DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryItems Standard Result Appearance White crystal White crystal Assay,HPLC 99%min
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryManufacturer supply 1,4-Dioxaspiro[4.5]decan-8-one CAS 4746-97-8 with steady supply Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermedia
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
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inquiry1,4-cyclohexanedione monoacetal is used to synthesize medicine and liquid crystal materials.It is used to prepare a series of potent analgesic compounds. 1,4-Cyclohexanedione monoethylene ketal is also used as a building block for the synthesis of tr
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquirySuperior quality, moderate price & quick delivery. Appearance:white to beige crystalline powder or crystals Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Intermediates of Liqu
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inquiry1,4-Dioxaspiro[4.5]decan-8-one Chemical Properties Melting point 70-73 °C (lit.) Boiling point 112C density 1.0887 (rough estimate) refractive index 1.4430 (estimate) storage temp. Store below +30°C. solubility Soluble
Cas:4746-97-8
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inquirydimethyl 2,5-dioxocyclohexane-1,4-dicarboxylate
ethylene glycol
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With 1-butyl-3-methylimidazolium hydrogen sulfate; water; 1-ethylimidazolium tetrafluoroborate at 110 - 132℃; for 5.5h; Temperature; Reagent/catalyst; | 97.8% |
ethylene glycol
1,4-Cyclohexanedione
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With triethylmethylammonium chloride at 50℃; for 1h; Temperature; Reagent/catalyst; | 96% |
With toluene-4-sulfonic acid In benzene at 100℃; for 1.5h; | 35% |
With toluene-4-sulfonic acid In benzene for 4h; Heating; |
Bis<1,4-dioxaspiro<4.5>decan-8-yliden>hydrazin
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With HOF* CH3CN In dichloromethane at 0℃; for 0.0166667h; | 95% |
3,5-dimethyl-1H-pyrazole
A
cyclohexanedione monoethylene ketal
B
1,4-Cyclohexanedione
Conditions | Yield |
---|---|
In dichloromethane; ethyl acetate | A 91% B n/a |
1,4-dioxaspiro[4.5]deca-6,9-dien-8-one
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With hydrogen; N-ethyl-N,N-diisopropylamine; 1% Pd/C In 2-methyltetrahydrofuran at 30℃; under 75007.5 Torr; Autoclave; | 91% |
4,4-ethylenedioxycyclohexan-1-ol
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With Oxone; sodium ortho-iodobenzenesulfonate; sodium sulfate In ethyl acetate at 70℃; for 8h; Inert atmosphere; | 86% |
With potassium peroxymonosulfate; sodium ortho-iodobenzenesulfonate; sodium sulfate In ethyl acetate at 70℃; for 8h; | 86% |
With pyridine; chromium(VI) oxide | |
With tert.-butylhydroperoxide; Cs5V14As8O42Cl In water; acetone at 20℃; for 48h; | 20 %Chromat. |
With tert.-butylhydroperoxide; Cs5V14As8O42Cl In water; acetone at 20℃; for 48h; Sealed tube; |
1,4,9,12-Tetraoxa-dispiro[4.2.4.2]tetradecane
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With formaldehyd; silica gel; iron(III) chloride In water for 1h; Ring cleavage; | 86% |
With water In acetic acid; trifluoroacetic acid at 45℃; for 14h; |
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With periodic acid In tetrahydrofuran; diethyl ether at -10℃; for 0.333333h; | 86% |
