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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Fenoglimod in stock

Cas:162359-55-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Fingolimod supplier in China

Cas:162359-55-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Fingolimod

Cas:162359-55-9

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Fingolimod

Cas:162359-55-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Gilenya CAS NO:162359-55-9 Grade:Medical scientific research and export Molecular formula:C19H33NO2 Molecular weight:307.47 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data sto

Gilenya/ CAS:162359-55-9/Gilenya raw material/ high-quality

Cas:162359-55-9

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Professional ManufacturerCAS 162359-55-9 with best price

Cas:162359-55-9

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material Fingolimod API cas:162359-55-9

Cas:162359-55-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Gilenia CAS162359-55-9

Cas:162359-55-9

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Gilenia CAS:162359-55-9

Cas:162359-55-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,3-Propanediol,2-amino-2-[2-(4-octylphenyl)ethyl]- 162359-55-9

Cas:162359-55-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Gilenia CAS:162359-55-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Gilenia CAS:162359-55-9

Cas:162359-55-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,3-Propanediol,2-amino-2-[2-(4-octylphenyl)ethyl]-

Cas:162359-55-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1,3-Propanediol,2-amino-2-[2-(4-octylphenyl)ethyl]-

Cas:162359-55-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

GILENYA

Cas:162359-55-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Fenoglimod

Cas:162359-55-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Fingolimod

Cas:162359-55-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Fingolimod API cas:162359-55-9

Cas:162359-55-9

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta

1,3-Propanediol,2-amino-2-[2-(4-octylphenyl)ethyl]-

Cas:162359-55-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: Fingolimod CAS No.:162359-55-9 Molecule Formula:C19H33NO2 Molecule Weight:307.47 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPEC

Best Quality Fingolimod with good supplier

Cas:162359-55-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

162359-55-9? Gilenia

Cas:162359-55-9

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Fingolimod

Cas:162359-55-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Fingolimod

Cas:162359-55-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Fingolimod API cas:162359-55-9

Cas:162359-55-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Fingolimod API cas:162359-55-9

Cas:162359-55-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Fingolimod API cas:162359-55-9

Cas:162359-55-9

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Senova Technology Company Limited

We have most reliable quality, competitive prices and full documents for this APIs 1. GMP WORKSHOP 2. DMF Appearance:White to off-white powder Storage:2~8℃,protected from light

Fingolimod/Gilenia

Cas:162359-55-9

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Fingolimod API cas:162359-55-9

Cas:162359-55-9

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

1,3-Propanediol,2-amino-2-[2-(4-octylphenyl)ethyl]-

Cas:162359-55-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Fingolimod 1g

Cas:162359-55-9

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Fingolimod

Cas:162359-55-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

5-(tert-butyloxycarbonylamino)-2,2-dimethyl-5-(4-octylphenethyl)-1,3-dioxane
885605-36-7

5-(tert-butyloxycarbonylamino)-2,2-dimethyl-5-(4-octylphenethyl)-1,3-dioxane

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 12h;96%
Stage #1: 5-(tert-butyloxycarbonylamino)-2,2-dimethyl-5-(4-octylphenethyl)-1,3-dioxane With water; trifluoroacetic acid In dichloromethane at 20℃;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water
95%
Stage #1: 5-(tert-butyloxycarbonylamino)-2,2-dimethyl-5-(4-octylphenethyl)-1,3-dioxane With hydrogenchloride In methanol; water at 50℃; for 3h;
Stage #2: With sodium hydroxide In water pH=8 - 9;
69%
C33H59NO2Si

C33H59NO2Si

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane95%
2-nitro-2-[2-(4-octyl-phenyl)ethyl]propane-1,3-diol
374077-88-0

