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inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------
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inquiryProduct description: Product name Diethyl acetamidomalonate CAS number 1068-90-2 Assay ≥99% Appearance White crystalline powder Capacity 500mt/year Application Pharmaceutical
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inquiryhigh quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai
Diethyl acetylaminomalonate Structural formula: CAS NO.: 1068-90-2 EINEC RN.: 213-952-9 Molecular Formula: C9H15NO5 Molecular Weight: 217
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inquiryName Diethyl acetamidomalonate Synonyms Acetamidomalonic acid diethyl ester CAS NO. 1068-90-2 Molecular Formula C9H15NO5 Mo
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inquiryAppearance:White to light yellow powder Storage:room temperature Package:25kg/drum Application:Diethyl 2-Acetamidomalonate, is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds. It is an i
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inquiryAppearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Courie
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inquirydiethyl aminomalonate hydrochloride
acetic anhydride
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; | 99% |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 100% |
diethyl aminomalonate hydrochloride
acetyl chloride
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 96% |
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; | 96% |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 96% |
Conditions | Yield |
---|---|
With 2,2′-biquinoline-4,4'-dicarboxylic acid disodium salt; acetic acid; copper(l) chloride at 80 - 110℃; for 8h; | 93% |
Conditions | Yield |
---|---|
With zinc In water | 90% |
Multi-step reaction with 2 steps 1: H2 / 10percent Pd/C / ethanol / 20520 Torr 2: ethanol View Scheme | |
Multi-step reaction with 2 steps 1: palladium coal; ethanol / 2280 - 3040 Torr / Hydrogenation 2: ethanol View Scheme |
Conditions | Yield |
---|---|
With sodium nitrite Addition; Isonitrosoylation; N-acetylation; | 87% |
aminomalonic acid diethyl ester
Triethyl orthoacetate
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
for 2h; Reflux; | 87% |
diethyl malonate
A
1,4-dioxane
B
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With acetic acid; sodium nitrite In water | A n/a B 86% |
Conditions | Yield |
---|---|
With chloroform; tris-(2-chloro-ethyl)-amine; sulfuric acid |
diethyl acetylmalonate
A
methylcarbamoyl-malonic acid diethyl ester
B
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With hydrogen azide; chloroform; sulfuric acid | |
With sodium azide; chloroform; sulfuric acid |
aminomalonic acid diethyl ester
acetic anhydride
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With ethanol | |
With pyridine | |
In ethanol Yield given; | |
With triethylamine In tetrahydrofuran at 23℃; for 1h; |
diethyl oximinomalonate
acetic anhydride
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With nickel | |
With acetic acid; zinc |
diethyl nitromalonate
acetic anhydride
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With nickel Hydrogenation; | |
With palladium on activated charcoal at 60℃; under 58840.6 Torr; Hydrogenation; |
acetic anhydride
α-Benzolazo-malonsaeure-diethylester
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With acetic acid; zinc |
Conditions | Yield |
---|---|
beim Kochen der Kalium-Verbindung; |
aminomalonic acid diethyl ester
acetyl chloride
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With pyridine | |
With sodium carbonate In dichloromethane; water for 2h; Acetylation; | |
With benzothiazole-2-sulphonic acid In diethyl ether at 0 - 25℃; for 1h; |
methanol
ethene
carbon monoxide
sodium diethyl (acetylamino)malonate
A
1-acetamidopropanetricarboxylic acid 1,1-diethyl-3-methyl ester
B
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
Yield given. Multistep reaction. Yields of byproduct given; |
acetylamino-bromomethyl-malonic acid diethyl ester
A
diethyl 2-acetylaminobutanedioate
B
diethyl α-acetamido, α-methylmalonate
C
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
carbon-skeleton rearrangement mediated by hydrophobic Vitamin B12 covalent bound to a lipid species in a bilayer membrane; 1.) NaBH4, complex 1, 2.) N,N-bis(hexadecyl)-Nα-(6-sulfohexanoyl)-L-alaninamide, irradiation; other medium for irradiation; | A 2 % Chromat. B 57 % Chromat. C 25 % Chromat. |