8-Methylsulfanyl-8-(toluene-4-sulfonyl)-1,4-dioxa-spiro[4.5]decane
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In 1,4-dioxane; water Irradiation; | 83% |
ethyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With potassium hydroxide In water for 6h; Ambient temperature; | 80% |
With magnesium chloride In N,N,N,N,N,N-hexamethylphosphoric triamide at 150℃; for 2h; | 92 % Chromat. |
C20H24O5
A
cyclohexanedione monoethylene ketal
(1S,2R)-1,4-Dimethyl-1,2-dihydro-naphthalene-1,2-diol
Conditions | Yield |
---|---|
With acetic acid; zinc at 16℃; for 0.333333h; | A 77% B n/a |
1,4,9,12-Tetraoxa-dispiro[4.2.4.2]tetradecane
1,4-Cyclohexanedione
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene at 100℃; for 1.25h; | 74% |
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
Stage #1: 4(-Ethylenedioxy)cyclohexanone oxime O-acetate With dicobalt octacarbonyl; triethylamine In diethyl ether at 20℃; for 0.25h; deoximation; Stage #2: With water In methanol at 20℃; for 0.5h; Hydrolysis; | 74% |
8-methylene-1,4-dioxaspiro[4.5]decane
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With 2,6-dimethylpyridine; sodium periodate; ruthenium(III) chloride trihydrate In dichloromethane; water; acetonitrile at 20℃; for 1h; Inert atmosphere; | 72% |
8,8-Dimethoxy-1,4-dioxa-spiro[4.5]decane
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
In water; dimethyl sulfoxide at 150℃; for 8h; | 64.7% |
1,4,9,12-Tetraoxa-dispiro[4.2.4.2]tetradecane
A
cyclohexanedione monoethylene ketal
B
1,4-Cyclohexanedione
Conditions | Yield |
---|---|
With formaldehyd; silica gel; iron(III) chloride at 20℃; for 0.416667h; | A 58% B 22 % Chromat. |
N,N-dimethylformamide ethylene acetal
1,4-Cyclohexanedione
A
cyclohexanedione monoethylene ketal
B
1,4,9,12-Tetraoxa-dispiro[4.2.4.2]tetradecane
Conditions | Yield |
---|---|
With acetic acid In dichloromethane at 20℃; for 30h; | A 34% B 7% |
ethylene glycol
1,4-Cyclohexanedione
A
cyclohexanedione monoethylene ketal
B
1,4,9,12-Tetraoxa-dispiro[4.2.4.2]tetradecane
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene Heating; | A 28% B 25% |
With toluene-4-sulfonic acid In hexane; benzene Heating; | A 24% B 25% |
ethyl 3-<2-<2-(ethoxycarbonyl)ethyl><1,3>dioxolan-2-yl>propionate
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With sodium; xylene |
ethyl 3-<2-<2-(ethoxycarbonyl)ethyl><1,3>dioxolan-2-yl>propionate
A
cyclohexanedione monoethylene ketal
B
ethyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate
Conditions | Yield |
---|---|
With sodium; xylene |
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With lithium tetrafluoroborate In acetonitrile for 0.5h; Product distribution; Heating; var. reag.: 0.1M HF in water, 15 min, RT; |
tetrachloromethane
ethyl 3-<2-<2-(ethoxycarbonyl)ethyl><1,3>dioxolan-2-yl>propionate
sodium Oleate
A
cyclohexanedione monoethylene ketal
B
ethyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate
4-oximinocyclohexanone ethylene ketal
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: Et3N / diethyl ether / 7 h / 20 °C 2.1: Co2(CO)8; Et3N / diethyl ether / 0.25 h / 20 °C 2.2: 74 percent / H2O / methanol / 0.5 h / 20 °C View Scheme |
2.2-Bis-β-chlorethyl-1.3-dioxolan
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 62 percent / NaH / dimethylformamide / 25 - 60 °C 2: 83 percent / NaHCO3 / dioxane; H2O / Irradiation View Scheme |
4-hydroxycyclohexanone
