR, and IR spectroscopy of rhodium(I) complexes [Rh(η4-nbd)(TppAn)] (1), [Rh(η4-cod)(TppAn)] (2) and [Rh(CO)2(TppAn)] (3) (nbd=2,5-norbornadiene; cod=cycloocta-1,5-diene) have been performed. In all cases square planar complexes containing the TppAn ligand in a...
Two series of pseudo-tetrahedral nickel (II) complexes bearing the bulky hydrotris(3-phenyl)- or hydrotris(3-tert-butylpyrazol-1-yl)borato ligands, TpPhNiL and TptBuNiL respectively, have been synthesized and characterized with the intent of investigating the affects of substituent size on the r...
A new neo-clerodane diterpenoid, scutorientalin D, was isolated from the acetone extract of the aerial parts of Scutellaria orientalis subsp. pinnatifida. The structure and configuration of this compound was established by spectroscopic and molecular mechanics methods as (13S)-11β, 19-diacetoxy...
The role of 5′-methylthioadenosine (MTA), formed during the process of polyamine biosynthesis, on differentiation of osteoprogenitor cells was assessed by its effects on alkaline phosphatase (ALP) activity, bone nodule formation and osteopontin contents of cultured rat calvaria (RC) cells. Thes...
5′-Deoxy-5′-difluoromethylthioadenosine (DFMTA) caused potent time-dependent inactivation of S-adenosyl-L-homocysteine hydrolase. The mechanism of this inactivation was investigated.
The present study was designed to identify immunomodulatory components from the leech salivary gland of Haemadipsa sylvestris. The Sephadex G-50, ResourceTM S column chromatography and reverse-phase high performance liquid chromatography (RP-HPLC) were used to isolate and purify the salivary gla...
Pain remains a major concern in patients suffering from metastatic cancer to the bone and more knowledge of the condition, as well as novel treatment avenues, are called for. Neuropeptide Y (NPY) is a highly conserved peptide that appears to play a central role in nociceptive signaling in inflam...
Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Our aim w...
In this work, an organic nonlinear optical material (E)-1-(4-bromophenyl)-3-(4-(dimethylamino)phenyl)prop-2-en-1-one (C17H16NOBr) was synthesized by reacting 4-bromoacetophenone and N,N-dimethyl benzaldehyde in ethanol in the presence of sodium hydroxide. FT-IR and FT-Raman spectra were recorded...
3-[4-Di(2-hydroxyethyl)amino]phenyl-l-(2-furyl)-2-propene-l-one DAFP has been synthesized as a model compound for the study of molecular interactions in the solid-state and liquid environments with different polarity. The UV/vis absorption spectra of this compound have been studied in 35 solvent...
The synthesis of tri(2-furyl)(8-quinolylmethyl)phosphonium bromide and 2-[2-tri(2-furyl)phosphoniophenyl]benzimidazole perchlorate is described, the latter involving a nickel(II)-catalysed displacement of bromine from 2-(2-bromophenyl)benzimidazole by tri(2-furyl)phosphine. X-ray structural stud...
A novel series of HDAC inhibitors demonstrating class I and IIb subtype selectivity have been identified using a scaffold-hopping strategy. Several designed compounds showed better selectivity for class I and IIb over class IIa HDAC isoforms comparing to the FDA approved HDAC targeting drug SAHA...
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