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Hangzhou Think Chemical Co. Ltd

Product: Fingolimod Intermediate Chemical name: Benzene, 1-(2-iodoethyl)-4-octyl[CAS:162358-07-8] Or 1-(2-Iodoethyl)-4-octylbenzene HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and c

Good quality 1-(2-Iodoethyl)-4-octylbenzene for Fingolimod manufacture

Cas:162358-07-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

1-(2-Iodoethyl)-4-octylbenzene

Cas:162358-07-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

Benzene, 1-(2-iodoethyl)-4-octyl- Basic information Product Name: Benzene, 1-(2-iodoethyl)-4-octyl- Synonyms: Benzene, 1-(2-iodoethyl)-4-octyl-;1-(2-Iodoethyl)-4-oc

Benzene, 1-(2-iodoethyl)-4-octyl-

Cas:162358-07-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-(4-Octylphenyl)-1-iodoethane

Cas:162358-07-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

1- (2-iodoethyl) -4-Octylbenzene CAS 162358-07-8

Cas:162358-07-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM--Benzene, 1-(2-iodoethyl)-4-octyl-

Cas:162358-07-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 162358-07-8 with best quality

Cas:162358-07-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name: Benzene, 1-(2-iodoethyl)-4-octyl- CAS No.: 162358-07-8 Molecular formula: C16H25I Molecular weight: 344 Appearance: white powder Storage:Store in cool and dry place, away from sun

Benzene, 1-(2-iodoethyl)-4-octyl-

Cas:162358-07-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-(2-Iodoethyl)-4-octylbenzene 162358-07-8

Cas:162358-07-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Benzene, 1-(2-iodoethyl)-4-octyl- CAS:162358-07-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit

Benzene, 1-(2-iodoethyl)-4-octyl- CAS:162358-07-8

Cas:162358-07-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

1-(2-Iodoethyl)-4-octylbenzene for Fingolimod CAS NO.162358-07-8

Cas:162358-07-8

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Benzene, 1-(2-iodoethyl)-4-octyl- CAS 162358-07-8

Cas:162358-07-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-(2-Iodoethyl)-4-octylbenzene

Cas:162358-07-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-(2-Iodoethyl)-4-octylbenzene

Cas:162358-07-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Ai

Benzene, 1-(2-iodoethyl)-4-octyl-

Cas:162358-07-8

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

BENZENE, 1-(2-IODOETHYL)-4-OCTYL-

Cas:162358-07-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Benzene, 1-(2-iodoethyl)-4-octyl-

Cas:162358-07-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1-(2-Iodoethyl)-4-octylbenzene

Cas:162358-07-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Benzene, 1-(2-iodoethyl)-4-octyl-

Cas:162358-07-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Allylpalladium chloride dimer

Cas:162358-07-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Benzene, 1-(2-iodoethyl)-4-octyl-

Cas:162358-07-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

1-(2-Iodoethyl)-4-octylbenzene

Cas:162358-07-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 1-(2-Iodoethyl)-4-Octylbenzene CAS No.:162358-07-8 Molecule Formula:C16H25I Molecule Weight:344.27 Purity: 98.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TEST

Best Quality 1-(2-Iodoethyl)-4-Octylbenzene

Cas:162358-07-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home an

Benzene, 1-(2-iodoethyl)-4-octyl-

Cas:162358-07-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

1-(2-Iodoethyl)-4-octylbenzene

Cas:162358-07-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Hangzhou Fandachem Co.,Ltd, a China-based chemical company, specialize in exporting 1-(2-Iodoethyl)-4-octylbenzene , CAS:162358-07-8 Please contact us by email freely. We are leading exporter in China. If you really need this cargo

1-(2-Iodoethyl)-4-octylbenzene , CAS:162358-07-8 from Fandachem

Cas:162358-07-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1-(2-Iodoethyl)-4-octylbenzene for Fingolimod CAS NO.162358-07-8 CAS NO.162358-07-8

