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Hubei Vanz Pharm Co.,Ltd

We are both manufacture and trader , have very good quality and competitive price, meanwhile , we have exported to other market 100kg every month. Appearance:white powder Storage:Nomal Package:25kg/drum Application:intermediates Transportation:Nor

Linezolid CAS 165800-03-3

Cas:165800-03-3

Min.Order:1 Kilogram

FOB Price: $280.0

Type:Manufacturers

inquiry

Shanghai Biobond Pharmaceutical Co.,Ltd

1, have high quality with low price 2, chiral impurity is controlled below 0.1%. 3, can be produced in big scale. 4, the procedure of it is very suitalbe for medicine registering 5, we can provide total the DMF for Appearance:white Storage

linezolid

Cas:165800-03-3

Min.Order:10 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Linezolid in stock

Cas:165800-03-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

----------------------------------------------------------------------- Hangzhou Dingyan Chem is a leading manufacturer and supplier of chemicals in China.We develop,produce and distribute high quality pharmaceuticals, intermediates, special ch

High purity Linezolid with high quality and best price cas:165800-03-3

Cas:165800-03-3

Min.Order:1 Kilogram

FOB Price: $480.0 / 700.0

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Product Description Linezolid LongFine specializes in controling the quality and reducing the impurities of Linezolid. Our Linezolid is with the best quality and the most competitive p

CAS:165800-03-3 Linezolid

Cas:165800-03-3

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Linezolid tablets 600mg

Cas:165800-03-3

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Linezolid Cas 165800-03-3 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:Cool dry place Package:1kg/foill bag;25kg/dru

High quality Linezolid Cas 165800-03-3 with reasonable price

Cas:165800-03-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

Sleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric

linezolid

Cas:165800-03-3

Min.Order:10000 Gram

FOB Price: $1300.0

Type:Manufacturers

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

Linezolid and Intermediate

Cas:165800-03-3

Min.Order:1 Kilogram

FOB Price: $200.0 / 300.0

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Linezolid

Cas:165800-03-3

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Linezolid 165800-03-3

Cas:165800-03-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Hot Selling Linezolid Powder 165800-03-3 with Best Price From Biolang Lab

Cas:165800-03-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 165800-03-3 with competitive price

Cas:165800-03-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Linezolid

Cas:165800-03-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Linezolid/ LIDE PHARMA- Factory supply / Best price

Cas:165800-03-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Name Linezolid Synonyms (S)-N-[[3-(3-Fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide Molecular Structure

Linezolid CAS: 165800-03-3

Cas:165800-03-3

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Powder Storage:Store in sealed containers at cool & d

Synthetic Oxazolidinone Antibiotics Drugs CAS 165800-03-3 APIs Linezolid powder

Cas:165800-03-3

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White solid Storage:Room temperature Package:1kg/bag Application:APIs Transportation:Express/Sea/Air Port:Any port in china

High Purity Linezolid with high quality

Cas:165800-03-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Factory Supply Hot Selling High Quality Linezolid CAS 165800-03-3 with Reasonable Price and Fast Delivery

Cas:165800-03-3

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 8 years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized in APIs, chemical inte

Hotsale linezolid ,CAS:165800-03-3

Cas:165800-03-3

Min.Order:10 Gram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

Linezolid

Cas:165800-03-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Linezolid 99%

Cas:165800-03-3

Min.Order:1 Kilogram

FOB Price: $86.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Linezolid CAS:165800-03-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Linezolid CAS:165800-03-3

Cas:165800-03-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Acetamide,N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-

Cas:165800-03-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

High quality Linezolid 99% powder

Cas:165800-03-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:165800-03-3

Cas:165800-03-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Linezolid

Cas:165800-03-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

Linezolid

Cas:165800-03-3

Min.Order:10 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Synthetic route

(2R)-1-{acetyl[3-fluoro-4-(morpholin-4-yl)-phenyl]-3-chloropropene}acetate

(2R)-1-{acetyl[3-fluoro-4-(morpholin-4-yl)-phenyl]-3-chloropropene}acetate

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With ammonium hydroxide In methanol at 20 - 25℃; for 12h;98%
N-(3-(3-fluoro-4-(morpholin-4-yl)phenyl)-2-oxooxazolidin-5(S)-ylmethyl)amine benzoate
1609632-44-1

N-(3-(3-fluoro-4-(morpholin-4-yl)phenyl)-2-oxooxazolidin-5(S)-ylmethyl)amine benzoate

acetic anhydride
108-24-7

acetic anhydride

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
In dichloromethane at 20 - 24℃;97%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

N-[(2R)-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-hydroxypropyl]acetamide

