Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:369-34-6
Min.Order:1 Kilogram
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:369-34-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryFactory supply 3,4-Difluoronitrobenzene CAS 369-34-6 with reasonable price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food
Cas:369-34-6
Min.Order:10 Kilogram
FOB Price: $10.0
Type:Trading Company
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:369-34-6
Min.Order:1 Gram
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Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Cas:369-34-6
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Cas:369-34-6
Min.Order:1 Metric Ton
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Type:Manufacturers
inquiryHigh Quality,High Purity 3,4-Difluoronitrobenzene Basic information Product Name: 3,4-Difluoronitrobenzene Synonyms: 1,2-difluoro-4-nitro-benzen;Benzene, 1,2-difluoro-4-nitro-;1,2-DIFL
Cas:369-34-6
Min.Order:1 Metric Ton
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Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:369-34-6
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:369-34-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:369-34-6
Min.Order:1 Kilogram
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Type:Trading Company
inquiryProduct name 3,4-Difluoronitrobenzene Cas number 369-34-6 Molecular formula C6H3F2NO2 Molecular weight 159.09 Appearance
Cas:369-34-6
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv
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Cas:369-34-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry3,4-Difluoronitrobenzene Basic information Product Name: 3,4-Difluoronitrobenzene Synonyms: 1,2-difluoro-4-nitro-benzen;Benzene, 1,2-difluoro-4-nitro-;3,4-DIFLUORONITROBENZENE;1,2-DIFLUORO-4-NITROBENZENE;1-NITRO-3,4-DIFLUOROBENZENE;Benzene, 1,2
Cas:369-34-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:369-34-6
Min.Order:1 Kilogram
FOB Price: $70.0
Type:Trading Company
inquiry3,4-Difluoronitrobenzene CAS:369-34-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in
Cas:369-34-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:369-34-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:369-34-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:369-34-6
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:369-34-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:369-34-6
Min.Order:4 Kilogram
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Type:Lab/Research institutions
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:369-34-6
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:369-34-6
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:369-34-6
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct name: 3,4-Difluoronitrobenzene CAS No.: 369-34-6 Molecule Formula:C6H5FN2O2 Molecule Weight:156.11 Purity: 99.0% Package: 200kg/drum Description:Colorless to pale yellow liquid Manufacture Standards:Enterprise Standard TE
Cas:369-34-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With molecular sieve; nitric acid; acetic anhydride at 0℃; for 3h; other reagent: nitric acid/sulfuric acid; | 98% |
With sulfuric acid; nitric acid at 20℃; for 0.0180556h; Temperature; | 97.3% |
With sulfuric acid; nitric acid at 60 - 70℃; for 6h; | 91% |
4,5-difluoro-2-nitrobenzoic acid
3,4-difluoronitrobenzene
Conditions | Yield |
---|---|
With copper In 1-methyl-pyrrolidin-2-one at 250℃; for 0.5h; | 94% |
3,4-dichloronitrobenzene
A
3,4-difluoronitrobenzene
B
3-chloro-4-fluoronitrobenzene
Conditions | Yield |
---|---|
With potassium fluoride; tetraphenylphosphonium bromide at 175 - 195℃; for 30h; Yields of byproduct given; | A n/a B 79% |
With potassium fluoride; 2-(4-chlorophenyl)propene copolymer-grafted tetraphenylphosphonium chloride; cross-linked styrene In sulfolane at 210℃; for 7h; | A 12% B 64% |
With potassium fluoride; tetraphenylphosphonium bromide at 175 - 195℃; for 30h; Yield given. Yields of byproduct given; |
Conditions | Yield |
---|---|
With potassium fluoride; 3,4,5,6-tetrafluorophthaloyldifluoride In sulfolane at 200℃; for 13h; | 77% |
