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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Manufacturer 3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3,4-Difluoronitrobenzene Manufacturer/High quality/Best price/In stock

Cas:369-34-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Factory supply 3,4-Difluoronitrobenzene CAS 369-34-6 with reasonable price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food

Factory supply 3,4-Difluoronitrobenzene CAS 369-34-6 with reasonable price

Cas:369-34-6

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 1,2-difluoro-4-nitrobenzene

Cas:369-34-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% 3,4-Difluoronitrobenzene 369-34-6 Producer

Cas:369-34-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

3, 4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

3,4-Difluoronitrobenzene -- CHemwill

Cas:369-34-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

High Quality,High Purity 3,4-Difluoronitrobenzene Basic information Product Name: 3,4-Difluoronitrobenzene Synonyms: 1,2-difluoro-4-nitro-benzen;Benzene, 1,2-difluoro-4-nitro-;1,2-DIFL

1-NITRO-3,4-DIFLUOROBENZENE

Cas:369-34-6

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 369-34-6 with best quality

Cas:369-34-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

3,4-Difluoronitrobenzene CAS369-34-6

Cas:369-34-6

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name 3,4-Difluoronitrobenzene Cas number 369-34-6 Molecular formula C6H3F2NO2 Molecular weight 159.09 Appearance

3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

3,4-Difluoronitrobenzene 369-34-6

Cas:369-34-6

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3,4-Difluoronitrobenzene 369-34-6

Cas:369-34-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

3,4-Difluoronitrobenzene Basic information Product Name: 3,4-Difluoronitrobenzene Synonyms: 1,2-difluoro-4-nitro-benzen;Benzene, 1,2-difluoro-4-nitro-;3,4-DIFLUORONITROBENZENE;1,2-DIFLUORO-4-NITROBENZENE;1-NITRO-3,4-DIFLUOROBENZENE;Benzene, 1,2

3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:1 Kilogram

FOB Price: $70.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

3,4-Difluoronitrobenzene CAS:369-34-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in

3,4-Difluoronitrobenzene CAS:369-34-6

Cas:369-34-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:369-34-6

Cas:369-34-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

cas 369-34-6 cas 369-34-6 3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3,4-DIFLUORONITROBENZENE

Cas:369-34-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

3,4-Difluoronitrobenzene

Cas:369-34-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 3,4-Difluoronitrobenzene CAS No.: 369-34-6 Molecule Formula:C6H5FN2O2 Molecule Weight:156.11 Purity: 99.0% Package: 200kg/drum Description:Colorless to pale yellow liquid Manufacture Standards:Enterprise Standard TE

Lower Price 3,4-Difluoronitrobenzene on stock

Cas:369-34-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

ortho-difluorobenzene
367-11-3

ortho-difluorobenzene

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

Conditions
ConditionsYield
With molecular sieve; nitric acid; acetic anhydride at 0℃; for 3h; other reagent: nitric acid/sulfuric acid;98%
With sulfuric acid; nitric acid at 20℃; for 0.0180556h; Temperature;97.3%
With sulfuric acid; nitric acid at 60 - 70℃; for 6h;91%
4,5-difluoro-2-nitrobenzoic acid
20372-63-8

4,5-difluoro-2-nitrobenzoic acid

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

Conditions
ConditionsYield
With copper In 1-methyl-pyrrolidin-2-one at 250℃; for 0.5h;94%
3,4-dichloronitrobenzene
99-54-7

3,4-dichloronitrobenzene

A

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

B

3-chloro-4-fluoronitrobenzene
350-30-1

3-chloro-4-fluoronitrobenzene

Conditions
ConditionsYield
With potassium fluoride; tetraphenylphosphonium bromide at 175 - 195℃; for 30h; Yields of byproduct given;A n/a
B 79%
With potassium fluoride; 2-(4-chlorophenyl)propene copolymer-grafted tetraphenylphosphonium chloride; cross-linked styrene In sulfolane at 210℃; for 7h;A 12%
B 64%
With potassium fluoride; tetraphenylphosphonium bromide at 175 - 195℃; for 30h; Yield given. Yields of byproduct given;
1-chloro-2,4-dinitro-benzene
97-00-7

1-chloro-2,4-dinitro-benzene

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

Conditions
ConditionsYield
With potassium fluoride; 3,4,5,6-tetrafluorophthaloyldifluoride In sulfolane at 200℃; for 13h;77%
2,4-Dinitrofluorobenzene
70-34-8

2,4-Dinitrofluorobenzene

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

Conditions
ConditionsYield
With potassium fluoride; benzene-1,2,4,5-tetracarbonyl chloride In sulfolane at 200℃; for 4h;58%
4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

