Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:199327-61-2
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/575.html Product Name 7-Methoxy-6-(3-morpholin-4-ylpro
Cas:199327-61-2
Min.Order:1 Gram
FOB Price: $52.0
Type:Lab/Research institutions
inquiryPurity 98% with good quality Competitive price Prompt shipment Appearance:White powder Storage:Store in cool dry place Package:25 kg/drum Application:Pharmaceutical intermediates Port:Shanghai, Nanjing
Cas:199327-61-2
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:199327-61-2
Min.Order:1
Negotiable
Type:Other
inquiryHigh quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr
Cas:199327-61-2
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:199327-61-2
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryName:7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one CAS NO:199327-61-2 Grade:Gefitinib intermediate Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security witho
Cas:199327-61-2
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:199327-61-2
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryHenan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com
Cas:199327-61-2
Min.Order:1 Gram
FOB Price: $1000.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:199327-61-2
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:199327-61-2
Min.Order:1 Kilogram
FOB Price: $7.0 / 9.0
Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:199327-61-2
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:199327-61-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
Cas:199327-61-2
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiry7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one CAS: 199327-61-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, sp
Cas:199327-61-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:199327-61-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:199327-61-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:199327-61-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry7-methoxy-6-(3-morpholin-4-yl-propoxy)quinazolin-4(3H)-one(CAS:199327-61-2) is is an important pharmaceutical intermediate of Gilteritinib and one of the most competitive products in our company. Please feel free to contact us for more details. Appea
Cas:199327-61-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:199327-61-2
Min.Order:0
Negotiable
Type:Manufacturers
inquiryAppearance:White Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Gefitinib intermediate Transportation:Common products:Sea/Air/Courier Dangerous Chem:Sea/Ai
Cas:199327-61-2
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:199327-61-2
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:199327-61-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scientists co
Cas:199327-61-2
Min.Order:100 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiry1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product
Cas:199327-61-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:199327-61-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:199327-61-2
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:White Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Gefitinib interm
Cas:199327-61-2
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:199327-61-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Synonyms: 7-METHOXY-6-(3-MORPHOLINOPROPOXY)QUINAZOLIN-4(3H)-ONE;7-Methoxy-6-(…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton
Cas:199327-61-2
Min.Order:0
Negotiable
Type:Other
inquiry4 (3-bromopropyl)-morpholine
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With 1-butyl-3-methylimidazolium Tetrafluoroborate In tetrahydrofuran at 65 - 70℃; for 5h; | 93.8% |
4-(3-chloropropyl)morpholine
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With 1-butyl-3-methylimidazolium Tetrafluoroborate In N,N-dimethyl-formamide at 55 - 60℃; for 5h; | 93.7% |
4-(3-iodopropyl)morpholine
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With 1-butyl-3-methylimidazolium Tetrafluoroborate In N,N-dimethyl-formamide at 75 - 80℃; for 5h; | 91.2% |
formamidine acetic acid
methyl 5-(3-morpholinopropoxy)-2-amino-4-methoxy-benzoate
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
In ethanol for 4h; Reflux; | 88% |
In methanol at 50 - 60℃; for 6h; | 81.73% |
In 2-methoxy-ethanol at 115℃; for 2h; | 78% |
In methanol at 50 - 60℃; for 6h; |
2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide
formaldehyd
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
In water at 130℃; for 48h; | 88% |
