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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Manufacturer/High quality/Best price/In stock

Cas:199327-61-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/575.html Product Name 7-Methoxy-6-(3-morpholin-4-ylpro

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

Cas:199327-61-2

Min.Order:1 Gram

FOB Price: $52.0

Type:Lab/Research institutions

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Nanjing Yuance Industry&Trade Co., Ltd.

Purity 98% with good quality Competitive price Prompt shipment Appearance:White powder Storage:Store in cool dry place Package:25 kg/drum Application:Pharmaceutical intermediates Port:Shanghai, Nanjing

7-Methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one

Cas:199327-61-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

CAS:199327-61-2/High quality/Factory supply

Cas:199327-61-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

7-Methoxy-6-[3-(4-morpholinyl)-propoxy]-4-(1H)-quinazolinone

Cas:199327-61-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one CAS NO:199327-61-2 Grade:Gefitinib intermediate Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security witho

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

Cas:199327-61-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

Cas:199327-61-2

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 199327-61-2 with competitive price

Cas:199327-61-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one CAS199327-61-2

Cas:199327-61-2

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one 199327-61-2

Cas:199327-61-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

Cas:199327-61-2

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one CAS: 199327-61-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, sp

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one CAS: 199327-61-2

Cas:199327-61-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

Cas:199327-61-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one/ LIDE PHARMA- Factory supply / Best price

Cas:199327-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

Cas:199327-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

7-methoxy-6-(3-morpholin-4-yl-propoxy)quinazolin-4(3H)-one(CAS:199327-61-2) is is an important pharmaceutical intermediate of Gilteritinib and one of the most competitive products in our company. Please feel free to contact us for more details. Appea

7-methoxy-6-(3-morpholin-4-yl-propoxy)quinazolin-4(3H)-one

Cas:199327-61-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

7-Methoxy-6-(3-Morpholin-4-Ylpropoxy)Quinazolin-4(3H)-One

Cas:199327-61-2

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:White Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Gefitinib intermediate Transportation:Common products:Sea/Air/Courier Dangerous Chem:Sea/Ai

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

Cas:199327-61-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

Cas:199327-61-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

7-METHOXY-6-(3-MORPHOLINOPROPOXY)-3,4-DIHYDROQUINAZOLIN-4-ONE

Cas:199327-61-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scientists co

7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(3H)-quinazolinone

Cas:199327-61-2

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

Cas:199327-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

Cas:199327-61-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

Cas:199327-61-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:White Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Gefitinib interm

Intermediate of gefitinib-

Cas:199327-61-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Manufacturer/High quality/Best price/In stock

Cas:199327-61-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

Product Name: 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Synonyms: 7-METHOXY-6-(3-MORPHOLINOPROPOXY)QUINAZOLIN-4(3H)-ONE;7-Methoxy-6-(…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one

Cas:199327-61-2

Min.Order:0

Negotiable

Type:Other

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Synthetic route

C9H6N2O3(2-)*2Na(1+)

C9H6N2O3(2-)*2Na(1+)

4 (3-bromopropyl)-morpholine
125422-83-5

4 (3-bromopropyl)-morpholine

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With 1-butyl-3-methylimidazolium Tetrafluoroborate In tetrahydrofuran at 65 - 70℃; for 5h;93.8%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

C9H6N2O3(2-)*2K(1+)

C9H6N2O3(2-)*2K(1+)

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With 1-butyl-3-methylimidazolium Tetrafluoroborate In N,N-dimethyl-formamide at 55 - 60℃; for 5h;93.7%
4-(3-iodopropyl)morpholine
1417436-51-1

4-(3-iodopropyl)morpholine

C9H6N2O3(2-)*2K(1+)

C9H6N2O3(2-)*2K(1+)

