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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Acetamide, N-[(2S)-2-(Acetyloxy)-3-Chloropropyl]- supplier in China

Cas:183905-31-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Acetamide, N-[(2S)-2-(Acetyloxy)-3-Chloropropyl]-

Cas:183905-31-9

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(S)-N-[2-(Acetyloxy)-3-chloropropyl]acetamide

Cas:183905-31-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

N-[(2S)-2-(acetyloxy)-3-chloropropyl]-acetamide

Cas:183905-31-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Acetamide CAS NO:183905-31-9 Grade:Medical scientific research and export Molecular formula: C7H12NCl Molecular weight:193.5 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data s

Acetamide/ CAS:183905-31-9 /Acetamide raw material/ high-quality

Cas:183905-31-9

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1486.html Product Name (S)-1-[(Acetylamino)methyl]-2-ch

(S)-1-[(Acetylamino)methyl]-2-chloroethyl acetate

Cas:183905-31-9

Min.Order:1 Gram

FOB Price: $4.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company

TIANFU-CHEM -AcetaMide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]-

Cas:183905-31-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

AcetaMide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]-

Cas:183905-31-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 183905-31-9 with competitive price

Cas:183905-31-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: (S)-N-[2-(Acetyloxy)-3-chloropropyl]acetamide Synonyms: Acetamide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]-; N-[(2S)-2-(acetyloxy)-3-chloropropyl]-acetamide; Intermediate of Linezolid 1; (S)-1-[(Acetylamino)methyl]-2-chloroethyl acetate CAS: 18

(S)-N-[2-(Acetyloxy)-3-chloropropyl]acetamide CAS:183905-31-9

Cas:183905-31-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

AcetaMide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]- CAS NO 183905-31-9

Cas:183905-31-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Acetamide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]- 183905-31-9

Cas:183905-31-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

AcetaMide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]- 99%

Cas:183905-31-9

Min.Order:1 Kilogram

FOB Price: $86.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

AcetaMide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]- CAS:183905-31-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializin

AcetaMide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]- CAS:183905-31-9

Cas:183905-31-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Acetamide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]-

Cas:183905-31-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Acetamide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]-

Cas:183905-31-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c

Acetamide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]-

Cas:183905-31-9

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

AcetaMide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]-

Cas:183905-31-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

AcetaMide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]-

Cas:183905-31-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(S)-1-ACETAMIDO-3-CHLOROPROPAN-2-YL ACETATE

Cas:183905-31-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

AcetaMide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]-

Cas:183905-31-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

AcetaMide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]-

Cas:183905-31-9

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Shanghai Send Pharmaceutical Technology Co., Ltd.

low price high quality high purity good sevice stock Appearance:off-White Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical int

AcetaMide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]-

Cas:183905-31-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

(S)-1-Acetamido-3-chloropropan-2-yl acetate

Cas:183905-31-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Acetamide, N-[(2S)-2-(Acetyloxy)-3-Chloropropyl]-

Cas:183905-31-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

AcetaMide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]-

Cas:183905-31-9

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical

(S)-N-[2-(Acetyloxy)-3-chloropropyl]acetamide

Cas:183905-31-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Acetamide, N-[(2S)-2-(acetyloxy)-3-chloropropyl]-

Cas:183905-31-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: (S)-N-[2-(Acetyloxy)-3-Chloropropyl]acetamide CAS No.: 183905-31-9 Molecule Formula:C7H12ClNO3 Molecule Weight:No Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

Lower Price (S)-N-[2-(Acetyloxy)-3-Chloropropyl]acetamide

Cas:183905-31-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

acetic anhydride
108-24-7

acetic anhydride

(S)-1-amino-3-chloropropan-2-ol
53494-57-8

(S)-1-amino-3-chloropropan-2-ol

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

Conditions
ConditionsYield
With triethylamine at 0 - 20℃; for 4h;98%
With pyridine In tetrahydrofuran at 35 - 45℃; for 12h;
(S)-1-amino-3-chloro-2-propanol hydrochloride

