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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,4-Difluoro-2-(1-H-1.2.4-Trizaol-1-Yl)Acetophenone supplier in China

Cas:86404-63-9

Min.Order:1 Metric Ton

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for 2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone Cas 86404-63-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:Stor

Top quality 2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone Cas 86404-63-9 with best price

Cas:86404-63-9

Min.Order:25 Kilogram

FOB Price: $82.0 / 85.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

Cas:86404-63-9

Min.Order:1 Kilogram

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Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone Manufacturer/High quality/Best price/In stock

Cas:86404-63-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2',4'-Difluoro-2-(1H-1,2,4-triazol-1-yl)-acetophenone

Cas:86404-63-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

86404-63-9 2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

Cas:86404-63-9

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

2, 4-Difluoro-Alpha- (1H-1, 2, 4-triazolyl) Acetophenone CAS No. 86404-63-9

Cas:86404-63-9

Min.Order:1 Kilogram

FOB Price: $10.0 / 16.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 86404-63-9 with best quality

Cas:86404-63-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone/ LIDE PHARMA- Factory supply / Best price

Cas:86404-63-9

Min.Order:0

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Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Product Name: 2,4-Difluoro-2-(1-H-1.2.4-trizaol-1-yl)acetophenone CAS No: 86404-63-9 Molecular Formula: C10H7F2N3O Assay: 98.5%(HPLC) Appearance:White powder Storage:Store in cool and dry place, a

2,4-Difluoro-2-(1-H-1.2.4-trizaol-1-yl)acetophenone

Cas:86404-63-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethanone,1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 86404-63-9

Cas:86404-63-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

Cas:86404-63-9

Min.Order:1 Kilogram

FOB Price: $30.0 / 35.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply 2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made

2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

Cas:86404-63-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethanone,1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-

Cas:86404-63-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:86404-63-9

Cas:86404-63-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Voriconazole Intermediate/CAS 86404-63-9

Cas:86404-63-9

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

Cas:86404-63-9

Min.Order:1 Kilogram

FOB Price: $6.0 / 10.0

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,4-Difluoro-Alpha-(1H-1,2,4-Triazolyl)Acetophenone

Cas:86404-63-9

Min.Order:0

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Type:Manufacturers

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Triumph International Development Limilted

Appearance:White or off-white Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se

2',4'-Difluoro-alpha-(1H-1,2,4-Triazol-1-yl)Acetophenone

Cas:86404-63-9

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

Cas:86404-63-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Fluconazole intermediate CAS: 86404-63-9

Cas:86404-63-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

Cas:86404-63-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

2,4-DIFLUORO-2-(1H-1,2,4-TRIAZOLE-1-YL)ACETOPHENONE

Cas:86404-63-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Fluconazole intermediate

Cas:86404-63-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone 95%

Cas:86404-63-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

Cas:86404-63-9

Min.Order:1 Kilogram

FOB Price: $65.0 / 76.0

Type:Trading Company

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Buy 2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

Cas:86404-63-9

Min.Order:0

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Type:Trading Company

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Synthetic route

1,2,4-Triazole
288-88-0

1,2,4-Triazole

2-chloro-1-(2,4-dichlorophenyl)ethanone
51336-94-8

2-chloro-1-(2,4-dichlorophenyl)ethanone

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 85℃; for 0.833333h; microwave irradiation;99%
With sodium hydrogencarbonate In toluene for 5h; Reflux;87%
With sodium hydrogencarbonate In toluene for 5h; Reflux;87%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

α-amino-2,4-difluoroacetophenone

α-amino-2,4-difluoroacetophenone

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
With sodium sulfite In nitromethane; hexane at 9 - 45℃; for 9h; Temperature;91%
2-(3-chloro-1H-1,2,4-triazol-1-yl)-1-(2,4-difluorophenyl)ethanone

2-(3-chloro-1H-1,2,4-triazol-1-yl)-1-(2,4-difluorophenyl)ethanone

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; under 7500.75 Torr; for 5h;89.1%
3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
188416-35-5

3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

A

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

B

4-chloro-5-fluoro-6-ethylpyrimidine
137234-74-3

4-chloro-5-fluoro-6-ethylpyrimidine

Conditions
ConditionsYield
With hydrogenchloride In water at 60 - 70℃; Temperature; Reagent/catalyst; Solvent;A 88.4%
B n/a
2,4-difluorobromobenzene
348-57-2