Conditions | Yield |
---|---|
With potassium fluoride; benzene-1,2,4,5-tetracarbonyl chloride In sulfolane at 200℃; for 4h; | 58% |
Conditions | Yield |
---|---|
With formic acid; fluorine at 10℃; for 1.75h; Fluorination; | 53% |
1-chloro-2,4-dinitro-benzene
A
3,4-difluoronitrobenzene
B
1,4-difluoro-2-nitrobenzene
Conditions | Yield |
---|---|
With potassium fluoride; tetraphenylphosphonium bromide; Phthaloyl dichloride In sulfolane; toluene at 190℃; for 6h; | A 46% B 3 % Chromat. |
With potassium fluoride; Phthaloyl dichloride; tetraphenylphosphonium bromide In sulfolane 1) 150 deg C, 2 h, 2) 190 deg C, 6 h; | A 46% B 3% |
2,4-Dinitrofluorobenzene
A
3,4-difluoronitrobenzene
B
N,N-dimethyl-formamide
Conditions | Yield |
---|---|
With potassium fluoride at 145℃; | |
With potassium fluoride at 155℃; |
1-chloro-2,4-dinitro-benzene
A
3,4-difluoronitrobenzene
B
N,N-dimethyl-formamide
Conditions | Yield |
---|---|
With potassium fluoride at 155℃; | |
With potassium fluoride at 145℃; |
1-fluoro-2-fluorosulfonyl-4-nitrobenzene
A
3,4-difluoronitrobenzene
B
2,5-difluorobenzenesulfonyl fluoride
Conditions | Yield |
---|---|
With potassium fluoride; tetraphenylphosphonium bromide In sulfolane; toluene at 210℃; under 300 Torr; Title compound not separated from byproducts; | |
With potassium fluoride; tetraphenylphosphonium bromide In sulfolane at 210℃; under 270 - 300 Torr; for 5h; Yield given. Yields of byproduct given; |
N,N-dimethyl-formamide
1-chloro-2,4-dinitro-benzene
3,4-difluoronitrobenzene
Conditions | Yield |
---|---|
at 150℃; |
3,4-difluoronitrobenzene
Conditions | Yield |
---|---|
at 160℃; under 20 Torr; |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 80 percent / phosphoryl chloride / acetonitrile; tetrahydrothiophene 1,1-dioxide; N,N-dimethyl-acetamide / 1 h / 70 °C 2: 90 percent / Ph4PBr, KF / tetrahydrothiophene 1,1-dioxide / 16 h / 130 - 140 °C 3: KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 300 Torr View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 100 percent / 1) 30percent fumic H2SO4 2) NaOH / 16 h / 110 - 115 °C 2: 80 percent / phosphoryl chloride / acetonitrile; tetrahydrothiophene 1,1-dioxide; N,N-dimethyl-acetamide / 1 h / 70 °C 3: 90 percent / Ph4PBr, KF / tetrahydrothiophene 1,1-dioxide / 16 h / 130 - 140 °C 4: KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 300 Torr View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / Ph4PBr, KF / tetrahydrothiophene 1,1-dioxide / 16 h / 130 - 140 °C 2: KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 300 Torr View Scheme |
2,4-dichloronitrobenzene
3,4-dichloronitrobenzene
3,4-difluoronitrobenzene
Conditions | Yield |
---|---|
With potassium fluoride In sulfolane |
Conditions | Yield |
---|---|
With potassium fluoride; cesium fluoride In sulfolane | |
With potassium fluoride In sulfolane; dichloromethane | |
With potassium fluoride; bis(triphenylphosphine)iminium chloride In dimethyl sulfoxide at 150℃; for 8h; Inert atmosphere; | 5 %Chromat. |
2,3,4-trifluoronitrobenzene
A
3,4-difluoronitrobenzene
B
1,2-difluoro-3-nitrobenzene
C
2,3,4-trifluoroaniline
Conditions | Yield |
---|---|
With Dimethylphenylsilane; o-phenylenebis(diphenylphosphine); potassium tert-butylate; copper(l) chloride In tetrahydrofuran for 12h; Inert atmosphere; Reflux; Overall yield = 95 %Spectr.; regioselective reaction; |
nitrobenzene
A
3-fluoro-1-nitrobenzene
B
3,4-difluoronitrobenzene
C
1,4-difluoro-2-nitrobenzene
D
4-Fluoronitrobenzene
E
ortho-nitrofluorobenzene
Conditions | Yield |
---|---|
With xenon difluoride; boron trifluoride diethyl etherate at 0 - 25℃; Reagent/catalyst; Cooling with ice; | A 0.16 mmol B 0.001 mmol C 0.016 mmol D 0.01 mmol E 0.05 mmol |
morpholine
3,4-difluoronitrobenzene
3-fluoro-4-(4-morpholinyl)nitrobenzene
Conditions | Yield |
---|---|
Stage #1: morpholine; 3,4-difluoronitrobenzene In tetrahydrofuran at 0 - 20℃; for 1.25h; Stage #2: With citric acid In tetrahydrofuran; water for 1h; | 100% |
In tetrahydrofuran at 0 - 20℃; for 1.25h; | 100% |
In tetrahydrofuran at 20℃; for 1.25h; Cooling with ice-salt bath; | 100% |
Conditions | Yield |
---|---|
With sodium hexamethyldisilazane In tetrahydrofuran at -78℃; | 100% |