(S)-1-amino-3-chloro-2-propanol hydrochloride

acetic anhydride
108-24-7

acetic anhydride

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 30℃; for 20h;90.6%
acetic anhydride
108-24-7

acetic anhydride

(2S)-1-amino-3-chloropropan-2-ol hydrogen chloride

(2S)-1-amino-3-chloropropan-2-ol hydrogen chloride

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 20 - 40℃; for 22h;89%
With pyridine In dichloromethane at 18 - 40℃; for 5h;75%
With pyridine at 20℃;47.98%
(S)-1-amino-3-chloro-2-propanol hydrochloride

(S)-1-amino-3-chloro-2-propanol hydrochloride

acetyl chloride
75-36-5

acetyl chloride

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 10h;86.1%
acetic anhydride
108-24-7

acetic anhydride

(2S)-1-amino-3-chloropropan-2-ol hydrogen chloride

(2S)-1-amino-3-chloropropan-2-ol hydrogen chloride

A

(1S)-2-{acetyl[(2S)-2-(acetyloxy)-3-chloropropyl]amino}-1-(chloromethyl)ethyl acetate

(1S)-2-{acetyl[(2S)-2-(acetyloxy)-3-chloropropyl]amino}-1-(chloromethyl)ethyl acetate

B

(1S)-2-{bis[(2S)-2-(acetyloxy)-3-chloropropyl]amino}-1-(chloromethyl)ethyl acetate

(1S)-2-{bis[(2S)-2-(acetyloxy)-3-chloropropyl]amino}-1-(chloromethyl)ethyl acetate

C

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

Conditions
ConditionsYield
With pyridine In dichloromethane for 19h; Time; Temperature;A n/a
B 0.27%
C 82.9%
(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine
168828-90-8

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

(R)-1-acetamido-3-((((S)-3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)amino)propan-2-yl acetate

(R)-1-acetamido-3-((((S)-3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)amino)propan-2-yl acetate

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 2h;97.9%
[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester
1313613-18-1

[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

(S)-N-[{3-(4-(3-oxomorpholin-4-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl}methyl]acetamide
1429334-00-8

(S)-N-[{3-(4-(3-oxomorpholin-4-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl}methyl]acetamide

Conditions
ConditionsYield
With lithium tert-butoxide In dichloromethane; N,N-dimethyl-formamide for 10h; Reagent/catalyst; Reflux;93%
N-ethoxycarbonyl-3-fluoro-4-morpholinyl aniline
565176-83-2

N-ethoxycarbonyl-3-fluoro-4-morpholinyl aniline

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
With lithium; tert-butyl alcohol In tetrahydrofuran; N,N-dimethyl acetamide; isopropyl alcohol at 0 - 20℃; Reagent/catalyst; Solvent; Concentration;90.3%
N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

N-[(2S)oxiranylmethyl]acetamide
183805-10-9

N-[(2S)oxiranylmethyl]acetamide

Conditions
ConditionsYield
With potassium carbonate In methanol for 2h; Ambient temperature;89%
(1-fluoro-5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-carbamic acid ethyl ester
741721-41-5

(1-fluoro-5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-carbamic acid ethyl ester

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

(S)-N-[3-(1-fluoro-5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide
741721-36-8

(S)-N-[3-(1-fluoro-5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

Conditions
ConditionsYield
Stage #1: (1-fluoro-5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-carbamic acid ethyl ester With methanol; lithium tert-butoxide In DMF (N,N-dimethyl-formamide); hexane at 20℃; for 3.5h;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In DMF (N,N-dimethyl-formamide); hexane at 20℃; for 18.5h;
88%
With lithium tert-butoxide In hexane; N,N-dimethyl-formamide
benzyl-carbamic acid benzyl ester
39896-97-4

benzyl-carbamic acid benzyl ester

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

C13H16N2O3

C13H16N2O3

Conditions
ConditionsYield
Stage #1: benzyl-carbamic acid benzyl ester With lithium tert-butoxide In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In tetrahydrofuran; methanol at 10 - 25℃; for 15.5h;
82.7%
(4-bromo-3-fluoro-phenyl)-carbamic acid methyl ester
396076-65-6

(4-bromo-3-fluoro-phenyl)-carbamic acid methyl ester

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

(5S)-N-[[3-(3-fluoro-4-bromophenyl)-2-oxo-oxazolidin-5-yl]methyl]acetamide
856677-05-9