2,4-difluorobromobenzene

1-morpholino-2-(1H-1,2,4-triazol-1-yl)ethanone

1-morpholino-2-(1H-1,2,4-triazol-1-yl)ethanone

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
Stage #1: 2,4-difluorobromobenzene With magnesium In tetrahydrofuran at 35℃; Inert atmosphere;
Stage #2: 1-morpholino-2-(1H-1,2,4-triazol-1-yl)ethanone In tetrahydrofuran for 4h; Inert atmosphere;
87%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

2-chloro-1-(2,4-dichlorophenyl)ethanone
51336-94-8

2-chloro-1-(2,4-dichlorophenyl)ethanone

A

1-(2,4-difluorophenyl-2-[1,2,4]triazol-4-yl)ethan-1-one
168479-96-7

1-(2,4-difluorophenyl-2-[1,2,4]triazol-4-yl)ethan-1-one

B

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
With baseA n/a
B 85%
1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

2-(1H-1,2,4-triazol-1-yl)acetyl chloride

2-(1H-1,2,4-triazol-1-yl)acetyl chloride

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
With aluminum (III) chloride In 1,2-dichloro-ethane at 0 - 20℃;80.1%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

2-bromo-2',4'-difluoroacetophenone
102429-07-2

2-bromo-2',4'-difluoroacetophenone

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 80 - 90℃; Inert atmosphere;76.2%
Stage #1: 1,2,4-Triazole With potassium carbonate In chloroform at 20℃; for 0.5h;
Stage #2: 2-bromo-2',4'-difluoroacetophenone In chloroform at 20℃; for 5h; Solvent;
71.1%
With triethylamine In acetone at 20℃; for 0.5h;
2-chloro-1-(2,4-dichlorophenyl)ethanone
51336-94-8

2-chloro-1-(2,4-dichlorophenyl)ethanone

sodium triazole
41253-21-8

sodium triazole

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 70 - 75℃; for 12h; Temperature; Solvent; Inert atmosphere;76%
1-(2,4-difluorophenacyl)-4-amino-(1H-1,2,4-triazolium) chloride

1-(2,4-difluorophenacyl)-4-amino-(1H-1,2,4-triazolium) chloride

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite for 0.25h; Ambient temperature;73%
1,2,3-triazole
288-36-8

1,2,3-triazole

2-chloro-1-(2,4-dichlorophenyl)ethanone
51336-94-8

2-chloro-1-(2,4-dichlorophenyl)ethanone

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 20℃; for 24h;70%
With potassium carbonate In acetonitrile65%
2-chloro-1-(2,4-dichlorophenyl)ethanone
51336-94-8

2-chloro-1-(2,4-dichlorophenyl)ethanone

3H-1,2,4-triazole
28647-13-4

3H-1,2,4-triazole

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
Stage #1: 3H-1,2,4-triazole With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In dichloromethane for 0.166667h;
Stage #2: 2-chloro-1-(2,4-dichlorophenyl)ethanone In dichloromethane at 20℃; for 6h; Cooling with ice;
67.3%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

chloroacetyl chloride
79-04-9

chloroacetyl chloride

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
Stage #1: 1,3-Difluorobenzene; chloroacetyl chloride With aluminum (III) chloride In 1,2-dichloro-ethane at 25℃; for 7h;
Stage #2: 1,2,4-Triazole With sodium hydrogencarbonate In toluene for 4h; Reflux;
55%
(2R,3S)-2-(2,4-Difluoro-phenyl)-3-methanesulfonyl-1-[1,2,4]triazol-1-yl-butan-2-ol
182699-15-6

(2R,3S)-2-(2,4-Difluoro-phenyl)-3-methanesulfonyl-1-[1,2,4]triazol-1-yl-butan-2-ol

A

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

B

(2R,3R)-2-(2,4-difluorophenyl)-3-(methylsulfonyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2R,3R)-2-(2,4-difluorophenyl)-3-(methylsulfonyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Conditions
ConditionsYield
With sodium hydroxide at 45℃; for 14h;A 42%
B 52%
4-amino-1,2,4-triazole
584-13-4

