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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one Manufacturer/High quality/Best price/In stock

Cas:160129-45-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

Tolvaptan[CAS:150683-30-0] 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]Azepin-5-one[CAS:160129-45-3] Product: Tolvaptan Intermediate Chemical name: 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]Azepin-5-one[CAS:160129-45-3] Batch No: 20101019-2 Man

Good quality 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one supplier in China

Cas:160129-45-3

Min.Order:1 Kilogram

Negotiable

Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

7-Chloro-1, 2, 3, 4-Tetrahydro-5H-1-Benzazepin-5-One

Cas:160129-45-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

Cas:160129-45-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE CAS:160129-45-3 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one Manufacturer/High quality/Best price/In stock

Cas:160129-45-3

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--160129-45-3--7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had es

TIANFUCHEM--160129-45-3--7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE factory price

Cas:160129-45-3

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 160129-45-3 with competitive price

Cas:160129-45-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 160129-45-3

Cas:160129-45-3

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE CAS NO160129-45-3

Cas:160129-45-3

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro- 160129-45-3

Cas:160129-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro-/ LIDE PHARMA- Factory supply / Best price

Cas:160129-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

receptor antagonist, 37-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE CAS:160129-45-3

Cas:160129-45-3

Min.Order:1 Kilogram

FOB Price: $27.0 / 29.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE CAS:160129-45-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing

7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE CAS:160129-45-3

Cas:160129-45-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro-

Cas:160129-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro-

Cas:160129-45-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Tolvaptan intermediate Product Name: 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE Synonyms: 5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro-;7-Chlorobenzo[b]azepan-5-one;7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one;7-Chloro-1,2,3,4

Tolvaptan intermediate 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE Manufactuered in China best quality

Cas:160129-45-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

7-Chloro-1,2,3,4-Tetrahydrobenzo[B]Azepin-5-One

Cas:160129-45-3

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Courie

7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

Cas:160129-45-3

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

Cas:160129-45-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

Cas:160129-45-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

7-CHLORO-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE

Cas:160129-45-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro-

Cas:160129-45-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one Manufacturer

Cas:160129-45-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

Cas:160129-45-3

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:light yellow crystal Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide intermedia

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

Cas:160129-45-3

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one CAS No.: 160129-45-3 Molecule Formula:C10H10ClNO Molecule Weight:195.65 Purity: 99.0% Package: 25kg/drum Description:Yellow to lilght yellow powder Manufacture Standards:En

Lower Price 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one

Cas:160129-45-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

Cas:160129-45-3

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

Cas:160129-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

Cas:160129-45-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one

Cas:160129-45-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Synthetic route

methyl 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carboxylate

methyl 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carboxylate

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
With hydrogenchloride In water at 50℃; for 3h; Reagent/catalyst; Temperature;90.3%
7-chloro-1-(4-methylbenzenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one
193686-76-9

7-chloro-1-(4-methylbenzenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
Stage #1: 7-chloro-1-(4-methylbenzenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one With sulfuric acid In water at 0 - 10℃; for 2.5h;
Stage #2: With sodium hydroxide In water
89%
With PPA at 80 - 100℃; for 1.5h; detosylation;81%
With PPA at 100℃;
ethyl 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carboxylate

ethyl 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carboxylate

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
With formic acid at 150℃; for 3h;88.1%
1-allyl-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine

1-allyl-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
With 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine In dichloromethane at 35℃; for 8h; Inert atmosphere;88%
methyl 7-chloro-5-oxo-1-p-toluenesulfonyl-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carboxylate

methyl 7-chloro-5-oxo-1-p-toluenesulfonyl-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carboxylate

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
With sulfuric acid at 50℃; for 2h; Temperature;84.6%
Multi-step reaction with 2 steps
1: sulfuric acid / 2 h / 40 °C
2: hydrogenchloride / water / 3 h / 50 °C
View Scheme
4-chlorobenzenesulfonyl chloride
5202-89-1

4-chlorobenzenesulfonyl chloride

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 85 percent / pyridine / 20 °C
2.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C
3.1: t-BuOK / toluene / 0.5 h / Heating
3.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating
4.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
View Scheme
5-chloro-2-nitrobenzoic acid
2516-95-2