(5S)-N-[[3-(3-fluoro-4-bromophenyl)-2-oxo-oxazolidin-5-yl]methyl]acetamide

Conditions
ConditionsYield
Stage #1: (4-bromo-3-fluoro-phenyl)-carbamic acid methyl ester With lithium tert-butoxide In methanol; N,N-dimethyl-formamide at 5℃; for 1.5h; Inert atmosphere;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In methanol; N,N-dimethyl-formamide at 25℃; for 20h; Inert atmosphere;
82.5%
With lithium tert-butoxide In methanol; N,N-dimethyl-formamide at 20℃; for 20h;
[4-(3,6-dihydro-2H-pyridin-1-yl)-3-fluoro-phenyl]-carbamic acid benzyl ester
847256-99-9

[4-(3,6-dihydro-2H-pyridin-1-yl)-3-fluoro-phenyl]-carbamic acid benzyl ester

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

N-{3-[4-(3,6-dihydro-2H-pyridin-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
847257-00-5

N-{3-[4-(3,6-dihydro-2H-pyridin-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide

Conditions
ConditionsYield
Stage #1: [4-(3,6-dihydro-2H-pyridin-1-yl)-3-fluoro-phenyl]-carbamic acid benzyl ester With lithium tert-butoxide In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide) at 0 - 20℃;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide) at 0 - 20℃;
82%
N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline
1416314-75-4

N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

(S)-N-((3-(3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)-phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
1416314-55-0

(S)-N-((3-(3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)-phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Conditions
ConditionsYield
Stage #1: N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline; N-[(2S)-2-acetoxy-3-chloropropyl]acetamide With methanol In tetrahydrofuran at -5℃; for 0.166667h; Inert atmosphere;
Stage #2: With lithium tert-butoxide In tetrahydrofuran at -5 - 17℃; for 16h; Inert atmosphere;
Stage #3: With acetic acid In tetrahydrofuran at 10℃; for 0.5h; Inert atmosphere;
82%
With lithium tert-butoxide In tetrahydrofuran; methanol at -5 - 20℃; Concentration; Inert atmosphere; Large scale;82%
Stage #1: N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline With lithium tert-butoxide In tetrahydrofuran for 0.0833333h; Inert atmosphere; Cooling with ice;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In tetrahydrofuran at 20℃; for 36h; Cooling with ice;
38.2%
Stage #1: N-benzyloxycarbonyl-3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)aniline With lithium tert-butoxide In tetrahydrofuran for 0.0833333h; Inert atmosphere; Cooling with ice;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In tetrahydrofuran at 20℃; for 36h;
38.2%
benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate
168828-81-7, 1027135-00-7

benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
Stage #1: benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate With lithium tert-butoxide In tetrahydrofuran; methanol; N,N-dimethyl-formamide
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide at 21℃; for 21h; Solvent;
80.6%
Stage #1: benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate With lithium tert-butoxide In tetrahydrofuran; methanol at 10 - 25℃; Large scale;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide at 8℃; Temperature; Large scale;
With lithium tert-butoxide In tetrahydrofuran; methanol at 20℃; for 16h;83 g
Stage #1: benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate With lithium tert-butoxide In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 0 - 5℃; for 4h; Inert atmosphere;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 0 - 20℃; for 46h; Temperature; Inert atmosphere;
isobutyl 4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluorophenylcarbamate
473871-38-4

isobutyl 4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluorophenylcarbamate

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

PNU-288034

PNU-288034

Conditions
ConditionsYield
Stage #1: isobutyl 4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluorophenylcarbamate; N-[(2S)-2-acetoxy-3-chloropropyl]acetamide With methanol In acetonitrile at 0 - 5℃; Large scale;
Stage #2: With lithium tert-butoxide In tetrahydrofuran; acetonitrile at 16℃; Temperature; Time; Solvent; Large scale;
80.3%
With lithium tert-butoxide In tetrahydrofuran; methanol; acetonitrile at 4 - 16℃; for 15.5h; Solvent; Time; Temperature;77.6%
(3-fluoro-4-iodophenyl)carbamic acid methyl ester