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: benzene; toluene-4-sulfonic acid / Erwaermen des Reaktionsprodukts mit methanol. Natronlauge 2: chromium (VI)-oxide; pyridine View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: benzene; toluene-4-sulfonic acid / Entfernen des entstehenden Wassers 2: sodium; xylene View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: benzene; toluene-4-sulfonic acid 2: chromium (VI)-oxide; pyridine View Scheme |
4-methoxycyclohexanone ethylene ketal
cyclohexanedione monoethylene ketal
Conditions | Yield |
---|---|
With calcium hypochlorite; acetic acid In water; acetonitrile at 0℃; regioselective reaction; | 76 mg |
cyclohexanedione monoethylene ketal
bromobenzene
4-hydroxy-4-phenyl-cyclohexanone ethylene ketal
Conditions | Yield |
---|---|
Stage #1: bromobenzene With magnesium In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Reflux; Stage #2: cyclohexanedione monoethylene ketal In tetrahydrofuran for 0.5h; Inert atmosphere; Reflux; | 100% |
Stage #1: bromobenzene With iodine; magnesium In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Stage #2: cyclohexanedione monoethylene ketal In tetrahydrofuran at 0 - 55℃; Inert atmosphere; | 41% |
With tert.-butyl lithium 1.) THF, -60 deg C, 3 h, 2.) THF, RT, overnight; Yield given. Multistep reaction; | |
Stage #1: bromobenzene With n-butyllithium In tetrahydrofuran; hexane at -40℃; for 0.5h; Inert atmosphere; Stage #2: cyclohexanedione monoethylene ketal In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; |
cyclohexanedione monoethylene ketal
diethoxyphosphoryl-acetic acid ethyl ester
ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate
Conditions | Yield |
---|---|
With sodium hydride In 1,2-dimethoxyethane for 11.5h; Ambient temperature; | 100% |
With sodium hydride In tetrahydrofuran at 0℃; for 0.666667h; Horner-Wadsworth-Emmons reaction; | 100% |
Stage #1: cyclohexanedione monoethylene ketal With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 1h; Stage #2: diethoxyphosphoryl-acetic acid ethyl ester In tetrahydrofuran; mineral oil at -20 - 20℃; for 3h; | 100% |
cyclohexanedione monoethylene ketal
1-chloroethyl p-tolyl sulfoxide
8-[1-Chloro-1-(toluene-4-sulfinyl)-ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol
Conditions | Yield |
---|---|
at -70℃; | 100% |
With lithium diisopropyl amide In tetrahydrofuran at -70℃; | 90% |
With lithium diisopropyl amide 1.) THF; Multistep reaction; |
cyclohexanedione monoethylene ketal
benzylamine
4-(N-benzylamino)cyclohexanone ethylene acetal
Conditions | Yield |
---|---|
Stage #1: cyclohexanedione monoethylene ketal; benzylamine With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 20h; Stage #2: With sodium hydroxide In dichloromethane; water | 100% |
Stage #1: cyclohexanedione monoethylene ketal; benzylamine With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 2h; Stage #2: With water; sodium hydrogencarbonate In dichloromethane | 100% |
Stage #1: cyclohexanedione monoethylene ketal; benzylamine In dichloromethane at 20℃; for 6h; Molecular sieve; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 1h; | 99% |
cyclohexanedione monoethylene ketal
4,4-ethylenedioxycyclohexan-1-ol
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol for 2.5h; | 100% |
With sodium tetrahydroborate In methanol at 0 - 20℃; for 3h; | 100% |
With sodium tetrahydroborate In methanol at 0 - 20℃; | 100% |