2-nitro-2-[2-(4-octyl-phenyl)ethyl]propane-1,3-diol

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; palladium 10% on activated carbon In methanol; isopropyl alcohol at 20 - 50℃; under 750.075 - 26252.6 Torr; for 2.66667h;93%
With hydrogenchloride; hydrogen; palladium 10% on activated carbon In methanol; isopropyl alcohol at 20 - 50℃; under 750.075 - 26252.6 Torr; for 2.66667h;93%
With hydrogen; nickel82%
With palladium 10% on activated carbon; hydrogen In methanol at 25 - 30℃; under 3000.3 - 3750.38 Torr; for 5h; Solvent; Temperature; Pressure;2 g
With palladium 10% on activated carbon; ammonium formate In methanol at 20℃; for 5h; Reagent/catalyst; Temperature; Time;
C22H33NO4

C22H33NO4

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Stage #1: C22H33NO4 With 5%-palladium/activated carbon; hydrogen In ethanol at 40 - 45℃; under 1500.15 - 2250.23 Torr; for 5h; Autoclave; Inert atmosphere;
Stage #2: With hydrogenchloride In ethanol; water at 60 - 65℃; for 4h; Reagent/catalyst; Temperature; Solvent;
92.1%
(3-nitro-5-(4-octylphenyl)tetrahydrofuran-3-yl)-methanol
1369968-69-3

(3-nitro-5-(4-octylphenyl)tetrahydrofuran-3-yl)-methanol

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; palladium 10% on activated carbon In methanol; isopropyl alcohol at 100℃; under 26252.6 Torr; for 2h;86%
With hydrogenchloride; hydrogen; palladium 10% on activated carbon In methanol; isopropyl alcohol at 100℃; under 26252.6 Torr; for 2h;86%
diethyl 2-amino-2-(4-octylphenethyl)malonate
162358-62-5

diethyl 2-amino-2-(4-octylphenethyl)malonate

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
With sodium tetrahydroborate; lithium chloride In tetrahydrofuran; ethanol at 0 - 20℃; Inert atmosphere;85%
With lithium bromide; sodium borohydrid In ethanol; water
5-ethynyl-2,2-dimethyl-[1,3]dioxan-(N-tert-butyloxycarbonyl)-5-ylamine
364631-74-3

5-ethynyl-2,2-dimethyl-[1,3]dioxan-(N-tert-butyloxycarbonyl)-5-ylamine

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / Et3N; CuI / Pd(PPh3)4 / dimethylformamide / 3 h / 20 °C
2: 99 percent / H2 / Pd/C / benzene / 5 h / 20 °C / 760 Torr
3: 96 percent / aq. TFA / CH2Cl2 / 12 h / 20 °C
View Scheme
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

resin-bound p-methylphenylboronic acid

resin-bound p-methylphenylboronic acid

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 71 percent / Ni(0)
2: 81 percent / diethyl ether / 0 °C
3: m-CPBA / CH2Cl2 / 20 °C
4: 76 percent / MgSO4; NaNO2 / methanol / 4 h / Heating
5: 61 percent / Me3SiCl; NaI / acetonitrile / 20 °C
6: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr
7: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h
8: 82 percent / H2 / Raney-Ni
View Scheme
1-octylzinc(II) iodide
150529-78-5

1-octylzinc(II) iodide

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 71 percent / Ni(0)
2: 81 percent / diethyl ether / 0 °C
3: m-CPBA / CH2Cl2 / 20 °C
4: 76 percent / MgSO4; NaNO2 / methanol / 4 h / Heating
5: 61 percent / Me3SiCl; NaI / acetonitrile / 20 °C
6: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr
7: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h
8: 82 percent / H2 / Raney-Ni
View Scheme
4-octylbenzaldehyde
49763-66-8

4-octylbenzaldehyde

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 81 percent / diethyl ether / 0 °C
2: m-CPBA / CH2Cl2 / 20 °C
3: 76 percent / MgSO4; NaNO2 / methanol / 4 h / Heating
4: 61 percent / Me3SiCl; NaI / acetonitrile / 20 °C
5: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr
6: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h
7: 82 percent / H2 / Raney-Ni
View Scheme
1-(4-octyl-phenyl)-prop-2-en-1-ol

