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Hubei Lidu New Material Technology Co., Ltd

Hubei Lidu New Materials Technology Co. , Ltd. is located in No. 12,3C Industrial Park, Zhongxiang Economic Development Zone, Hubei Province. The company is committed to fine chemical raw materials, pharmaceutical intermediates and other production,

Gefitinib

Cas:184475-35-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Gefitinib

Cas:184475-35-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Yangzhou Qinyuan Pharmatech Co.,Ltd

Cas no. 184475-35-2 Gefitinib Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team. 3.Track record of quality

Gefitinib

Cas:184475-35-2

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Gefitinib Manufacturer/High quality/Best price/In stock

Cas:184475-35-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications Iressa CAS:184475-35-2

Cas:184475-35-2

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

professional supplier for Gefitinib cas no 184475-35-2 API

Cas:184475-35-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Gefitinib Cas 184475-35-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Slight white to white crystalline powder Storage:Cool dry place Package:1kg/foi

High quality Gefitinib Cas 184475-35-2 with best price and fast delivery

Cas:184475-35-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Gefitinib

Cas:184475-35-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Gefitinib

Cas:184475-35-2

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Gefitinib 184475-35-2 GMP Manufacturer

Cas:184475-35-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

Gefitinib

Cas:184475-35-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Gefitinib

Cas:184475-35-2

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Gefitinib

Cas:184475-35-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Gefitinib 99% Min Cas No.184475-35-2

Cas:184475-35-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Gefitinib

Cas:184475-35-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Iressa The alias:GEFITINIB CAS NO: 184475-35-2 Molecular formula:C22H24ClFN4O3 Molecular weight:446.9024 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without

Iressa/CAS:184475-35-2/Raw material supply

Cas:184475-35-2

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Gefitinib Synonyms: Gefitinib N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;IRESSA;GEFITINIB;AKOS 91371;n-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;N-(3-

Gefitinib 184475-35-2

Cas:184475-35-2

Min.Order:1 Kilogram

FOB Price: $230.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Gefitinib

Cas:184475-35-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing

Gefitinib CAS No.:184475-35-2

Cas:184475-35-2

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 184475-35-2 with best quality

Cas:184475-35-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Legal Gefitinib CAS NO.184475-35-2

Cas:184475-35-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name: Gefitinib Synonyms: Gefitinib N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;IRESSA;GEFITINIB;AKOS 91371;n-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;N-(3

Geftinib CAS: 184475-35-2

Cas:184475-35-2

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 184475-35-2 Gefitinib with best price

Cas:184475-35-2

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

GMP Pharmaceutical Gefitinib Powder API High Purity CAS 184475-35-2

Cas:184475-35-2

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Gefitinib 184475-35-2

Cas:184475-35-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

High Purity Gefitinib / IRESSA / GEFITINIB 100% Safe Customs Clearance

Cas:184475-35-2

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

1. DMF is available. It is used for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Antineoplastic. Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying

Gefitinib

Cas:184475-35-2

Min.Order:1 Kilogram

FOB Price: $50.0 / 200.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Gefitinib

Cas:184475-35-2

Min.Order:1 Kilogram

FOB Price: $124.0 / 150.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Gefitinib CAS:184475-35-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Gefitinib CAS:184475-35-2

Cas:184475-35-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Iressa

Cas:184475-35-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline
199327-59-8

4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With potassium hydroxide In isopropyl alcohol at 20℃;99%
In isopropyl alcohol at 80℃; for 0.533333h; Microwave irradiation;92%
With N,N,N,N,-tetramethylethylenediamine; nickel dichloride In tetrahydrofuran at 50℃; for 0.333333h; Concentration; Temperature; Reagent/catalyst;92.5%
3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

4-iodo-7-methoxy-6-[3-(4- morpholinyl)propoxy]quinazoline

4-iodo-7-methoxy-6-[3-(4- morpholinyl)propoxy]quinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
In isopropyl alcohol Reflux;92.46%
3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