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With 1-butyl-3-methylimidazolium Tetrafluoroborate In N,N-dimethyl-formamide at 75 - 80℃; for 5h;91.2%
formamidine acetic acid
3473-63-0

formamidine acetic acid

methyl 5-(3-morpholinopropoxy)-2-amino-4-methoxy-benzoate
214472-41-0

methyl 5-(3-morpholinopropoxy)-2-amino-4-methoxy-benzoate

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
In ethanol for 4h; Reflux;88%
In methanol at 50 - 60℃; for 6h;81.73%
In 2-methoxy-ethanol at 115℃; for 2h;78%
In methanol at 50 - 60℃; for 6h;
2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide
246512-44-7

2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide

formaldehyd
50-00-0

formaldehyd

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
In water at 130℃; for 48h;88%
7-methoxy-6-(3'-N-morpholino)propoxyquinazoline
1208902-96-8

7-methoxy-6-(3'-N-morpholino)propoxyquinazoline

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Stage #1: 7-methoxy-6-(3'-N-morpholino)propoxyquinazoline With ammonium cerium (IV) nitrate; acetic acid In water
Stage #2: With sodium hydroxide In water
87%
With peracetic acid; sulfuric acid In ethanol at 60℃; for 12h;85%
2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile
675126-26-8

2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile

formic acid
64-18-6

formic acid

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Stage #1: 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile With iron(III) chloride; hydrazine hydrate In methanol; water for 3h; Heating;
Stage #2: formic acid With hydrogenchloride In water at 90 - 130℃; Further stages.;
86%
Stage #1: 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile With iron(III) chloride; hydrazine hydrate In methanol; water at 80℃; for 3.5h;
Stage #2: formic acid With hydrogenchloride In water at 130℃; for 4h;
68.65%
Stage #1: 2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile With iron(III) chloride; hydrazine hydrate In methanol; water for 3h; Reflux;
Stage #2: formic acid With hydrogenchloride In water at 130℃; for 3.5h;
58%
C16H20N2O6

C16H20N2O6

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With formamidine acetic acid82%
2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide
246512-44-7

2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide

formic acid
64-18-6

formic acid

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Stage #1: 2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide; formic acid With formamide at 20 - 100℃;
Stage #2: at 100℃; for 7h;
78%
Stage #1: 2-amino-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide; formic acid In dichloromethane at 100℃; for 5h; Acidic conditions;
Stage #2: With hydrogenchloride In water at 70℃; for 3h; Acidic aqueous solution;
Stage #3: With sodium hydroxide In water at 20 - 25℃; Alkaline aqueous solution;
With formamide at 20℃; for 8h; Reflux;3.3 g
methyl 5-(3-morpholinopropoxy)-2-amino-4-methoxy-benzoate
214472-41-0

methyl 5-(3-morpholinopropoxy)-2-amino-4-methoxy-benzoate

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
at 170℃; for 3h;71.1%
ethyl 2-amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)benzoate
1040264-49-0

ethyl 2-amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)benzoate

formamidine acetic acid
3473-63-0

formamidine acetic acid

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
In 2-methoxy-ethanol for 8h; Heating;69.2%
In methanol for 6h; Reflux;
C16H23N3O5

C16H23N3O5

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With trichlorophosphate In toluene for 2h; Reflux;40%
4-(3-chloropropyl)morpholine
7357-67-7

4-(3-chloropropyl)morpholine

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 391.5 g / potassium carbonate / dimethylformamide / 3 h / 100 °C
2.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating
3.1: 349 g / acetic anhydride / 3 h / 110 °C
4.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
5.2: 86 percent / HCl / H2O / 90 - 130 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C
2.1: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C
3.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C
4.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C
5.1: formamide / 20 - 100 °C
5.2: 78 percent / 7 h / 100 °C
View Scheme
4-methoxy-3-[3-(morpholin-4-yl)propoxy]benzonitrile
675126-28-0