5-chloro-2-nitrobenzoic acid

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 100 percent / K2CO3 / acetone / 0.5 h / Heating
2.1: SnCl2*2H2O; conc. HCl / ethanol / 20 °C
3.1: 85 percent / pyridine / 20 °C
4.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C
5.1: t-BuOK / toluene / 0.5 h / Heating
5.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating
6.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
View Scheme
methyl 5-chloro-2-nitrobenzoate
51282-49-6

methyl 5-chloro-2-nitrobenzoate

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: SnCl2*2H2O; conc. HCl / ethanol / 20 °C
2.1: 85 percent / pyridine / 20 °C
3.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C
4.1: t-BuOK / toluene / 0.5 h / Heating
4.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating
5.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
View Scheme
N-p-toluenesulfonyl-5-chloro-anthranilic acid methyl ester
247237-38-3

N-p-toluenesulfonyl-5-chloro-anthranilic acid methyl ester

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C
2.1: t-BuOK / toluene / 0.5 h / Heating
2.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating
3.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
View Scheme
methyl 5-chloro-2-[N-(3-ethoxycarbonyl)propyl-N-p-toluenesulfonyl]aminobenzoate
247237-43-0

methyl 5-chloro-2-[N-(3-ethoxycarbonyl)propyl-N-p-toluenesulfonyl]aminobenzoate

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: t-BuOK / toluene / 0.5 h / Heating
1.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating
2.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
View Scheme
ethyl 7-chloro-5-oxo-1-p-toluenesulfonyl-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carboxylate

ethyl 7-chloro-5-oxo-1-p-toluenesulfonyl-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carboxylate

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
Stage #1: ethyl 7-chloro-5-oxo-1-p-toluenesulfonyl-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carboxylate With sulfuric acid In water at 75℃; for 2h;
Stage #2: With sodium hydroxide In water pH=7.5 - 8;
Stage #1: ethyl 7-chloro-5-oxo-1-p-toluenesulfonyl-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carboxylate With sulfuric acid; water at 75℃; for 2h;
Stage #2: With sodium hydroxide In water at 20℃; pH=7.5 - 8.0;
160 g
5-chloro-2-(diallylamino)benzaldehyde

5-chloro-2-(diallylamino)benzaldehyde

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 5,5-dimethyl-1,3-cyclohexadiene / 18 h / 175 °C / Sealed tube
2: sulfuric acid / water / 11 h / 90 °C
3: 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine / dichloromethane / 8 h / 35 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: 5,5-dimethyl-1,3-cyclohexadiene / 18 h / 175 °C
2.1: sulfuric acid / water / 11 h / 90 °C
3.1: 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine / dichloromethane / 8 h / Inert atmosphere; Reflux
3.2: Cooling with ice
4.1: sodium hydrogencarbonate / water
View Scheme
1-allyl-7-chloro-2,3,4,5-tetrahydro-1H-2,5-epoxybenzo[b]azepine

1-allyl-7-chloro-2,3,4,5-tetrahydro-1H-2,5-epoxybenzo[b]azepine

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid / water / 11 h / 90 °C
2: 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine / dichloromethane / 8 h / 35 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sulfuric acid / water / 11 h / 90 °C
2.1: 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine / dichloromethane / 8 h / Inert atmosphere; Reflux
2.2: Cooling with ice
3.1: sodium hydrogencarbonate / water
View Scheme
5-chloro-2-fluorobenzaldehyde
96515-79-6

5-chloro-2-fluorobenzaldehyde

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / water; acetonitrile / 72 h / Reflux
2: 5,5-dimethyl-1,3-cyclohexadiene / 18 h / 175 °C / Sealed tube
3: sulfuric acid / water / 11 h / 90 °C
4: 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine / dichloromethane / 8 h / 35 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetonitrile; water / 60 h / Reflux
2.1: 5,5-dimethyl-1,3-cyclohexadiene / 18 h / 175 °C
3.1: sulfuric acid / water / 11 h / 90 °C
4.1: 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine / dichloromethane / 8 h / Inert atmosphere; Reflux
4.2: Cooling with ice
5.1: sodium hydrogencarbonate / water
View Scheme
7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine hydrochloride

