Product: Fingolimod Intermediate Chemical name: Benzene, 1-(2-iodoethyl)-4-octyl[CAS:162358-07-8] Or 1-(2-Iodoethyl)-4-octylbenzene HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and c
Cas:162358-07-8
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:162358-07-8
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryBenzene, 1-(2-iodoethyl)-4-octyl- Basic information Product Name: Benzene, 1-(2-iodoethyl)-4-octyl- Synonyms: Benzene, 1-(2-iodoethyl)-4-octyl-;1-(2-Iodoethyl)-4-oc
Cas:162358-07-8
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:162358-07-8
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:162358-07-8
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:162358-07-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:162358-07-8
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryProduct Name: Benzene, 1-(2-iodoethyl)-4-octyl- CAS No.: 162358-07-8 Molecular formula: C16H25I Molecular weight: 344 Appearance: white powder Storage:Store in cool and dry place, away from sun
Cas:162358-07-8
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:162358-07-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryBenzene, 1-(2-iodoethyl)-4-octyl- CAS:162358-07-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit
Cas:162358-07-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,
Cas:162358-07-8
Min.Order:20 Metric Ton
Negotiable
Type:Trading Company
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:162358-07-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:162358-07-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:162358-07-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAppearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Ai
Cas:162358-07-8
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:162358-07-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:162358-07-8
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:162358-07-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:162358-07-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:162358-07-8
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:162358-07-8
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:162358-07-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct name: 1-(2-Iodoethyl)-4-Octylbenzene CAS No.:162358-07-8 Molecule Formula:C16H25I Molecule Weight:344.27 Purity: 98.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TEST
Cas:162358-07-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home an
Cas:162358-07-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
Hangzhou Fandachem Co.,Ltd, a China-based chemical company, specialize in exporting 1-(2-Iodoethyl)-4-octylbenzene , CAS:162358-07-8 Please contact us by email freely. We are leading exporter in China. If you really need this cargo
Cas:162358-07-8
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:162358-07-8
Min.Order:1 Metric Ton
FOB Price: $7.0 / 8.0
Type:Trading Company
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence
Cas:162358-07-8
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryLIDE PHARMACEUTICALS LIMITED is a professional leading manufacturer of chemicals and APIs in China. Our core business line covers APIs, Intermediates, Flavours and fragrances, Specialty chemicals, Dietary additives etc.We are specialized in chemical
Cas:162358-07-8
Min.Order:1 Gram
FOB Price: $10.0
Type:Lab/Research institutions
inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
Cas:162358-07-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry4-octylphenethyl methanesulfonate
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
With lithium iodide In tetrahydrofuran at 20℃; for 4h; | 5.37 g |
With sodium iodide In butanone for 2h; Iodination; Heating; | 16.0 g |
With sodium iodide In tetrahydrofuran at 20℃; | 70 g |
With tetra-(n-butyl)ammonium iodide; sodium iodide for 3h; Inert atmosphere; | 150 g |
With sodium iodide In acetone at 20℃; for 19h; | 0.44 g |
p-hydroxyphenethyl alcohol
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 98 percent / NaHSO4 on silica / hexane / 26 h / Heating 2: 94 percent / pyridine / CH2Cl2 / 1 h / 20 °C 3: 20 percent / Fe(acac)3; NMP / tetrahydrofuran / 1 h 4: Et3N / CH2Cl2 / 1 h 5: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C View Scheme |
2-(4-hydroxyphenyl)ethyl acetate
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 94 percent / pyridine / CH2Cl2 / 1 h / 20 °C 2: 20 percent / Fe(acac)3; NMP / tetrahydrofuran / 1 h 3: Et3N / CH2Cl2 / 1 h 4: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C View Scheme |
2-(4-Octylphenyl)ethyl alcohol