4-methylpiperidin
3,4-difluoronitrobenzene
3-fluoro-4-(4-methyl-1-piperidinyl)nitrobenzene
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile for 17h; Heating; | 100% |
In acetonitrile at 80℃; for 16h; |
4,5,6,7-tetrahydrothieno[3,2-c]pyridine
3,4-difluoronitrobenzene
5-(2-fluoro-4-nitrophenyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine
Conditions | Yield |
---|---|
In acetonitrile at 75 - 78℃; for 2h; | 100% |
1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol
3,4-difluoronitrobenzene
4-(2-fluoro-4-nitrophenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 100℃; for 1h; | 100% |
With caesium carbonate In ISOPROPYLAMIDE at 100℃; for 1h; | 82% |
With caesium carbonate In ISOPROPYLAMIDE at 100℃; for 1h; | 82% |
3,4-difluoronitrobenzene
methylamine hydrochloride
N-methyl-2-fluoro-4-nitroaniline
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 24h; | 100% |
3,4-difluoronitrobenzene
piperidin-3-ol hydrochloride
1-(2-fluoro-4-nitrophenyl)-piperidin-3-ol
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 50 - 60℃; for 3h; | 100% |
3,4-difluoronitrobenzene
diethyl malonate
1,3-diethyl 2-(2-fluoro-4-nitrophenyl)propanedioate
Conditions | Yield |
---|---|
Stage #1: diethyl malonate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 70℃; | 100% |
Stage #1: diethyl malonate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide; mineral oil at 70℃; | 86% |
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 5h; | 80% |
Stage #1: diethyl malonate With sodium hydride In dimethyl sulfoxide at 0 - 20℃; for 2.16667h; Stage #2: 3,4-difluoronitrobenzene In dimethyl sulfoxide at 0 - 20℃; for 2h; | |
Stage #1: diethyl malonate With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1.5h; Inert atmosphere; Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 0 - 20℃; | 13 g |
Conditions | Yield |
---|---|
In acetonitrile for 4h; Reflux; | 100% |
In acetonitrile for 4h; Reflux; | 100% |
In acetonitrile for 4h; Reflux; | 73% |
In acetonitrile for 4h; Reflux; |
3,4-difluoronitrobenzene
3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-ol
5-[4-(2-Fluoro-4-nitrophenoxy)biphenyl-3-yl]-1-methyl-1H-pyrazole
Conditions | Yield |
---|---|
Stage #1: 3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-ol With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 20℃; for 16h; | 100% |
3,4-difluoronitrobenzene
4-adamantylphenol
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 20℃; for 4h; | 100% |
With potassium carbonate In dimethyl sulfoxide at 20℃; for 4h; | 703mg |
3,4-difluoronitrobenzene
3-fluoro-4-hydrazinonitrobenzene
Conditions | Yield |
---|---|
With hydrazine In ethanol at 80℃; for 2h; | 99.2% |
With pyridine; hydrazine hydrate at 20℃; for 0.833333h; | 98% |
With potassium carbonate; hydrazine hydrate In acetonitrile | 94% |
Thiomorpholin
3,4-difluoronitrobenzene
(4-(2-fluoro-4-nitrophenyl)thiomorpholine)
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile 1.) RT, 2.) reflux, 24 h; | 99% |
With N-ethyl-N,N-diisopropylamine In acetonitrile at 140℃; for 0.25h; Microwave irradiation; | 99% |
Stage #1: Thiomorpholin With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.5h; Inert atmosphere; Stage #2: 3,4-difluoronitrobenzene In acetonitrile Inert atmosphere; Reflux; | 99% |
piperazine
3,4-difluoronitrobenzene
1-(2-fluoro-4-nitrophenyl)piperazine
Conditions | Yield |
---|---|
In acetonitrile at 80℃; for 2h; | 99% |
In acetonitrile at 80℃; for 6h; | 98% |
In acetonitrile at 80℃; for 3h; | 97.7% |
1,2,3,4-tetrahydroisoquinoline
3,4-difluoronitrobenzene
N-(2-fluoro-4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
In acetonitrile for 5.5h; Heating / reflux; | 99% |
With potassium carbonate In dimethyl sulfoxide for 1h; Substitution; Heating; | 93% |
With triethylamine In ethyl acetate for 3h; Heating / reflux; |
piperidine
3,4-difluoronitrobenzene
1-(2-fluoro-4-nitrophenyl)piperidine
Conditions | Yield |
---|---|
With triethylamine In ethyl acetate at 20℃; | 99% |
With triethylamine In ethyl acetate at 20℃; | 99% |
With triethylamine In ethyl acetate at 20℃; | 99% |
hexamethylene imine
3,4-difluoronitrobenzene