(3-fluoro-4-iodophenyl)carbamic acid methyl ester

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

(S)-N-[3-(3-fluoro-4-iodophenyl)-2-oxo-1,3-oxazolidine-5-ylmethyl]acetamide
149524-45-8

(S)-N-[3-(3-fluoro-4-iodophenyl)-2-oxo-1,3-oxazolidine-5-ylmethyl]acetamide

Conditions
ConditionsYield
Stage #1: (3-fluoro-4-iodophenyl)carbamic acid methyl ester With lithium tert-butoxide In methanol; N,N-dimethyl-formamide at 45℃; for 1.5h; Inert atmosphere;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In methanol; N,N-dimethyl-formamide at 20℃; for 30h; Inert atmosphere;
79.5%
Stage #1: (3-fluoro-4-iodophenyl)carbamic acid methyl ester With lithium tert-butoxide In N,N-dimethyl-formamide at 30 - 35℃; for 1h; Inert atmosphere;
Stage #2: With methanol In N,N-dimethyl-formamide at 5 - 10℃; for 1.5h; Inert atmosphere;
Stage #3: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;
79.5%
Stage #1: (3-fluoro-4-iodophenyl)carbamic acid methyl ester With lithium tert-butoxide In N,N-dimethyl-formamide at 30 - 35℃; for 1h; Inert atmosphere;
Stage #2: With methanol In N,N-dimethyl-formamide at 5 - 10℃; for 1.5h; Inert atmosphere;
Stage #3: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In N,N-dimethyl-formamide at 10 - 20℃; for 24h; Inert atmosphere;
79.5%
In methanol at 25℃; for 24h;
methyl N-(3-iodo-4-fluorophenyl)carbamate

methyl N-(3-iodo-4-fluorophenyl)carbamate

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

(S)-N-[3-(3-fluoro-4-iodophenyl)-2-oxo-1,3-oxazolidine-5-ylmethyl]acetamide
149524-45-8

(S)-N-[3-(3-fluoro-4-iodophenyl)-2-oxo-1,3-oxazolidine-5-ylmethyl]acetamide

Conditions
ConditionsYield
Stage #1: methyl N-(3-iodo-4-fluorophenyl)carbamate With methanol; potassium tert-butylate In N,N-dimethyl-formamide at 0 - 5℃; for 1.5h; Inert atmosphere;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;
79.5%
N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

benzyl benzyl(4-(((benzyloxy)carbonyl)amino)-2-fluorophenyl)carbamate
181997-29-5

benzyl benzyl(4-(((benzyloxy)carbonyl)amino)-2-fluorophenyl)carbamate

benzyl 4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl(benzyl)carbamate
182059-57-0

benzyl 4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl(benzyl)carbamate

Conditions
ConditionsYield
Stage #1: benzyl benzyl(4-{[(benzyloxy)carbonyl]amino}-2-fluorophenyl)carbamate With lithium tert-butoxide In tetrahydrofuran at -5℃; for 0.25h; Inert atmosphere;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide With acetic acid In tetrahydrofuran; methanol at 0 - 5℃; for 17h;
79%
Stage #1: benzyl benzyl(4-{[(benzyloxy)carbonyl]amino}-2-fluorophenyl)carbamate With lithium tert-butoxide In tetrahydrofuran for 0.25h; Inert atmosphere; Cooling with ice;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In tetrahydrofuran at 20℃;
51.1%
Stage #1: benzyl benzyl(4-{[(benzyloxy)carbonyl]amino}-2-fluorophenyl)carbamate With lithium tert-butoxide In tetrahydrofuran for 0.25h; Inert atmosphere; Cooling with ice;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In tetrahydrofuran; methanol at 20℃;
51.1%
(3-fluoro-4-iodophenyl)carbamic acid benzyl ester
1097722-53-6

(3-fluoro-4-iodophenyl)carbamic acid benzyl ester

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

(S)-N-[3-(3-fluoro-4-iodophenyl)-2-oxo-1,3-oxazolidine-5-ylmethyl]acetamide
149524-45-8

