Products

Refine

Country

Business Type

Certificate

Display

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

We are the manufacturer of this product in China. Our price is the lowest in China. CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD., founded in 1984, engages in pharmaceutical research, development, production, process design and techni

Tolvaptan high purity, low price in China

Cas:150683-30-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

Sleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric

N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-...

Cas:150683-30-0

Min.Order:10000 Gram

FOB Price: $1300.0

Type:Manufacturers

inquiry

Hangzhou Think Chemical Co. Ltd

Tolvaptan[CAS:150683-30-0] 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]Azepin-5-one[CAS:160129-45-3] Items Specifications Results Appearance: light yellow or green crystalline powder Complies Solubil

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Tolvaptan

Cas:150683-30-0

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Tolvaptan 150683-30-0 GMP Manufacturer

Cas:150683-30-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality tolvaptan

Cas:150683-30-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Tolvaptan

Cas:150683-30-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory Supply Tolvaptan powder CAS 150683-30-0

Cas:150683-30-0

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - Tolvaptan

Cas:150683-30-0

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Pharmaceutical Raw Material CAS 150683-30-0 99% Purityopc 41061 Powder with Best Price

Cas:150683-30-0

Min.Order:1 Gram

FOB Price: $108.0 / 138.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Tolvaptan CAS NO.150683-30-0

Cas:150683-30-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Tolvaptan/ LIDE PHARMA- Factory supply / Best price

Cas:150683-30-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product: Tolvaptan CAS: 150683-30-0 Molecular Formula: C26H25CLN2O3 Assay:99.0% min Appearacne: White powder Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:pharmaceutical

Tolvaptan

Cas:150683-30-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 150683-30-0 Tolvaptan with best price

Cas:150683-30-0

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Tolvaptan 150683-30-0

Cas:150683-30-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Non-peptide selective antidiuretic hormone receptor antagonist Tolvaptan CAS:150683-30-0

Cas:150683-30-0

Min.Order:50 Gram

FOB Price: $576.0 / 630.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Tolvaptan CAS:150683-30-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Tolvaptan CAS:150683-30-0

Cas:150683-30-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Tolvaptan

Cas:150683-30-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Tolvaptan

Cas:150683-30-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Tolvaptan Synonyms: Tolvaptan powder;Tolvptan;(R)-N-(4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide;N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-

Tolvaptan high purity best quality

Cas:150683-30-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white powder without visible impurities Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Tolvaptan

Cas:150683-30-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Tolvaptan/OPC 41061/CAS 150683-30-0/EINECS 691-537-5

Cas:150683-30-0

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

≥98.0% min Appearance:A white or off-white crystalline powder Storage:Room temperature Package:25kg/drum or as required Application:used in medicine Transportation:by sea by air express Port:China main port

Tolvaptan ≥98.0% min Pharmaceutical API made in china

Cas:150683-30-0

Min.Order:5 Kilogram

Negotiable

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Tolvaptan 150683-30-0

Cas:150683-30-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Tolvaptan

Cas:150683-30-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Pharma Grade Anticonvulsant Raw Powder Tolvaptan

Cas:150683-30-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

moderate price & quick delivery. Appearance:White Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Tolvaptan (OPC-41061) is a select

Tolvaptan

Cas:150683-30-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: Tolvaptan CAS No.:150683-30-0 Molecule Formula:C26H25ClN2O3 Molecule Weight:448.94 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Best Quality Tolvaptan

Cas:150683-30-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Tolvaptan Tablets

Cas:150683-30-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best PriceTolvaptan

Cas:150683-30-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

MOP-21826
137973-76-3

MOP-21826

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate at 0℃; for 2h;96%
With methanol; sodium tetrahydroborate at 20℃; for 5h;94%
With sodium bis(2-methoxyethoxy)aluminium dihydride In tetrahydrofuran at -5 - 20℃; Solvent;94.2%
MOP-21826
137973-76-3

MOP-21826

A

C34H32ClN3O4

C34H32ClN3O4

B

C42H36ClN3O5

C42H36ClN3O5

C

C42H38ClN3O5

C42H38ClN3O5

D

C42H38ClN3O5

C42H38ClN3O5

E

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Stage #1: MOP-21826 With sodium tetrahydroborate In methanol for 1h;
Stage #2: With hydrogenchloride In methanol; water at 20℃;
A n/a
B n/a
C n/a
D n/a
E 90%
(±)-7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol

(±)-7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol

2-methyl-4-(2-methylbenzoylamino)benzoic acid chloride
331947-69-4

2-methyl-4-(2-methylbenzoylamino)benzoic acid chloride

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
With 2,6-dimethylpyridine In N,N-dimethyl acetamide; water at 0℃; for 2h; Reagent/catalyst;72%
2,2-dimethyl-propionic acid 7-chloro-1-[2-methyl-4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

2,2-dimethyl-propionic acid 7-chloro-1-[2-methyl-4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 50℃; for 2h;
With sodium hydroxide; ethanol; water at 50℃; for 2h;
(rac)-7-chloro-4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl pivalate
804498-94-0

(rac)-7-chloro-4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl pivalate

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 96 percent / hydroxylamine hydrochloride; sodium acetate / ethanol; H2O / 2 h / Heating
2: PCl5 / CH2Cl2 / 2 h / 20 °C
3: acetic acid; Zn / 0.5 h / Heating
4: BH3*THF / tetrahydrofuran / 0.5 h / Heating
5: 98 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
6: 82 percent / hydrochloric acid; SnCl2 / ethanol / 2 h / Heating
7: triethylamine / CH2Cl2 / 1 h / 20 °C
8: NaOH / ethanol; H2O / 2 h / 50 °C
View Scheme
2,2-dimethylpropionic acid 7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester
863762-10-1

2,2-dimethylpropionic acid 7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 98 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
2: 82 percent / hydrochloric acid; SnCl2 / ethanol / 2 h / Heating
3: triethylamine / CH2Cl2 / 1 h / 20 °C
4: NaOH / ethanol; H2O / 2 h / 50 °C
View Scheme
2,2-dimethyl-propionic acid 7-chloro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

2,2-dimethyl-propionic acid 7-chloro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: BH3*THF / tetrahydrofuran / 0.5 h / Heating
2: 98 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
3: 82 percent / hydrochloric acid; SnCl2 / ethanol / 2 h / Heating
4: triethylamine / CH2Cl2 / 1 h / 20 °C
5: NaOH / ethanol; H2O / 2 h / 50 °C
View Scheme
2,2-dimethylpropionic acid 4-[(E)-hydroxyimino]-7-chloro-1,2,3,4-tetrahydronaphthalen-1-yl ester
863762-02-1

2,2-dimethylpropionic acid 4-[(E)-hydroxyimino]-7-chloro-1,2,3,4-tetrahydronaphthalen-1-yl ester

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: PCl5 / CH2Cl2 / 2 h / 20 °C
2: acetic acid; Zn / 0.5 h / Heating
3: BH3*THF / tetrahydrofuran / 0.5 h / Heating
4: 98 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
5: 82 percent / hydrochloric acid; SnCl2 / ethanol / 2 h / Heating
6: triethylamine / CH2Cl2 / 1 h / 20 °C
7: NaOH / ethanol; H2O / 2 h / 50 °C
View Scheme
2,2-dimethyl-propionic acid 3,3,7-trichloro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

2,2-dimethyl-propionic acid 3,3,7-trichloro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: acetic acid; Zn / 0.5 h / Heating
2: BH3*THF / tetrahydrofuran / 0.5 h / Heating
3: 98 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
4: 82 percent / hydrochloric acid; SnCl2 / ethanol / 2 h / Heating
5: triethylamine / CH2Cl2 / 1 h / 20 °C
6: NaOH / ethanol; H2O / 2 h / 50 °C
View Scheme
2,2-dimethylpropionic acid 7-chloro-1-(4-amino-2-methylbenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester
863762-24-7

2,2-dimethylpropionic acid 7-chloro-1-(4-amino-2-methylbenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / CH2Cl2 / 1 h / 20 °C
2: NaOH / ethanol; H2O / 2 h / 50 °C
View Scheme
2,2-dimethylpropionic acid 7-chloro-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester
863762-20-3

2,2-dimethylpropionic acid 7-chloro-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl ester