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 1 h 2: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 1 h / 20 °C 2: 16.0 g / NaI / butan-2-one / 2 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane / 0.5 h 1.2: 3 h / 0 - 20 °C 2.1: sodium iodide / tetrahydrofuran / 20 °C View Scheme |
acetic acid 2-(4-octylphenyl)ethyl ester
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 93 percent / NaOMe / methanol / 8 h / 20 °C 2: Et3N / CH2Cl2 / 1 h 3: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 3.40 g / NaOMe; MeOH / 2 h / Heating 2: Et3N / CH2Cl2 / 1 h / 20 °C 3: 16.0 g / NaI / butan-2-one / 2 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium methylate / methanol / 3 h / 20 °C 2.1: triethylamine / dichloromethane / 0.5 h 2.2: 3 h / 0 - 20 °C 3.1: sodium iodide / tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C 2: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C View Scheme |
acetic acid 2-[4-(trifluoromethanesulfonyloxy)phenyl]ethyl ester
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 20 percent / Fe(acac)3; NMP / tetrahydrofuran / 1 h 2: Et3N / CH2Cl2 / 1 h 3: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C View Scheme |
n-octanoic acid chloride
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C 2: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 3: 3.40 g / NaOMe; MeOH / 2 h / Heating 4: Et3N / CH2Cl2 / 1 h / 20 °C 5: 16.0 g / NaI / butan-2-one / 2 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0 - 20 °C 2.1: triethylsilane; trifluoroacetic acid / 20 °C 3.1: sodium methylate / methanol / 3 h / 20 °C 4.1: triethylamine / dichloromethane / 0.5 h 4.2: 3 h / 0 - 20 °C 5.1: sodium iodide / tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: aluminum (III) chloride / 0.01 h / 0.25 - 0.3 °C 1.2: 0 h / 0.2 - 0.5 °C 2.1: sodium hydroxide / water; methanol / 1.5 h / 0.1 - 0.3 °C 3.1: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave 4.1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C 5.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C View Scheme |
acetic acid phenethyl ester
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C 2: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 3: 3.40 g / NaOMe; MeOH / 2 h / Heating 4: Et3N / CH2Cl2 / 1 h / 20 °C 5: 16.0 g / NaI / butan-2-one / 2 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1.1: aluminum (III) chloride / 0.01 h / 0.25 - 0.3 °C 1.2: 0 h / 0.2 - 0.5 °C 2.1: sodium hydroxide / water; methanol / 1.5 h / 0.1 - 0.3 °C 3.1: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave 4.1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C 5.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C View Scheme |
2-(4-octanoylphenyl)ethyl acetate
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 2: 3.40 g / NaOMe; MeOH / 2 h / Heating 3: Et3N / CH2Cl2 / 1 h / 20 °C 4: 16.0 g / NaI / butan-2-one / 2 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1.1: triethylsilane; trifluoroacetic acid / 20 °C 2.1: sodium methylate / methanol / 3 h / 20 °C 3.1: triethylamine / dichloromethane / 0.5 h 3.2: 3 h / 0 - 20 °C 4.1: sodium iodide / tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydroxide / water; methanol / 1.5 h / 0.1 - 0.3 °C 2: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave 3: sodium hydroxide / water; methanol / 0.2 - 0.3 °C 4: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C View Scheme |
1-(2-bromoethyl)-4-octylbenzene
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
In butanone |
4'-(2-iodoethyl)octanophenone
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
With triethylsilane In trifluoroacetic acid |
1H-imidazole
2-(4-Octylphenyl)ethyl alcohol
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
With iodine; triphenylphosphine In ether (200 ml)-acetonitrile |
Phenyl acetate
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0 - 20 °C 2.1: triethylsilane; trifluoroacetic acid / 20 °C 3.1: sodium methylate / methanol / 3 h / 20 °C 4.1: triethylamine / dichloromethane / 0.5 h 4.2: 3 h / 0 - 20 °C 5.1: sodium iodide / tetrahydrofuran / 20 °C View Scheme |
4'-(2-hydroxyethyl)octanophenone
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave 2: sodium hydroxide / water; methanol / 0.2 - 0.3 °C 3: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C View Scheme |
4-iodophenethyl alcohol
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; triethylamine / 17 h / 20 °C / Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 17 h / 20 °C 3: triethylamine / dichloromethane / 3 h / 0 - 20 °C 4: sodium iodide / acetone / 19 h / 20 °C View Scheme |
n-octyne
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; triethylamine / 17 h / 20 °C / Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 17 h / 20 °C 3: triethylamine / dichloromethane / 3 h / 0 - 20 °C 4: sodium iodide / acetone / 19 h / 20 °C View Scheme |
