Pramipexole Intermediate (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine CAS:106092-09-5 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of b
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/636.html Product Name (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine CAS No.
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inquiryName: (6S)-4,5,6,7-Tetrahydro-1,3-Benzothiazol-2,6-Diamine Molecular Formula:C7H11N3S Molecular Weight:169.24 CAS No.:106092-09-5 Appearance:White To Similar White Powder Appearance:White To Similar White Powde Storage:Store in cool and dry plac
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(S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine CAS: 106092-09-5 Specification product name (s)-4,5,6,7-tetrahydro-2,6-benzothiazolediamine cas no. 106092-09-5 appearance white powder assay
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquirySuperior quality, moderate price & quick delivery. Appearance:Pale beige solid Storage:Keep away of light,cool place Package: 1kg/drum or 25kg/drum or as per your request. Application:(S)-N-Despropyl Pramipexole is a (S)-Pramipexole (P7
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inquiryProduct name: (-)-2,6-Diamino-4,5,6,7-Tetrahydroben Thiazole CAS No.:106092-09-5 Molecule Formula:C7H11N3S Molecule Weight:169.25 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryProduct Name: (S)-4,5,6,7-Tetrahydro-2,6-benzothiazolediamine Synonyms: (6S)-4,5,6,7-TETRAHYDRO-1,3-BENZOTHIAZOL-2,6-DIAMINE;(6S)-4,5,6,7-TETRAHYDRO-…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton
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inquiry(S)-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine tartrate trihydrate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Stage #1: (S)-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine tartrate trihydrate With water; pyrographite at 80℃; for 1h; Stage #2: With water; potassium hydroxide; sodium hydroxide at 10 - 20℃; for 0.5h; pH=12; Temperature; | 92% |
Stage #1: (S)-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine tartrate trihydrate With hydrogenchloride In water Acidic aqueous solution; Stage #2: With sodium hydroxide at 50℃; pH=<= 7; Alkaline aqueous solution; | |
With sodium hydroxide; water at 25 - 35℃; for 1.83333 - 1.91667h; pH=11.0 - 12.0; | |
Stage #1: (S)-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine tartrate trihydrate With hydrogenchloride In water carbon treatment; Stage #2: With potassium hydroxide In water at 25 - 30℃; for 1.5h; |
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
With hydrogenchloride; water In tetrahydrofuran at 80℃; for 12h; | 90% |
2,6-diamino-4,5,6,7-tetrahydro-benzthiazole
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
With L-Tartaric acid In ethanol at 80℃; for 3h; | 87.8% |
With D-tartaric acid In water at 75℃; for 2h; Temperature; | 48.4% |
Stage #1: 2,6-diamino-4,5,6,7-tetrahydro-benzthiazole With L-Tartaric acid In water at 75℃; for 1h; Stage #2: With hydrogenchloride In water | 27.9% |
2,6-diamino-4,5,6,7-tetrahydro benzothiazole, (S)-tartarate salt
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
With hydrogenchloride; potassium hydroxide In water at 0 - 5℃; for 1 - 2h; | 1.05% |
2,6-diamino-4,5,6,7-tetrahydro-benzthiazole
A
(R)-4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2,6-diamine
B
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
optical resolution with chiral tartaric acid; | |
Purification / work up; Resolution of racemate; |
N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)acetamide hydrobromide
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: water; sulfuric acid / 10 h / Reflux 1.2: 1.5 h / 0 - 30 °C 2.1: water / 70 °C / Reflux; Resolution of racemate 3.1: hydrogenchloride / water / carbon treatment 3.2: 1.5 h / 25 - 30 °C View Scheme |
N-(4-oxocyclohexyl)acetamide