4-bromo-7-methoxy-6-[3-(4- morpholinyl)propoxy]quinazoline

4-bromo-7-methoxy-6-[3-(4- morpholinyl)propoxy]quinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
In isopropyl alcohol Reflux;92.06%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With 18-crown-6 ether; potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 3h; Reagent/catalyst; Temperature;92%
With tetrabutylammomium bromide; sodium carbonate; potassium iodide In iso-butanol Reflux;90%
In N,N-dimethyl-formamide at 80 - 90℃; Concentration;88%
4-(3-((4-chloro-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine
320366-66-3

4-(3-((4-chloro-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide Reflux;91%
4-(3'-chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline dihydrochloride

4-(3'-chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline dihydrochloride

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With sodium hydroxide In water at 30 - 70℃; for 1.5h; pH=11 - 13;90.7%
3-morpholinopropyl 4-methylbenzenesulfonate
957621-67-9

3-morpholinopropyl 4-methylbenzenesulfonate

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 6h; Solvent; Temperature;89.5%
2-amino-4-methoxy-5-[(3-morpholin-4-yl)propoxy]benzonitrile
675126-27-9

2-amino-4-methoxy-5-[(3-morpholin-4-yl)propoxy]benzonitrile

3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Stage #1: 2-amino-4-methoxy-5-[(3-morpholin-4-yl)propoxy]benzonitrile; N,N-dimethyl-formamide dimethyl acetal With acetic acid In toluene at 85 - 90℃; for 2h;
Stage #2: 3-chloro-4-fluorophenylamine With acetic acid In toluene at 75 - 85℃; for 2.5h; Inert atmosphere;
89.5%
methanesulfonic acid 3-morpholin-4-yl-propyl ester
1018895-28-7

methanesulfonic acid 3-morpholin-4-yl-propyl ester

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 6h; Solvent; Temperature;89.2%
4-(methylthio)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline
958669-55-1

4-(methylthio)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline

3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With 3-chloro-4-fluoroaniline hydrochloride In isopropyl alcohol for 24h; Heating;85%
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Stage #1: 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one With thionyl chloride; N,N-dimethyl-formamide for 1h; Reflux;
Stage #2: 3-chloro-4-fluorophenylamine In isopropyl alcohol for 1h; Reflux;
84%
With potassium carbonate In isopropyl alcohol at 80 - 85℃; for 1h;82%
Stage #1: 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one With thionyl chloride In N,N-dimethyl-formamide for 2h; Heating;
Stage #2: 3-chloro-4-fluorophenylamine In N,N-dimethyl-formamide at 100℃; for 1h; Further stages.;
73%
Stage #1: 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one With triethylamine; trichlorophosphate In toluene at 5 - 70℃;
Stage #2: 3-chloro-4-fluorophenylamine In isopropyl alcohol; toluene at 70℃; for 1h;
62.86%
Stage #1: 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one With thionyl chloride for 4h; Reflux;
Stage #2: 3-chloro-4-fluorophenylamine In i-Amyl alcohol for 6h; Reflux;
2-amino-4-methoxy-5-[(3-morpholin-4-yl)propoxy]benzonitrile
675126-27-9

2-amino-4-methoxy-5-[(3-morpholin-4-yl)propoxy]benzonitrile

N'-(3-chloro-4-fluorophenyl)-N,N-dimethylmethanimidamide

N'-(3-chloro-4-fluorophenyl)-N,N-dimethylmethanimidamide

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With acetic acid at 130℃; for 1h;84%
With acetic acid; sodium sulfate In toluene at 130℃; for 4h;70%
2-chloro-N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine

2-chloro-N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With N,N,N,N,-tetramethylethylenediamine; acetic acid; zinc In methanol at 0 - 45℃; for 24h;82%
morpholine
110-91-8

morpholine

6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine
912556-91-3

6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With potassium iodide In N,N-dimethyl-formamide at 60℃; for 0.5h;78%
3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