N-[(2R)-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-hydroxypropyl]acetamide

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;95%
With triethylamine In dichloromethane at 0 - 20℃; for 2h;95%
(S)-N-[(2-oxo-5-oxazolidinyl)methyl]acetamide

(S)-N-[(2-oxo-5-oxazolidinyl)methyl]acetamide

1-oxo-3-fluoro-4-(4-morpholinyl)benzene

1-oxo-3-fluoro-4-(4-morpholinyl)benzene

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With triethylamine; dicyclohexyl-carbodiimide In acetonitrile at 80℃; Reagent/catalyst; Solvent; Temperature;94.2%
acetyl chloride
75-36-5

acetyl chloride

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine
168828-90-8

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 20℃; for 2h;92.8%
With triethylamine In dichloromethane at 0 - 20℃; for 1h;85%
With triethylamine In dichloromethane at 20℃; Inert atmosphere;73 mg
[(S)-N-[[3-(3-fluoro-4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide dihydrochloride

[(S)-N-[[3-(3-fluoro-4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide dihydrochloride

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With water; potassium carbonate In ethyl acetate at 60 - 65℃;92%
Stage #1: [(S)-N-[[3-(3-fluoro-4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide dihydrochloride With potassium carbonate In water; ethyl acetate at 60 - 65℃;
Stage #2: In toluene at 20 - 100℃;
92%
With sodium hydroxide In water at 0 - 2℃;
acetamide monosodium
57450-20-1

acetamide monosodium

(R)-methyl methanesulfonate
174649-09-3

(R)-methyl methanesulfonate

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With N,N-dimethyl-formamide at 50℃; Temperature; Inert atmosphere;92%
N-ethoxycarbonyl-3-fluoro-4-morpholinyl aniline
565176-83-2

N-ethoxycarbonyl-3-fluoro-4-morpholinyl aniline

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With lithium; tert-butyl alcohol In tetrahydrofuran; N,N-dimethyl acetamide; isopropyl alcohol at 0 - 20℃; Reagent/catalyst; Solvent; Concentration;90.3%
N-(5S)-((3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide phthalimide

N-(5S)-((3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide phthalimide

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With hydrazine hydrate In methanol at 55℃; Concentration; Temperature; Heating; Industrial scale;90.2%
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
168828-84-0

(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one

thioacetic acid
507-09-5

thioacetic acid

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
Stage #1: (R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one; tiolacetic acid at 23℃; for 7h;
Stage #2: With potassium hydroxide In water at 23℃;
90%
at 23℃; for 7h; Inert atmosphere;90%
Ambient temperature;86%
at 20℃; for 15h;85%
at 20℃; for 15h;
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

acetic anhydride
108-24-7

acetic anhydride

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
Stage #1: 2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione With hydrazine In methanol; water at 60℃; for 1h;
Stage #2: acetic anhydride With triethylamine at 0 - 20℃; for 2h;
89.1%
Stage #1: 2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione With hydrazine hydrate In methanol at 30 - 70℃;
Stage #2: acetic anhydride at 10 - 30℃; Concentration;
145 g
Stage #1: 2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione With hydrazine hydrate In methanol for 1h; Reflux;
Stage #2: acetic anhydride With triethylamine at 10 - 30℃; for 1h;
9 g
Stage #1: 2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione With hydrazine hydrate In methanol for 2h; Reflux;
Stage #2: acetic anhydride In dichloromethane at 0 - 10℃;
acetic anhydride
108-24-7

acetic anhydride

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine
168828-90-8

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 20 - 40℃; under 608.041 - 912.061 Torr; for 2h; Product distribution / selectivity;88%
With triethylamine In ethyl acetate at 25℃; for 2h; Product distribution / selectivity;88%
at 0℃;88%
(S)-5-(aminomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one acetate

(S)-5-(aminomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one acetate

acetic anhydride
108-24-7

acetic anhydride

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
In water at 50℃; under 608.041 - 912.061 Torr; for 2h;88%
linezolid

linezolid

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With dimethylsulfide borane complex In tetrahydrofuran at 0℃; Inert atmosphere; Molecular sieve;88%
N-tert-octyl-N-(((S)-3-(3-fluoro-4-morpholinophenyl)-2-oxazolidin-5-yl)methyl)acetamide
1215006-12-4

N-tert-octyl-N-(((S)-3-(3-fluoro-4-morpholinophenyl)-2-oxazolidin-5-yl)methyl)acetamide