(S)-N-[3-(3-fluoro-4-iodophenyl)-2-oxo-1,3-oxazolidine-5-ylmethyl]acetamide

Conditions
ConditionsYield
Stage #1: (3-fluoro-4-iodophenyl)carbamic acid benzyl ester With lithium tert-butoxide In methanol; N,N-dimethyl-formamide at 45℃; for 1.5h; Inert atmosphere;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In methanol; N,N-dimethyl-formamide at 20℃; for 30h; Inert atmosphere;
78.5%
[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-carbamic acid benzyl ester
1207472-10-3

[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-carbamic acid benzyl ester

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

(5S)-N-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
957796-51-9

(5S)-N-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide

Conditions
ConditionsYield
Stage #1: [3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-carbamic acid benzyl ester With lithium 2-methylpropan-2-olate In tetrahydrofuran at 20℃; for 3h;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In tetrahydrofuran; methanol at 10 - 20℃; for 21h;
77%
N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

2-methylpropyl [3-fluoro-4-(tetrahydro-2H-thiopyran-4-yl)phenyl]carbamate
288570-78-5

2-methylpropyl [3-fluoro-4-(tetrahydro-2H-thiopyran-4-yl)phenyl]carbamate

N-{[(5S)-3-(3-fluoro-4-tetrahydro-2H-thiopyran-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

N-{[(5S)-3-(3-fluoro-4-tetrahydro-2H-thiopyran-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

Conditions
ConditionsYield
With 2-methylbutan-2-ol (lithium salt) In methanol; N,N-dimethyl-formamide at 2 - 23℃;73.9%
{4-[(1α,5α,6α)-6-(tert-butyldimethylsilanyloxy)-3-azabicyclo[3.1.0]hex-3-yl]-3,5-difluorophenyl}carbamic acid benzyl ester
681425-46-7

{4-[(1α,5α,6α)-6-(tert-butyldimethylsilanyloxy)-3-azabicyclo[3.1.0]hex-3-yl]-3,5-difluorophenyl}carbamic acid benzyl ester

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

(S)-N-(3-{4-[(1α,5α,6α)-6-(tert-butyldimethylsilanyloxy)-3-azabicyclo[3.1.0]hex-3-yl]-3,5-difluorophenyl}-2-oxooxazolidin-5-ylmethyl)acetamide

(S)-N-(3-{4-[(1α,5α,6α)-6-(tert-butyldimethylsilanyloxy)-3-azabicyclo[3.1.0]hex-3-yl]-3,5-difluorophenyl}-2-oxooxazolidin-5-ylmethyl)acetamide

Conditions
ConditionsYield
With lithium tert-butoxide In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 20℃; for 20h;73%
With methanol; lithium butoxide In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 20h;73%
(1α,5α,6α)-3-(4-benzyloxycarbonylamino-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid tert-butyl ester
681424-90-8

(1α,5α,6α)-3-(4-benzyloxycarbonylamino-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid tert-butyl ester

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

(S)-(1α,5α,6α)-3-{4-[5-(acetylaminomethyl)-2-oxooxazolidin-3-yl]-2,6-difluorophenyl}-3-azabicyclo[3.1.0]hexane-6-carboxylic acid tert-butyl ester
681424-86-2

(S)-(1α,5α,6α)-3-{4-[5-(acetylaminomethyl)-2-oxooxazolidin-3-yl]-2,6-difluorophenyl}-3-azabicyclo[3.1.0]hexane-6-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With lithium tert-butoxide In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 20℃; for 20h;72%
With methanol; lithium butoxide In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 20h;72%
[9-(tetrahydro-pyran-2-yloxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-3-yl]-carbamic acid ethyl ester
741721-64-2

[9-(tetrahydro-pyran-2-yloxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-3-yl]-carbamic acid ethyl ester

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

N-{2-oxo-3-[9-(tetrahydro-pyran-2-yloxy)-6,7.8.9-tetrahydro-5H-cyclohepta[b]pyridin-3-yl]-oxazolidin-5(S)-ylmethyl}-acetamide
741721-66-4

N-{2-oxo-3-[9-(tetrahydro-pyran-2-yloxy)-6,7.8.9-tetrahydro-5H-cyclohepta[b]pyridin-3-yl]-oxazolidin-5(S)-ylmethyl}-acetamide