N′-[2-cyano-5-methoxy-4-{3-(4-morpholinyl)propoxy}phenyl]-N,N-dimethylformamidine

N′-[2-cyano-5-methoxy-4-{3-(4-morpholinyl)propoxy}phenyl]-N,N-dimethylformamidine

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With acetic acid at 130℃; for 3h; Temperature;78%
With acetic acid In 5,5-dimethyl-1,3-cyclohexadiene at 135℃;71.1%
With acetic acid at 125 - 130℃; for 3h;70%
4 (3-bromopropyl)-morpholine
125422-83-5

4 (3-bromopropyl)-morpholine

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 12h;78%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
184475-71-6

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

A

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)-N-(3-morpholinopropyl)-quinazoline-4-amine

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)-N-(3-morpholinopropyl)-quinazoline-4-amine

B

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Stage #1: 4-(3-chloropropyl)morpholine; 4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline With hydrogenchloride
Stage #2: With potassium carbonate In dimethyl sulfoxide at 80℃; for 2h; Reagent/catalyst;
A 13.5 %Chromat.
B 64.5%
C37H37ClFN4O5Pol

C37H37ClFN4O5Pol

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; not specified;44%
morpholine
110-91-8

morpholine

4-(3′-chloro-4′-fluoroanilino)-6-(3-bromopropoxy)-7-methoxyquinazoline

4-(3′-chloro-4′-fluoroanilino)-6-(3-bromopropoxy)-7-methoxyquinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
In N,N-dimethyl-formamide27%
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: P2S5 / pyridine / 24 h / Heating
2.1: aq. NaOH / methanol / 15 - 20 °C
2.2: 8.3 g / methanol; H2O / 5 h / 20 °C
3.1: 85 percent / 3-chloro-4-fluoroaniline hydrochloride / propan-2-ol / 24 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 90 percent / POCl3; triethylamine / toluene / 24 h / 58 °C
2: 91 percent / triethylamine / propan-2-ol / 288 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: oxalyl chloride / CHCl3; dimethylformamide / Heating
2: 70 percent / dimethylformamide / 1 h / 145 °C
View Scheme
Multi-step reaction with 3 steps
1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide; acetonitrile / 3 h / 40 - 45 °C
2: hydrogenchloride / methanol; water / 1 h / 20 °C
3: sodium hydroxide / water / 1.5 h / 30 - 70 °C / pH 11 - 13
View Scheme
7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazolin-4(3H)-thione
958669-54-0

7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazolin-4(3H)-thione

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aq. NaOH / methanol / 15 - 20 °C
1.2: 8.3 g / methanol; H2O / 5 h / 20 °C
2.1: 85 percent / 3-chloro-4-fluoroaniline hydrochloride / propan-2-ol / 24 h / Heating
View Scheme
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 391.5 g / potassium carbonate / dimethylformamide / 3 h / 100 °C
2.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating
3.1: 349 g / acetic anhydride / 3 h / 110 °C
4.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
5.2: 86 percent / HCl / H2O / 90 - 130 °C
6.1: thionyl chloride / dimethylformamide / 2 h / Heating
6.2: 73 percent / dimethylformamide / 1 h / 100 °C
View Scheme
Multi-step reaction with 7 steps
1.1: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C
2.1: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C
3.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C
4.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C
5.1: formamide / 20 - 100 °C
5.2: 78 percent / 7 h / 100 °C
6.1: 90 percent / POCl3; triethylamine / toluene / 24 h / 58 °C
7.1: 91 percent / triethylamine / propan-2-ol / 288 h / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 78 °C
2.1: acetic acid; sulfuric acid / 0.5 h / 0 - 40 °C
2.2: 6 h / 40 °C
3.1: sodium thiosulphite / water / 2 h / 45 °C
3.2: 0.83 h / 70 °C
4.1: sodium sulfate; acetic acid / toluene / 4 h / 130 °C
View Scheme
4-methoxy-3-[3-(morpholin-4-yl)propoxy]benzonitrile
675126-28-0