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: bromine; acetic acid / 0.75 h / 25 - 35 °C 1.2: 3 h / Reflux 2.1: water; sulfuric acid / 10 h / Reflux 2.2: 1.5 h / 0 - 30 °C 3.1: water / 70 °C / Reflux; Resolution of racemate 4.1: hydrogenchloride / water / carbon treatment 4.2: 1.5 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 4 steps 1: bromine; acetic acid / 1 h / 60 °C 2: 1 h 3: water; hydrogen bromide / 15 h / Reflux 4: L-Tartaric acid / 75 °C View Scheme | |
Multi-step reaction with 4 steps 1: acetic acid; bromine / 4 h / 60 °C 2: 60 °C / Reflux 3: hydrogen bromide / Reflux 4: L-Tartaric acid / ethanol / 3 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; bromine / 3 h / 20 °C 1.2: 0.5 h / 110 - 120 °C 2.1: hydrogen bromide / water / 6 h / 100 - 105 °C 3.1: L-Tartaric acid / water / 1 h / 75 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; bromine 2.1: 120 °C 2.2: Reflux 3.1: D-tartaric acid / water / 0.33 h / 58 °C View Scheme |
N-(2-amino-4,5,6,7-tetrahydrobenzo[1,2-d]thiazol-6-yl)acetamide
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: water; hydrogen bromide / 15 h / Reflux 2: L-Tartaric acid / 75 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen bromide / Reflux 2: L-Tartaric acid / ethanol / 3 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen bromide / water / 6 h / 100 - 105 °C 2: L-Tartaric acid / water / 1 h / 75 °C View Scheme |
2-bromo-4-acetamidocyclohexanone
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1 h 2: water; hydrogen bromide / 15 h / Reflux 3: L-Tartaric acid / 75 °C View Scheme | |
Multi-step reaction with 3 steps 1: 60 °C / Reflux 2: hydrogen bromide / Reflux 3: L-Tartaric acid / ethanol / 3 h / 80 °C View Scheme |
2-amino-6-oxo-4,5,6,7-tetrahydrobenzothiazole
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 0.5 h / 100 °C 2: Sucrose / aq. phosphate buffer; n-heptane / 16 h / 30 °C / pH 7 3: pyridine / 2 h / 0 - 20 °C 4: sodium azide / N,N-dimethyl-formamide / 6 h / 20 - 70 °C / Inert atmosphere 5: polymer bonded triphenyl phosphine / tetrahydrofuran; water / 12 h / 40 °C 6: hydrogenchloride; water / tetrahydrofuran / 12 h / 80 °C View Scheme |
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: pyridine / 2 h / 0 - 20 °C 2: sodium azide / N,N-dimethyl-formamide / 6 h / 20 - 70 °C / Inert atmosphere 3: polymer bonded triphenyl phosphine / tetrahydrofuran; water / 12 h / 40 °C 4: hydrogenchloride; water / tetrahydrofuran / 12 h / 80 °C View Scheme |
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 - 70 °C / Inert atmosphere 2: polymer bonded triphenyl phosphine / tetrahydrofuran; water / 12 h / 40 °C 3: hydrogenchloride; water / tetrahydrofuran / 12 h / 80 °C View Scheme |
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: polymer bonded triphenyl phosphine / tetrahydrofuran; water / 12 h / 40 °C 2: hydrogenchloride; water / tetrahydrofuran / 12 h / 80 °C View Scheme |
cyclohexanedione monoethylene ketal
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere 2.1: sodium acetate; N-Bromosuccinimide / tetrahydrofuran; water / 2 h / 20 °C 2.2: 20 - 80 °C 3.1: hydrogenchloride; water / tetrahydrofuran / 4 h / Reflux 4.1: 0.5 h / 100 °C 5.1: Sucrose / aq. phosphate buffer; n-heptane / 16 h / 30 °C / pH 7 6.1: pyridine / 2 h / 0 - 20 °C 7.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 - 70 °C / Inert atmosphere 8.1: polymer bonded triphenyl phosphine / tetrahydrofuran; water / 12 h / 40 °C 9.1: hydrogenchloride; water / tetrahydrofuran / 12 h / 80 °C View Scheme |
1,4-cyclohexanedione-1-ethylene acetal 4-trimethylsilyl enol ether
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: sodium acetate; N-Bromosuccinimide / tetrahydrofuran; water / 2 h / 20 °C 1.2: 20 - 80 °C 2.1: hydrogenchloride; water / tetrahydrofuran / 4 h / Reflux 3.1: 0.5 h / 100 °C 4.1: Sucrose / aq. phosphate buffer; n-heptane / 16 h / 30 °C / pH 7 5.1: pyridine / 2 h / 0 - 20 °C 6.1: sodium azide / N,N-dimethyl-formamide / 6 h / 20 - 70 °C / Inert atmosphere 7.1: polymer bonded triphenyl phosphine / tetrahydrofuran; water / 12 h / 40 °C 8.1: hydrogenchloride; water / tetrahydrofuran / 12 h / 80 °C View Scheme |
