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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2-Methyl-4-(2-methylbenzoylamino)benzoic acid Manufacturer/High quality/Best price/In stock

Cas:317374-08-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Tolvaptan Intermediates supplier in China

Cas:317374-08-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Tolvaptan Intermediates

Cas:317374-08-6

Min.Order:1

Negotiable

Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2-Methyl-4-(2-methylbenzoylamino)benzoic acid

Cas:317374-08-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

2-methyl-4-[(2-methylbenzoyl)amino]benzoic Acid CAS NO.317374-08-6

Cas:317374-08-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Methyl-4-(2-methyl-benzoylamino)benzoic acid

Cas:317374-08-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 317374-08-6 with best quality

Cas:317374-08-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

2-methyl-4-(2-methyl-benzoylamino)-benzoic acid 317374-08-6

Cas:317374-08-6

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

2-Methyl-4-(2-methylbenzoylamino)benzoic acid/ LIDE PHARMA- Factory supply / Best price

Cas:317374-08-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 2-methyl-4-(2-methyl-benzoylamino)-benzoic acid CAS: 317374-08-6 MF: C16H15NO3 MW: 269.3 EINECS: 1312995-182-4 Mol File: Mol File 2-methyl-4-(2-methyl-benzoylamino)-benzoic acid Structure 2-methyl-4-(2-methyl-benzoy

2-Methyl-4-(2-methylbenzoylamino)benzoic acid

Cas:317374-08-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

2-methyl-4-(2-methyl-benzoylamino)-benzoic acid CAS:317374-08-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing

2-methyl-4-(2-methyl-benzoylamino)-benzoic acid CAS:317374-08-6

Cas:317374-08-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Methyl-4-(2-methylbenzoylamino)benzoic acid

Cas:317374-08-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 2-methyl-4-(2-methyl-benzoylamino)-benzoic acid Synonyms: 4-(2-MethylbenzaMido)-2-Methyl-benzoic acid;2-Methyl-4-(2-methylbenzamido);2-methyl-4-(2-methyl-benzoylamino)-benzoic acid;2-methyl-4-(2-methyl-p-nitrobenzoic acid benzoyl p

2-methyl-4-(2-methyl-benzoylamino)-benzoic acid supplier best quality

Cas:317374-08-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Methyl-4-(2-methylbenzoylamino)benzoic acid

Cas:317374-08-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Methyl-4-(2-Methyl-Benzoylamino)Benzoic Acid

Cas:317374-08-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Methyl-4-(2-methylbenzoylamino)benzoic acid

Cas:317374-08-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Tolvaptan Intermediates

Cas:317374-08-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - 2-methyl-4-(2-methyl-benzoylamino)-benzoic acid

Cas:317374-08-6

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 2-Methyl-4-(2-Methylbenzoylamino)Benzoic Acid CAS No.: 317374-08-6 Molecule Formula:C16H15NO3 Molecule Weight:269.30 Purity: 99.0% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise

High Quality 2-Methyl-4-(2-Methylbenzoylamino)Benzoic Acid

Cas:317374-08-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

2-methyl-4-(2-methyl-benzoylamino)-benzoic acid

Cas:317374-08-6

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-methyl-4-(2-methyl-benzoylamino)-benzoic acid

Cas:317374-08-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

Tolvaptan Side Chain

Cas:317374-08-6

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-Methyl-4-(2-methylbenzoylamino)benzoic acid

Cas:317374-08-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-Methyl-4-(2-methylbenzoylamino)benzoic acid

Cas:317374-08-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2-Methyl-4-(2-methylbenzoylamino)benzoic acid

Cas:317374-08-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Methyl-4-(2-methylbenzamido)benzoic acid

Cas:317374-08-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Product Name: 2-methyl-4-(2-methyl-benzoylamino)-benzoic acid Synonyms: 2-methyl-4-(2-methyl-benzoylamino)-benzoic acid;2-methyl-4-(2-methyl-p-nitrob…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton

2-Methyl-4-(2-methylbenzoylamino)benzoic acid

Cas:317374-08-6

Min.Order:0

Negotiable

Type:Other

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-Methyl-4-(2-methylbenzoylamino)benzoic acid

Cas:317374-08-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2-Methyl-4-(2-methylbenzoylamino)benzoic acid

Cas:317374-08-6

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2-Methyl-4-(2-methylbenzoylamino)benzoic acid