1-(4-octyl-phenyl)-prop-2-en-1-ol

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: m-CPBA / CH2Cl2 / 20 °C
2: 76 percent / MgSO4; NaNO2 / methanol / 4 h / Heating
3: 61 percent / Me3SiCl; NaI / acetonitrile / 20 °C
4: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr
5: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h
6: 82 percent / H2 / Raney-Ni
View Scheme
(4-octyl-phenyl)-oxiranyl-methanol
374077-79-9

(4-octyl-phenyl)-oxiranyl-methanol

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 76 percent / MgSO4; NaNO2 / methanol / 4 h / Heating
2: 61 percent / Me3SiCl; NaI / acetonitrile / 20 °C
3: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr
4: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h
5: 82 percent / H2 / Raney-Ni
View Scheme
1-((E)-3-Nitro-propenyl)-4-octyl-benzene

1-((E)-3-Nitro-propenyl)-4-octyl-benzene

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr
2: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h
3: 82 percent / H2 / Raney-Ni
View Scheme
1-(3-nitropropyl)-4-octylbenzene
374077-87-9

1-(3-nitropropyl)-4-octylbenzene

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h
2: 82 percent / H2 / Raney-Ni
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / methanol / 2 h / 68 °C
2: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 25 - 30 °C / 3000.3 - 3750.38 Torr
View Scheme
3-nitro-1-(4-octyl-phenyl)-propane-1,2-diol
374077-82-4

3-nitro-1-(4-octyl-phenyl)-propane-1,2-diol

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 61 percent / Me3SiCl; NaI / acetonitrile / 20 °C
2: 76 percent / H2 / 10 percent Pd/C / ethanol / 1 h / 20 °C / 30002.4 Torr
3: 51 percent / Amberlyst A-21 / CH2Cl2 / 7 h
4: 82 percent / H2 / Raney-Ni
View Scheme
n-octanoic acid chloride
111-64-8

n-octanoic acid chloride

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C
2.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C
3.1: 3.40 g / NaOMe; MeOH / 2 h / Heating
4.1: Et3N / CH2Cl2 / 1 h / 20 °C
5.1: 16.0 g / NaI / butan-2-one / 2 h / Heating
6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
6.2: 61 percent / ethanol / 3 h / 65 °C
7.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C
8.1: 8.25 g / pyridine / 16 h / 20 °C
9.1: 2 N aq. LiOH / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 9 steps
1: aluminum (III) chloride / dichloromethane / 2 h / -5 - 30 °C
2: hydrogen; 5%-palladium/activated carbon / methanol / 2585.81 - 3102.97 Torr
3: aluminum (III) chloride / dichloromethane / 2 h / -5 - 30 °C
4: bromine / dichloromethane; 1,4-dioxane / 4 h / 0 - 5 °C
5: sodium ethanolate / ethanol / 3.5 h / 25 - 70 °C / Inert atmosphere
6: sodium tetrahydroborate; ethanol / tetrahydrofuran / 3 h / 5 - 15 °C
7: hydrogenchloride / acetone / 2 h / 25 - 30 °C
8: hydrogen; 5%-palladium/activated carbon / methanol / 3 h / 20 °C
9: lithium hydroxide / methanol / 2 h / 25 - 30 °C / Reflux
View Scheme
Multi-step reaction with 9 steps
1: aluminum (III) chloride / dichloromethane / 2 h / -5 - 30 °C
2: hydrogen; 5%-palladium/activated carbon / methanol / 2585.81 - 3102.97 Torr
3: aluminum (III) chloride / dichloromethane / 2 h / -5 - 30 °C
4: bromine / dichloromethane; 1,4-dioxane / 4 h / 0 - 5 °C
5: sodium ethanolate / ethanol / 3.5 h / 25 - 70 °C / Inert atmosphere
6: sodium tetrahydroborate; ethanol / tetrahydrofuran / 3 h / 5 - 15 °C
7: methanesulfonic acid / methanol / 2 h / 25 - 30 °C / Reflux
8: hydrogen; palladium / methanol / 2585.81 - 3102.97 Torr
9: lithium hydroxide / methanol / 2 h / 25 - 30 °C / Reflux
View Scheme
Multi-step reaction with 9 steps
1: aluminum (III) chloride / dichloromethane / 2 h / -5 - 30 °C
2: hydrogen; 5%-palladium/activated carbon / methanol / 2585.81 - 3102.97 Torr
3: aluminum (III) chloride / dichloromethane / 2 h / -5 - 30 °C
4: bromine / dichloromethane; 1,4-dioxane / 4 h / 0 - 5 °C
5: sodium ethanolate / ethanol / 3.5 h / 25 - 70 °C / Inert atmosphere
6: sodium tetrahydroborate; ethanol / tetrahydrofuran / 3 h / 5 - 15 °C
7: methanesulfonic acid / methanol / 2 h / 25 - 30 °C / Reflux
8: lithium hydroxide / methanol / 2 h / Reflux
9: hydrogen; 5%-palladium/activated carbon / methanol / 2585.81 - 3102.97 Torr
View Scheme
Multi-step reaction with 8 steps
1.1: aluminum (III) chloride / 0.01 h / 0.25 - 0.3 °C
1.2: 0 h / 0.2 - 0.5 °C
2.1: sodium hydroxide / water; methanol / 1.5 h / 0.1 - 0.3 °C
3.1: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave
4.1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C
5.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C
6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere
6.2: 0.4 - 0.45 °C / Inert atmosphere
7.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C
7.2: 0.01 h / 0 - 0.5 °C
7.3: 0 h / 0.15 - 0.5 °C
8.1: sodium hydroxide / water; methanol / 2 h / Reflux
View Scheme
acetic acid phenethyl ester
103-45-7