cyclohexanedione monoethylene ketal
ethyl (triphenylphosphoranylidene)acetate
ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate
Conditions | Yield |
---|---|
In toluene for 24h; Heating; | 100% |
In benzene for 12h; Heating / reflux; | 90% |
In benzene for 24h; Wittig reaction; Heating; | 90% |
In benzene for 24h; Wittig Reaction; Heating / reflux; | 90% |
In benzene for 1h; Heating; | 89% |
cyclohexanedione monoethylene ketal
methyl (triphenylphosphoranylidene)acetate
8-(methoxyformylmethylene)-1,4-dioxaspiro[4.5]decane
Conditions | Yield |
---|---|
In toluene for 45h; Inert atmosphere; Reflux; | 100% |
In toluene Heating; | 94% |
In toluene for 18h; Heating / reflux; | 81% |
In toluene for 18h; Inert atmosphere; Reflux; | 60% |
cyclohexanedione monoethylene ketal
Methyltriphenylphosphonium bromide
8-methylene-1,4-dioxaspiro[4.5]decane
Conditions | Yield |
---|---|
With potassium tert-butylate In benzene at 25℃; for 1h; | 100% |
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran; hexane at -78 - 0℃; for 0.666667h; Stage #2: cyclohexanedione monoethylene ketal In tetrahydrofuran; hexane at 20℃; | 92% |
With sodium hydride In dimethyl sulfoxide | 90% |
propylamine
cyclohexanedione monoethylene ketal
4-propylaminocyclohexan-1-one ethylene acetal
Conditions | Yield |
---|---|
Stage #1: propylamine With hydrogenchloride In methanol at 0 - 5℃; for 0.5h; pH=6 - 7; Stage #2: cyclohexanedione monoethylene ketal In methanol at 5℃; for 0.25h; Stage #3: With hydrogenchloride; sodium cyanoborohydride; sodium carbonate more than 3 stages; | 100% |
With hydrogen; palladium 10% on activated carbon In methanol under 3000.3 Torr; | 100% |
With hydrogen; palladium 10% on activated carbon In methanol under 3000.3 Torr; | 100% |
cyclohexanedione monoethylene ketal
ethyl 2-cyanoacetate
2-amino-6-(2'-spiro[1',3']dioxolane)-6,7-dihydro-4H-benzo[b]thiophen-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With morpholine; sulfur In ethanol at 50℃; for 16h; Gewald's 2-aminothiophene reaction; | 100% |
With morpholine; sulfur In ethanol at 20℃; for 96h; | 99% |
With morpholine; sulfur In ethanol at 20℃; for 96h; | 99% |
cyclohexanedione monoethylene ketal
(1-hexadecyl)triphenylphosphonium bromide
8-hexadecylidene-1,4-dioxaspiro[4.5]decane
Conditions | Yield |
---|---|
Stage #1: (1-hexadecyl)triphenylphosphonium bromide With potassium hexamethylsilazane In tetrahydrofuran at 20℃; for 15h; Stage #2: cyclohexanedione monoethylene ketal In tetrahydrofuran at 20℃; for 12h; Wittig reaction; | 100% |
cyclohexanedione monoethylene ketal
1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate
Conditions | Yield |
---|---|
With potassium hexamethylsilazane In tetrahydrofuran; toluene at -78℃; for 4h; | 100% |
Stage #1: cyclohexanedione monoethylene ketal With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 2h; Stage #2: phenylbis[(trifluoromethyl)sulfonyl]amine In tetrahydrofuran; hexane at -78℃; Cooling; | 33% |
cyclohexanedione monoethylene ketal
8-[1-chloro-1-(p-tolylsulfinyl)propyl]-1,4-dioxaspiro[4.5]decan-8-ol
Conditions | Yield |
---|---|
100% |
cyclohexanedione monoethylene ketal
1,4-dioxaspiro[4.5]decan-8-amine
Conditions | Yield |
---|---|
With ammonia; hydrogen; palladium 10% on activated carbon In methanol under 3000.3 Torr; | 100% |
With ammonium formate; C25H31ClIrN2OP at 50℃; for 18h; Leukardt-Wallach Amination; Sealed tube; | 99% |
