3,4-Difluoronitrobenzene supplier

Name
3,4-Difluoronitrobenzene
EINECS 206-718-2
CAS No. 369-34-6
Article Data28
CAS DataBase
Density 1.45 g/cm³
Solubility insoluble in water
Melting Point -12 °C
Formula C₆H₃F₂NO₂
Boiling Point 200 °C at 760 mmHg
Molecular Weight 159.092
Flash Point 80.6 °C
Transport Information
Appearance clear yellow liquid
Safety 26-36/37/39
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xi,Xn
Synonyms Benzene, 1,2-difluoro-4-nitro-;1,2-Difluoro-4-nitrobenzene;3,4-Difluoro nitrobenzene;3,4-Difluoro-1-Nitrobenzene;2,4-Difluoro Nitrobenzene;
PSA 45.82000
LogP 2.39620

Synthetic route

: 367-11-3
ortho-difluorobenzene

: 369-34-6
3,4-difluoronitrobenzene

Conditions

Conditions	Yield
With molecular sieve; nitric acid; acetic anhydride at 0℃; for 3h; other reagent: nitric acid/sulfuric acid;	98%
With sulfuric acid; nitric acid at 20℃; for 0.0180556h; Temperature;	97.3%
With sulfuric acid; nitric acid at 60 - 70℃; for 6h;	91%

: 20372-63-8
4,5-difluoro-2-nitrobenzoic acid

: 369-34-6
3,4-difluoronitrobenzene

Conditions

Conditions	Yield
With copper In 1-methyl-pyrrolidin-2-one at 250℃; for 0.5h;	94%

: 99-54-7
3,4-dichloronitrobenzene

A: 369-34-6
3,4-difluoronitrobenzene

B: 350-30-1
3-chloro-4-fluoronitrobenzene

Conditions

Conditions	Yield
With potassium fluoride; tetraphenylphosphonium bromide at 175 - 195℃; for 30h; Yields of byproduct given;	A n/a B 79%
With potassium fluoride; 2-(4-chlorophenyl)propene copolymer-grafted tetraphenylphosphonium chloride; cross-linked styrene In sulfolane at 210℃; for 7h;	A 12% B 64%
With potassium fluoride; tetraphenylphosphonium bromide at 175 - 195℃; for 30h; Yield given. Yields of byproduct given;

: 97-00-7
1-chloro-2,4-dinitro-benzene

: 369-34-6
3,4-difluoronitrobenzene

Conditions

Conditions	Yield
With potassium fluoride; 3,4,5,6-tetrafluorophthaloyldifluoride In sulfolane at 200℃; for 13h;	77%

: 70-34-8
2,4-Dinitrofluorobenzene

: 369-34-6
3,4-difluoronitrobenzene

Conditions

Conditions	Yield
With potassium fluoride; benzene-1,2,4,5-tetracarbonyl chloride In sulfolane at 200℃; for 4h;	58%

: 350-46-9
4-Fluoronitrobenzene

: 369-34-6
3,4-difluoronitrobenzene

Conditions

Conditions	Yield
With formic acid; fluorine at 10℃; for 1.75h; Fluorination;	53%

: 97-00-7
1-chloro-2,4-dinitro-benzene

A: 369-34-6
3,4-difluoronitrobenzene

B: 364-74-9
1,4-difluoro-2-nitrobenzene

Conditions

Conditions	Yield
With potassium fluoride; tetraphenylphosphonium bromide; Phthaloyl dichloride In sulfolane; toluene at 190℃; for 6h;	A 46% B 3 % Chromat.
With potassium fluoride; Phthaloyl dichloride; tetraphenylphosphonium bromide In sulfolane 1) 150 deg C, 2 h, 2) 190 deg C, 6 h;	A 46% B 3%

: 70-34-8
2,4-Dinitrofluorobenzene

A: 369-34-6
3,4-difluoronitrobenzene

B: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

Conditions

Conditions	Yield
With potassium fluoride at 145℃;
With potassium fluoride at 155℃;