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 82 percent / hydrochloric acid; SnCl2 / ethanol / 2 h / Heating
2: triethylamine / CH2Cl2 / 1 h / 20 °C
3: NaOH / ethanol; H2O / 2 h / 50 °C
View Scheme
4-chlorobenzenesulfonyl chloride
5202-89-1

4-chlorobenzenesulfonyl chloride

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: 85 percent / pyridine / 20 °C
2.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C
3.1: t-BuOK / toluene / 0.5 h / Heating
3.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating
4.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
5.1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C
6.1: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
7.1: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C
8.1: 30 percent / NaBH4 / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1: sodium carbonate / acetonitrile / 5 h / 80 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
3: potassium tert-butylate / toluene / 1 h / 120 °C
4: acetic acid; hydrogenchloride / water / 6 h / 100 °C
5: hydrogenchloride; tin(II) chloride dihdyrate / ethanol / 4 h / 20 °C
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
7: sodium tetrahydroborate; methanol / 2 h / 0 °C
View Scheme
5-chloro-2-nitrobenzoic acid
2516-95-2

5-chloro-2-nitrobenzoic acid

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: 100 percent / K2CO3 / acetone / 0.5 h / Heating
2.1: SnCl2*2H2O; conc. HCl / ethanol / 20 °C
3.1: 85 percent / pyridine / 20 °C
4.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C
5.1: t-BuOK / toluene / 0.5 h / Heating
5.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating
6.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
7.1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C
8.1: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
9.1: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C
10.1: 30 percent / NaBH4 / methanol / 1 h / 20 °C
View Scheme
2-methyl-4-nitrobenzoyl chloride
30459-70-2

2-methyl-4-nitrobenzoyl chloride

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C
2: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
3: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C
4: 30 percent / NaBH4 / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / dichloromethane; water / pH 7 - 8
2.1: tin(ll) chloride / methanol / 16 h / 20 °C
3.1: sodium hydrogencarbonate / dichloromethane / 0 - 5 °C / pH 7 - 8
4.1: sodium tetrahydroborate; methanol / 1 h / 20 °C
4.2: pH 6 - 7
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / water; dichloromethane / 0 - 5 °C / pH 7.0 - 8.0
2.1: tin(IV) chloride / methanol / 16 h / 20 °C
3.1: sodium hydrogencarbonate / water; dichloromethane / 0 - 5 °C / pH 7.0 - 8.0
4.1: sodium tetrahydroborate / methanol / 1 h / 20 °C
4.2: pH 6.0 - 7.0
View Scheme
Multi-step reaction with 4 steps
1.1: magnesium hydroxide / acetonitrile / 0.5 h / 10 °C
1.2: 5 h
2.1: methanol; tin(II) chloride dihdyrate / 23 h / 10 °C
3.1: magnesium hydroxide / dichloromethane; water / 0.5 h / 10 °C
3.2: 3 h
4.1: sodium tetrahydroborate; methanol / 1 h
View Scheme
2-methyl-4-nitrobenzoic acid
1975-51-5

2-methyl-4-nitrobenzoic acid

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: SOCl2
2: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C
3: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
4: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C
5: 30 percent / NaBH4 / methanol / 1 h / 20 °C
View Scheme
methyl 5-chloro-2-nitrobenzoate
51282-49-6