acetic acid phenethyl ester

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C
2.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C
3.1: 3.40 g / NaOMe; MeOH / 2 h / Heating
4.1: Et3N / CH2Cl2 / 1 h / 20 °C
5.1: 16.0 g / NaI / butan-2-one / 2 h / Heating
6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
6.2: 61 percent / ethanol / 3 h / 65 °C
7.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C
8.1: 8.25 g / pyridine / 16 h / 20 °C
9.1: 2 N aq. LiOH / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 8 steps
1.1: aluminum (III) chloride / 0.01 h / 0.25 - 0.3 °C
1.2: 0 h / 0.2 - 0.5 °C
2.1: sodium hydroxide / water; methanol / 1.5 h / 0.1 - 0.3 °C
3.1: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave
4.1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C
5.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C
6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere
6.2: 0.4 - 0.45 °C / Inert atmosphere
7.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C
7.2: 0.01 h / 0 - 0.5 °C
7.3: 0 h / 0.15 - 0.5 °C
8.1: sodium hydroxide / water; methanol / 2 h / Reflux
View Scheme
diethyl 2-acetamido-2-[2-(4-octylphenyl)ethyl]malonate
162358-08-9

diethyl 2-acetamido-2-[2-(4-octylphenyl)ethyl]malonate

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C
2: 8.25 g / pyridine / 16 h / 20 °C
3: 2 N aq. LiOH / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: lithium chloride; ethanol; sodium tetrahydroborate / tetrahydrofuran / 72.5 h / 0 - 20 °C
2: sodium hydroxide / methanol / 5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C
1.2: 0.01 h / 0 - 0.5 °C
1.3: 0 h / 0.15 - 0.5 °C
2.1: sodium hydroxide / water; methanol / 2 h / Reflux
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
1.2: 61 percent / ethanol / 3 h / 65 °C
2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C
3.1: 8.25 g / pyridine / 16 h / 20 °C
4.1: 2 N aq. LiOH / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere
1.2: 0.4 - 0.45 °C / Inert atmosphere
2.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C
2.2: 0.01 h / 0 - 0.5 °C
2.3: 0 h / 0.15 - 0.5 °C
3.1: sodium hydroxide / water; methanol / 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: caesium carbonate; tetrabutylammomium bromide / toluene / Inert atmosphere; Reflux
2.1: calcium chloride / ethanol; water
2.2: 10 - 15 °C
2.3: Reflux
View Scheme
2-(4-Octylphenyl)ethyl alcohol
162358-05-6