Cas:317374-08-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Synthetic route

4-amino-2-methylbenzoic acid
2486-75-1

4-amino-2-methylbenzoic acid

ortho-toluoyl chloride
933-88-0

ortho-toluoyl chloride

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
With pyridine In chloroform at 0 - 40℃; for 8h; Reagent/catalyst; Solvent; Temperature;95.6%
carbon monoxide
201230-82-2

carbon monoxide

2-bromo-5-(2-methylbenzoylamino)toluene
317374-07-5

2-bromo-5-(2-methylbenzoylamino)toluene

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
Stage #1: carbon monoxide; 2-bromo-5-(2-methylbenzoylamino)toluene With palladium diacetate; tributyl-amine; cesium acetate; triphenylphosphine In N,N-dimethyl-formamide at 120℃; for 3h; carbonylation; Hydrolysis;
Stage #2: With sodium hydroxide In N,N-dimethyl-formamide; toluene at 20℃; for 0.5h;
81%
2-methyl-4-(2-methylbenzoylamino)acetophenone
928151-34-2

2-methyl-4-(2-methylbenzoylamino)acetophenone

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
Stage #1: 2-methyl-4-(2-methylbenzoylamino)acetophenone With sodium hypochlorite; water In isopropyl alcohol at 5 - 60℃; for 1h;
Stage #2: With hydrogenchloride In water at 20℃; Product distribution / selectivity;
77.2%
carbon monoxide
201230-82-2

carbon monoxide

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
160129-45-3

7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

2-bromo-5-(2-methylbenzoylamino)toluene
317374-07-5

2-bromo-5-(2-methylbenzoylamino)toluene

A

MOP-21826
137973-76-3

MOP-21826

B

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
With cesium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; palladium diacetate In N,N-dimethyl-formamide Heating;A n/a
B 75%
oxalyl dichloride
79-37-8

oxalyl dichloride

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
Stage #1: 2-methyl-N-m-tolylbenzamide; aluminum (III) chloride In dichloromethane at 3℃; for 0.166667h;
Stage #2: oxalyl dichloride In dichloromethane at 2 - 7℃; for 5h;
Stage #3: With hydrogenchloride; sodium hydroxide; water Product distribution / selectivity; more than 3 stages;
65.8%
1-{2-[2-methyl-4-(2-methylbenzoyl-amino)phenyl]-2-oxoethyl}pyridinium chloride

1-{2-[2-methyl-4-(2-methylbenzoyl-amino)phenyl]-2-oxoethyl}pyridinium chloride

1-{2-[4-methyl-2-(2-methylbenzoylamino)phenyl]-2-oxoethyl}pyridinium chloride
928151-38-6

1-{2-[4-methyl-2-(2-methylbenzoylamino)phenyl]-2-oxoethyl}pyridinium chloride

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
Stage #1: 1-{2-[2-methyl-4-(2-methylbenzoyl-amino)phenyl]-2-oxoethyl}pyridinium chloride; 1-{2-[4-methyl-2-(2-methylbenzoylamino)phenyl]-2-oxoethyl}pyridinium chloride With sodium hydroxide; water In methanol at 60 - 76℃; for 4h;
Stage #2: With hydrogenchloride In methanol; water at 60 - 76℃; pH=1; Product distribution / selectivity;
60.5%
2-chloro-2'-methyl-4'-(2-methylbenzoylamino)-acetophenone
928151-35-3

2-chloro-2'-methyl-4'-(2-methylbenzoylamino)-acetophenone

2-chloro-4'-methyl-2'-(2-methylbenzoylamino)aceto-phenone
928151-36-4

2-chloro-4'-methyl-2'-(2-methylbenzoylamino)aceto-phenone

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
Stage #1: 2-chloro-2'-methyl-4'-(2-methylbenzoylamino)-acetophenone; 2-chloro-4'-methyl-2'-(2-methylbenzoylamino)aceto-phenone With sodium hypochlorite; water In isopropyl alcohol at 10 - 20℃; for 0.5 - 1h;
Stage #2: With hydrogenchloride In water; isopropyl alcohol Product distribution / selectivity;
57%
tolvaptan
150683-30-0