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 17 h / 20 °C 2: triethylamine / dichloromethane / 3 h / 0 - 20 °C 3: sodium iodide / acetone / 19 h / 20 °C View Scheme |
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
With water; zinc In acetonitrile at 25℃; for 12h; Sealed tube; Inert atmosphere; | 93% |
With water; zinc In acetonitrile at 25℃; for 12h; Inert atmosphere; Sealed tube; | 93% |
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
With water-d2; zinc In acetonitrile at 25℃; for 12h; Time; Inert atmosphere; Sealed tube; | 92% |
With water-d2; zinc In acetonitrile at 25℃; for 12h; Inert atmosphere; Sealed tube; | 92% |
2-acetylaminomalonic acid diethyl ester
1-(2-iodoethyl)-4-octylbenzene
diethyl 2-acetamido-2-[2-(4-octylphenyl)ethyl]malonate
Conditions | Yield |
---|---|
With tetra-(n-butyl)ammonium iodide; caesium carbonate In dimethyl sulfoxide at 25 - 85℃; Inert atmosphere; | 88% |
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium hydride In N,N-dimethyl-formamide for 30h; Stage #2: 2-(4-octylphenyl)-1-iodoethane In N,N-dimethyl-formamide at 50 - 60℃; for 1h; | 82% |
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol at 20℃; for 0.5h; Metallation; Stage #2: 2-(4-octylphenyl)-1-iodoethane In ethanol at 65℃; for 3h; Alkylation; Further stages.; | 61% |
(S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Stage #1: (S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h; Stage #2: 2-(4-octylphenyl)-1-iodoethane In tetrahydrofuran at -78 - -15℃; for 4h; | 83% |
diethyl 4-(tetrahydropyran-2-yloxy)butane-1,1-dicarboxylate
1-(2-iodoethyl)-4-octylbenzene
diethyl 2-[2-(4-octylphenyl)ethyl]-2-[3-(tetrahydro-2H-pyran-2-yloxy)propyl]malonate
Conditions | Yield |
---|---|
Stage #1: diethyl 4-(tetrahydropyran-2-yloxy)butane-1,1-dicarboxylate With sodium hydride In N,N-dimethyl-formamide for 0.5h; Metallation; Stage #2: 2-(4-octylphenyl)-1-iodoethane In N,N-dimethyl-formamide for 3h; Alkylation; Further stages.; | 76% |
1-(2-iodoethyl)-4-octylbenzene
ethyl 2-acetamido-2-cyanoacetate
ethyl 2-acetamido-2-cyano-4-(4-octylphenyl)butyrate
Conditions | Yield |
---|---|
Stage #1: ethyl 2-acetamido-2-cyanoacetate With sodium ethanolate In ethanol at 20℃; for 0.5h; Metallation; Stage #2: 2-(4-octylphenyl)-1-iodoethane In ethanol at 65℃; for 3h; Alkylation; Further stages.; | 75% |
diethyl 3-(tetrahydropyran-2-yloxy)propane-1,1-dicarboxylate
1-(2-iodoethyl)-4-octylbenzene
2-[2-(4-octyl-phenyl)-ethyl]-2-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-malonic acid diethyl ester
Conditions | Yield |
---|---|
Stage #1: diethyl 3-(tetrahydropyran-2-yloxy)propane-1,1-dicarboxylate With sodium hydride In N,N-dimethyl-formamide for 0.5h; Metallation; Stage #2: 2-(4-octylphenyl)-1-iodoethane In N,N-dimethyl-formamide for 3h; Alkylation; Further stages.; |
1-(2-iodoethyl)-4-octylbenzene
fingolimod
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 1.2: 61 percent / ethanol / 3 h / 65 °C 2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 3.1: 8.25 g / pyridine / 16 h / 20 °C 4.1: 2 N aq. LiOH / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere 1.2: 0.4 - 0.45 °C / Inert atmosphere 2.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C 2.2: 0.01 h / 0 - 0.5 °C 2.3: 0 h / 0.15 - 0.5 °C 3.1: sodium hydroxide / water; methanol / 2 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: caesium carbonate; tetrabutylammomium bromide / toluene / Inert atmosphere; Reflux 2.1: calcium chloride / ethanol; water 2.2: 10 - 15 °C 2.3: Reflux View Scheme |
1-(2-iodoethyl)-4-octylbenzene
2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 1.2: 75 percent / ethanol / 3 h / 65 °C 2.1: 54 percent / LiBH4 / tetrahydrofuran / 6 h / Heating 3.1: 66 percent / aq. HCl; AcOH / 7 h / Heating View Scheme |
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: NaH / dimethylformamide / 0.5 h 1.2: dimethylformamide / 3 h 2.1: 1 N aq. HCl / methanol / 5 h 3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C 4.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C 5.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C 6.1: benzene / 1 h / Heating View Scheme |
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1.1: NaH / dimethylformamide / 0.5 h 1.2: dimethylformamide / 3 h 2.1: 1 N aq. HCl / methanol / 5 h 3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C 4.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C 5.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C 6.1: benzene / 1 h / Heating 7.1: benzene / 7 h / Heating 8.1: LiBH4 / tetrahydrofuran / 0.5 h / Heating 9.1: pyridine / 13 h / 20 °C 10.1: Me3SiI / CH2Cl2 / 7 h 10.2: pyridine / 13 h 11.1: 2 M aq. LiOH / tetrahydrofuran; methanol / 2 h / Heating View Scheme |