Conditions
ConditionsYield
With formic acid; fluorine at 10℃; for 1.75h; Fluorination;53%
1-chloro-2,4-dinitro-benzene
97-00-7

1-chloro-2,4-dinitro-benzene

A

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

B

1,4-difluoro-2-nitrobenzene
364-74-9

1,4-difluoro-2-nitrobenzene

Conditions
ConditionsYield
With potassium fluoride; tetraphenylphosphonium bromide; Phthaloyl dichloride In sulfolane; toluene at 190℃; for 6h;A 46%
B 3 % Chromat.
With potassium fluoride; Phthaloyl dichloride; tetraphenylphosphonium bromide In sulfolane 1) 150 deg C, 2 h, 2) 190 deg C, 6 h;A 46%
B 3%
2,4-Dinitrofluorobenzene
70-34-8

2,4-Dinitrofluorobenzene

A

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

B

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

Conditions
ConditionsYield
With potassium fluoride at 145℃;
With potassium fluoride at 155℃;
1-chloro-2,4-dinitro-benzene
97-00-7

1-chloro-2,4-dinitro-benzene

A

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

B

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

Conditions
ConditionsYield
With potassium fluoride at 155℃;
With potassium fluoride at 145℃;
1-fluoro-2-fluorosulfonyl-4-nitrobenzene
115561-03-0

1-fluoro-2-fluorosulfonyl-4-nitrobenzene

A

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

B

2,5-difluorobenzenesulfonyl fluoride
62094-86-4

2,5-difluorobenzenesulfonyl fluoride

Conditions
ConditionsYield
With potassium fluoride; tetraphenylphosphonium bromide In sulfolane; toluene at 210℃; under 300 Torr; Title compound not separated from byproducts;
With potassium fluoride; tetraphenylphosphonium bromide In sulfolane at 210℃; under 270 - 300 Torr; for 5h; Yield given. Yields of byproduct given;
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

1-chloro-2,4-dinitro-benzene
97-00-7

1-chloro-2,4-dinitro-benzene

potassium fluoride

potassium fluoride

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

Conditions
ConditionsYield
at 150℃;
2-fluoro-5-nitro-benzenediazonium-tetrafluoroborate

2-fluoro-5-nitro-benzenediazonium-tetrafluoroborate

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

Conditions
ConditionsYield
at 160℃; under 20 Torr;
2-chloro-5-nitrobenzenesulphonic acid sodium salt
946-30-5

2-chloro-5-nitrobenzenesulphonic acid sodium salt

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / phosphoryl chloride / acetonitrile; tetrahydrothiophene 1,1-dioxide; N,N-dimethyl-acetamide / 1 h / 70 °C
2: 90 percent / Ph4PBr, KF / tetrahydrothiophene 1,1-dioxide / 16 h / 130 - 140 °C
3: KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 300 Torr
View Scheme
4-chlorobenzonitrile
100-00-5

4-chlorobenzonitrile

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 100 percent / 1) 30percent fumic H2SO4 2) NaOH / 16 h / 110 - 115 °C
2: 80 percent / phosphoryl chloride / acetonitrile; tetrahydrothiophene 1,1-dioxide; N,N-dimethyl-acetamide / 1 h / 70 °C
3: 90 percent / Ph4PBr, KF / tetrahydrothiophene 1,1-dioxide / 16 h / 130 - 140 °C
4: KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 300 Torr
View Scheme
5-nitro-2-chlorobenzenesulfonyl chloride
4533-95-3

5-nitro-2-chlorobenzenesulfonyl chloride

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / Ph4PBr, KF / tetrahydrothiophene 1,1-dioxide / 16 h / 130 - 140 °C
2: KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 300 Torr
View Scheme
2,4-dichloronitrobenzene
611-06-3

2,4-dichloronitrobenzene

3,4-dichloronitrobenzene
99-54-7

3,4-dichloronitrobenzene

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

Conditions
ConditionsYield
With potassium fluoride In sulfolane
3-chloro-4-fluoronitrobenzene
350-30-1

3-chloro-4-fluoronitrobenzene

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

Conditions
ConditionsYield
With potassium fluoride; cesium fluoride In sulfolane
With potassium fluoride In sulfolane; dichloromethane
With potassium fluoride; bis(triphenylphosphine)iminium chloride In dimethyl sulfoxide at 150℃; for 8h; Inert atmosphere;5 %Chromat.
2,3,4-trifluoronitrobenzene
771-69-7