1-(2-fluoro-4-nitrophenyl)azepane
Conditions | Yield |
---|---|
Stage #1: hexamethylene imine With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.5h; Inert atmosphere; Stage #2: 3,4-difluoronitrobenzene In acetonitrile Inert atmosphere; Reflux; | 99% |
With N-ethyl-N,N-diisopropylamine In acetonitrile for 17h; Heating; | |
With caesium carbonate In DMF (N,N-dimethyl-formamide) | |
With caesium carbonate In N,N-dimethyl-formamide | |
With triethylamine In ethyl acetate at 80℃; for 20h; |
(2R)-2-aminobutan-1-ol
3,4-difluoronitrobenzene
(2R)-(+)-2-(2-fluoro-4-nitrophenyl)amino-1-butanol
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 90℃; for 12h; | 99% |
(2-hydroxyethyl)(methyl)amine
3,4-difluoronitrobenzene
2-[2-Fluoro(methyl)-4-nitroanilino]ethanol
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 100℃; for 1.5h; | 99% |
With N-ethyl-N,N-diisopropylamine In ethyl acetate at 0 - 20℃; for 24h; | 79% |
3-(hydroxymethy)piperidine
3,4-difluoronitrobenzene
[3-fluoro-4-(3-hydroxymethylpiperidino)]nitrobenzene
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 1h; | 99% |
With triethylamine In methanol at 50 - 60℃; for 24h; | 96% |
With triethylamine In methanol at 50 - 60℃; for 24h; | 96% |
3,4-difluoronitrobenzene
phenylmethanethiol
1-(benzylsulfanyl)-2-fluoro-4-nitrobenzene
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h; regioselective reaction; | 99% |
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 2h; | 96% |
With potassium carbonate In N,N-dimethyl-formamide at 15℃; for 3h; |
3,4-difluoronitrobenzene
diethylamine
N,N-diethyl-2-fluoro-4-nitroaniline
Conditions | Yield |
---|---|
With triethylamine In ethyl acetate for 0.5h; | 99% |
With triethylamine In ethyl acetate at 20℃; for 0.5h; Cooling with ice; | 99% |
With triethylamine In ethyl acetate for 0.5h; Cooling with ice; | 99% |
With triethylamine In methanol at 50 - 60℃; for 24h; | 81% |
With triethylamine In methanol at 50 - 60℃; for 24h; | 81% |
3,4-difluoronitrobenzene
2-Methylpiperidin
[3-fluoro-4-(2-methylpiperidino)]nitrobenzene
Conditions | Yield |
---|---|
With triethylamine In methanol at 50 - 60℃; for 28h; | 99% |
With triethylamine In methanol at 50 - 60℃; for 28h; | 99% |
4,4-dimethyl-4-silapiperidine hydrochloride
3,4-difluoronitrobenzene
1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane
Conditions | Yield |
---|---|
Stage #1: 4,4-dimethyl-4-silapiperidine hydrochloride With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 0 - 20℃; for 12h; | 99% |
Stage #1: 4,4-dimethyl-4-silapiperidine hydrochloride With triethylamine In ethyl acetate at 25℃; for 0.166667h; Stage #2: 3,4-difluoronitrobenzene In ethyl acetate at 0 - 25℃; for 6h; | 70% |
Stage #1: 4,4-dimethyl-4-silapiperidine hydrochloride With triethylamine In ethyl acetate at 25℃; for 0.166667h; Stage #2: 3,4-difluoronitrobenzene In ethyl acetate at 0 - 25℃; for 6h; | 70% |
With triethylamine In ethyl acetate at 0 - 20℃; for 6h; Inert atmosphere; | 69% |
Stage #1: 4,4-dimethyl-4-silapiperidine hydrochloride With triethylamine In N,N-dimethyl-formamide at 20 - 25℃; for 0.166667h; Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 20 - 25℃; Cooling with ice; | 28.1 g |
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 20℃; for 19h; | 99% |
With potassium carbonate In dimethyl sulfoxide at 20℃; for 19h; | 99% |
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 20℃; for 23h; | 99% |
With potassium carbonate In dimethyl sulfoxide at 20℃; for 23h; | 99% |
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 20℃; for 22h; | 99% |
With potassium carbonate In dimethyl sulfoxide at 20℃; for 22h; | 99% |
4-piperidinemethanol
3,4-difluoronitrobenzene
(1-(2-fluoro-4-nitrophenyl)piperidin-4-yl)methanol
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 0 - 25℃; for 12h; | 98.8% |
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 100℃; |
3,4-difluoronitrobenzene
6-bromo-1-methyl-1H-indazol-5-ol
6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 60 - 65℃; for 15h; Large scale; | 98.1% |
With potassium carbonate In tetrahydrofuran at 55℃; for 14h; | 72% |
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