4-amino-1,2,4-triazole

(2,4-diF)C6H3C(O)CH2X, X=Cl or Br

(2,4-diF)C6H3C(O)CH2X, X=Cl or Br

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite 1.) i-PrOH; Multistep reaction;
1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: AlCl3
2: anhydrous potassium carbonate / CHCl3 / Heating
View Scheme
Multi-step reaction with 2 steps
1: CH2Cl2
View Scheme
Multi-step reaction with 2 steps
1: 80 percent / aluminum chloride / 1,2-dichloro-ethane / 7.5 h / 0 - 30 °C
2: 69 percent / sodium bicarbonate / toluene / 4 h / Heating
View Scheme
1-(((2R,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole
135270-13-2

1-(((2R,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 84 percent / H2O; dimethylsulfoxide / 3 h / 55 °C
2: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
3: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C
View Scheme
(E)-2-(2,4-difluorophenyl)-2-buten-1-ol
173787-23-0

(E)-2-(2,4-difluorophenyl)-2-buten-1-ol

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 96 percent / Ti(O-iPr)4, t-butyl hydroperoxide, (-)-diethyl (2S,3S)-tartrate / CH2Cl2 / 48 h / -20 °C
2: 77 percent / dimethylsulfoxide; H2O / 3 h / 55 °C
3: Et3N / toluene / 0.5 h / 0 °C
4: 15percent aq. KOH / toluene / 2 h / 0 °C
5: 72 percent / NaOH / dimethylsulfoxide / 3 h / 80 °C
6: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
7: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C
View Scheme
Multi-step reaction with 6 steps
1: 96 percent / Ti(O-iPr)4, t-butyl hydroperoxide, (-)-diethyl (2S,3S)-tartrate / CH2Cl2 / 48 h / -20 °C
2: Et3N / CH2Cl2 / 0.5 h / 0 °C
3: 49 percent / NaOH / dimethylsulfoxide / 1 h / 80 °C
4: 84 percent / H2O; dimethylsulfoxide / 3 h / 55 °C
5: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
6: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C
View Scheme
(S)-2-(2,4-Difluoro-phenyl)-2-((S)-1-methylsulfanyl-ethyl)-oxirane
147383-77-5

(S)-2-(2,4-Difluoro-phenyl)-2-((S)-1-methylsulfanyl-ethyl)-oxirane

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 72 percent / NaOH / dimethylsulfoxide / 3 h / 80 °C
2: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
3: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C
View Scheme
(2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-butane-1,2-diol
182699-16-7

(2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-butane-1,2-diol

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Et3N / toluene / 0.5 h / 0 °C
2: 15percent aq. KOH / toluene / 2 h / 0 °C
3: 72 percent / NaOH / dimethylsulfoxide / 3 h / 80 °C
4: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
5: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C
View Scheme
Methanesulfonic acid (2R,3R)-2-(2,4-difluoro-phenyl)-3-methyl-oxiranylmethyl ester
182699-20-3

Methanesulfonic acid (2R,3R)-2-(2,4-difluoro-phenyl)-3-methyl-oxiranylmethyl ester

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 49 percent / NaOH / dimethylsulfoxide / 1 h / 80 °C
2: 84 percent / H2O; dimethylsulfoxide / 3 h / 55 °C
3: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
4: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C
View Scheme
Methanesulfonic acid (2R,3S)-2-(2,4-difluoro-phenyl)-2-hydroxy-3-methylsulfanyl-butyl ester

Methanesulfonic acid (2R,3S)-2-(2,4-difluoro-phenyl)-2-hydroxy-3-methylsulfanyl-butyl ester

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 15percent aq. KOH / toluene / 2 h / 0 °C
2: 72 percent / NaOH / dimethylsulfoxide / 3 h / 80 °C
3: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
4: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C
View Scheme
(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxymethyl-3-methyloxirane
182699-17-8