methyl 5-chloro-2-nitrobenzoate

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: SnCl2*2H2O; conc. HCl / ethanol / 20 °C
2.1: 85 percent / pyridine / 20 °C
3.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C
4.1: t-BuOK / toluene / 0.5 h / Heating
4.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating
5.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
6.1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C
7.1: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
8.1: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C
9.1: 30 percent / NaBH4 / methanol / 1 h / 20 °C
View Scheme
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C
2: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
3: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C
4: 30 percent / NaBH4 / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / dichloromethane; water / pH 7 - 8
2.1: tin(ll) chloride / methanol / 16 h / 20 °C
3.1: sodium hydrogencarbonate / dichloromethane / 0 - 5 °C / pH 7 - 8
4.1: sodium tetrahydroborate; methanol / 1 h / 20 °C
4.2: pH 6 - 7
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / water; dichloromethane / 0 - 5 °C / pH 7.0 - 8.0
2.1: tin(IV) chloride / methanol / 16 h / 20 °C
3.1: sodium hydrogencarbonate / water; dichloromethane / 0 - 5 °C / pH 7.0 - 8.0
4.1: sodium tetrahydroborate / methanol / 1 h / 20 °C
4.2: pH 6.0 - 7.0
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate; triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide; water / 8 h / 120 °C / 22502.3 Torr / Autoclave
2: iron; ammonium chloride / water; methanol / 6 h / 35 - 40 °C
3: pyridine / dichloromethane / 2 h / 0 - 10 °C
4: sodium tetrahydroborate; methanol / 1 h / 15 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: magnesium hydroxide / acetonitrile / 0.5 h / 10 °C
1.2: 5 h
2.1: methanol; tin(II) chloride dihdyrate / 23 h / 10 °C
3.1: magnesium hydroxide / dichloromethane; water / 0.5 h / 10 °C
3.2: 3 h
4.1: sodium tetrahydroborate; methanol / 1 h
View Scheme
N-p-toluenesulfonyl-5-chloro-anthranilic acid methyl ester
247237-38-3

N-p-toluenesulfonyl-5-chloro-anthranilic acid methyl ester

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C
2.1: t-BuOK / toluene / 0.5 h / Heating
2.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating
3.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
4.1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C
5.1: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
6.1: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C
7.1: 30 percent / NaBH4 / methanol / 1 h / 20 °C
View Scheme
7-chloro-1-(4-methylbenzenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one
193686-76-9

7-chloro-1-(4-methylbenzenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
2: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C
3: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
4: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C
5: 30 percent / NaBH4 / methanol / 1 h / 20 °C
View Scheme
1-(4-amino-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
137977-97-0

1-(4-amino-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C
2: 30 percent / NaBH4 / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / water; dichloromethane / 0 - 5 °C / pH 7.0 - 8.0
2.1: sodium tetrahydroborate / methanol / 1 h / 20 °C
2.2: pH 6.0 - 7.0
View Scheme
1-(4-nitro-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
137982-91-3

1-(4-nitro-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
2: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C
3: 30 percent / NaBH4 / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: tin(ll) chloride / methanol / 16 h / 20 °C
2.1: sodium hydrogencarbonate / dichloromethane / 0 - 5 °C / pH 7 - 8
3.1: sodium tetrahydroborate; methanol / 1 h / 20 °C
3.2: pH 6 - 7
View Scheme
Multi-step reaction with 3 steps
1.1: tin(IV) chloride / methanol / 16 h / 20 °C
2.1: sodium hydrogencarbonate / water; dichloromethane / 0 - 5 °C / pH 7.0 - 8.0
3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C
3.2: pH 6.0 - 7.0
View Scheme
methyl 5-chloro-2-[N-(3-ethoxycarbonyl)propyl-N-p-toluenesulfonyl]aminobenzoate
247237-43-0

methyl 5-chloro-2-[N-(3-ethoxycarbonyl)propyl-N-p-toluenesulfonyl]aminobenzoate

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: t-BuOK / toluene / 0.5 h / Heating
1.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating
2.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
3.1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C
4.1: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
5.1: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C
6.1: 30 percent / NaBH4 / methanol / 1 h / 20 °C
View Scheme
C13H16ClNO4

C13H16ClNO4

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
2: potassium tert-butylate / toluene / 1 h / 120 °C
3: acetic acid; hydrogenchloride / water / 6 h / 100 °C
4: hydrogenchloride; tin(II) chloride dihdyrate / ethanol / 4 h / 20 °C
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
6: sodium tetrahydroborate; methanol / 2 h / 0 °C
View Scheme
C21H21ClN2O7

C21H21ClN2O7

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium tert-butylate / toluene / 1 h / 120 °C
2: acetic acid; hydrogenchloride / water / 6 h / 100 °C
3: hydrogenchloride; tin(II) chloride dihdyrate / ethanol / 4 h / 20 °C
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
5: sodium tetrahydroborate; methanol / 2 h / 0 °C
View Scheme
C20H17ClN2O6

C20H17ClN2O6

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic acid; hydrogenchloride / water / 6 h / 100 °C
2: hydrogenchloride; tin(II) chloride dihdyrate / ethanol / 4 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
4: sodium tetrahydroborate; methanol / 2 h / 0 °C
View Scheme
C18H16Cl2N2O4