7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine hydrochloride

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

Conditions
ConditionsYield
With sodium hydrogencarbonate In water745 mg
2-methyl-4-nitrobenzoyl chloride
30459-70-2

2-methyl-4-nitrobenzoyl chloride

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

1-(4-nitro-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
137982-91-3

1-(4-nitro-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Stage #1: 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one With magnesium hydroxide In acetonitrile at 10℃; for 0.5h;
Stage #2: 2-methyl-4-nitrobenzoyl chloride In acetonitrile for 5h;
95%
With sodium hydroxide In acetonitrile at 20℃; for 1h;73%
With triethylamine In dichloromethane at 20℃; for 2h; Acylation;32%
carbon monoxide
201230-82-2

carbon monoxide

2-bromo-5-nitrotoluene
7149-70-4

2-bromo-5-nitrotoluene

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

1-(4-nitro-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
137982-91-3

1-(4-nitro-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; triphenylphosphine In water; N,N-dimethyl-formamide at 120℃; under 22502.3 Torr; for 8h; Temperature; Pressure; Autoclave;92.7%
2-methoxy-4-nitrobenzoyl chloride
39787-83-2

2-methoxy-4-nitrobenzoyl chloride

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

7-chloro-1-(2-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
247237-91-8

7-chloro-1-(2-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
With pyridine Acylation;92%
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

2-bromoethanol
540-51-2

2-bromoethanol

C12H14ClNO2

C12H14ClNO2

Conditions
ConditionsYield
With triethylamine In ethanol for 15h; Reflux;90.4%
3-chloro-4-nitro-benzoic acid chloride
55737-29-6

3-chloro-4-nitro-benzoic acid chloride

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

7-chloro-1-(3-chloro-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
247237-89-4

7-chloro-1-(3-chloro-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 2h; Acylation;89%
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

1-bromo-3-propanol
627-18-9

1-bromo-3-propanol

C13H16ClNO2

C13H16ClNO2

Conditions
ConditionsYield
With potassium hydrogencarbonate In N,N-dimethyl-formamide for 12h; Reflux;87.9%
carbon monoxide
201230-82-2

carbon monoxide

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

2-bromo-5-(2-methylbenzoylamino)toluene
317374-07-5

2-bromo-5-(2-methylbenzoylamino)toluene

MOP-21826
137973-76-3

MOP-21826

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; palladium diacetate In N,N-dimethyl-formamide at 125℃; for 3h;85%
With 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium diacetate; triphenylphosphine In N,N-dimethyl-formamide at 20 - 125℃; for 3h;85%
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepine
313673-94-8

7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepine

Conditions
ConditionsYield
With hydrazine hydrate; potassium hydroxide In 1,2-dimethoxyethane at 160℃; for 4h;77%
carbon monoxide
201230-82-2

carbon monoxide

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

2-bromo-5-(2-methylbenzoylamino)toluene
317374-07-5

2-bromo-5-(2-methylbenzoylamino)toluene

A

MOP-21826
137973-76-3

MOP-21826

B

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
With cesium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; palladium diacetate In N,N-dimethyl-formamide Heating;A n/a
B 75%
4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

7-chloro-1-(4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
137984-92-0

7-chloro-1-(4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 2h; Acylation;57%
2-chloro-4-nitrobenzoyl chloride
7073-36-1

2-chloro-4-nitrobenzoyl chloride

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

7-chloro-1-(2-chloro-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
137977-93-6

7-chloro-1-(2-chloro-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 2h; Acylation;57%
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

(±)-7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol

(±)-7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol

Conditions
ConditionsYield
With C19H29N4Ru(1+)*C24H20B(1-); potassium hydroxide In isopropyl alcohol at 80℃; for 2h; Inert atmosphere; Schlenk technique;56%
3-methoxy-4-nitrobenzoic acid chloride
67579-92-4