4-methoxy-3-[3-(morpholin-4-yl)propoxy]benzonitrile

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
2.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
2.2: 86 percent / HCl / H2O / 90 - 130 °C
3.1: thionyl chloride / dimethylformamide / 2 h / Heating
3.2: 73 percent / dimethylformamide / 1 h / 100 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C
2.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C
3.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C
4.1: formamide / 20 - 100 °C
4.2: 78 percent / 7 h / 100 °C
5.1: 90 percent / POCl3; triethylamine / toluene / 24 h / 58 °C
6.1: 91 percent / triethylamine / propan-2-ol / 288 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid; sulfuric acid / 0.5 h / 0 - 40 °C
1.2: 6 h / 40 °C
2.1: sodium thiosulphite / water / 2 h / 45 °C
2.2: 0.83 h / 70 °C
3.1: sodium sulfate; acetic acid / toluene / 4 h / 130 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic acid; nitric acid / 3 h / 20 °C
2: ammonium formate; 15% palladium on carbon / ethanol / 2 h / 60 - 65 °C
3: acetic acid / 1 h / 130 °C
View Scheme
Multi-step reaction with 3 steps
1.1: nitric acid; sulfuric acid / dichloromethane / 3.5 h / 0 - 40 °C
2.1: sodium thiosulfate / water / 2 h / 48 - 53 °C
3.1: acetic acid / toluene / 2 h / 85 - 90 °C
3.2: 2.5 h / 75 - 85 °C / Inert atmosphere
View Scheme
2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile
675126-26-8

2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
1.2: 86 percent / HCl / H2O / 90 - 130 °C
2.1: thionyl chloride / dimethylformamide / 2 h / Heating
2.2: 73 percent / dimethylformamide / 1 h / 100 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C
2.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C
3.1: formamide / 20 - 100 °C
3.2: 78 percent / 7 h / 100 °C
4.1: 90 percent / POCl3; triethylamine / toluene / 24 h / 58 °C
5.1: 91 percent / triethylamine / propan-2-ol / 288 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: sodium dithionite / water / 2.5 h / 50 °C
2: acetic acid / toluene / 3 h / 105 °C / Dean-Stark
3: acetic acid / 3 h / 125 - 130 °C
View Scheme
isovanillin
621-59-0

isovanillin

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 391.5 g / potassium carbonate / dimethylformamide / 3 h / 100 °C
2.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating
3.1: 349 g / acetic anhydride / 3 h / 110 °C
4.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
5.2: 86 percent / HCl / H2O / 90 - 130 °C
6.1: thionyl chloride / dimethylformamide / 2 h / Heating
6.2: 73 percent / dimethylformamide / 1 h / 100 °C
View Scheme
Multi-step reaction with 8 steps
1.1: 88 percent / sodium formate; formic acid; hydroxylamine sulfate / 8 h / 85 °C
2.1: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C
3.1: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C
4.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C
5.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C
6.1: formamide / 20 - 100 °C
6.2: 78 percent / 7 h / 100 °C
7.1: 90 percent / POCl3; triethylamine / toluene / 24 h / 58 °C
8.1: 91 percent / triethylamine / propan-2-ol / 288 h / Heating
View Scheme
Multi-step reaction with 10 steps
1.1: aminosulfonic acid; sodium chlorite / water / 2 h / 5 - 8 °C
2.1: hydrogenchloride / 4 h / 50 - 55 °C
3.1: potassium carbonate; potassium iodide / acetone / 25 - 30 °C
3.2: Reflux
4.1: nitric acid; acetic acid / 14 h / 25 - 35 °C
5.1: acetic acid; iron / 50 - 60 °C
6.1: ethyl acetate / 12 h / Reflux
7.1: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C
8.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C
9.1: methanesulfonic acid / chloroform / 5 h / Reflux
10.1: potassium iodide; sodium carbonate; tetrabutylammomium bromide / iso-butanol / Reflux
View Scheme
4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldoxime
934191-95-4