C18H16Cl2N2O4

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dichloromethane / 4.5 h / 20 °C / Reflux
2: hydrogenchloride; tin(II) chloride dihdyrate / water; ethanol / 3 h / 20 °C
3: triethylamine / dichloromethane / 2.25 h / 20 °C
4: sodium tetrahydroborate; methanol / 5 h / 20 °C
View Scheme
4-chloro-aniline
106-47-8

4-chloro-aniline

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: sodium carbonate / acetonitrile / 4 h / 80 °C
2: triethylamine / dichloromethane / 3 h / 20 °C
3: sodium hydroxide / 1.5 h / 50 °C
4: thionyl chloride / dichloromethane / 2 h / 20 °C / Reflux
5: dichloromethane / 4.5 h / 20 °C / Reflux
6: hydrogenchloride; tin(II) chloride dihdyrate / water; ethanol / 3 h / 20 °C
7: triethylamine / dichloromethane / 2.25 h / 20 °C
8: sodium tetrahydroborate; methanol / 5 h / 20 °C
View Scheme
ethyl 4-(4-chlorophenylamino)butanoate

ethyl 4-(4-chlorophenylamino)butanoate

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: triethylamine / dichloromethane / 3 h / 20 °C
2: sodium hydroxide / 1.5 h / 50 °C
3: thionyl chloride / dichloromethane / 2 h / 20 °C / Reflux
4: dichloromethane / 4.5 h / 20 °C / Reflux
5: hydrogenchloride; tin(II) chloride dihdyrate / water; ethanol / 3 h / 20 °C
6: triethylamine / dichloromethane / 2.25 h / 20 °C
7: sodium tetrahydroborate; methanol / 5 h / 20 °C
View Scheme
C20H21ClN2O5

C20H21ClN2O5

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium hydroxide / 1.5 h / 50 °C
2: thionyl chloride / dichloromethane / 2 h / 20 °C / Reflux
3: dichloromethane / 4.5 h / 20 °C / Reflux
4: hydrogenchloride; tin(II) chloride dihdyrate / water; ethanol / 3 h / 20 °C
5: triethylamine / dichloromethane / 2.25 h / 20 °C
6: sodium tetrahydroborate; methanol / 5 h / 20 °C
View Scheme
Dibenzyl N,N-diisopropylphosphoramidite
108549-23-1

Dibenzyl N,N-diisopropylphosphoramidite

tolvaptan
150683-30-0

tolvaptan

C40H38ClN2O6P

C40H38ClN2O6P

Conditions
ConditionsYield
Stage #1: Dibenzyl N,N-diisopropylphosphoramidite; tolvaptan With 1H-tetrazole In dichloromethane at 20℃; for 2h;
Stage #2: With 3-chloro-benzenecarboperoxoic acid In dichloromethane at -40 - 0℃; for 1h;
97.2%
Multi-step reaction with 2 steps
1: 2H-tetrazole / dichloromethane / 2 h / 20 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / -40 - 0 °C
View Scheme
tolvaptan
150683-30-0

tolvaptan

C26H26ClN2O6P
942619-74-1

C26H26ClN2O6P

Conditions
ConditionsYield
Stage #1: tolvaptan With triethylamine; trichlorophosphate In 1,2-dimethoxyethane at -15 - -12℃; for 2h;
Stage #2: With sodium hydroxide; water In 1,2-dimethoxyethane; toluene at 0 - 50℃;
Stage #3: With hydrogenchloride; water at 10℃; Product distribution / selectivity;
97%
Multi-step reaction with 3 steps
1: 2H-tetrazole / dichloromethane / 2 h / 20 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / -40 - 0 °C
3: 5%-palladium/activated carbon; hydrogen / ethanol / 0.17 h
View Scheme
Multi-step reaction with 2 steps
1.1: 1H-tetrazole / dichloromethane / 2 h / 20 °C
1.2: 1 h / -40 - 0 °C
2.1: 5%-palladium/activated carbon; hydrogen / ethanol
View Scheme
methanol
67-56-1