2-(4-Octylphenyl)ethyl alcohol

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: Et3N / CH2Cl2 / 1 h / 20 °C
2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating
3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
3.2: 61 percent / ethanol / 3 h / 65 °C
4.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C
5.1: 8.25 g / pyridine / 16 h / 20 °C
6.1: 2 N aq. LiOH / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere
2.2: 0.4 - 0.45 °C / Inert atmosphere
3.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C
3.2: 0.01 h / 0 - 0.5 °C
3.3: 0 h / 0.15 - 0.5 °C
4.1: sodium hydroxide / water; methanol / 2 h / Reflux
View Scheme
acetic acid 2-(4-octylphenyl)ethyl ester
162358-04-5

acetic acid 2-(4-octylphenyl)ethyl ester

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 3.40 g / NaOMe; MeOH / 2 h / Heating
2.1: Et3N / CH2Cl2 / 1 h / 20 °C
3.1: 16.0 g / NaI / butan-2-one / 2 h / Heating
4.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
4.2: 61 percent / ethanol / 3 h / 65 °C
5.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C
6.1: 8.25 g / pyridine / 16 h / 20 °C
7.1: 2 N aq. LiOH / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C
2.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere
3.2: 0.4 - 0.45 °C / Inert atmosphere
4.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C
4.2: 0.01 h / 0 - 0.5 °C
4.3: 0 h / 0.15 - 0.5 °C
5.1: sodium hydroxide / water; methanol / 2 h / Reflux
View Scheme
acetic acid
64-19-7

acetic acid

fingolimod
162359-55-9

fingolimod

2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol acetate
1227170-83-3

2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol acetate

Conditions
ConditionsYield
In ethyl acetate at 75℃; Product distribution / selectivity;99.4%
propionic acid
802294-64-0

propionic acid

fingolimod
162359-55-9

fingolimod

2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol propionate
1227170-84-4

2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol propionate

Conditions
ConditionsYield
In ethyl acetate at 70℃; Product distribution / selectivity;96.9%
fingolimod
162359-55-9

fingolimod

fingolimod hydrochloride

fingolimod hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 30 - 35℃; for 4h;96.5%
With hydrogenchloride In methanol at 25 - 55℃; for 0.5h;93.88%
With hydrogenchloride In n-heptane; isopropyl alcohol at 0 - 50℃; for 0.416667h;91%
malonic acid
141-82-2

malonic acid

fingolimod
162359-55-9

fingolimod

2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol malonate

2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol malonate

Conditions
ConditionsYield
In isopropyl alcohol at 82℃; Product distribution / selectivity;92.3%
fingolimod
162359-55-9

fingolimod

2-amino-2-(fluoromethyl)-4-(4-octylphenyl)butan-1-ol

2-amino-2-(fluoromethyl)-4-(4-octylphenyl)butan-1-ol

Conditions
ConditionsYield
With diethylamino-sulfur trifluoride In dichloromethane at -78 - 20℃;5%
Stage #1: fingolimod With diethylamino-sulfur trifluoride In dichloromethane at -78 - 20℃;
Stage #2: With trifluoroacetic acid In water; acetonitrile
Stage #3: With sodium hydroxide In methanol
2%
With diethylamino-sulfur trifluoride In dichloromethane at -78 - 20℃;2%
benzyl chloroformate
501-53-1

benzyl chloroformate

fingolimod
162359-55-9

fingolimod

2-(benzyloxycarbonyl)amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol
402616-41-5