Cas:162358-07-8

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence

1-(2-Iodoethyl)-4-octylbenzene

Cas:162358-07-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional leading manufacturer of chemicals and APIs in China. Our core business line covers APIs, Intermediates, Flavours and fragrances, Specialty chemicals, Dietary additives etc.We are specialized in chemical

1-(2-IODOETHYL)-4-OCTYBENZENE

Cas:162358-07-8

Min.Order:1 Gram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

1-(2-iodoethyl)-4-octylbenzene

Cas:162358-07-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-octylphenethyl methanesulfonate
162358-06-7

4-octylphenethyl methanesulfonate

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
With lithium iodide In tetrahydrofuran at 20℃; for 4h;5.37 g
With sodium iodide In butanone for 2h; Iodination; Heating;16.0 g
With sodium iodide In tetrahydrofuran at 20℃;70 g
With tetra-(n-butyl)ammonium iodide; sodium iodide for 3h; Inert atmosphere;150 g
With sodium iodide In acetone at 20℃; for 19h;0.44 g
p-hydroxyphenethyl alcohol
501-94-0

p-hydroxyphenethyl alcohol

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 98 percent / NaHSO4 on silica / hexane / 26 h / Heating
2: 94 percent / pyridine / CH2Cl2 / 1 h / 20 °C
3: 20 percent / Fe(acac)3; NMP / tetrahydrofuran / 1 h
4: Et3N / CH2Cl2 / 1 h
5: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C
View Scheme
2-(4-hydroxyphenyl)ethyl acetate
58556-55-1

2-(4-hydroxyphenyl)ethyl acetate

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 94 percent / pyridine / CH2Cl2 / 1 h / 20 °C
2: 20 percent / Fe(acac)3; NMP / tetrahydrofuran / 1 h
3: Et3N / CH2Cl2 / 1 h
4: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C
View Scheme
2-(4-Octylphenyl)ethyl alcohol
162358-05-6

2-(4-Octylphenyl)ethyl alcohol

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N / CH2Cl2 / 1 h
2: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: Et3N / CH2Cl2 / 1 h / 20 °C
2: 16.0 g / NaI / butan-2-one / 2 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 0.5 h
1.2: 3 h / 0 - 20 °C
2.1: sodium iodide / tetrahydrofuran / 20 °C
View Scheme
acetic acid 2-(4-octylphenyl)ethyl ester
162358-04-5

acetic acid 2-(4-octylphenyl)ethyl ester

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 93 percent / NaOMe / methanol / 8 h / 20 °C
2: Et3N / CH2Cl2 / 1 h
3: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 3.40 g / NaOMe; MeOH / 2 h / Heating
2: Et3N / CH2Cl2 / 1 h / 20 °C
3: 16.0 g / NaI / butan-2-one / 2 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: sodium methylate / methanol / 3 h / 20 °C
2.1: triethylamine / dichloromethane / 0.5 h
2.2: 3 h / 0 - 20 °C
3.1: sodium iodide / tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C
2: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C
View Scheme
acetic acid 2-[4-(trifluoromethanesulfonyloxy)phenyl]ethyl ester
712223-57-9

acetic acid 2-[4-(trifluoromethanesulfonyloxy)phenyl]ethyl ester

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 20 percent / Fe(acac)3; NMP / tetrahydrofuran / 1 h
2: Et3N / CH2Cl2 / 1 h
3: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C
View Scheme
n-octanoic acid chloride
111-64-8

n-octanoic acid chloride

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C
2: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C
3: 3.40 g / NaOMe; MeOH / 2 h / Heating
4: Et3N / CH2Cl2 / 1 h / 20 °C
5: 16.0 g / NaI / butan-2-one / 2 h / Heating
View Scheme
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0 - 20 °C
2.1: triethylsilane; trifluoroacetic acid / 20 °C
3.1: sodium methylate / methanol / 3 h / 20 °C
4.1: triethylamine / dichloromethane / 0.5 h
4.2: 3 h / 0 - 20 °C
5.1: sodium iodide / tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / 0.01 h / 0.25 - 0.3 °C
1.2: 0 h / 0.2 - 0.5 °C
2.1: sodium hydroxide / water; methanol / 1.5 h / 0.1 - 0.3 °C
3.1: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave
4.1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C
5.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C
View Scheme
acetic acid phenethyl ester
103-45-7