(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxymethyl-3-methyloxirane

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 77 percent / dimethylsulfoxide; H2O / 3 h / 55 °C
2: Et3N / toluene / 0.5 h / 0 °C
3: 15percent aq. KOH / toluene / 2 h / 0 °C
4: 72 percent / NaOH / dimethylsulfoxide / 3 h / 80 °C
5: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
6: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C
View Scheme
Multi-step reaction with 5 steps
1: Et3N / CH2Cl2 / 0.5 h / 0 °C
2: 49 percent / NaOH / dimethylsulfoxide / 1 h / 80 °C
3: 84 percent / H2O; dimethylsulfoxide / 3 h / 55 °C
4: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
5: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C
View Scheme
tert-Butyl-[(Z)-2-(2,4-difluoro-phenyl)-but-2-enyloxy]-dimethyl-silane

tert-Butyl-[(Z)-2-(2,4-difluoro-phenyl)-but-2-enyloxy]-dimethyl-silane

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 96 percent / Bu4NF / tetrahydrofuran / 1 h / 0 °C
2: 96 percent / Ti(O-iPr)4, t-butyl hydroperoxide, (-)-diethyl (2S,3S)-tartrate / CH2Cl2 / 48 h / -20 °C
3: 77 percent / dimethylsulfoxide; H2O / 3 h / 55 °C
4: Et3N / toluene / 0.5 h / 0 °C
5: 15percent aq. KOH / toluene / 2 h / 0 °C
6: 72 percent / NaOH / dimethylsulfoxide / 3 h / 80 °C
7: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
8: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C
View Scheme
Multi-step reaction with 7 steps
1: 96 percent / Bu4NF / tetrahydrofuran / 1 h / 0 °C
2: 96 percent / Ti(O-iPr)4, t-butyl hydroperoxide, (-)-diethyl (2S,3S)-tartrate / CH2Cl2 / 48 h / -20 °C
3: Et3N / CH2Cl2 / 0.5 h / 0 °C
4: 49 percent / NaOH / dimethylsulfoxide / 1 h / 80 °C
5: 84 percent / H2O; dimethylsulfoxide / 3 h / 55 °C
6: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
7: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C
View Scheme
(2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-1-[1,2,4]triazol-1-yl-butan-2-ol
182699-19-0

(2R,3S)-2-(2,4-Difluoro-phenyl)-3-methylsulfanyl-1-[1,2,4]triazol-1-yl-butan-2-ol

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / Na2WO4*2H2O, aq. H2O2, aq. HCl / toluene / 1 h / 60 °C
2: 42 percent / 0.5 M aq. NaOH / 14 h / 45 °C
View Scheme
2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
182230-43-9

2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

A

C6H7FN2

C6H7FN2

B

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
With sodium hydroxide In water at 45℃; for 3h;
(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

A

C6H7FN2

C6H7FN2

B

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
With sodium hydroxide In water; ethyl acetate at 60℃; for 4h;
(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

A

C6H7FN2

C6H7FN2

B

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

Conditions
ConditionsYield
With sodium hydroxide In water at 50℃; for 5h; Concentration;
trimethylsulfoxonium iodide
1774-47-6

trimethylsulfoxonium iodide

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole
86386-76-7, 123632-22-4, 141113-42-0, 150024-48-9

1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

Conditions
ConditionsYield
With sodium hydroxide In toluene at 80℃; for 0.833333h; Corey-Chaykovsky epoxidation; microwave irradiation;97%
With sodium hydride In tetrahydrofuran; dimethyl sulfoxide at 25℃; for 2h; Inert atmosphere;91%
Stage #1: trimethylsulfoxonium iodide; 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone In dichloromethane at 20℃; for 0.166667h;
Stage #2: With potassium hydroxide In dichloromethane; water at 40 - 45℃; for 12h;
90%
propargyl bromide
106-96-7

propargyl bromide

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

2‑(2,4‑difluorophenyl)‑1‑(1H‑1,2,4‑triazol‑1‑yl)pent‑4‑yn‑2‑ol
917078-24-1

2‑(2,4‑difluorophenyl)‑1‑(1H‑1,2,4‑triazol‑1‑yl)pent‑4‑yn‑2‑ol

Conditions
ConditionsYield
With zinc In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 5h;95%
With zinc In tetrahydrofuran; N,N-dimethyl-formamide at 25℃; for 5h;95%
With zinc In tetrahydrofuran; N,N-dimethyl-formamide at 60℃; for 7h;95%
1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