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
Stage #1: N-tert-octyl-N-(((S)-3-(3-fluoro-4-morpholinophenyl)-2-oxazolidin-5-yl)methyl)acetamide With hydrogenchloride In water; ethyl acetate at 55℃; for 2h;
Stage #2: With sodium hydroxide In water; ethyl acetate pH=10; Product distribution / selectivity;
87%
N-{(2R)-2-[(3-fluoro-4-(morpholin-4-yl)phenyl)amino]-2-hydroxyethyl}acetamide

N-{(2R)-2-[(3-fluoro-4-(morpholin-4-yl)phenyl)amino]-2-hydroxyethyl}acetamide

methyl chloroformate
79-22-1

methyl chloroformate

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
Stage #1: N-{(2R)-2-[(3-fluoro-4-(morpholin-4-yl)phenyl)amino]-2-hydroxyethyl}acetamide With aluminum oxide; sodium hydroxide In dichloromethane at 50 - 60℃; for 0.5h;
Stage #2: methyl chloroformate In dichloromethane for 2h; pH=8 - 10; Reagent/catalyst; Temperature;
86.1%
N-[3-phthalimido-2-(R)-acetyloxypropyl]-N-[3-fluoro-4-(4-morpholinyl)phenyl]carbamic acid ethyl ester

N-[3-phthalimido-2-(R)-acetyloxypropyl]-N-[3-fluoro-4-(4-morpholinyl)phenyl]carbamic acid ethyl ester

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With potassium carbonate; methylamine In methanol Reagent/catalyst; Reflux;86%
acetic anhydride
108-24-7

acetic anhydride

(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
168828-84-0

(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In methanol at 20℃; under 1034.32 Torr; for 3h;85%
With hydrogen; palladium 10% on activated carbon In dichloromethane under 1103.36 Torr; for 6h;80%
Stage #1: acetic anhydride; (R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one With hydrogen; acetic acid; palladium 10% on activated carbon In ethyl acetate at 25 - 35℃; under 1551.49 Torr; for 3h;
Stage #2: With sodium carbonate In water; ethyl acetate for 0.166667h; Product distribution / selectivity;
78%
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
168828-82-8

(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol

thioacetic acid
507-09-5

thioacetic acid

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
Stage #1: (R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol With methanesulfonyl chloride
Stage #2: With sodium azide
Stage #3: tiolacetic acid stereoselective reaction;
81%
benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate
168828-81-7, 1027135-00-7

benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
Stage #1: benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate With lithium tert-butoxide In tetrahydrofuran; methanol; N,N-dimethyl-formamide
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide at 21℃; for 21h; Solvent;
80.6%
Stage #1: benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate With lithium tert-butoxide In tetrahydrofuran; methanol at 10 - 25℃; Large scale;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide at 8℃; Temperature; Large scale;
With lithium tert-butoxide In tetrahydrofuran; methanol at 20℃; for 16h;83 g
Stage #1: benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate With lithium tert-butoxide In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 0 - 5℃; for 4h; Inert atmosphere;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 0 - 20℃; for 46h; Temperature; Inert atmosphere;
(S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt
1334229-25-2

(S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt

acetic anhydride
108-24-7

acetic anhydride

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With triethylamine In dichloromethane at 5 - 20℃; for 5h; Product distribution / selectivity;80%
Stage #1: (S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt With hydrogenchloride In water at 20℃; pH=Ca. 0.5;
Stage #2: With sodium hydroxide In water; ethyl acetate pH=4.5 - 4.7;
Stage #3: acetic anhydride With sodium hydroxide In dichloromethane; water at 20℃; for 3h; pH=4.5 - 4.7; Concentration; pH-value; Time;
80%
Stage #1: (S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-tolueneaulfonate salt With hydrogenchloride In water at 20℃; pH=0.5;
Stage #2: With sodium hydroxide In water; ethyl acetate pH=4.5 - 4.7;
Stage #3: acetic anhydride With sodium hydroxide In dichloromethane; water at 20℃; for 3h; pH=4.5 - 4.7; Time;
80%
acetyl chloride
75-36-5

acetyl chloride

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine
168828-90-8

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

A

(S)-N-acetyl-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

(S)-N-acetyl-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

B

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;A 8%
B 79%
N-tert-butyl-N-(((S)-3-(3-fluoro-4-morpholinophenyl)-2-oxazolidin-5-yl)methyl)acetamide
1215006-11-3

N-tert-butyl-N-(((S)-3-(3-fluoro-4-morpholinophenyl)-2-oxazolidin-5-yl)methyl)acetamide