acetic acid phenethyl ester

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C
2: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C
3: 3.40 g / NaOMe; MeOH / 2 h / Heating
4: Et3N / CH2Cl2 / 1 h / 20 °C
5: 16.0 g / NaI / butan-2-one / 2 h / Heating
View Scheme
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / 0.01 h / 0.25 - 0.3 °C
1.2: 0 h / 0.2 - 0.5 °C
2.1: sodium hydroxide / water; methanol / 1.5 h / 0.1 - 0.3 °C
3.1: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave
4.1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C
5.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C
View Scheme
2-(4-octanoylphenyl)ethyl acetate
162358-03-4

2-(4-octanoylphenyl)ethyl acetate

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C
2: 3.40 g / NaOMe; MeOH / 2 h / Heating
3: Et3N / CH2Cl2 / 1 h / 20 °C
4: 16.0 g / NaI / butan-2-one / 2 h / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: triethylsilane; trifluoroacetic acid / 20 °C
2.1: sodium methylate / methanol / 3 h / 20 °C
3.1: triethylamine / dichloromethane / 0.5 h
3.2: 3 h / 0 - 20 °C
4.1: sodium iodide / tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydroxide / water; methanol / 1.5 h / 0.1 - 0.3 °C
2: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave
3: sodium hydroxide / water; methanol / 0.2 - 0.3 °C
4: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C
View Scheme
1-(2-bromoethyl)-4-octylbenzene
268557-54-6

1-(2-bromoethyl)-4-octylbenzene

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
In butanone
4'-(2-iodoethyl)octanophenone
219307-01-4

4'-(2-iodoethyl)octanophenone

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
With triethylsilane In trifluoroacetic acid
1H-imidazole
288-32-4

1H-imidazole

ethyl acetate n-hexane

ethyl acetate n-hexane

2-(4-Octylphenyl)ethyl alcohol
162358-05-6

2-(4-Octylphenyl)ethyl alcohol

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
With iodine; triphenylphosphine In ether (200 ml)-acetonitrile
Phenyl acetate
122-79-2

Phenyl acetate

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0 - 20 °C
2.1: triethylsilane; trifluoroacetic acid / 20 °C
3.1: sodium methylate / methanol / 3 h / 20 °C
4.1: triethylamine / dichloromethane / 0.5 h
4.2: 3 h / 0 - 20 °C
5.1: sodium iodide / tetrahydrofuran / 20 °C
View Scheme
4'-(2-hydroxyethyl)octanophenone
219307-07-0

4'-(2-hydroxyethyl)octanophenone

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave
2: sodium hydroxide / water; methanol / 0.2 - 0.3 °C
3: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C
View Scheme
4-iodophenethyl alcohol
52914-23-5

4-iodophenethyl alcohol

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; triethylamine / 17 h / 20 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 17 h / 20 °C
3: triethylamine / dichloromethane / 3 h / 0 - 20 °C
4: sodium iodide / acetone / 19 h / 20 °C
View Scheme
n-octyne
629-05-0

n-octyne

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; triethylamine / 17 h / 20 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 17 h / 20 °C
3: triethylamine / dichloromethane / 3 h / 0 - 20 °C
4: sodium iodide / acetone / 19 h / 20 °C
View Scheme
2-(4-(oct-1-yn-1-yl)phenyl)-1-ethanol

2-(4-(oct-1-yn-1-yl)phenyl)-1-ethanol

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 17 h / 20 °C
2: triethylamine / dichloromethane / 3 h / 0 - 20 °C
3: sodium iodide / acetone / 19 h / 20 °C
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