1-(2,4-difluorophenyl)-1-hydroxy-2-(1H-1,2,4-triazol-1-yl)ethane

1-(2,4-difluorophenyl)-1-hydroxy-2-(1H-1,2,4-triazol-1-yl)ethane

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate In tetrahydrofuran at 20℃; for 3h;93%
With methanol; sodium tetrahydroborate In tetrahydrofuran at 20℃; for 3h;90.3%
With sodium tetrahydroborate In methanol at 20℃; for 0.5h;85%
1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane
188416-28-6

1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

(2RS,3SR)-2-(2,4-difluorophenyl)-3-(6-chloro-5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride

(2RS,3SR)-2-(2,4-difluorophenyl)-3-(6-chloro-5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride

Conditions
ConditionsYield
Stage #1: 1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane With pyridine; zinc/copper couple; Cinchonin In tetrahydrofuran at -5℃; for 2h; Inert atmosphere;
Stage #2: 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone In tetrahydrofuran at 0 - 5℃; for 12h; Inert atmosphere;
Stage #3: With hydrogenchloride In tetrahydrofuran; water for 0.166667h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere;
90%
4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

(Z)-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one

(Z)-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one

Conditions
ConditionsYield
With piperidine; acetic acid In toluene Aldol Condensation; Reflux;89.4%
trimethylsulfoxonium iodide

trimethylsulfoxonium iodide

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole
86386-76-7, 123632-22-4, 141113-42-0, 150024-48-9

1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; dimethyl sulfoxide at 25℃; for 2h;89%
carbon disulfide
75-15-0

carbon disulfide

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

3-(1H-1,2,4-triazol-1-yl)-7-fluoro-4H-thiochromen-4-one

3-(1H-1,2,4-triazol-1-yl)-7-fluoro-4H-thiochromen-4-one

Conditions
ConditionsYield
With manganese(IV) oxide; sodium acetate In dimethyl sulfoxide at 20℃;88%
Nitroethane
79-24-3

Nitroethane

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

(2R,3R)-3-nitro-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

(2R,3R)-3-nitro-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Conditions
ConditionsYield
With benzoyl chloride; (3ξ,8α,9R)-cinchonan-6',9-diol In N,N-dimethyl acetamide at -10℃;87.2%
Stage #1: Nitroethane With sodium t-butanolate In tetrahydrofuran at 0 - 5℃; for 2h; Inert atmosphere;
Stage #2: 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone In tetrahydrofuran at -20 - 15℃; for 16h;
Stage #3: With (S)-Malic acid In methanol; isopropyl alcohol for 0.5h; Resolution of racemate; Reflux;
410 g
1-(4-chloro-5-fluoropyrimidin-6-yl)chloroethane

1-(4-chloro-5-fluoropyrimidin-6-yl)chloroethane

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

(2RS,3SR)-2-(2,4-difluorophenyl)-3-(6-chloro-5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride

(2RS,3SR)-2-(2,4-difluorophenyl)-3-(6-chloro-5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride

Conditions
ConditionsYield
Stage #1: 1-(4-chloro-5-fluoropyrimidin-6-yl)chloroethane With α-picoline; zinc/copper couple; Cinchonin In tetrahydrofuran for 2h; Inert atmosphere;
Stage #2: 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone In tetrahydrofuran at 45 - 50℃; for 2h; Inert atmosphere;
Stage #3: With hydrogenchloride In tetrahydrofuran; water for 0.166667h; Inert atmosphere;
87.1%
1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane
188416-28-6

1-(4-chloro-5-fluoropyrimidin-6-yl)bromoethane

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
188416-35-5

3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Conditions
ConditionsYield
With lead; samarium diiodide; 1-benzyl-3-(2-pyridylmethyl)-1H-benzimidazolium chloride; iodine; zinc In tetrahydrofuran at -5 - 40℃; for 1.33333h; Inert atmosphere;87%
With zinc(II) chloride Reformatsky Reaction;
With hydrogenchloride; zinc In tetrahydrofuran; water
trimethylsulphoxonium iodide
1030268-24-6

trimethylsulphoxonium iodide

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole
86386-76-7, 123632-22-4, 141113-42-0, 150024-48-9

1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

Conditions
ConditionsYield
With sodium hydroxide In toluene at 60℃; for 3h;86%
With sodium hydroxide; cetyltrimethylammonim bromide In water; toluene at 60℃; for 4h;66%
With cetyl trimethyl ammonium bromide; sodium hydroxide In toluene at 60℃; for 3h;
C16H20BrFN2O4S