2,3,4-trifluoronitrobenzene

A

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

B

1,2-difluoro-3-nitrobenzene
6921-22-8

1,2-difluoro-3-nitrobenzene

C

2,3,4-trifluoroaniline
3862-73-5

2,3,4-trifluoroaniline

Conditions
ConditionsYield
With Dimethylphenylsilane; o-phenylenebis(diphenylphosphine); potassium tert-butylate; copper(l) chloride In tetrahydrofuran for 12h; Inert atmosphere; Reflux; Overall yield = 95 %Spectr.; regioselective reaction;
nitrobenzene
98-95-3

nitrobenzene

A

3-fluoro-1-nitrobenzene
402-67-5

3-fluoro-1-nitrobenzene

B

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

C

1,4-difluoro-2-nitrobenzene
364-74-9

1,4-difluoro-2-nitrobenzene

D

4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

E

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Conditions
ConditionsYield
With xenon difluoride; boron trifluoride diethyl etherate at 0 - 25℃; Reagent/catalyst; Cooling with ice;A 0.16 mmol
B 0.001 mmol
C 0.016 mmol
D 0.01 mmol
E 0.05 mmol
morpholine
110-91-8

morpholine

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

3-fluoro-4-(4-morpholinyl)nitrobenzene
2689-39-6

3-fluoro-4-(4-morpholinyl)nitrobenzene

Conditions
ConditionsYield
Stage #1: morpholine; 3,4-difluoronitrobenzene In tetrahydrofuran at 0 - 20℃; for 1.25h;
Stage #2: With citric acid In tetrahydrofuran; water for 1h;
100%
In tetrahydrofuran at 0 - 20℃; for 1.25h;100%
In tetrahydrofuran at 20℃; for 1.25h; Cooling with ice-salt bath;100%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

(2,3-difluoro-6-nitrophenyl)trimethylsilane

(2,3-difluoro-6-nitrophenyl)trimethylsilane

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran at -78℃;100%
4-methylpiperidin
626-58-4

4-methylpiperidin

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

3-fluoro-4-(4-methyl-1-piperidinyl)nitrobenzene
250371-81-4

3-fluoro-4-(4-methyl-1-piperidinyl)nitrobenzene

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 17h; Heating;100%
In acetonitrile at 80℃; for 16h;
4,5,6,7-tetrahydrothieno[3,2-c]pyridine
54903-50-3

4,5,6,7-tetrahydrothieno[3,2-c]pyridine

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

5-(2-fluoro-4-nitrophenyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine
765314-18-9

5-(2-fluoro-4-nitrophenyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine

Conditions
ConditionsYield
In acetonitrile at 75 - 78℃; for 2h;100%
1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol
924909-16-0, 370866-00-5

1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

4-(2-fluoro-4-nitrophenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine
949556-47-2

4-(2-fluoro-4-nitrophenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 100℃; for 1h;100%
With caesium carbonate In ISOPROPYLAMIDE at 100℃; for 1h;82%
With caesium carbonate In ISOPROPYLAMIDE at 100℃; for 1h;82%
3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

methylamine hydrochloride
593-51-1

methylamine hydrochloride

N-methyl-2-fluoro-4-nitroaniline
124431-92-1

N-methyl-2-fluoro-4-nitroaniline

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 24h;100%
3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

piperidin-3-ol hydrochloride
64051-79-2

piperidin-3-ol hydrochloride

1-(2-fluoro-4-nitrophenyl)-piperidin-3-ol
916988-48-2

1-(2-fluoro-4-nitrophenyl)-piperidin-3-ol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50 - 60℃; for 3h;100%
3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

diethyl malonate
105-53-3

diethyl malonate

1,3-diethyl 2-(2-fluoro-4-nitrophenyl)propanedioate
318471-58-8

1,3-diethyl 2-(2-fluoro-4-nitrophenyl)propanedioate

Conditions
ConditionsYield
Stage #1: diethyl malonate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 70℃;
100%
Stage #1: diethyl malonate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h;
Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide; mineral oil at 70℃;
86%
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 5h;80%
Stage #1: diethyl malonate With sodium hydride In dimethyl sulfoxide at 0 - 20℃; for 2.16667h;
Stage #2: 3,4-difluoronitrobenzene In dimethyl sulfoxide at 0 - 20℃; for 2h;
Stage #1: diethyl malonate With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1.5h; Inert atmosphere;
Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 0 - 20℃;
13 g
3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

ethanolamine
141-43-5

ethanolamine

2-(2-fluoro-4-nitrophenylamino)ethanol

2-(2-fluoro-4-nitrophenylamino)ethanol

Conditions
ConditionsYield
In acetonitrile for 4h; Reflux;100%
In acetonitrile for 4h; Reflux;100%
In acetonitrile for 4h; Reflux;73%
In acetonitrile for 4h; Reflux;
3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-ol
1354786-75-6