4-methoxy-3-[3-(morpholin-4-yl)propoxy]benzonitrile

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
2.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
2.2: 86 percent / HCl / H2O / 90 - 130 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C
2.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C
3.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C
4.1: formamide / 20 - 100 °C
4.2: 78 percent / 7 h / 100 °C
View Scheme
Multi-step reaction with 4 steps
1: nitric acid; sulfuric acid; acetic acid / 37 h / 0 - 20 °C
2: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 1.5 h / 50 °C
3: palladium on activated charcoal / ethyl acetate; dichloromethane / 1.8 h / Reflux
4: formamide / 8 h / 20 °C / Reflux
View Scheme
isovanillin
621-59-0

isovanillin

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 391.5 g / potassium carbonate / dimethylformamide / 3 h / 100 °C
2.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating
3.1: 349 g / acetic anhydride / 3 h / 110 °C
4.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
5.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
5.2: 86 percent / HCl / H2O / 90 - 130 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 88 percent / sodium formate; formic acid; hydroxylamine sulfate / 8 h / 85 °C
2.1: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C
3.1: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C
4.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C
5.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C
6.1: formamide / 20 - 100 °C
6.2: 78 percent / 7 h / 100 °C
View Scheme
Multi-step reaction with 4 steps
1.1: formic acid; dihydrogen peroxide / 0 - 4 °C
1.2: Reflux
2.1: sodium carbonate / N,N-dimethyl-formamide / 10 h / 85 °C
3.1: trimethylaluminum / hexane; dichloromethane / 5 h / 0 °C / Inert atmosphere; Reflux
4.1: trichlorophosphate / toluene / 2 h / Reflux
View Scheme
4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldoxime
934191-95-4

4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldoxime

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 349 g / acetic anhydride / 3 h / 110 °C
2.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
3.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
3.2: 86 percent / HCl / H2O / 90 - 130 °C
View Scheme
4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldehyde
861453-11-4

4-methoxy-3-[3-(4-morpholinyl)propoxy]benzaldehyde

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 391 g / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating
2.1: 349 g / acetic anhydride / 3 h / 110 °C
3.1: 329 g / aq. nitric acid / acetic acid / 8 h / 45 - 50 °C
4.1: FeCl3; hydrazine hydrate / H2O; methanol / 3 h / Heating
4.2: 86 percent / HCl / H2O / 90 - 130 °C
View Scheme
2-amino-4-methoxy-5-[(3-morpholin-4-yl)propoxy]benzonitrile
675126-27-9

2-amino-4-methoxy-5-[(3-morpholin-4-yl)propoxy]benzonitrile

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C
2.1: formamide / 20 - 100 °C
2.2: 78 percent / 7 h / 100 °C
View Scheme
2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile
675126-26-8

2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C
2.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C
3.1: formamide / 20 - 100 °C
3.2: 78 percent / 7 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 1.5 h / 50 °C
2: palladium on activated charcoal / ethyl acetate; dichloromethane / 1.8 h / Reflux
3: formamide / 8 h / 20 °C / Reflux
View Scheme
2-methoxy-5-cyanophenol
52805-46-6

2-methoxy-5-cyanophenol

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C
2.1: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C
3.1: 75 percent / sodium dithionite / H2O / 20 - 50 °C
4.1: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C
5.1: formamide / 20 - 100 °C
5.2: 78 percent / 7 h / 100 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 85 °C
2: nitric acid; sulfuric acid; acetic acid / 37 h / 0 - 20 °C
3: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 1.5 h / 50 °C
4: palladium on activated charcoal / ethyl acetate; dichloromethane / 1.8 h / Reflux
5: formamide / 8 h / 20 °C / Reflux
View Scheme
3-hydroxy-4-methoxybenzoate
6702-50-7