7-methoxy-6-(3'-N-morpholino)propoxyquinazoline
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Stage #1: 7-methoxy-6-(3'-N-morpholino)propoxyquinazoline With ammonium cerium (IV) nitrate; acetic acid In water Stage #2: With sodium hydroxide In water | 87% |
With peracetic acid; sulfuric acid In ethanol at 60℃; for 12h; | 85% |
2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile
formic acid
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Stage #1: 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile With iron(III) chloride; hydrazine hydrate In methanol; water for 3h; Heating; Stage #2: formic acid With hydrogenchloride In water at 90 - 130℃; Further stages.; | 86% |
Stage #1: 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile With iron(III) chloride; hydrazine hydrate In methanol; water at 80℃; for 3.5h; Stage #2: formic acid With hydrogenchloride In water at 130℃; for 4h; | 68.65% |
Stage #1: 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile With iron(III) chloride; hydrazine hydrate In methanol; water for 3h; Reflux; Stage #2: formic acid With hydrogenchloride In water at 130℃; for 3.5h; | 58% |
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With formamidine acetic acid | 82% |
2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide
formic acid
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Stage #1: 2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide; formic acid With formamide at 20 - 100℃; Stage #2: at 100℃; for 7h; | 78% |
Stage #1: 2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide; formic acid In dichloromethane at 100℃; for 5h; Acidic conditions; Stage #2: With hydrogenchloride In water at 70℃; for 3h; Acidic aqueous solution; Stage #3: With sodium hydroxide In water at 20 - 25℃; Alkaline aqueous solution; | |
With formamide at 20℃; for 8h; Reflux; | 3.3 g |
ammonium formate
formamide
methyl 5-(3-morpholinopropoxy)-2-amino-4-methoxy-benzoate
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
at 170℃; for 3h; | 71.1% |
ethyl 2-amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)benzoate
formamidine acetic acid
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
In 2-methoxy-ethanol for 8h; Heating; | 69.2% |
In methanol for 6h; Reflux; |
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With trichlorophosphate In toluene for 2h; Reflux; | 40% |
4-(3-chloropropyl)morpholine
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 391.5 g / potassium carbonate / dimethylformamide / 3 h / 100 °C 2.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating 3.1: 349 g / acetic anhydride / 3 h / 110 °C 4.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 5.2: 86 percent / HCl / H2O / 90 - 130 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C 2.1: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C 3.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C 4.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C 5.1: formamide / 20 - 100 °C 5.2: 78 percent / 7 h / 100 °C View Scheme |
4-methoxy-3-[3-(morpholin-4-yl)propoxy]benzonitrile
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 2.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 2.2: 86 percent / HCl / H2O / 90 - 130 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C 2.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C 3.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C 4.1: formamide / 20 - 100 °C 4.2: 78 percent / 7 h / 100 °C View Scheme | |
Multi-step reaction with 4 steps 1: nitric acid; sulfuric acid; acetic acid / 37 h / 0 - 20 °C 2: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 1.5 h / 50 °C 3: palladium on activated charcoal / ethyl acetate; dichloromethane / 1.8 h / Reflux 4: formamide / 8 h / 20 °C / Reflux View Scheme |
isovanillin
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 391.5 g / potassium carbonate / dimethylformamide / 3 h / 100 °C 2.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating 3.1: 349 g / acetic anhydride / 3 h / 110 °C 4.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 5.2: 86 percent / HCl / H2O / 90 - 130 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: 88 percent / sodium formate; formic acid; hydroxylamine sulfate / 8 h / 85 °C 2.1: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C 3.1: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C 4.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C 5.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C 6.1: formamide / 20 - 100 °C 6.2: 78 percent / 7 h / 100 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: formic acid; dihydrogen peroxide / 0 - 4 °C 1.2: Reflux 2.1: sodium carbonate / N,N-dimethyl-formamide / 10 h / 85 °C 3.1: trimethylaluminum / hexane; dichloromethane / 5 h / 0 °C / Inert atmosphere; Reflux 4.1: trichlorophosphate / toluene / 2 h / Reflux View Scheme |