3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-ol

5-[4-(2-Fluoro-4-nitrophenoxy)biphenyl-3-yl]-1-methyl-1H-pyrazole
1354786-76-7

5-[4-(2-Fluoro-4-nitrophenoxy)biphenyl-3-yl]-1-methyl-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-ol With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 20℃; for 16h;
100%
3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

4-adamantylphenol
29799-07-3

4-adamantylphenol

(3r,5r,7r)-1-(4-(2-fluoro-4-nitrophenoxy)phenyl)adamantane

(3r,5r,7r)-1-(4-(2-fluoro-4-nitrophenoxy)phenyl)adamantane

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 20℃; for 4h;100%
With potassium carbonate In dimethyl sulfoxide at 20℃; for 4h;703mg
3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

3-fluoro-4-hydrazinonitrobenzene
127350-92-9

3-fluoro-4-hydrazinonitrobenzene

Conditions
ConditionsYield
With hydrazine In ethanol at 80℃; for 2h;99.2%
With pyridine; hydrazine hydrate at 20℃; for 0.833333h;98%
With potassium carbonate; hydrazine hydrate In acetonitrile94%
Thiomorpholin
123-90-0

Thiomorpholin

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

(4-(2-fluoro-4-nitrophenyl)thiomorpholine)
168828-70-4

(4-(2-fluoro-4-nitrophenyl)thiomorpholine)

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile 1.) RT, 2.) reflux, 24 h;99%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 140℃; for 0.25h; Microwave irradiation;99%
Stage #1: Thiomorpholin With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 3,4-difluoronitrobenzene In acetonitrile Inert atmosphere; Reflux;
99%
piperazine
110-85-0

piperazine

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

1-(2-fluoro-4-nitrophenyl)piperazine
154590-33-7

1-(2-fluoro-4-nitrophenyl)piperazine

Conditions
ConditionsYield
In acetonitrile at 80℃; for 2h;99%
In acetonitrile at 80℃; for 6h;98%
In acetonitrile at 80℃; for 3h;97.7%
1,2,3,4-tetrahydroisoquinoline
91-21-4

1,2,3,4-tetrahydroisoquinoline

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

N-(2-fluoro-4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline
449175-25-1

N-(2-fluoro-4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
In acetonitrile for 5.5h; Heating / reflux;99%
With potassium carbonate In dimethyl sulfoxide for 1h; Substitution; Heating;93%
With triethylamine In ethyl acetate for 3h; Heating / reflux;
piperidine
110-89-4

piperidine

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

1-(2-fluoro-4-nitrophenyl)piperidine
172967-04-3

1-(2-fluoro-4-nitrophenyl)piperidine

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 20℃;99%
With triethylamine In ethyl acetate at 20℃;99%
With triethylamine In ethyl acetate at 20℃;99%
hexamethylene imine
111-49-9

hexamethylene imine

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

1-(2-fluoro-4-nitrophenyl)azepane
250371-80-3

1-(2-fluoro-4-nitrophenyl)azepane

Conditions
ConditionsYield
Stage #1: hexamethylene imine With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 3,4-difluoronitrobenzene In acetonitrile Inert atmosphere; Reflux;
99%
With N-ethyl-N,N-diisopropylamine In acetonitrile for 17h; Heating;
With caesium carbonate In DMF (N,N-dimethyl-formamide)
With caesium carbonate In N,N-dimethyl-formamide
With triethylamine In ethyl acetate at 80℃; for 20h;
(2R)-2-aminobutan-1-ol
5856-63-3

(2R)-2-aminobutan-1-ol

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

(2R)-(+)-2-(2-fluoro-4-nitrophenyl)amino-1-butanol
329229-75-6

(2R)-(+)-2-(2-fluoro-4-nitrophenyl)amino-1-butanol

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 90℃; for 12h;99%
(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

2-[2-Fluoro(methyl)-4-nitroanilino]ethanol
677727-07-0

2-[2-Fluoro(methyl)-4-nitroanilino]ethanol

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 100℃; for 1.5h;99%
With N-ethyl-N,N-diisopropylamine In ethyl acetate at 0 - 20℃; for 24h;79%
3-(hydroxymethy)piperidine
4606-65-9