: 97-00-7
1-chloro-2,4-dinitro-benzene

A: 369-34-6
3,4-difluoronitrobenzene

B: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

Conditions

Conditions	Yield
With potassium fluoride at 155℃;
With potassium fluoride at 145℃;

: 115561-03-0
1-fluoro-2-fluorosulfonyl-4-nitrobenzene

A: 369-34-6
3,4-difluoronitrobenzene

B: 62094-86-4
2,5-difluorobenzenesulfonyl fluoride

Conditions

Conditions	Yield
With potassium fluoride; tetraphenylphosphonium bromide In sulfolane; toluene at 210℃; under 300 Torr; Title compound not separated from byproducts;
With potassium fluoride; tetraphenylphosphonium bromide In sulfolane at 210℃; under 270 - 300 Torr; for 5h; Yield given. Yields of byproduct given;

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 97-00-7
1-chloro-2,4-dinitro-benzene

potassium fluoride: potassium fluoride

: 369-34-6
3,4-difluoronitrobenzene

Conditions

Conditions	Yield
at 150℃;

...Expand

2-fluoro-5-nitro-benzenediazonium-tetrafluoroborate: 2-fluoro-5-nitro-benzenediazonium-tetrafluoroborate

: 369-34-6
3,4-difluoronitrobenzene

Conditions

Conditions	Yield
at 160℃; under 20 Torr;

: 946-30-5
2-chloro-5-nitrobenzenesulphonic acid sodium salt

: 369-34-6
3,4-difluoronitrobenzene

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 80 percent / phosphoryl chloride / acetonitrile; tetrahydrothiophene 1,1-dioxide; N,N-dimethyl-acetamide / 1 h / 70 °C 2: 90 percent / Ph4PBr, KF / tetrahydrothiophene 1,1-dioxide / 16 h / 130 - 140 °C 3: KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 300 Torr View Scheme

: 100-00-5
4-chlorobenzonitrile

: 369-34-6
3,4-difluoronitrobenzene

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 100 percent / 1) 30percent fumic H2SO4 2) NaOH / 16 h / 110 - 115 °C 2: 80 percent / phosphoryl chloride / acetonitrile; tetrahydrothiophene 1,1-dioxide; N,N-dimethyl-acetamide / 1 h / 70 °C 3: 90 percent / Ph4PBr, KF / tetrahydrothiophene 1,1-dioxide / 16 h / 130 - 140 °C 4: KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 300 Torr View Scheme

Yield

Multi-step reaction with 4 steps
1: 100 percent / 1) 30percent fumic H2SO4 2) NaOH / 16 h / 110 - 115 °C
2: 80 percent / phosphoryl chloride / acetonitrile; tetrahydrothiophene 1,1-dioxide; N,N-dimethyl-acetamide / 1 h / 70 °C
3: 90 percent / Ph4PBr, KF / tetrahydrothiophene 1,1-dioxide / 16 h / 130 - 140 °C
4: KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 300 Torr
View Scheme

: 4533-95-3
5-nitro-2-chlorobenzenesulfonyl chloride

: 369-34-6
3,4-difluoronitrobenzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / Ph4PBr, KF / tetrahydrothiophene 1,1-dioxide / 16 h / 130 - 140 °C 2: KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 300 Torr View Scheme

: 611-06-3
2,4-dichloronitrobenzene

: 99-54-7
3,4-dichloronitrobenzene

: 369-34-6
3,4-difluoronitrobenzene

Conditions

Conditions	Yield
With potassium fluoride In sulfolane

: 350-30-1
3-chloro-4-fluoronitrobenzene

: 369-34-6
3,4-difluoronitrobenzene

Conditions

Conditions	Yield
With potassium fluoride; cesium fluoride In sulfolane
With potassium fluoride In sulfolane; dichloromethane
With potassium fluoride; bis(triphenylphosphine)iminium chloride In dimethyl sulfoxide at 150℃; for 8h; Inert atmosphere;	5 %Chromat.