1-ethyl-4-octylbenzene

1-ethyl-4-octylbenzene

Conditions
ConditionsYield
With water; zinc In acetonitrile at 25℃; for 12h; Sealed tube; Inert atmosphere;93%
With water; zinc In acetonitrile at 25℃; for 12h; Inert atmosphere; Sealed tube;93%
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

1-(ethyl-2-d)-4-octylbenzene

1-(ethyl-2-d)-4-octylbenzene

Conditions
ConditionsYield
With water-d2; zinc In acetonitrile at 25℃; for 12h; Time; Inert atmosphere; Sealed tube;92%
With water-d2; zinc In acetonitrile at 25℃; for 12h; Inert atmosphere; Sealed tube;92%
2-acetylaminomalonic acid diethyl ester
1068-90-2

2-acetylaminomalonic acid diethyl ester

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

diethyl 2-acetamido-2-[2-(4-octylphenyl)ethyl]malonate
162358-08-9

diethyl 2-acetamido-2-[2-(4-octylphenyl)ethyl]malonate

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; caesium carbonate In dimethyl sulfoxide at 25 - 85℃; Inert atmosphere;88%
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium hydride In N,N-dimethyl-formamide for 30h;
Stage #2: 2-(4-octylphenyl)-1-iodoethane In N,N-dimethyl-formamide at 50 - 60℃; for 1h;
82%
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol at 20℃; for 0.5h; Metallation;
Stage #2: 2-(4-octylphenyl)-1-iodoethane In ethanol at 65℃; for 3h; Alkylation; Further stages.;
61%
(S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine
78342-42-4

(S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

(2R,5S)-5-isopropyl-3,6-dimethoxy-2-(4-octylphenethyl)-2,5-dihydro-pyrazine

(2R,5S)-5-isopropyl-3,6-dimethoxy-2-(4-octylphenethyl)-2,5-dihydro-pyrazine

Conditions
ConditionsYield
Stage #1: (S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h;
Stage #2: 2-(4-octylphenyl)-1-iodoethane In tetrahydrofuran at -78 - -15℃; for 4h;
83%
diethyl 4-(tetrahydropyran-2-yloxy)butane-1,1-dicarboxylate
22455-91-0

diethyl 4-(tetrahydropyran-2-yloxy)butane-1,1-dicarboxylate

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

diethyl 2-[2-(4-octylphenyl)ethyl]-2-[3-(tetrahydro-2H-pyran-2-yloxy)propyl]malonate
177260-23-0

diethyl 2-[2-(4-octylphenyl)ethyl]-2-[3-(tetrahydro-2H-pyran-2-yloxy)propyl]malonate

Conditions
ConditionsYield
Stage #1: diethyl 4-(tetrahydropyran-2-yloxy)butane-1,1-dicarboxylate With sodium hydride In N,N-dimethyl-formamide for 0.5h; Metallation;
Stage #2: 2-(4-octylphenyl)-1-iodoethane In N,N-dimethyl-formamide for 3h; Alkylation; Further stages.;
76%
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

ethyl 2-acetamido-2-cyanoacetate
90877-70-6, 4977-62-2

ethyl 2-acetamido-2-cyanoacetate

ethyl 2-acetamido-2-cyano-4-(4-octylphenyl)butyrate
296282-66-1

ethyl 2-acetamido-2-cyano-4-(4-octylphenyl)butyrate

Conditions
ConditionsYield
Stage #1: ethyl 2-acetamido-2-cyanoacetate With sodium ethanolate In ethanol at 20℃; for 0.5h; Metallation;
Stage #2: 2-(4-octylphenyl)-1-iodoethane In ethanol at 65℃; for 3h; Alkylation; Further stages.;
75%
diethyl 3-(tetrahydropyran-2-yloxy)propane-1,1-dicarboxylate
25823-84-1

diethyl 3-(tetrahydropyran-2-yloxy)propane-1,1-dicarboxylate

1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

2-[2-(4-octyl-phenyl)-ethyl]-2-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-malonic acid diethyl ester
1026240-85-6