3-(hydroxymethy)piperidine

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

[3-fluoro-4-(3-hydroxymethylpiperidino)]nitrobenzene
1097722-40-1

[3-fluoro-4-(3-hydroxymethylpiperidino)]nitrobenzene

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 1h;99%
With triethylamine In methanol at 50 - 60℃; for 24h;96%
With triethylamine In methanol at 50 - 60℃; for 24h;96%
3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

phenylmethanethiol
100-53-8

phenylmethanethiol

1-(benzylsulfanyl)-2-fluoro-4-nitrobenzene
1242618-52-5

1-(benzylsulfanyl)-2-fluoro-4-nitrobenzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h; regioselective reaction;99%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 2h;96%
With potassium carbonate In N,N-dimethyl-formamide at 15℃; for 3h;
3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

diethylamine
109-89-7

diethylamine

N,N-diethyl-2-fluoro-4-nitroaniline
2689-37-4

N,N-diethyl-2-fluoro-4-nitroaniline

Conditions
ConditionsYield
With triethylamine In ethyl acetate for 0.5h;99%
With triethylamine In ethyl acetate at 20℃; for 0.5h; Cooling with ice;99%
With triethylamine In ethyl acetate for 0.5h; Cooling with ice;99%
With triethylamine In methanol at 50 - 60℃; for 24h;81%
With triethylamine In methanol at 50 - 60℃; for 24h;81%
3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

2-Methylpiperidin
109-05-7, 3000-79-1

2-Methylpiperidin

[3-fluoro-4-(2-methylpiperidino)]nitrobenzene
423736-55-4

[3-fluoro-4-(2-methylpiperidino)]nitrobenzene

Conditions
ConditionsYield
With triethylamine In methanol at 50 - 60℃; for 28h;99%
With triethylamine In methanol at 50 - 60℃; for 28h;99%
4,4-dimethyl-4-silapiperidine hydrochloride
130596-62-2

4,4-dimethyl-4-silapiperidine hydrochloride

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane
1430321-42-8

1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

Conditions
ConditionsYield
Stage #1: 4,4-dimethyl-4-silapiperidine hydrochloride With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 0 - 20℃; for 12h;
99%
Stage #1: 4,4-dimethyl-4-silapiperidine hydrochloride With triethylamine In ethyl acetate at 25℃; for 0.166667h;
Stage #2: 3,4-difluoronitrobenzene In ethyl acetate at 0 - 25℃; for 6h;
70%
Stage #1: 4,4-dimethyl-4-silapiperidine hydrochloride With triethylamine In ethyl acetate at 25℃; for 0.166667h;
Stage #2: 3,4-difluoronitrobenzene In ethyl acetate at 0 - 25℃; for 6h;
70%
With triethylamine In ethyl acetate at 0 - 20℃; for 6h; Inert atmosphere;69%
Stage #1: 4,4-dimethyl-4-silapiperidine hydrochloride With triethylamine In N,N-dimethyl-formamide at 20 - 25℃; for 0.166667h;
Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 20 - 25℃; Cooling with ice;
28.1 g
para-tert-butylphenol
98-54-4

para-tert-butylphenol

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

1-(4-(tert-butyl)phenoxy)-2-fluoro-4-nitrobenzene

1-(4-(tert-butyl)phenoxy)-2-fluoro-4-nitrobenzene

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 20℃; for 19h;99%
With potassium carbonate In dimethyl sulfoxide at 20℃; for 19h;99%
3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

p-cyclohexylphenol
1131-60-8

p-cyclohexylphenol

1-(4-cyclohexylphenoxy)-2-fluoro-4-nitrobenzene

1-(4-cyclohexylphenoxy)-2-fluoro-4-nitrobenzene

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 20℃; for 23h;99%
With potassium carbonate In dimethyl sulfoxide at 20℃; for 23h;99%
4-t-amylphenol
80-46-6

4-t-amylphenol

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

2-fluoro-4-nitro-1-(4-(tert-pentyl)phenoxy)benzene

2-fluoro-4-nitro-1-(4-(tert-pentyl)phenoxy)benzene

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 20℃; for 22h;99%
With potassium carbonate In dimethyl sulfoxide at 20℃; for 22h;99%
4-piperidinemethanol
6457-49-4

4-piperidinemethanol

3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

(1-(2-fluoro-4-nitrophenyl)piperidin-4-yl)methanol
1260805-31-9

(1-(2-fluoro-4-nitrophenyl)piperidin-4-yl)methanol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 25℃; for 12h;98.8%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 100℃;
3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

6-bromo-1-methyl-1H-indazol-5-ol
1403767-19-0

6-bromo-1-methyl-1H-indazol-5-ol

6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole
1206800-24-9

6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 60 - 65℃; for 15h; Large scale;98.1%
With potassium carbonate In tetrahydrofuran at 55℃; for 14h;72%
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