2-amino-6-(ethylenedioxy)-4,5,6,7-tetrahydrobenzothiazole
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: hydrogenchloride; water / tetrahydrofuran / 4 h / Reflux 2: 0.5 h / 100 °C 3: Sucrose / aq. phosphate buffer; n-heptane / 16 h / 30 °C / pH 7 4: pyridine / 2 h / 0 - 20 °C 5: sodium azide / N,N-dimethyl-formamide / 6 h / 20 - 70 °C / Inert atmosphere 6: polymer bonded triphenyl phosphine / tetrahydrofuran; water / 12 h / 40 °C 7: hydrogenchloride; water / tetrahydrofuran / 12 h / 80 °C View Scheme |
2-Acetylamino-6-oxo-4,5,6,7-tetrahydrobenzothiazole
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Sucrose / aq. phosphate buffer; n-heptane / 16 h / 30 °C / pH 7 2: pyridine / 2 h / 0 - 20 °C 3: sodium azide / N,N-dimethyl-formamide / 6 h / 20 - 70 °C / Inert atmosphere 4: polymer bonded triphenyl phosphine / tetrahydrofuran; water / 12 h / 40 °C 5: hydrogenchloride; water / tetrahydrofuran / 12 h / 80 °C View Scheme |
N-(4-oxocyclohexyl)acetamide
thiourea
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
Stage #1: N-(4-oxocyclohexyl)acetamide; thiourea With bromine In water at 45 - 80℃; for 2h; Large scale; Stage #2: With hydrogen bromide In water for 3h; Reflux; Large scale; |
propionic acid anhydride
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
(S)‑2‑amino‑6‑propionamido‑4,5,6,7‑tetrahydrobenzothiazole
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at -10℃; Temperature; | 97.2% |
With triethylamine In tetrahydrofuran at -5℃; for 2h; | 90% |
Stage #1: propionic acid anhydride; (S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine With triethylamine In tetrahydrofuran at -10 - -4℃; for 1.83333h; Stage #2: With potassium carbonate In tetrahydrofuran; water for 1.33333h; Product distribution / selectivity; | 89% |
propyl bromide
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
Conditions | Yield |
---|---|
In 1-methyl-pyrrolidin-2-one at 20℃; for 72h; Product distribution / selectivity; | 96% |
In N,N-dimethyl acetamide at 20℃; for 72h; Product distribution / selectivity; | 80% |
di-tert-butyl dicarbonate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
tert-butyl (S)-(2-amino-4,5,6,7-tetrahydrobenzo[1,2-d]thiazol-6-yl)carbamate
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran at -5 - 0℃; for 6h; | 95% |
In methanol at 0 - 25℃; for 1h; | 90% |
In tetrahydrofuran at 0 - 20℃; for 16h; | 80.8% |
In tetrahydrofuran at 0 - 20℃; |
1-Chloropropane
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
pramipexole
Conditions | Yield |
---|---|
With NPs-Fe3O4(at)SiO2(at)[PrMIM]PW In acetonitrile at 50℃; Reagent/catalyst; | 95% |
2-Nitrobenzenesulfonyl chloride
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
(S)-N-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-2-nitrobenzenesulfonamide
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at -10 - 25℃; | 94.6% |
With triethylamine In tetrahydrofuran at -10 - 25℃; for 1.5h; Inert atmosphere; | 94% |
With triethylamine In tetrahydrofuran at -10 - 25℃; for 1h; |
2-bromo-5-methoxy-benzoic acid
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
C15H17N3O3S
Conditions | Yield |
---|---|
With copper; potassium carbonate In ethyl methyl ether at 25 - 30℃; for 2h; Ullmann reaction; Inert atmosphere; Sonication; | 92% |
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
ortho-chlorobenzoic acid
C14H15N3O2S
Conditions | Yield |
---|---|
With copper; potassium carbonate In ethyl methyl ether at 25 - 30℃; for 1.5h; Ullmann reaction; Inert atmosphere; Sonication; | 90% |
propyl tosylate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole p-toluenesulfonic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In water; acetonitrile at 76℃; for 6h; Reagent/catalyst; Solvent; Temperature; | 88.2% |
In N,N-dimethyl-formamide at 20℃; for 96h; | 64% |
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide | 54% |
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