: 771-69-7
2,3,4-trifluoronitrobenzene

A: 369-34-6
3,4-difluoronitrobenzene

B: 6921-22-8
1,2-difluoro-3-nitrobenzene

C: 3862-73-5
2,3,4-trifluoroaniline

Conditions

Conditions	Yield
With Dimethylphenylsilane; o-phenylenebis(diphenylphosphine); potassium tert-butylate; copper(l) chloride In tetrahydrofuran for 12h; Inert atmosphere; Reflux; Overall yield = 95 %Spectr.; regioselective reaction;

...Expand

: 98-95-3
nitrobenzene

A: 402-67-5
3-fluoro-1-nitrobenzene

B: 369-34-6
3,4-difluoronitrobenzene

C: 364-74-9
1,4-difluoro-2-nitrobenzene

D: 350-46-9
4-Fluoronitrobenzene

E: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With xenon difluoride; boron trifluoride diethyl etherate at 0 - 25℃; Reagent/catalyst; Cooling with ice;	A 0.16 mmol B 0.001 mmol C 0.016 mmol D 0.01 mmol E 0.05 mmol

...Expand

: 110-91-8
morpholine

: 369-34-6
3,4-difluoronitrobenzene

: 2689-39-6
3-fluoro-4-(4-morpholinyl)nitrobenzene

Conditions

Conditions	Yield
Stage #1: morpholine; 3,4-difluoronitrobenzene In tetrahydrofuran at 0 - 20℃; for 1.25h; Stage #2: With citric acid In tetrahydrofuran; water for 1h;	100%
In tetrahydrofuran at 0 - 20℃; for 1.25h;	100%
In tetrahydrofuran at 20℃; for 1.25h; Cooling with ice-salt bath;	100%

: 75-77-4
chloro-trimethyl-silane

: 369-34-6
3,4-difluoronitrobenzene

: (2,3-difluoro-6-nitrophenyl)trimethylsilane

Conditions

Conditions	Yield
With sodium hexamethyldisilazane In tetrahydrofuran at -78℃;	100%

: 626-58-4
4-methylpiperidin

: 369-34-6
3,4-difluoronitrobenzene

: 250371-81-4
3-fluoro-4-(4-methyl-1-piperidinyl)nitrobenzene

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 17h; Heating;	100%
In acetonitrile at 80℃; for 16h;

: 54903-50-3
4,5,6,7-tetrahydrothieno[3,2-c]pyridine

: 369-34-6
3,4-difluoronitrobenzene

: 765314-18-9
5-(2-fluoro-4-nitrophenyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine

Conditions

Conditions	Yield
In acetonitrile at 75 - 78℃; for 2h;	100%

: 924909-16-0, 370866-00-5
1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol

: 369-34-6
3,4-difluoronitrobenzene

: 949556-47-2
4-(2-fluoro-4-nitrophenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 100℃; for 1h;	100%
With caesium carbonate In ISOPROPYLAMIDE at 100℃; for 1h;	82%
With caesium carbonate In ISOPROPYLAMIDE at 100℃; for 1h;	82%

: 369-34-6
3,4-difluoronitrobenzene

: 593-51-1
methylamine hydrochloride

: 124431-92-1
N-methyl-2-fluoro-4-nitroaniline

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 24h;	100%

: 369-34-6
3,4-difluoronitrobenzene

: 64051-79-2
piperidin-3-ol hydrochloride

: 916988-48-2
1-(2-fluoro-4-nitrophenyl)-piperidin-3-ol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50 - 60℃; for 3h;	100%