4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldoxime
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 349 g / acetic anhydride / 3 h / 110 °C 2.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 3.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 3.2: 86 percent / HCl / H2O / 90 - 130 °C View Scheme |
4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldehyde
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating 2.1: 349 g / acetic anhydride / 3 h / 110 °C 3.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C 4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating 4.2: 86 percent / HCl / H2O / 90 - 130 °C View Scheme |
2-amino-4-methoxy-5-[(3-morpholin-4-yl)propoxy]benzonitrile
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C 2.1: formamide / 20 - 100 °C 2.2: 78 percent / 7 h / 100 °C View Scheme |
2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C 2.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C 3.1: formamide / 20 - 100 °C 3.2: 78 percent / 7 h / 100 °C View Scheme | |
Multi-step reaction with 3 steps 1: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 1.5 h / 50 °C 2: palladium on activated charcoal / ethyl acetate; dichloromethane / 1.8 h / Reflux 3: formamide / 8 h / 20 °C / Reflux View Scheme |
2-methoxy-5-cyanophenol
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C 2.1: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C 3.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C 4.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C 5.1: formamide / 20 - 100 °C 5.2: 78 percent / 7 h / 100 °C View Scheme | |
Multi-step reaction with 5 steps 1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 85 °C 2: nitric acid; sulfuric acid; acetic acid / 37 h / 0 - 20 °C 3: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 1.5 h / 50 °C 4: palladium on activated charcoal / ethyl acetate; dichloromethane / 1.8 h / Reflux 5: formamide / 8 h / 20 °C / Reflux View Scheme |
3-hydroxy-4-methoxybenzoate
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 76 percent / potassium carbonate / acetone / 24 h / Heating 2: 82 percent / nitric acid; trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C 3: 60 percent / 1 h / 100 °C 4: hydrogen / palladium on activated carbon / methanol 5: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium carbonate / N,N-dimethyl-formamide / 10 h / 85 °C 2: trimethylaluminum / hexane; dichloromethane / 5 h / 0 °C / Inert atmosphere; Reflux 3: trichlorophosphate / toluene / 2 h / Reflux View Scheme |
methyl 3-(3-chloropropoxy)-4-methoxybenzoate
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 82 percent / nitric acid; trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C 2: 60 percent / 1 h / 100 °C 3: hydrogen / palladium on activated carbon / methanol 4: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C View Scheme |
methyl 4-methoxy-5-(3-chloropropoxy)-2-nitrobenzoate
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 60 percent / 1 h / 100 °C 2: hydrogen / palladium on activated carbon / methanol 3: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C View Scheme |
4-methoxy-5-(3-morpholinylpropoxy)-2-nitrobenzoic acid methyl ester
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / palladium on activated carbon / methanol 2: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C View Scheme |
gefitinib
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With ammonia In hydrogenchloride | |
With ammonia In hydrogenchloride | |
Stage #1: gefitinib With hydrogenchloride In water for 6h; Heating / reflux; Stage #2: With ammonia In water at 0℃; | |
Stage #1: gefitinib With hydrogenchloride In water for 6h; Heating / reflux; Stage #2: With ammonium hydroxide In water |
C16H14N2O2
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogen; palladium on activated charcoal 2: potassium carbonate / N,N-dimethyl-formamide 3: peracetic acid; sulfuric acid / ethanol / 12 h / 60 °C View Scheme |
6-hydroxy-7-methoxyquinazoline
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide 2: peracetic acid; sulfuric acid / ethanol / 12 h / 60 °C View Scheme |
3-benzyloxy-4-methoxybenzaldehyde