3-methoxyphenyl isocyanate
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(3-methoxyphenyl)urea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 85% |
propionic acid anhydride
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
pramipexole
Conditions | Yield |
---|---|
Stage #1: propionic acid anhydride; (S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine With triethylamine In tetrahydrofuran at -10 - 0℃; for 2h; Stage #2: With borane-THF at 50 - 55℃; for 1h; | 85% |
p-chlorphenylisocyanate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(4-chlorophenyl)urea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 84% |
o-chlorophenyl isocyanate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(2-chlorophenyl)urea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 84% |
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
m-chlorophenyl isocyanate
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(3-chlorophenyl)urea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 84% |
o-fluorophenyl isothiocyanate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(2-fluorophenyl)thiourea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 84% |
4-fluorophenyl isothiocyanate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(4-fluorophenyl)thiourea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 84% |
1-Isocyanato-2-methoxy-benzene
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(2-methoxyphenyl)urea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 83% |
para-fluorophenyl isocyanate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(4-fluorophenyl)urea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 83% |
phenyl isothiocyanate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-phenylthiourea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 83% |
4-Methoxyphenyl isothiocyanate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(4-methoxyphenyl)thiourea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 83% |
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
3-methoxyphenyl isothiocyanate
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(3-methoxyphenyl)thiourea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 83% |
4-Methoxyphenyl isocyanate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(4-methoxyphenyl)urea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 82% |
phenyl isocyanate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-phenylurea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 81% |
2-chlorophenylisothiocyanate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(2-chlorophenyl)thiourea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 81% |
4-Chlorophenyl isothiocyanate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(4-chlorophenyl)thiourea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 81% |
3-chlorophenyl-isothiocyanate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(3-chlorophenyl)thiourea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 81% |
propionaldehyde
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
pramipexole
Conditions | Yield |
---|---|
Stage #1: propionaldehyde; (S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine With sulfuric acid In methanol at 0℃; for 1.5h; Stage #2: With sodium tetrahydroborate In methanol at 0 - 25℃; for 1.83333 - 1.91667h; | 80.1% |
Stage #1: propionaldehyde; (S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine In methanol at 5℃; for 0.25h; Stage #2: With sodium tris(acetoxy)borohydride In methanol at 5 - 25℃; for 0.583333h; Stage #3: With hydrogenchloride; sodium hydroxide more than 3 stages; | 69% |
With sodium tetrahydroborate; sulfuric acid In methanol; dichloromethane at 3 - 8℃; |
2,4-dichlorophenyl isocyanate
(S)-4,5,6,7-tetrahydrobenzo[d]thiazol-2,6-diamine
1-((S)-2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(2,4-dichlorophenyl)urea
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 78% |
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