2-[2-(4-octyl-phenyl)-ethyl]-2-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-malonic acid diethyl ester

Conditions
ConditionsYield
Stage #1: diethyl 3-(tetrahydropyran-2-yloxy)propane-1,1-dicarboxylate With sodium hydride In N,N-dimethyl-formamide for 0.5h; Metallation;
Stage #2: 2-(4-octylphenyl)-1-iodoethane In N,N-dimethyl-formamide for 3h; Alkylation; Further stages.;
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

fingolimod
162359-55-9

fingolimod

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
1.2: 61 percent / ethanol / 3 h / 65 °C
2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C
3.1: 8.25 g / pyridine / 16 h / 20 °C
4.1: 2 N aq. LiOH / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere
1.2: 0.4 - 0.45 °C / Inert atmosphere
2.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C
2.2: 0.01 h / 0 - 0.5 °C
2.3: 0 h / 0.15 - 0.5 °C
3.1: sodium hydroxide / water; methanol / 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: caesium carbonate; tetrabutylammomium bromide / toluene / Inert atmosphere; Reflux
2.1: calcium chloride / ethanol; water
2.2: 10 - 15 °C
2.3: Reflux
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid
296282-46-7

2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
1.2: 75 percent / ethanol / 3 h / 65 °C
2.1: 54 percent / LiBH4 / tetrahydrofuran / 6 h / Heating
3.1: 66 percent / aq. HCl; AcOH / 7 h / Heating
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

3-isocyanato-3-[2-(4-octyl-phenyl)-ethyl]-dihydro-furan-2-one

3-isocyanato-3-[2-(4-octyl-phenyl)-ethyl]-dihydro-furan-2-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: NaH / dimethylformamide / 0.5 h
1.2: dimethylformamide / 3 h
2.1: 1 N aq. HCl / methanol / 5 h
3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C
4.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C
5.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C
6.1: benzene / 1 h / Heating
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

2-amino-2-[2-(4-octylphenyl)ethyl]butane-1,4-diol

2-amino-2-[2-(4-octylphenyl)ethyl]butane-1,4-diol

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: NaH / dimethylformamide / 0.5 h
1.2: dimethylformamide / 3 h
2.1: 1 N aq. HCl / methanol / 5 h
3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C
4.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C
5.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C
6.1: benzene / 1 h / Heating
7.1: benzene / 7 h / Heating
8.1: LiBH4 / tetrahydrofuran / 0.5 h / Heating
9.1: pyridine / 13 h / 20 °C
10.1: Me3SiI / CH2Cl2 / 7 h
10.2: pyridine / 13 h
11.1: 2 M aq. LiOH / tetrahydrofuran; methanol / 2 h / Heating
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

N-[1-cyano-1-hydroxymethyl-3-(4-octylphenyl)propyl]acetamide
296282-78-5

N-[1-cyano-1-hydroxymethyl-3-(4-octylphenyl)propyl]acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
1.2: 75 percent / ethanol / 3 h / 65 °C
2.1: 54 percent / LiBH4 / tetrahydrofuran / 6 h / Heating
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

3-[2-(4-octyl-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-carboxylic acid
1027589-49-6

3-[2-(4-octyl-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: NaH / dimethylformamide / 0.5 h
1.2: dimethylformamide / 3 h
2.1: 1 N aq. HCl / methanol / 5 h
3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

2-amino-2-[2-(4-octylphenyl)ethyl]pentane-1,5-diol

2-amino-2-[2-(4-octylphenyl)ethyl]pentane-1,5-diol

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: NaH / dimethylformamide / 0.5 h
1.2: 76 percent / dimethylformamide / 3 h
2.1: KOH / ethanol / 6 h / 50 °C
3.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C
4.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C
5.1: benzene / 1 h / Heating
6.1: benzene / 7 h / Heating
7.1: LiBH4 / tetrahydrofuran / 3 h / Heating
8.1: 5 N aq. KOH / tetrahydrofuran; methanol / 13 h / Heating
9.1: HCl; MeOH / diethyl ether / 0.5 h
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