C16H20BrFN2O4S

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

C26H28F3N5O5S

C26H28F3N5O5S

Conditions
ConditionsYield
With zinc In diethyl ether; water at 25℃; for 0.5h; Inert atmosphere;86%
samarium diiodide

samarium diiodide

diiodomethane
75-11-6

diiodomethane

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazolo-1-yl)-3-iodopropane-2-ol
150194-53-9

2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazolo-1-yl)-3-iodopropane-2-ol

Conditions
ConditionsYield
In tetrahydrofuran; dichloromethane82%
carbon dioxide
124-38-9

carbon dioxide

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

2-hydroxy-3-(1,2,4-triazol-1-yl)-7-fluorochromone

2-hydroxy-3-(1,2,4-triazol-1-yl)-7-fluorochromone

Conditions
ConditionsYield
With 18-crown-6 ether; potassium carbonate In dimethyl sulfoxide at 20℃; for 10h;81%
With 18-crown-6 ether; potassium carbonate In dimethyl sulfoxide at 20℃; for 10h;81%
1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

2-bromopropionitrile
19481-82-4

2-bromopropionitrile

3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butyronitrile

3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butyronitrile

Conditions
ConditionsYield
With trichlorosilane; zinc In tetrahydrofuran at -10℃; for 14h; Inert atmosphere;80.8%
acetaldehyde
75-07-0

acetaldehyde

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

C12H11F2N3O2

C12H11F2N3O2

Conditions
ConditionsYield
With potassium tert-butylate In dichloromethane at 20℃; Inert atmosphere; Molecular sieve;80%
ferrocenecarboxaldehyde
12093-10-6

ferrocenecarboxaldehyde

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

1-ferrocenyl-3-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-prop-2-en-1-one

1-ferrocenyl-3-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-prop-2-en-1-one

Conditions
ConditionsYield
With piperidine; acetic acid In toluene byproducts: H2O; under N2 atm.; to stirred soln. of ligand, ferrocenecarboxaldehyde in dry toluene added five drops of piperidine and 5 drops of glacial acetic acid at room temp.; mixt. heated to reflux; kept at this temp. for 4-6 h,while water evapd. off; toluene evapd. off; residue purified by chromy. on silica gel (ethyl acetate/petroleum ether as eluent); elem. anal.;79.6%
4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

(Z)-1-(2,4-difluorophenyl)-3-(4-(dimethylamino)phenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one

(Z)-1-(2,4-difluorophenyl)-3-(4-(dimethylamino)phenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one

Conditions
ConditionsYield
With piperidine; acetic acid In toluene Aldol Condensation; Reflux;79.3%
4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

(Z)-1-(2,4-difluorophenyl)-3-(4-methylphenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one

(Z)-1-(2,4-difluorophenyl)-3-(4-methylphenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one

Conditions
ConditionsYield
With piperidine; acetic acid In toluene Aldol Condensation; Reflux;79%
methyl 2-[6-(1-bromo-ethyl)-5-fluoropyrimidin-4-yl-sulfanyl]benzoate
1258386-28-5

methyl 2-[6-(1-bromo-ethyl)-5-fluoropyrimidin-4-yl-sulfanyl]benzoate

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

methyl 2-{6-[(1S,2R/1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-ylpropyl]-5-fluoropyrimidin-4-ylsulfanyl}benzoate

methyl 2-{6-[(1S,2R/1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-ylpropyl]-5-fluoropyrimidin-4-ylsulfanyl}benzoate

Conditions
ConditionsYield
Stage #1: methyl 2-[6-(1-bromo-ethyl)-5-fluoropyrimidin-4-yl-sulfanyl]benzoate; 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone With lead; iodine; zinc In tetrahydrofuran at 5 - 25℃; Inert atmosphere;
Stage #2: With water; ammonium chloride In ethyl acetate Product distribution / selectivity;
77.6%
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone
86404-63-9

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

(Z)-1-(2,4-difluorophenyl)-3-(4-methoxyphenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one

(Z)-1-(2,4-difluorophenyl)-3-(4-methoxyphenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one

Conditions
ConditionsYield
With piperidine; acetic acid In toluene Aldol Condensation; Reflux;76.2%
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