Conditions
ConditionsYield
With lithium tert-butoxide In methanol; N,N-dimethyl-formamide71%
Stage #1: [9-(tetrahydro-pyran-2-yloxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-3-yl]-carbamic acid ethyl ester With methanol; lithium tert-butoxide In DMF (N,N-dimethyl-formamide); hexane at 20℃; for 1h;
Stage #2: N-[(2S)-2-acetoxy-3-chloropropyl]acetamide In DMF (N,N-dimethyl-formamide); hexane at 0 - 20℃;
isopropyl 3,5-difluoro-4-[exo-(1R,5S)-3-oxabicyclo[3.1.0]hex-6-yl]phenylcarbamate

isopropyl 3,5-difluoro-4-[exo-(1R,5S)-3-oxabicyclo[3.1.0]hex-6-yl]phenylcarbamate

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

N-[((5S)-3-{3,5-difluoro-4-[exo-(1R,5S)-3-oxabicyclo[3.1.0]hex-6-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide

N-[((5S)-3-{3,5-difluoro-4-[exo-(1R,5S)-3-oxabicyclo[3.1.0]hex-6-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide

Conditions
ConditionsYield
With lithium tert-butoxide In methanol; DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 20h;71%
[4-(3-azabicyclo[3.1.0]hex-3-yl)-3,5-difluorophenyl]carbamic acid benzyl ester
681425-48-9

[4-(3-azabicyclo[3.1.0]hex-3-yl)-3,5-difluorophenyl]carbamic acid benzyl ester

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

(S)-N-{3-[4-(3-azabicyclo[3.1.0]hex-3-yl)-3,5-difluorophenyl]-2-oxooxazolidin-5-ylmethyl}acetamide

(S)-N-{3-[4-(3-azabicyclo[3.1.0]hex-3-yl)-3,5-difluorophenyl]-2-oxooxazolidin-5-ylmethyl}acetamide

Conditions
ConditionsYield
With lithium tert-butoxide In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 20℃; for 20h;70%
With methanol; lithium butoxide In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 20h;70%
[(1α,5α,6α)-3-(4-benzyloxycarbonylamino-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester
681425-28-5

[(1α,5α,6α)-3-(4-benzyloxycarbonylamino-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

(S)-((1α,5α,6α)-3-{4-[5-(acetylaminomethyl)-2-oxooxazolidin-3-yl]-2,6-difluorophenyl}-3-azabicyclo[3.1.0]hex-6-yl)carbamic acid tert-butyl ester
681425-26-3

(S)-((1α,5α,6α)-3-{4-[5-(acetylaminomethyl)-2-oxooxazolidin-3-yl]-2,6-difluorophenyl}-3-azabicyclo[3.1.0]hex-6-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With lithium tert-butoxide In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 20℃; for 20h;70%
With methanol; lithium butoxide In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 20h;70%
benzyl 3-fluoro-4-[exo-(1R,5S)-3-oxabicyclo[3.1.0]hex-6-yl]phenylcarbamate

benzyl 3-fluoro-4-[exo-(1R,5S)-3-oxabicyclo[3.1.0]hex-6-yl]phenylcarbamate

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

N-[((5S)-3-{3-fluoro-4-[exo-(1R,5S)-3-oxabicyclo[3.1.0]hex-6-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide

N-[((5S)-3-{3-fluoro-4-[exo-(1R,5S)-3-oxabicyclo[3.1.0]hex-6-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide

Conditions
ConditionsYield
With lithium tert-butoxide In methanol; DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 20h;70%
benzyl 3-fluoro-4-[(1α,5α,6β)-3-thiabicyclo[3.1.0]hex-6-yl]phenylcarbamate
858367-38-1

benzyl 3-fluoro-4-[(1α,5α,6β)-3-thiabicyclo[3.1.0]hex-6-yl]phenylcarbamate

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide
183905-31-9

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

N-[((5S)-3-{3-fluoro-4-[(1α,5α,6β)-3-thiabicyclo[3.1.0]hex-6-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide

N-[((5S)-3-{3-fluoro-4-[(1α,5α,6β)-3-thiabicyclo[3.1.0]hex-6-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]acetamide

Conditions
ConditionsYield
With lithium tert-butoxide In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 0 - 20℃; for 20h;68%
With methanol; lithium tert-butoxide In N,N-dimethyl-formamide
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