tolvaptan

A

7-chloro-2,3-dihydro-1H-benzo[b]azepine
1316312-24-9

7-chloro-2,3-dihydro-1H-benzo[b]azepine

B

DM-4128

DM-4128

C

(4-amino-2-methylphenyl)(7-chloro-2,3-dihydro-1H-benzo[b]azepin-1-yl)methanone

(4-amino-2-methylphenyl)(7-chloro-2,3-dihydro-1H-benzo[b]azepin-1-yl)methanone

D

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
With hydrogenchloride; water In acetonitrile at 80℃; for 24h;
tolvaptan
150683-30-0

tolvaptan

A

DM-4128

DM-4128

B

N-(4-(7-chloro-2,3-dihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

N-(4-(7-chloro-2,3-dihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

C

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
With sodium hydroxide In acetonitrile at 80℃; for 17h;
methanol
67-56-1

methanol

tolvaptan
150683-30-0

tolvaptan

A

7-chloro-2,3-dihydro-1H-benzo[b]azepine
1316312-24-9

7-chloro-2,3-dihydro-1H-benzo[b]azepine

B

DM-4128

DM-4128

C

C11H14ClNO

C11H14ClNO

D

methyl 2-methyl-4-((2-methylbenzoyl)amino)benzoate

methyl 2-methyl-4-((2-methylbenzoyl)amino)benzoate

E

(4-amino-2-methylphenyl)(7-chloro-2,3-dihydro-1H-benzo[b]azepin-1-yl)methanone

(4-amino-2-methylphenyl)(7-chloro-2,3-dihydro-1H-benzo[b]azepin-1-yl)methanone

F

(4-amino-2-methylphenyl)(7-chloro-4-methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methanone

(4-amino-2-methylphenyl)(7-chloro-4-methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methanone

G

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
With hydrogenchloride; water at 80℃; for 24h;
methanol
67-56-1

methanol

tolvaptan
150683-30-0

tolvaptan

A

DM-4128

DM-4128

B

C11H14ClNO

C11H14ClNO

C

N-(4-(7-chloro-2,3-dihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

N-(4-(7-chloro-2,3-dihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

D

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
With sodium hydroxide at 80℃; for 17h;
2-methyl-4-aminobenzaldehyde
61594-81-8

2-methyl-4-aminobenzaldehyde

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride; sodium formate; formic acid / 3 h / 100 °C
2: water; sodium hydroxide / ethylene glycol / 6 h / 100 °C
3: pyridine / chloroform / 8 h / 0 - 40 °C
View Scheme
1-amino-3-methylbenzene
108-44-1

1-amino-3-methylbenzene

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: trichlorophosphate / 6 h / 0 - 60 °C
2: hydroxylamine hydrochloride; sodium formate; formic acid / 3 h / 100 °C
3: water; sodium hydroxide / ethylene glycol / 6 h / 100 °C
4: pyridine / chloroform / 8 h / 0 - 40 °C
View Scheme
(4R,5R)-4,5-bis(methoxymethoxy)-7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepine
926035-26-9

(4R,5R)-4,5-bis(methoxymethoxy)-7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepine

2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

(4R,5R)-4,5-bis(methoxymethoxy)-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine
926035-30-5

(4R,5R)-4,5-bis(methoxymethoxy)-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃;81%
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

2-methyl-4-(2-methylbenzoylamino)benzoic acid chloride
331947-69-4

2-methyl-4-(2-methylbenzoylamino)benzoic acid chloride

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; thionyl chloride In dichloromethane for 0.5h; Heating;
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane for 3h; Reflux;
With thionyl chloride In N,N-dimethyl acetamide at 0 - 25℃; for 2h; Reagent/catalyst; Temperature;
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

(4S,5S)-4,5-bis(methoxymethoxy)-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine
926035-31-6

(4S,5S)-4,5-bis(methoxymethoxy)-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: SOCl2; NMP / CH2Cl2 / 0.5 h / Heating
2: 85 percent / pyridine / CH2Cl2 / 20 °C
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

(4S,5R)-4,5-bis(methoxymethoxy)-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine
926035-32-7

(4S,5R)-4,5-bis(methoxymethoxy)-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: SOCl2; NMP / CH2Cl2 / 0.5 h / Heating
2: 86 percent / pyridine / CH2Cl2 / 20 °C
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

(4R,5S)-4,5-bis(methoxymethoxy)-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine
926035-33-8

(4R,5S)-4,5-bis(methoxymethoxy)-7-chloro-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: SOCl2; NMP / CH2Cl2 / 0.5 h / Heating
2: 83 percent / pyridine / CH2Cl2 / 20 °C
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