3-methoxy-4-nitrobenzoic acid chloride

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

7-chloro-1-(3-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
137982-83-3

7-chloro-1-(3-methoxy-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 2h; Acylation;31%
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C
2: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
3: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C
4: 30 percent / NaBH4 / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / dichloromethane; water / pH 7 - 8
2.1: tin(ll) chloride / methanol / 16 h / 20 °C
3.1: sodium hydrogencarbonate / dichloromethane / 0 - 5 °C / pH 7 - 8
4.1: sodium tetrahydroborate; methanol / 1 h / 20 °C
4.2: pH 6 - 7
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / water; dichloromethane / 0 - 5 °C / pH 7.0 - 8.0
2.1: tin(IV) chloride / methanol / 16 h / 20 °C
3.1: sodium hydrogencarbonate / water; dichloromethane / 0 - 5 °C / pH 7.0 - 8.0
4.1: sodium tetrahydroborate / methanol / 1 h / 20 °C
4.2: pH 6.0 - 7.0
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate; triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide; water / 8 h / 120 °C / 22502.3 Torr / Autoclave
2: iron; ammonium chloride / water; methanol / 6 h / 35 - 40 °C
3: pyridine / dichloromethane / 2 h / 0 - 10 °C
4: sodium tetrahydroborate; methanol / 1 h / 15 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: magnesium hydroxide / acetonitrile / 0.5 h / 10 °C
1.2: 5 h
2.1: methanol; tin(II) chloride dihdyrate / 23 h / 10 °C
3.1: magnesium hydroxide / dichloromethane; water / 0.5 h / 10 °C
3.2: 3 h
4.1: sodium tetrahydroborate; methanol / 1 h
View Scheme
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

1-(4-aminobenzoyl)-7-chloro-5-methoxy-2,3,4,5-tetrahydro-1H-1-benzazepine
247237-83-8

1-(4-aminobenzoyl)-7-chloro-5-methoxy-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 57 percent / Et3N / CH2Cl2 / 2 h / 20 °C
2: 99 percent / NaBH4 / methanol / 1 h / 20 °C
3: 71 percent / NaH / dimethylformamide / 1 h / 20 °C
4: 93 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
View Scheme
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

7-chloro-5-methoxy-1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine
247237-79-2

7-chloro-5-methoxy-1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 57 percent / Et3N / CH2Cl2 / 2 h / 20 °C
2: 99 percent / NaBH4 / methanol / 1 h / 20 °C
3: 71 percent / NaH / dimethylformamide / 1 h / 20 °C
View Scheme
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

1-(4-aminobenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
137984-95-3

1-(4-aminobenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 57 percent / Et3N / CH2Cl2 / 2 h / 20 °C
2: 66 percent / conc. HCl; H2 / PtO2 / acetic acid / 760 Torr
View Scheme
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

7-chloro-5-hydroxy-1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine
247237-78-1

7-chloro-5-hydroxy-1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 57 percent / Et3N / CH2Cl2 / 2 h / 20 °C
2: 99 percent / NaBH4 / methanol / 1 h / 20 °C
View Scheme
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

1-(4-amino-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
137977-97-0

1-(4-amino-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C
2: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / dichloromethane; water / pH 7 - 8
2: tin(ll) chloride / methanol / 16 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / water; dichloromethane / 0 - 5 °C / pH 7.0 - 8.0
2: tin(IV) chloride / methanol / 16 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate; triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide; water / 8 h / 120 °C / 22502.3 Torr / Autoclave
2: iron; ammonium chloride / water; methanol / 6 h / 35 - 40 °C
View Scheme
Multi-step reaction with 2 steps
1.1: magnesium hydroxide / acetonitrile / 0.5 h / 10 °C
1.2: 5 h
2.1: methanol; tin(II) chloride dihdyrate / 23 h / 10 °C
View Scheme
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

1-(4-amino-3-chlorobenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
247237-93-0

1-(4-amino-3-chlorobenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / Et3N / CH2Cl2 / 2 h / 20 °C
2: 86 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
View Scheme
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

1-(4-amino-2-methoxybenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
137976-75-1

1-(4-amino-2-methoxybenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / pyridine
2: 89 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C
View Scheme
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

1-(4-amino-3-methoxybenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
137982-87-7

1-(4-amino-3-methoxybenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 31 percent / Et3N / CH2Cl2 / 2 h / 20 °C
2: 83 percent / conc. HCl; H2 / PtO2 / acetic acid / 760 Torr
View Scheme

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