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: nitric acid / water 2: hydrogenchloride; iron / ethanol 3: ethanol / Reflux 4: hydrogen; palladium on activated charcoal 5: potassium carbonate / N,N-dimethyl-formamide 6: peracetic acid; sulfuric acid / ethanol / 12 h / 60 °C View Scheme |
2-aldehyde-4-benzyloxy-5-methoxy nitrobenzene
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogenchloride; iron / ethanol 2: ethanol / Reflux 3: hydrogen; palladium on activated charcoal 4: potassium carbonate / N,N-dimethyl-formamide 5: peracetic acid; sulfuric acid / ethanol / 12 h / 60 °C View Scheme |
5-benzyloxy-4-methoxy-2-aminobenzaldehyde
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: ethanol / Reflux 2: hydrogen; palladium on activated charcoal 3: potassium carbonate / N,N-dimethyl-formamide 4: peracetic acid; sulfuric acid / ethanol / 12 h / 60 °C View Scheme |
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline
Conditions | Yield |
---|---|
With thionyl chloride; N,N-dimethyl-formamide for 4h; Heating; | 99.3% |
With thionyl chloride In N,N-dimethyl-formamide at 84℃; for 1.5h; | 96.85% |
With thionyl chloride; N,N-dimethyl-formamide at 84℃; | 94% |
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
6-acetoxy-4-chloro-7-methoxyquinazoline
Conditions | Yield |
---|---|
With sulfuryl dichloride In acetonitrile at 55℃; Temperature; Concentration; | 93.7% |
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
4-(3-(4-chloro-7-methoxyquinazolin-6-yloxy)propyl)morpholine hydrochloride
Conditions | Yield |
---|---|
With triethylamine; trichlorophosphate In acetonitrile at 80 - 90℃; for 1h; Temperature; Reagent/catalyst; Solvent; | 84.1% |
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
3-chloro-4-fluorophenylamine
gefitinib
Conditions | Yield |
---|---|
Stage #1: 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one With thionyl chloride; N,N-dimethyl-formamide for 1h; Reflux; Stage #2: 3-chloro-4-fluorophenylamine In isopropyl alcohol for 1h; Reflux; | 84% |
With potassium carbonate In isopropyl alcohol at 80 - 85℃; for 1h; | 82% |
Stage #1: 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one With thionyl chloride In N,N-dimethyl-formamide for 2h; Heating; Stage #2: 3-chloro-4-fluorophenylamine In N,N-dimethyl-formamide at 100℃; for 1h; Further stages.; | 73% |
Stage #1: 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one With triethylamine; trichlorophosphate In toluene at 5 - 70℃; Stage #2: 3-chloro-4-fluorophenylamine In isopropyl alcohol; toluene at 70℃; for 1h; | 62.86% |
Stage #1: 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one With thionyl chloride for 4h; Reflux; Stage #2: 3-chloro-4-fluorophenylamine In i-Amyl alcohol for 6h; Reflux; |
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
propargyl bromide
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; | 54% |
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
2-fluoroethyl tosylate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 90 - 100℃; for 2h; | 27% |
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazolin-4(3H)-thione
Conditions | Yield |
---|---|
With tetraphosphorus decasulfide In pyridine for 24h; Heating; |
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
4-(methylthio)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: P2S5 / pyridine / 24 h / Heating 2.1: aq. NaOH / methanol / 15 - 20 °C 2.2: 8.3 g / methanol; H2O / 5 h / 20 °C View Scheme |
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
gefitinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: P2S5 / pyridine / 24 h / Heating 2.1: aq. NaOH / methanol / 15 - 20 °C 2.2: 8.3 g / methanol; H2O / 5 h / 20 °C 3.1: 85 percent / 3-chloro-4-fluoroaniline hydrochloride / propan-2-ol / 24 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 90 percent / POCl3; triethylamine / toluene / 24 h / 58 °C 2: 91 percent / triethylamine / propan-2-ol / 288 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: oxalyl chloride / CHCl3; dimethylformamide / Heating 2: 70 percent / dimethylformamide / 1 h / 145 °C View Scheme | |
Multi-step reaction with 3 steps 1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide; acetonitrile / 3 h / 40 - 45 °C 2: hydrogenchloride / methanol; water / 1 h / 20 °C 3: sodium hydroxide / water / 1.5 h / 30 - 70 °C / pH 11 - 13 View Scheme |
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
O-Demethyl-Gefitinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 90 percent / POCl3; triethylamine / toluene / 24 h / 58 °C 2: 91 percent / triethylamine / propan-2-ol / 288 h / Heating 3: 54 percent / LiCl / dimethylformamide / 15 h / Heating View Scheme |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View