DM-4111

DM-4111

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: SOCl2; NMP / CH2Cl2 / 0.5 h / Heating
2: 85 percent / pyridine / CH2Cl2 / 20 °C
3: 82 percent / conc. HCl / methanol / 3.5 h / 60 °C
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

(4S,5R)-7-chloro-4,5-dihydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

(4S,5R)-7-chloro-4,5-dihydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: SOCl2; NMP / CH2Cl2 / 0.5 h / Heating
2: 86 percent / pyridine / CH2Cl2 / 20 °C
3: 87 percent / conc. HCl / methanol / 60 °C
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

(4R,5S)-7-chloro-4,5-dihydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

(4R,5S)-7-chloro-4,5-dihydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: SOCl2; NMP / CH2Cl2 / 0.5 h / Heating
2: 83 percent / pyridine / CH2Cl2 / 20 °C
3: 89 percent / conc. HCl / methanol / 60 °C
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

N-(4-(7-chloro-5-hydroxy-2,2-dideutero-3,4,5-trihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
1296212-19-5

N-(4-(7-chloro-5-hydroxy-2,2-dideutero-3,4,5-trihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux
2.1: triethylamine / dichloromethane / 4 h / 0 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C
3.2: 0 °C
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

N-(4-(5-(tert-butyldimethylsilyloxy)-7-chloro-2,2-dideutero-3,4,5-trihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
1296212-26-4

N-(4-(5-(tert-butyldimethylsilyloxy)-7-chloro-2,2-dideutero-3,4,5-trihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux
2: triethylamine / dichloromethane / 4 h / 0 °C
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

N-(4-(7-chloro-5-oxo-2,2-dideutero-3,4-dihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
1296212-27-5

N-(4-(7-chloro-5-oxo-2,2-dideutero-3,4-dihydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux
2.1: triethylamine / dichloromethane / 4 h / 0 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C
3.2: 0 °C
4.1: manganese(IV) oxide / dichloromethane / 8 h / Reflux
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

N-(4-(7-chloro-2,3-dihydro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
1296212-20-8

N-(4-(7-chloro-2,3-dihydro-5-hydroxy-2,2,4,4,5-pentadeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux
2.1: triethylamine / dichloromethane / 4 h / 0 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C
3.2: 0 °C
4.1: manganese(IV) oxide / dichloromethane / 8 h / Reflux
5.1: d(4)-methanol; sodium hydroxide / 18 h / 20 °C / Inert atmosphere
6.1: d(4)-methanol; sodium borodeuteride / 2 h / 0 °C
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

N-(4-(7-chloro-2,3-dihydro-5-oxo-2,2,4,4-tetradeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
1296212-28-6

N-(4-(7-chloro-2,3-dihydro-5-oxo-2,2,4,4-tetradeutero-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux
2.1: triethylamine / dichloromethane / 4 h / 0 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C
3.2: 0 °C
4.1: manganese(IV) oxide / dichloromethane / 8 h / Reflux
5.1: d(4)-methanol; sodium hydroxide / 18 h / 20 °C / Inert atmosphere
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

tolvaptan
150683-30-0

tolvaptan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / N,N-dimethyl acetamide / 2 h / 0 - 25 °C
2: 2,6-dimethylpyridine / N,N-dimethyl acetamide; water / 2 h / 0 °C
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

C34H32ClN3O4

C34H32ClN3O4

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: thionyl chloride / toluene / 3 h / Reflux
1.2: 1 h
2.1: thionyl chloride / dichloromethane / 4 h / Reflux
3.1: pyridine / ethyl acetate / 20 °C
4.1: potassium borohydride; ethanol / 1 h / 25 - 35 °C
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

C24H21ClN2O3

C24H21ClN2O3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: thionyl chloride / toluene / 3 h / Reflux
1.2: 1 h
2.1: thionyl chloride / dichloromethane / 4 h / Reflux
View Scheme
2-methyl-4-(2-methylbenzoylamino)benzoic acid
317374-08-6

2-methyl-4-(2-methylbenzoylamino)benzoic acid

C34H30ClN3O4

C34H30ClN3O4

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / toluene / 3 h / Reflux
1.2: 1 h
2.1: thionyl chloride / dichloromethane / 4 h / Reflux
3.1: pyridine / ethyl acetate / 20 °C
View Scheme
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