4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldoxime

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 349 g / acetic anhydride / 3 h / 110 °C
2.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
3.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
3.2: 86 percent / HCl / H2O / 90 - 130 °C
4.1: thionyl chloride / dimethylformamide / 2 h / Heating
4.2: 73 percent / dimethylformamide / 1 h / 100 °C
View Scheme
4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldehyde
861453-11-4

4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldehyde

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating
2.1: 349 g / acetic anhydride / 3 h / 110 °C
3.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
4.2: 86 percent / HCl / H2O / 90 - 130 °C
5.1: thionyl chloride / dimethylformamide / 2 h / Heating
5.2: 73 percent / dimethylformamide / 1 h / 100 °C
View Scheme
6-(3-chloropropoxy)-7-methoxyquinazolin-4(3H)-one
574738-93-5

6-(3-chloropropoxy)-7-methoxyquinazolin-4(3H)-one

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 86 percent / SOCl2 / dimethylformamide / 4 h / Heating
2: 93 percent / propan-2-ol / 3 h / Heating
3: 78 percent / KI / dimethylformamide / 0.5 h / 60 °C
View Scheme
4-chloro-6-(3-chloropropoxy)-7-methoxyquinazoline
692059-41-9

4-chloro-6-(3-chloropropoxy)-7-methoxyquinazoline

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / propan-2-ol / 3 h / Heating
2: 78 percent / KI / dimethylformamide / 0.5 h / 60 °C
View Scheme
3-hydroxy-4-methoxybenzoate
6702-50-7

3-hydroxy-4-methoxybenzoate

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 95 percent / K2CO3 / dimethylformamide / 4 h / 70 °C
2: 89 percent / nitric acid; acetic acid; acetic anhydride / 6 h / 20 °C
3: 77 percent / Fe; acetic acid / methanol / 0.5 h / 50 - 60 °C
4: 92 percent / ethanol / 6 h / Heating
5: 86 percent / SOCl2 / dimethylformamide / 4 h / Heating
6: 93 percent / propan-2-ol / 3 h / Heating
7: 78 percent / KI / dimethylformamide / 0.5 h / 60 °C
View Scheme
Multi-step reaction with 7 steps
1: 76 percent / potassium carbonate / acetone / 24 h / Heating
2: 82 percent / nitric acid; trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C
3: 60 percent / 1 h / 100 °C
4: hydrogen / palladium on activated carbon / methanol
5: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C
6: oxalyl chloride / CHCl3; dimethylformamide / Heating
7: 70 percent / dimethylformamide / 1 h / 145 °C
View Scheme
Multi-step reaction with 8 steps
1.1: potassium carbonate; potassium iodide / acetone / 25 - 30 °C
1.2: Reflux
2.1: nitric acid; acetic acid / 14 h / 25 - 35 °C
3.1: acetic acid; iron / 50 - 60 °C
4.1: ethyl acetate / 12 h / Reflux
5.1: oxalyl dichloride; N-ethyl-N,N-diisopropylamine / chloroform / 12 h / 60 - 65 °C
6.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 60 - 65 °C
7.1: methanesulfonic acid / chloroform / 5 h / Reflux
8.1: potassium iodide; sodium carbonate; tetrabutylammomium bromide / iso-butanol / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: sodium carbonate / N,N-dimethyl-formamide / 10 h / 85 °C
2.1: trimethylaluminum / hexane; dichloromethane / 5 h / 0 °C / Inert atmosphere; Reflux
3.1: trichlorophosphate / toluene / 2 h / Reflux
4.1: thionyl chloride; N,N-dimethyl-formamide / 1 h / Reflux
4.2: 1 h / Reflux
View Scheme
gefitinib
184475-35-2

gefitinib

7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-ol
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-ol