: 369-34-6
3,4-difluoronitrobenzene

: 105-53-3
diethyl malonate

: 318471-58-8
1,3-diethyl 2-(2-fluoro-4-nitrophenyl)propanedioate

Conditions

Conditions	Yield
Stage #1: diethyl malonate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 70℃;	100%
Stage #1: diethyl malonate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide; mineral oil at 70℃;	86%
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 5h;	80%
Stage #1: diethyl malonate With sodium hydride In dimethyl sulfoxide at 0 - 20℃; for 2.16667h; Stage #2: 3,4-difluoronitrobenzene In dimethyl sulfoxide at 0 - 20℃; for 2h;
Stage #1: diethyl malonate With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1.5h; Inert atmosphere; Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 0 - 20℃;	13 g

: 369-34-6
3,4-difluoronitrobenzene

: 141-43-5
ethanolamine

: 2-(2-fluoro-4-nitrophenylamino)ethanol

Conditions

Conditions	Yield
In acetonitrile for 4h; Reflux;	100%
In acetonitrile for 4h; Reflux;	100%
In acetonitrile for 4h; Reflux;	73%
In acetonitrile for 4h; Reflux;

: 369-34-6
3,4-difluoronitrobenzene

: 1354786-75-6
3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-ol

: 1354786-76-7
5-[4-(2-Fluoro-4-nitrophenoxy)biphenyl-3-yl]-1-methyl-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-ol With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 20℃; for 16h;	100%

: 369-34-6
3,4-difluoronitrobenzene

: 29799-07-3
4-adamantylphenol

: (3r,5r,7r)-1-(4-(2-fluoro-4-nitrophenoxy)phenyl)adamantane

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 20℃; for 4h;	100%
With potassium carbonate In dimethyl sulfoxide at 20℃; for 4h;	703mg

: 369-34-6
3,4-difluoronitrobenzene

: 127350-92-9
3-fluoro-4-hydrazinonitrobenzene

Conditions

Conditions	Yield
With hydrazine In ethanol at 80℃; for 2h;	99.2%
With pyridine; hydrazine hydrate at 20℃; for 0.833333h;	98%
With potassium carbonate; hydrazine hydrate In acetonitrile	94%

: 123-90-0
Thiomorpholin

: 369-34-6
3,4-difluoronitrobenzene

: 168828-70-4
(4-(2-fluoro-4-nitrophenyl)thiomorpholine)

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile 1.) RT, 2.) reflux, 24 h;	99%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 140℃; for 0.25h; Microwave irradiation;	99%
Stage #1: Thiomorpholin With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.5h; Inert atmosphere; Stage #2: 3,4-difluoronitrobenzene In acetonitrile Inert atmosphere; Reflux;	99%

: 110-85-0
piperazine

: 369-34-6
3,4-difluoronitrobenzene

: 154590-33-7
1-(2-fluoro-4-nitrophenyl)piperazine

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 2h;	99%
In acetonitrile at 80℃; for 6h;	98%
In acetonitrile at 80℃; for 3h;	97.7%

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 369-34-6
3,4-difluoronitrobenzene

: 449175-25-1
N-(2-fluoro-4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline

Conditions

Conditions	Yield
In acetonitrile for 5.5h; Heating / reflux;	99%
With potassium carbonate In dimethyl sulfoxide for 1h; Substitution; Heating;	93%
With triethylamine In ethyl acetate for 3h; Heating / reflux;

: 110-89-4
piperidine

: 369-34-6
3,4-difluoronitrobenzene

: 172967-04-3
1-(2-fluoro-4-nitrophenyl)piperidine

Conditions

Conditions	Yield
With triethylamine In ethyl acetate at 20℃;	99%
With triethylamine In ethyl acetate at 20℃;	99%
With triethylamine In ethyl acetate at 20℃;	99%