2-(benzyloxycarbonyl)amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol

Conditions
ConditionsYield
With potassium hydrogencarbonate In water; ethyl acetate at 20℃; for 2h; Schotten-Baumann reaction;5.29 g
With potassium hydrogencarbonate In water; ethyl acetate
benzyl chloroformate
501-53-1

benzyl chloroformate

fingolimod
162359-55-9

fingolimod

(R/S)-4-hydroxymethyl-4-[2-(4-octylphenyl)ethyl]oxazolidin-2-one
847672-61-1

(R/S)-4-hydroxymethyl-4-[2-(4-octylphenyl)ethyl]oxazolidin-2-one

Conditions
ConditionsYield
With sodium hydroxide at 20℃; for 48h;
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

fingolimod
162359-55-9

fingolimod

{2-methyl-4-[2-(4-octylphenyl)ethyl]-4,5-dihydro-1,3-oxazol-4-yl}methanol
402616-28-8

{2-methyl-4-[2-(4-octylphenyl)ethyl]-4,5-dihydro-1,3-oxazol-4-yl}methanol

Conditions
ConditionsYield
With N,N-diethyl-N-isopropylamine
fingolimod
162359-55-9

fingolimod

4-benzyloxymethyl-2-methyl-4-[2-(4-octyl-phenyl)-ethyl]-4,5-dihydro-oxazole
903894-66-6

4-benzyloxymethyl-2-methyl-4-[2-(4-octyl-phenyl)-ethyl]-4,5-dihydro-oxazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: iPrN(Et)2
2: NaH / tetrahydrofuran
View Scheme
fingolimod
162359-55-9

fingolimod

2-amino-2-benzyloxymethyl-4-(4-octyl-phenyl)-butan-1-ol
903894-68-8

2-amino-2-benzyloxymethyl-4-(4-octyl-phenyl)-butan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: iPrN(Et)2
2: NaH / tetrahydrofuran
3: HCl
View Scheme
fingolimod
162359-55-9

fingolimod

octanoic acid [1-benzyloxymethyl-1-hydroxymethyl-3-(4-octyl-phenyl)-propyl]-amide
903894-71-3

octanoic acid [1-benzyloxymethyl-1-hydroxymethyl-3-(4-octyl-phenyl)-propyl]-amide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: iPrN(Et)2
2.1: NaH / tetrahydrofuran
3.1: HCl
4.1: pyridine; chlorotrimethylsilane / 20 °C
4.2: 20 °C
View Scheme
fingolimod
162359-55-9

fingolimod

hexadecanoic acid [1-benzyloxymethyl-1-hydroxymethyl-3-(4-octyl-phenyl)-propyl]-amide
903894-70-2

hexadecanoic acid [1-benzyloxymethyl-1-hydroxymethyl-3-(4-octyl-phenyl)-propyl]-amide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: iPrN(Et)2
2.1: NaH / tetrahydrofuran
3.1: HCl
4.1: pyridine; chlorotrimethylsilane / 20 °C
4.2: 20 °C
View Scheme
fingolimod
162359-55-9

fingolimod

Octanoic acid [1-hydroxymethyl-3-(4-octyl-phenyl)-1-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxymethyl)-propyl]-amide

Octanoic acid [1-hydroxymethyl-3-(4-octyl-phenyl)-1-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxymethyl)-propyl]-amide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: iPrN(Et)2
2.1: NaH / tetrahydrofuran
3.1: HCl
4.1: pyridine; chlorotrimethylsilane / 20 °C
4.2: 20 °C
5.1: 37 percent / SnCl2; AgClO4; molecular sieves 4 Angstroem / H2O; diethyl ether
6.1: 53 percent / H2 / Pd/C / ethanol
View Scheme
fingolimod
162359-55-9

fingolimod

Hexadecanoic acid [1-hydroxymethyl-3-(4-octyl-phenyl)-1-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxymethyl)-propyl]-amide

Hexadecanoic acid [1-hydroxymethyl-3-(4-octyl-phenyl)-1-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxymethyl)-propyl]-amide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: iPrN(Et)2
2.1: NaH / tetrahydrofuran
3.1: HCl
4.1: pyridine; chlorotrimethylsilane / 20 °C
4.2: 20 °C
5.1: 74 percent / SnCl2; AgClO4; molecular sieves 4 Angstroem / H2O; diethyl ether
6.1: 76 percent / H2 / Pd/C / ethanol
View Scheme

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