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
Stage #1: N-tert-butyl-N-(((S)-3-(3-fluoro-4-morpholinophenyl)-2-oxazolidin-5-yl)methyl)acetamide With hydrogenchloride In 1,4-dioxane at 70℃; for 7h;
Stage #2: With sodium hydroxide In 1,4-dioxane; water at 20℃; pH=9; Product distribution / selectivity;
78%
(S)-N-(3-chloro-2-methoxycarbonyloxy-1-propyl)acetamide
1402550-23-5

(S)-N-(3-chloro-2-methoxycarbonyloxy-1-propyl)acetamide

3-fluoro-4-(morpholinyl)aniline
93246-53-8

3-fluoro-4-(morpholinyl)aniline

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 160℃; Solvent; Temperature;74.7%
(S)-N-(3-chloro-2-ethoxycarbonyloxy-1-propyl)acetamide
1402550-24-6

(S)-N-(3-chloro-2-ethoxycarbonyloxy-1-propyl)acetamide

3-fluoro-4-(morpholinyl)aniline
93246-53-8

3-fluoro-4-(morpholinyl)aniline

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 145 - 155℃; for 5h;74.5%
1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

N-[(2R)-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-hydroxypropyl]acetamide

N-[(2R)-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-hydroxypropyl]acetamide

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
In dichloromethane at 20℃;71%
In dichloromethane at 0 - 20℃; for 12h;37.6%
(S)-3-(3-fluoro-4-(morpholino)phenyl)-5-(2-(hydroxyimino)propyl)oxazolidin-2-one
1088111-01-6

(S)-3-(3-fluoro-4-(morpholino)phenyl)-5-(2-(hydroxyimino)propyl)oxazolidin-2-one

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
Stage #1: (S)-3-(3-fluoro-4-(morpholino)phenyl)-5-(2-(hydroxyimino)propyl)oxazolidin-2-one With triethylamine; p-toluenesulfonyl chloride In dichloromethane at 20℃; Beckmann rearrangement;
Stage #2: With triethylamine In water; isopropyl alcohol at 90℃; for 3h; Beckmann rearrangement;
70%
(S)-N-(3-chloro-2-benzyloxycarbonyloxy-1-propyl)acetamide
1402550-26-8

(S)-N-(3-chloro-2-benzyloxycarbonyloxy-1-propyl)acetamide

3-fluoro-4-(morpholinyl)aniline
93246-53-8

3-fluoro-4-(morpholinyl)aniline

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 145 - 155℃; for 5h;67.6%
benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate
168828-81-7, 1027135-00-7

benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate

N-[(2S)oxiranylmethyl]acetamide
183805-10-9

N-[(2S)oxiranylmethyl]acetamide

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
Stage #1: benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate With chloro-trimethyl-silane; potassium tert-butylate; lithium chloride In 1,4-dioxane at 20℃; for 0.833333h; Inert atmosphere;
Stage #2: N-[(2S)oxiranylmethyl]acetamide In 1,4-dioxane at 0 - 25℃; for 15.6667h; Solvent; Reagent/catalyst; Temperature;
67%
Stage #1: benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate With n-butyllithium
Stage #2: N-[(2S)oxiranylmethyl]acetamide
linezolid
165800-03-3

linezolid

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine
168828-90-8

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

Conditions
ConditionsYield
With hydrogenchloride In methanol Reflux;99%
With pyridine; hydroxylamine hydrochloride In ethanol for 48h; Sealed tube;
trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

linezolid
165800-03-3

linezolid

(S)-2,2,2-trifluoro-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
216869-19-1

(S)-2,2,2-trifluoro-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;91%
acryloyl chloride
814-68-6

acryloyl chloride

linezolid
165800-03-3

linezolid

(S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acrylamide

(S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acrylamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;88%
linezolid
165800-03-3

linezolid

Trichloroacetyl chloride
76-02-8

Trichloroacetyl chloride

(S)-2,2,2-trichloro-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

(S)-2,2,2-trichloro-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;86%
linezolid
165800-03-3

linezolid

(S)-2-(N-(4-(5-(acetamidomethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)formamido)ethyl formate

(S)-2-(N-(4-(5-(acetamidomethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)formamido)ethyl formate

Conditions
ConditionsYield
With pyridine; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 100℃; under 7500.75 - 22502.3 Torr; for 24h; Autoclave;85%
With pyridine; manganese (II) acetate tetrahydrate; cobalt(II) bromide In acetonitrile at 100℃; under 22502.3 Torr; for 24h;82%
chloroacetyl chloride
79-04-9

chloroacetyl chloride

linezolid
165800-03-3

linezolid

2-chloro-(S)-N-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]acetamide

2-chloro-(S)-N-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;83%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

linezolid
165800-03-3

linezolid

(S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)furan-2-carboxamide

(S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)furan-2-carboxamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;80%
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