: 111-49-9
hexamethylene imine

: 369-34-6
3,4-difluoronitrobenzene

: 250371-80-3
1-(2-fluoro-4-nitrophenyl)azepane

Conditions

Conditions	Yield
Stage #1: hexamethylene imine With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.5h; Inert atmosphere; Stage #2: 3,4-difluoronitrobenzene In acetonitrile Inert atmosphere; Reflux;	99%
With N-ethyl-N,N-diisopropylamine In acetonitrile for 17h; Heating;
With caesium carbonate In DMF (N,N-dimethyl-formamide)
With caesium carbonate In N,N-dimethyl-formamide
With triethylamine In ethyl acetate at 80℃; for 20h;

: 5856-63-3
(2R)-2-aminobutan-1-ol

: 369-34-6
3,4-difluoronitrobenzene

: 329229-75-6
(2R)-(+)-2-(2-fluoro-4-nitrophenyl)amino-1-butanol

Conditions

Conditions	Yield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 90℃; for 12h;	99%

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: 369-34-6
3,4-difluoronitrobenzene

: 677727-07-0
2-[2-Fluoro(methyl)-4-nitroanilino]ethanol

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 100℃; for 1.5h;	99%
With N-ethyl-N,N-diisopropylamine In ethyl acetate at 0 - 20℃; for 24h;	79%

: 4606-65-9
3-(hydroxymethy)piperidine

: 369-34-6
3,4-difluoronitrobenzene

: 1097722-40-1
[3-fluoro-4-(3-hydroxymethylpiperidino)]nitrobenzene

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 1h;	99%
With triethylamine In methanol at 50 - 60℃; for 24h;	96%
With triethylamine In methanol at 50 - 60℃; for 24h;	96%

: 369-34-6
3,4-difluoronitrobenzene

: 100-53-8
phenylmethanethiol

: 1242618-52-5
1-(benzylsulfanyl)-2-fluoro-4-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h; regioselective reaction;	99%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 2h;	96%
With potassium carbonate In N,N-dimethyl-formamide at 15℃; for 3h;

: 369-34-6
3,4-difluoronitrobenzene

: 109-89-7
diethylamine

: 2689-37-4
N,N-diethyl-2-fluoro-4-nitroaniline

Conditions

Conditions	Yield
With triethylamine In ethyl acetate for 0.5h;	99%
With triethylamine In ethyl acetate at 20℃; for 0.5h; Cooling with ice;	99%
With triethylamine In ethyl acetate for 0.5h; Cooling with ice;	99%
With triethylamine In methanol at 50 - 60℃; for 24h;	81%
With triethylamine In methanol at 50 - 60℃; for 24h;	81%

: 369-34-6
3,4-difluoronitrobenzene

: 109-05-7, 3000-79-1
2-Methylpiperidin

: 423736-55-4
[3-fluoro-4-(2-methylpiperidino)]nitrobenzene

Conditions

Conditions	Yield
With triethylamine In methanol at 50 - 60℃; for 28h;	99%
With triethylamine In methanol at 50 - 60℃; for 28h;	99%

: 130596-62-2
4,4-dimethyl-4-silapiperidine hydrochloride

: 369-34-6
3,4-difluoronitrobenzene

: 1430321-42-8
1-(2-fluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

Conditions

Conditions	Yield
Stage #1: 4,4-dimethyl-4-silapiperidine hydrochloride With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 0 - 20℃; for 12h;	99%
Stage #1: 4,4-dimethyl-4-silapiperidine hydrochloride With triethylamine In ethyl acetate at 25℃; for 0.166667h; Stage #2: 3,4-difluoronitrobenzene In ethyl acetate at 0 - 25℃; for 6h;	70%
Stage #1: 4,4-dimethyl-4-silapiperidine hydrochloride With triethylamine In ethyl acetate at 25℃; for 0.166667h; Stage #2: 3,4-difluoronitrobenzene In ethyl acetate at 0 - 25℃; for 6h;	70%
With triethylamine In ethyl acetate at 0 - 20℃; for 6h; Inert atmosphere;	69%
Stage #1: 4,4-dimethyl-4-silapiperidine hydrochloride With triethylamine In N,N-dimethyl-formamide at 20 - 25℃; for 0.166667h; Stage #2: 3,4-difluoronitrobenzene In N,N-dimethyl-formamide at 20 - 25℃; Cooling with ice;	28.1 g