N-(1-hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl) butan-2-yl) acetamide
249289-10-9

N-(1-hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl) butan-2-yl) acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
1.2: 61 percent / ethanol / 3 h / 65 °C
2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: caesium carbonate / dimethyl sulfoxide / 3 h / 60 °C / Inert atmosphere
1.2: 60 - 80 °C
2.1: sodium tetrahydroborate / methanol / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: caesium carbonate; tetrabutylammomium bromide / toluene / Inert atmosphere; Reflux
2.1: calcium acetate / isopropyl alcohol / 0.5 h / 10 - 15 °C
2.2: 10 - 15 °C
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

3-[2-(4-octyl-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-carboxylic acid ethyl ester
1027929-75-4

3-[2-(4-octyl-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaH / dimethylformamide / 0.5 h
1.2: dimethylformamide / 3 h
2.1: 1 N aq. HCl / methanol / 5 h
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

3-[2-(4-octyl-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-carbonyl azide

3-[2-(4-octyl-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-carbonyl azide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: NaH / dimethylformamide / 0.5 h
1.2: dimethylformamide / 3 h
2.1: 1 N aq. HCl / methanol / 5 h
3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C
4.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C
5.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

2-Methoxycarbonylamino-2-[2-(4-octylphenyl)ethyl]-γ-butyrolactone
177259-57-3

2-Methoxycarbonylamino-2-[2-(4-octylphenyl)ethyl]-γ-butyrolactone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: NaH / dimethylformamide / 0.5 h
1.2: dimethylformamide / 3 h
2.1: 1 N aq. HCl / methanol / 5 h
3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C
4.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C
5.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C
6.1: benzene / 1 h / Heating
7.1: benzene / 7 h / Heating
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

2-Methoxycarbonylamino-2-[2-(4-octylphenyl)ethyl]butane 1,4-diol
177258-50-3

2-Methoxycarbonylamino-2-[2-(4-octylphenyl)ethyl]butane 1,4-diol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: NaH / dimethylformamide / 0.5 h
1.2: dimethylformamide / 3 h
2.1: 1 N aq. HCl / methanol / 5 h
3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C
4.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C
5.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C
6.1: benzene / 1 h / Heating
7.1: benzene / 7 h / Heating
8.1: LiBH4 / tetrahydrofuran / 0.5 h / Heating
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

2-acetamido-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol diacetate
162358-09-0

2-acetamido-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol diacetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
1.2: 61 percent / ethanol / 3 h / 65 °C
2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C
3.1: 8.25 g / pyridine / 16 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere
1.2: 0.4 - 0.45 °C / Inert atmosphere
2.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C
2.2: 0.01 h / 0 - 0.5 °C
2.3: 0 h / 0.15 - 0.5 °C
View Scheme
Multi-step reaction with 3 steps
1.1: caesium carbonate; tetrabutylammomium bromide / toluene / Inert atmosphere; Reflux
2.1: calcium acetate / isopropyl alcohol / 0.5 h / 10 - 15 °C
2.2: 10 - 15 °C
3.1: pyridine / 0.08 h
3.2: 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1.1: caesium carbonate; tetrabutylammomium bromide / toluene / Inert atmosphere; Reflux
2.1: calcium acetate / isopropyl alcohol / 0.5 h / 10 - 15 °C
2.2: 10 - 15 °C
3.1: pyridine
3.2: 0 - 5 °C
View Scheme
1-(2-iodoethyl)-4-octylbenzene
162358-07-8

1-(2-iodoethyl)-4-octylbenzene

C24H34O6

C24H34O6

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: NaH / dimethylformamide / 0.5 h
1.2: dimethylformamide / 3 h
2.1: 1 N aq. HCl / methanol / 5 h
3.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C
4.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C
View Scheme
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