Stage #1: cyclohexanedione monoethylene ketal With sodium tris(acetoxy)borohydride; benzylamine In methanol; dichloromethane Stage #2: With hydrogen; palladium(II) hydroxide In methanol | 93% |
cyclohexanedione monoethylene ketal
N,N-phenylbistrifluoromethane-sulfonimide
1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate
Conditions | Yield |
---|---|
With potassium hexamethylsilazane In tetrahydrofuran; toluene at -78℃; for 4h; | 100% |
With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 20℃; for 0.5h; Inert atmosphere; | 100% |
With lithium hexamethyldisilazane at -78 - 20℃; Inert atmosphere; | 100% |
cyclohexanedione monoethylene ketal
allyl bromide
8-allyl-1,4-dioxaspiro[4,5]decan-8-ol
Conditions | Yield |
---|---|
With ammonium acetate; zinc In tetrahydrofuran cooling; | 100% |
Stage #1: allyl bromide With magnesium In diethyl ether at 20℃; for 1.5h; Stage #2: cyclohexanedione monoethylene ketal In diethyl ether at 20℃; for 3.5h; Grignard reaction; | |
With water; ammonium chloride; zinc In tetrahydrofuran at 20℃; | |
With ammonium chloride; zinc In tetrahydrofuran; water at 20℃; |
Conditions | Yield |
---|---|
Stage #1: Methoxyallene With n-butyllithium In diethyl ether; hexane at -40℃; for 0.5h; Inert atmosphere; Stage #2: cyclohexanedione monoethylene ketal In diethyl ether; hexane at -78℃; Inert atmosphere; | 100% |
Stage #1: Methoxyallene With n-butyllithium In diethyl ether; hexane at -40℃; for 0.333333h; Stage #2: cyclohexanedione monoethylene ketal In diethyl ether; hexane at -78℃; for 2.5h; Further stages.; |
cyclohexanedione monoethylene ketal
(2S)-2-amino-3-(4-methoxyphenyl)propan-1-ol
Conditions | Yield |
---|---|
With molecular sieve In dichloromethane at 20℃; for 2h; | 100% |
cyclohexanedione monoethylene ketal
o-hydroxyacetophenone
dispiro[chromane-2,1'-cyclohexane-4',2''-[1,3]dioxolan]-4-one
Conditions | Yield |
---|---|
With pyrrolidine In methanol for 10h; Heating / reflux; | 100% |
With pyrrolidine In ethanol at 80℃; for 12h; Kabe Chromanone Synthesis; |
cyclohexanedione monoethylene ketal
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide
1,4-dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran at -78 - -20℃; | 100% |
Stage #1: cyclohexanedione monoethylene ketal With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 0℃; for 1h; Stage #2: N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide In tetrahydrofuran at -78 - -40℃; for 4h; | 88% |
With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 20℃; for 2h; | 72% |
cyclohexanedione monoethylene ketal
1-[3-(trifluoromethoxy)phenyl]methanamine
N-[3-(trifluoromethoxy)benzyl]-1,4-dioxaspiro[4.5]decan-8-amine
Conditions | Yield |
---|---|
Stage #1: cyclohexanedione monoethylene ketal; 1-[3-(trifluoromethoxy)phenyl]methanamine With sodium tris(acetoxy)borohydride; acetic acid In tetrahydrofuran at 20℃; Stage #2: With sodium hydroxide In tetrahydrofuran; water | 100% |
cyclohexanedione monoethylene ketal
trimethylsilylacetylene
8-((trimethylsilyl)ethynyl)-1,4-dioxaspiro[4.5]decan-8-ol
Conditions | Yield |
---|---|
Stage #1: trimethylsilylacetylene With n-butyllithium In tetrahydrofuran; hexane at -76℃; for 1h; Stage #2: cyclohexanedione monoethylene ketal In tetrahydrofuran; hexane at -74℃; for 2h; | 100% |
With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere; | 77% |