Conditions
ConditionsYield
With hydrogenchloride for 6h; Heating;98%
sodium docusate
577-11-7

sodium docusate

gefitinib
184475-35-2

gefitinib

gefitinib docusate

gefitinib docusate

Conditions
ConditionsYield
With hydrogenchloride In dichloromethane; water at 20℃; for 3.5h;97%
propyl bromide
106-94-5

propyl bromide

gefitinib
184475-35-2

gefitinib

gefitinib-NP

gefitinib-NP

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; potassium hydroxide In tetrahydrofuran; acetonitrile at 50 - 60℃; for 24h; Inert atmosphere;95%
3-methoxy-4-hydroxybenzoic acid
121-34-6

3-methoxy-4-hydroxybenzoic acid

gefitinib
184475-35-2

gefitinib

C8H8O4*2C22H24ClFN4O3

C8H8O4*2C22H24ClFN4O3

Conditions
ConditionsYield
In methanol; acetonitrile at 50℃; for 4h; Temperature; Solvent;93.82%
1-bromo-butane
109-65-9

1-bromo-butane

gefitinib
184475-35-2

gefitinib

gefitinib-NB

gefitinib-NB

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; potassium hydroxide In tetrahydrofuran; acetonitrile at 50 - 60℃; for 24h; Inert atmosphere;93%
3-Carboxyphenol
99-06-9

3-Carboxyphenol

gefitinib
184475-35-2

gefitinib

C22H24ClFN4O3*C7H6O3

C22H24ClFN4O3*C7H6O3

Conditions
ConditionsYield
In methanol at 5 - 10℃; for 48.83h; Solvent;91.12%
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid
1135-24-6

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

gefitinib
184475-35-2

gefitinib

2C22H24ClFN4O3*C10H10O4

2C22H24ClFN4O3*C10H10O4

Conditions
ConditionsYield
In ethanol at 25 - 80℃; for 17h;90%
In ethanol at 25 - 80℃;582 mg
p-Coumaric Acid
7400-08-0

p-Coumaric Acid

gefitinib
184475-35-2

gefitinib

2C22H24ClFN4O3*C9H8O3

2C22H24ClFN4O3*C9H8O3

Conditions
ConditionsYield
In ethanol at 25 - 80℃;87.5%
In ethanol at 25 - 80℃; for 17h;87.5%
caffeic acid
331-39-5

caffeic acid

gefitinib
184475-35-2

gefitinib

2C22H24ClFN4O3*C9H8O4

2C22H24ClFN4O3*C9H8O4

Conditions
ConditionsYield
In ethanol at 25 - 80℃;83%
caffeic acid
331-39-5

caffeic acid

gefitinib
184475-35-2

gefitinib

2C22H24ClFN4O3*C9H8O4

2C22H24ClFN4O3*C9H8O4

Conditions
ConditionsYield
In ethanol at 25 - 80℃; for 18h;83%
gefitinib
184475-35-2

gefitinib

O-Demethyl-Gefitinib
847949-49-9

O-Demethyl-Gefitinib

Conditions
ConditionsYield
With pyridine hydrochloride at 170℃; for 3h;80%
With pyridine hydrochloride; potassium carbonate at 144℃; for 3h; Inert atmosphere;60.7%
With lithium chloride In N,N-dimethyl-formamide for 15h; Heating;54%
isopropyl bromide
75-26-3

isopropyl bromide

gefitinib
184475-35-2

gefitinib

gefitinib-NIP

gefitinib-NIP

Conditions
ConditionsYield
Stage #1: gefitinib With tetrabutylammomium bromide; potassium hydroxide In tetrahydrofuran; water for 0.5h; Inert atmosphere;
Stage #2: isopropyl bromide In tetrahydrofuran; water at 50 - 60℃;
80%
benzoic acid
65-85-0

benzoic acid

gefitinib
184475-35-2

gefitinib

(x)C7H6O2*C22H24ClFN4O3

(x)C7H6O2*C22H24ClFN4O3

Conditions
ConditionsYield
In tetrachloromethane; acetone at 60℃; for 0.5h;69.1%

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