3-hydroxy-4-methoxybenzoate

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 76 percent / potassium carbonate / acetone / 24 h / Heating
2: 82 percent / nitric acid; trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C
3: 60 percent / 1 h / 100 °C
4: hydrogen / palladium on activated carbon / methanol
5: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium carbonate / N,N-dimethyl-formamide / 10 h / 85 °C
2: trimethylaluminum / hexane; dichloromethane / 5 h / 0 °C / Inert atmosphere; Reflux
3: trichlorophosphate / toluene / 2 h / Reflux
View Scheme
methyl 3-(3-chloropropoxy)-4-methoxybenzoate
380844-22-4

methyl 3-(3-chloropropoxy)-4-methoxybenzoate

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 82 percent / nitric acid; trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C
2: 60 percent / 1 h / 100 °C
3: hydrogen / palladium on activated carbon / methanol
4: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C
View Scheme
methyl 4-methoxy-5-(3-chloropropoxy)-2-nitrobenzoate
380844-24-6

methyl 4-methoxy-5-(3-chloropropoxy)-2-nitrobenzoate

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 60 percent / 1 h / 100 °C
2: hydrogen / palladium on activated carbon / methanol
3: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C
View Scheme
4-methoxy-5-(3-morpholinylpropoxy)-2-nitrobenzoic acid methyl ester
214472-37-4

4-methoxy-5-(3-morpholinylpropoxy)-2-nitrobenzoic acid methyl ester

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / palladium on activated carbon / methanol
2: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C
View Scheme
gefitinib
184475-35-2

gefitinib

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With ammonia In hydrogenchloride
With ammonia In hydrogenchloride
Stage #1: gefitinib With hydrogenchloride In water for 6h; Heating / reflux;
Stage #2: With ammonia In water at 0℃;
Stage #1: gefitinib With hydrogenchloride In water for 6h; Heating / reflux;
Stage #2: With ammonium hydroxide In water
C16H14N2O2
1494468-50-6

C16H14N2O2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen; palladium on activated charcoal
2: potassium carbonate / N,N-dimethyl-formamide
3: peracetic acid; sulfuric acid / ethanol / 12 h / 60 °C
View Scheme
6-hydroxy-7-methoxyquinazoline
884344-38-1

6-hydroxy-7-methoxyquinazoline

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide
2: peracetic acid; sulfuric acid / ethanol / 12 h / 60 °C
View Scheme
3-benzyloxy-4-methoxybenzaldehyde
6346-05-0

3-benzyloxy-4-methoxybenzaldehyde

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: nitric acid / water
2: hydrogenchloride; iron / ethanol
3: ethanol / Reflux
4: hydrogen; palladium on activated charcoal
5: potassium carbonate / N,N-dimethyl-formamide
6: peracetic acid; sulfuric acid / ethanol / 12 h / 60 °C
View Scheme
2-aldehyde-4-benzyloxy-5-methoxy nitrobenzene
58662-50-3

2-aldehyde-4-benzyloxy-5-methoxy nitrobenzene

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogenchloride; iron / ethanol
2: ethanol / Reflux
3: hydrogen; palladium on activated charcoal
4: potassium carbonate / N,N-dimethyl-formamide
5: peracetic acid; sulfuric acid / ethanol / 12 h / 60 °C
View Scheme
5-benzyloxy-4-methoxy-2-aminobenzaldehyde
1042978-66-4

5-benzyloxy-4-methoxy-2-aminobenzaldehyde

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: ethanol / Reflux
2: hydrogen; palladium on activated charcoal
3: potassium carbonate / N,N-dimethyl-formamide
4: peracetic acid; sulfuric acid / ethanol / 12 h / 60 °C
View Scheme
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline
199327-59-8

4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide for 4h; Heating;99.3%
With thionyl chloride In N,N-dimethyl-formamide at 84℃; for 1.5h;96.85%
With thionyl chloride; N,N-dimethyl-formamide at 84℃;94%
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

6-acetoxy-4-chloro-7-methoxyquinazoline
230955-75-6

6-acetoxy-4-chloro-7-methoxyquinazoline

Conditions
ConditionsYield
With sulfuryl dichloride In acetonitrile at 55℃; Temperature; Concentration;93.7%
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