: 98-54-4
para-tert-butylphenol

: 369-34-6
3,4-difluoronitrobenzene

: 1-(4-(tert-butyl)phenoxy)-2-fluoro-4-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 20℃; for 19h;	99%
With potassium carbonate In dimethyl sulfoxide at 20℃; for 19h;	99%

: 369-34-6
3,4-difluoronitrobenzene

: 1131-60-8
p-cyclohexylphenol

: 1-(4-cyclohexylphenoxy)-2-fluoro-4-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 20℃; for 23h;	99%
With potassium carbonate In dimethyl sulfoxide at 20℃; for 23h;	99%

: 80-46-6
4-t-amylphenol

: 369-34-6
3,4-difluoronitrobenzene

: 2-fluoro-4-nitro-1-(4-(tert-pentyl)phenoxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 20℃; for 22h;	99%
With potassium carbonate In dimethyl sulfoxide at 20℃; for 22h;	99%

: 6457-49-4
4-piperidinemethanol

: 369-34-6
3,4-difluoronitrobenzene

: 1260805-31-9
(1-(2-fluoro-4-nitrophenyl)piperidin-4-yl)methanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 25℃; for 12h;	98.8%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 100℃;

: 369-34-6
3,4-difluoronitrobenzene

: 1403767-19-0
6-bromo-1-methyl-1H-indazol-5-ol

: 1206800-24-9
6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-methyl-1H-indazole

Conditions

Conditions	Yield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 60 - 65℃; for 15h; Large scale;	98.1%
With potassium carbonate In tetrahydrofuran at 55℃; for 14h;	72%

3,4-Difluoronitrobenzene Chemical Properties

IUPAC Name: 1,2-difluoro-4-nitrobenzene
Synonyms of 3,4-Difluoronitrobenzene (CAS NO.369-34-6): 1,2-Difluoro-4-nitrobenzene ; Benzene, 1,2-difluoro-4-nitro-
CAS NO: 369-34-6
Molecular Formula: C₆H₃F₂NO₂
Molecular Weight: 159.09
Molecular Structure:
EINECS: 206-718-2
H bond acceptors: 3
H bond donors: 0
Freely Rotating Bonds: 1
Polar Surface Area: 45.82 Å²
Index of Refraction: 1.509
Molar Refractivity: 32.78 cm³
Molar Volume: 109.6 cm³
Surface Tension: 40.6 dyne/cm
Density: 1.45 g/cm³
Flash Point: 80.6 °C
Enthalpy of Vaporization: 41.84 kJ/mol
Boiling Point: 200 °C at 760 mmHg
Vapour Pressure: 0.469 mmHg at 25°C
Melting Point: -12°C
Water Solubility: insoluble
Appearance: clear yellow liquid
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong bases
Product Categories: HALIDE;Aromatic Halides (substituted);Fluorine Compounds;Nitro Compounds

3,4-Difluoronitrobenzene Uses

3,4-Difluoronitrobenzene (CAS NO.369-34-6) is used as intermediates in medicine, pesticide.

3,4-Difluoronitrobenzene Safety Profile

Safety Information about 3,4-Difluoronitrobenzene (CAS NO.369-34-6)
Hazard Codes: Irritant Xi,Xn
Risk Statements: 36/37/38-20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 2810
WGK Germany: 3
RTECS: CZ5710000
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III

3,4-Difluoronitrobenzene Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Combustible liquid.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container.

Product Name

3,4-Difluoronitrobenzene

Synthetic route

3,4-Difluoronitrobenzene Chemical Properties

3,4-Difluoronitrobenzene Uses

3,4-Difluoronitrobenzene Safety Profile

3,4-Difluoronitrobenzene Specification

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