Stage #1: trimethylsilylacetylene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: cyclohexanedione monoethylene ketal In tetrahydrofuran; hexane at -78℃; for 1h; Stage #3: With water; ammonium chloride In tetrahydrofuran; hexane |
cyclohexanedione monoethylene ketal
1,1-dimethylhydrazine
2-[1,4-dioxaspiro[4.5 ]decan-8-ylidene]-1,1-dimethylhydrazine
Conditions | Yield |
---|---|
In toluene at 20℃; Dean-Stark; Reflux; | 100% |
In toluene Dean-Stark; Reflux; | 100% |
With trifluoroacetic acid In benzene Heating; | 86% |
With toluene-4-sulfonic acid In benzene for 6h; Reflux; | |
at 20℃; Neat (no solvent); |
4-fluoroindole
cyclohexanedione monoethylene ketal
3-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-4-fluoro-1H-indole
Conditions | Yield |
---|---|
With potassium hydroxide In methanol Heating; | 100% |
cyclohexanedione monoethylene ketal
4-Methylencyclohexanol
Conditions | Yield |
---|---|
Stage #1: cyclohexanedione monoethylene ketal With n-butyllithium; Methyltriphenylphosphonium bromide In tetrahydrofuran at -10 - 25℃; for 17h; Stage #2: With oxalic acid In water; acetone at 25℃; for 3.5h; Stage #3: With sodium tetrahydroborate In tetrahydrofuran at 25℃; for 3h; | 100% |
Multi-step reaction with 3 steps 1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -10 °C 1.2: 4 h / -10 - 20 °C 2.1: water; oxalic acid / acetone / 3 h / 20 °C 3.1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -10 °C 1.2: 4 h / 20 °C 2.1: oxalic acid / water; acetone / 3 h / 20 °C 3.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran / 1 h / -10 °C 1.2: 4 h / 20 °C 2.1: oxalic acid / water; acetone / 3 h / 20 °C 3.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C View Scheme |
cyclohexanedione monoethylene ketal
trimethylsilylacetylene
8-ethynyl-1,4-dioxaspiro[4.5]decan-8-ol
Conditions | Yield |
---|---|
Stage #1: trimethylsilylacetylene With n-butyllithium In tetrahydrofuran; hexane at -76℃; for 1h; Stage #2: cyclohexanedione monoethylene ketal In tetrahydrofuran; hexane at -74℃; for 2h; Stage #3: With potassium carbonate In methanol at 20℃; for 2h; | 100% |
Stage #1: trimethylsilylacetylene With n-butyllithium In tetrahydrofuran; hexane at -70℃; for 0.833333h; Stage #2: cyclohexanedione monoethylene ketal In tetrahydrofuran; hexane at -70℃; Stage #3: With methanol; potassium carbonate for 0.5h; | 98% |
cyclohexanedione monoethylene ketal
1-(1,4-dioxa-spiro[4.5]dec-8-yl)-4,4-difluoro-piperidine
Conditions | Yield |
---|---|
Stage #1: cyclohexanedione monoethylene ketal; 4,4-difluoropiperidine hydrochloride With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 20h; Stage #2: With sodium hydroxide In dichloromethane pH=12; | 100% |
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 24h; Inert atmosphere; | 2 g |
cyclohexanedione monoethylene ketal
methylamine
N-(1,4-dioxaspiro-[4,5]-decan-8-yliden)-methanamine
Conditions | Yield |
---|---|
In ethanol at 20℃; | 100% |
In ethanol at 20℃; for 2 - 24h; | 100% |
cyclohexanedione monoethylene ketal
trimethylsilyl cyanide
2-iodophenylamine
Conditions | Yield |
---|---|
With acetic acid at 20℃; for 12h; | 100% |
cyclohexanedione monoethylene ketal
isopropenylmagnesium bromide
Conditions | Yield |
---|---|
In tetrahydrofuran at 0 - 5℃; for 2h; Inert atmosphere; | 100% |
In tetrahydrofuran at 0 - 5℃; for 4h; Inert atmosphere; | |
In tetrahydrofuran at 5℃; for 2h; |
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