1-(2-iodoethyl)-4-octylbenzene
N-[1-cyano-1-hydroxymethyl-3-(4-octylphenyl)propyl]acetamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 1.2: 75 percent / ethanol / 3 h / 65 °C 2.1: 54 percent / LiBH4 / tetrahydrofuran / 6 h / Heating View Scheme |
1-(2-iodoethyl)-4-octylbenzene
3-[2-(4-octyl-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: NaH / dimethylformamide / 0.5 h 1.2: dimethylformamide / 3 h 2.1: 1 N aq. HCl / methanol / 5 h 3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C View Scheme |
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: NaH / dimethylformamide / 0.5 h 1.2: 76 percent / dimethylformamide / 3 h 2.1: KOH / ethanol / 6 h / 50 °C 3.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C 4.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C 5.1: benzene / 1 h / Heating 6.1: benzene / 7 h / Heating 7.1: LiBH4 / tetrahydrofuran / 3 h / Heating 8.1: 5 N aq. KOH / tetrahydrofuran; methanol / 13 h / Heating 9.1: HCl; MeOH / diethyl ether / 0.5 h View Scheme |
1-(2-iodoethyl)-4-octylbenzene
N-(1-hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl) butan-2-yl) acetamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 1.2: 61 percent / ethanol / 3 h / 65 °C 2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: caesium carbonate / dimethyl sulfoxide / 3 h / 60 °C / Inert atmosphere 1.2: 60 - 80 °C 2.1: sodium tetrahydroborate / methanol / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: caesium carbonate; tetrabutylammomium bromide / toluene / Inert atmosphere; Reflux 2.1: calcium acetate / isopropyl alcohol / 0.5 h / 10 - 15 °C 2.2: 10 - 15 °C View Scheme |
1-(2-iodoethyl)-4-octylbenzene
3-[2-(4-octyl-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: NaH / dimethylformamide / 0.5 h 1.2: dimethylformamide / 3 h 2.1: 1 N aq. HCl / methanol / 5 h View Scheme |
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: NaH / dimethylformamide / 0.5 h 1.2: dimethylformamide / 3 h 2.1: 1 N aq. HCl / methanol / 5 h 3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C 4.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C 5.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C View Scheme |
1-(2-iodoethyl)-4-octylbenzene
2-Methoxycarbonylamino-2-[2-(4-octylphenyl)ethyl]-γ-butyrolactone
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: NaH / dimethylformamide / 0.5 h 1.2: dimethylformamide / 3 h 2.1: 1 N aq. HCl / methanol / 5 h 3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C 4.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C 5.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C 6.1: benzene / 1 h / Heating 7.1: benzene / 7 h / Heating View Scheme |
1-(2-iodoethyl)-4-octylbenzene
2-Methoxycarbonylamino-2-[2-(4-octylphenyl)ethyl]butane 1,4-diol
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: NaH / dimethylformamide / 0.5 h 1.2: dimethylformamide / 3 h 2.1: 1 N aq. HCl / methanol / 5 h 3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C 4.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C 5.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C 6.1: benzene / 1 h / Heating 7.1: benzene / 7 h / Heating 8.1: LiBH4 / tetrahydrofuran / 0.5 h / Heating View Scheme |
1-(2-iodoethyl)-4-octylbenzene
2-acetamido-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol diacetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 1.2: 61 percent / ethanol / 3 h / 65 °C 2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 3.1: 8.25 g / pyridine / 16 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere 1.2: 0.4 - 0.45 °C / Inert atmosphere 2.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C 2.2: 0.01 h / 0 - 0.5 °C 2.3: 0 h / 0.15 - 0.5 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: caesium carbonate; tetrabutylammomium bromide / toluene / Inert atmosphere; Reflux 2.1: calcium acetate / isopropyl alcohol / 0.5 h / 10 - 15 °C 2.2: 10 - 15 °C 3.1: pyridine / 0.08 h 3.2: 0 - 5 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: caesium carbonate; tetrabutylammomium bromide / toluene / Inert atmosphere; Reflux 2.1: calcium acetate / isopropyl alcohol / 0.5 h / 10 - 15 °C 2.2: 10 - 15 °C 3.1: pyridine 3.2: 0 - 5 °C View Scheme |
1-(2-iodoethyl)-4-octylbenzene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: NaH / dimethylformamide / 0.5 h 1.2: dimethylformamide / 3 h 2.1: 1 N aq. HCl / methanol / 5 h 3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C 4.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C View Scheme |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View