methanol

tolvaptan
150683-30-0

tolvaptan

C27H28ClN2O5P
942619-87-6

C27H28ClN2O5P

Conditions
ConditionsYield
Stage #1: tolvaptan With pyridine; diphenyl hydrogen phosphite at 0 - 20℃; for 0.5h;
Stage #2: methanol at 20℃; for 0.5h;
91%
tolvaptan
150683-30-0

tolvaptan

fluorodeoxytolvaptan

fluorodeoxytolvaptan

Conditions
ConditionsYield
With 1,3-bis(2,6-diisopropylphenyl)-2-fluoroimidazolium tetrafluoroborate; cesium fluoride In toluene at 80℃; for 17h; Inert atmosphere; Schlenk technique; Sealed tube;86%
tolvaptan
150683-30-0

tolvaptan

C26H24ClN2O6P(2-)*2Na(1+)

C26H24ClN2O6P(2-)*2Na(1+)

Conditions
ConditionsYield
Stage #1: tolvaptan With triethylamine; trichlorophosphate In 1,2-dimethoxyethane at -18 - -13℃; for 2h; Inert atmosphere; Large scale;
Stage #2: With water; sodium hydroxide In 1,2-dimethoxyethane at -3 - 30℃; for 0.5h; Inert atmosphere; Large scale;
86%
Multi-step reaction with 4 steps
1: 2H-tetrazole / dichloromethane / 2 h / 20 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / -40 - 0 °C
3: 5%-palladium/activated carbon; hydrogen / ethanol / 0.17 h
4: sodium hydroxide / methanol; water / 0.08 h / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1.1: 1H-tetrazole / dichloromethane / 2 h / 20 °C
1.2: 1 h / -40 - 0 °C
2.1: 5%-palladium/activated carbon; hydrogen / ethanol
3.1: sodium hydroxide / methanol; water / 0.08 h / Cooling with ice
View Scheme
3-Hydroxypropionitrile
109-78-4

3-Hydroxypropionitrile

tolvaptan
150683-30-0

tolvaptan

C29H29ClN3O5P

C29H29ClN3O5P

Conditions
ConditionsYield
Stage #1: tolvaptan With pyridine; diphenyl hydrogen phosphite at 20℃; for 0.5h;
Stage #2: 3-Hydroxypropionitrile at 20℃; for 0.5h;
75%
tolvaptan
150683-30-0

tolvaptan

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

{7-chloro-1-[2-methyl-4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl} hexadecanoate
1094837-35-0

{7-chloro-1-[2-methyl-4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl} hexadecanoate

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃;74%
tolvaptan
150683-30-0

tolvaptan

C26H26ClN2O5P

C26H26ClN2O5P

Conditions
ConditionsYield
Stage #1: tolvaptan With triethylamine; phosphorus trichloride In tetrahydrofuran at -10℃; for 2h;
Stage #2: With sodium hydroxide; water In tetrahydrofuran at 0℃; Product distribution / selectivity;
60%
Stage #1: tolvaptan With pyridine; diphenyl hydrogen phosphite at 20℃; for 1h;
Stage #2: With water at 20℃; for 0.5h; Product distribution / selectivity;
24%
ethanol
64-17-5

ethanol

tolvaptan
150683-30-0

tolvaptan

C28H30ClN2O5P

C28H30ClN2O5P

Conditions
ConditionsYield
Stage #1: tolvaptan With pyridine; diphenyl hydrogen phosphite at 0 - 20℃; for 1h;
Stage #2: ethanol at 20℃; for 0.5h;
38%
methanol
67-56-1

methanol

tolvaptan
150683-30-0

tolvaptan

C28H30ClN2O6P

C28H30ClN2O6P

Conditions
ConditionsYield
Stage #1: tolvaptan With triethylamine; trichlorophosphate In tetrahydrofuran for 0.5h; Cooling with ice/methanol;
Stage #2: methanol With triethylamine In tetrahydrofuran for 0.5h;
33%
glycolic acid methyl ester
96-35-5

glycolic acid methyl ester

tolvaptan
150683-30-0

tolvaptan

C29H30ClN2O7P

C29H30ClN2O7P

Conditions
ConditionsYield
Stage #1: tolvaptan With pyridine; diphenyl hydrogen phosphite at 20℃; for 1h;
Stage #2: glycolic acid methyl ester at 20℃; for 12h;
20%

Downstream Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View