4-(3-(4-chloro-7-methoxyquinazolin-6-yloxy)propyl)morpholine hydrochloride
1383952-42-8

4-(3-(4-chloro-7-methoxyquinazolin-6-yloxy)propyl)morpholine hydrochloride

Conditions
ConditionsYield
With triethylamine; trichlorophosphate In acetonitrile at 80 - 90℃; for 1h; Temperature; Reagent/catalyst; Solvent;84.1%
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Stage #1: 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one With thionyl chloride; N,N-dimethyl-formamide for 1h; Reflux;
Stage #2: 3-chloro-4-fluorophenylamine In isopropyl alcohol for 1h; Reflux;
84%
With potassium carbonate In isopropyl alcohol at 80 - 85℃; for 1h;82%
Stage #1: 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one With thionyl chloride In N,N-dimethyl-formamide for 2h; Heating;
Stage #2: 3-chloro-4-fluorophenylamine In N,N-dimethyl-formamide at 100℃; for 1h; Further stages.;
73%
Stage #1: 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one With triethylamine; trichlorophosphate In toluene at 5 - 70℃;
Stage #2: 3-chloro-4-fluorophenylamine In isopropyl alcohol; toluene at 70℃; for 1h;
62.86%
Stage #1: 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one With thionyl chloride for 4h; Reflux;
Stage #2: 3-chloro-4-fluorophenylamine In i-Amyl alcohol for 6h; Reflux;
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

propargyl bromide
106-96-7

propargyl bromide

7-methoxy-6-[3-(morpholin-4-yl)propoxy]-3-(prop-2-yn-1-yl)quinazolin-4(3H)-one

7-methoxy-6-[3-(morpholin-4-yl)propoxy]-3-(prop-2-yn-1-yl)quinazolin-4(3H)-one

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃;54%
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

2-fluoroethyl tosylate
383-50-6

2-fluoroethyl tosylate

4-(3-((4-(2-fluoroethoxy)-7-methoxyquinazolin-6-yl)oxy)propyl)-morpholine

4-(3-((4-(2-fluoroethoxy)-7-methoxyquinazolin-6-yl)oxy)propyl)-morpholine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90 - 100℃; for 2h;27%
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazolin-4(3H)-thione
958669-54-0

7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazolin-4(3H)-thione

Conditions
ConditionsYield
With tetraphosphorus decasulfide In pyridine for 24h; Heating;
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

4-(methylthio)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline
958669-55-1

4-(methylthio)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: P2S5 / pyridine / 24 h / Heating
2.1: aq. NaOH / methanol / 15 - 20 °C
2.2: 8.3 g / methanol; H2O / 5 h / 20 °C
View Scheme
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: P2S5 / pyridine / 24 h / Heating
2.1: aq. NaOH / methanol / 15 - 20 °C
2.2: 8.3 g / methanol; H2O / 5 h / 20 °C
3.1: 85 percent / 3-chloro-4-fluoroaniline hydrochloride / propan-2-ol / 24 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 90 percent / POCl3; triethylamine / toluene / 24 h / 58 °C
2: 91 percent / triethylamine / propan-2-ol / 288 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: oxalyl chloride / CHCl3; dimethylformamide / Heating
2: 70 percent / dimethylformamide / 1 h / 145 °C
View Scheme
Multi-step reaction with 3 steps
1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide; acetonitrile / 3 h / 40 - 45 °C
2: hydrogenchloride / methanol; water / 1 h / 20 °C
3: sodium hydroxide / water / 1.5 h / 30 - 70 °C / pH 11 - 13
View Scheme
7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
199327-61-2

7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one

O-Demethyl-Gefitinib
847949-49-9

O-Demethyl-Gefitinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / POCl3; triethylamine / toluene / 24 h / 58 °C
2: 91 percent / triethylamine / propan-2-ol / 288 h / Heating
3: 54 percent / LiCl / dimethylformamide / 15 h / Heating
View Scheme

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