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With diethyl ether; aluminium amalgam |
Conditions | Yield |
---|---|
With pyridine |
acetoxyimino-malonic acid diethyl ester
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
Reduktion; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: NaH / tetrahydrofuran / 0.25 h / 23 °C 1.2: O-(4-nitrobenzoyl)-hydroxylamine / tetrahydrofuran / 23 °C 2.1: Et3N / tetrahydrofuran / 1 h / 23 °C View Scheme |
ethylesters of amino malonic acid
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 5 h / Reflux 2: 2 h / Reflux View Scheme |
benzyl chloride
2-acetylaminomalonic acid diethyl ester
2-(N-acetylamino)-2-benzylpropanedioic diethyl ester
Conditions | Yield |
---|---|
With 18-crown-6 ether; potassium carbonate In dichloromethane at 100 - 110℃; for 0.8h; Product distribution; var. solvents, var. time, other reaction partners; | 100% |
With 18-crown-6 ether; potassium carbonate In N,N-dimethyl-formamide at 100 - 110℃; for 0.8h; | 100% |
With ethanol; sodium ethanolate | |
With ethanol; sodium ethanolate |
allyl bromide
2-acetylaminomalonic acid diethyl ester
ethyl 2-acetamido-2-(ethoxycarbonyl)-4-pentenoate
Conditions | Yield |
---|---|
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol for 5h; Reflux; Stage #2: allyl bromide In ethanol for 15h; Reflux; | 100% |
With caesium carbonate In acetonitrile Heating; | 99% |
With ethanol; sodium | 97% |
propargyl bromide
2-acetylaminomalonic acid diethyl ester
diethyl α-acetamido-α-propargylmalonate
Conditions | Yield |
---|---|
With caesium carbonate In acetonitrile at 20℃; for 18h; | 100% |
With caesium carbonate In acetonitrile at 20℃; for 18h; | 99% |
With sodium hydride In N,N-dimethyl-formamide at 60℃; for 3h; | 95% |
Conditions | Yield |
---|---|
With 18-crown-6 ether; potassium carbonate In N,N-dimethyl-formamide at 100 - 110℃; for 0.5h; | 100% |
diethyl 2-bromoethylphosphonate
2-acetylaminomalonic acid diethyl ester
(N-acetylamino-3 bis-ethoxycarbonyl-3,3)-propylphosphonate de diethyle
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In acetonitrile for 8h; Heating; | 100% |
With sodium hydride In toluene at 110℃; for 24h; | 100% |
With sodium hydride; Diethyl carbonate In hexane; toluene; mineral oil at 110℃; for 24h; | 33.3 g |
bis(2-chloroethyl) 2-chloroethylphosphonate
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In acetonitrile for 8h; Heating; | 100% |
4-bromo-1-(bromomethyl)-2-nitrobenzene
2-acetylaminomalonic acid diethyl ester
Ethyl 2-Acetamido-2-(4'-bromo-2'-nitrobenzyl)malonate
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide | 100% |
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol at 20℃; for 0.5h; Stage #2: 4-bromo-1-(bromomethyl)-2-nitrobenzene In ethanol | 74% |
68% |
4-(bromomethyl)-1-fluoro-2-nitrobenzene
2-acetylaminomalonic acid diethyl ester
ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-3-(4'-fluoro-3'-nitrophenyl)propanoate
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide for 4h; Ambient temperature; | 100% |
With sodium hydride In N,N-dimethyl-formamide; mineral oil; pentane at 20℃; for 4h; | 100% |
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium hydride In tetrahydrofuran; mineral oil for 3h; Reflux; Stage #2: 4-(bromomethyl)-1-fluoro-2-nitrobenzene In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil Reflux; | 100% |
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium hydride In N,N-dimethyl-formamide; mineral oil Stage #2: 4-(bromomethyl)-1-fluoro-2-nitrobenzene In N,N-dimethyl-formamide; mineral oil at 20℃; for 24h; | 74% |
With sodium hydride In hexanes; N,N-dimethyl-formamide; mineral oil at 20℃; for 4h; |
2-acetylaminomalonic acid diethyl ester
6'-(bromomethyl)-3',4'-dihydro-4,4-dimethyl-7'-nitrospiro(cyclohexane-1,1'(2H)-naphthalene)
C27H38N2O7
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide for 2.5h; Ambient temperature; | 100% |
2-acetylaminomalonic acid diethyl ester
(4-methoxyphenyl)methyl methyl carbonate
2-acetylamino-2-(4-methoxybenzyl)malonic acid diethyl ester
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; N,O-bis-(trimethylsilyl)-acetamide; {(η4-1,5-cyclooctadiene)Pd(η3-allyl)}BF4; potassium acetate In tetrahydrofuran at 80℃; for 24h; | 100% |
With 1,1'-bis(diisopropylphosphino)ferrocene; {(η4-1,5-cyclooctadiene)Pd(η3-allyl)}BF4; caesium carbonate In N,N-dimethyl-formamide at 30℃; for 72h; Inert atmosphere; | 95% |
With 1,1'-bis-(diphenylphosphino)ferrocene; 1,5-cis,cis-cyclooctadiene; [PdCp(η3-C3H5)] In tetrahydrofuran at 80℃; | 92% |
2-isopropyl-4-chloromethylthiazole
2-acetylaminomalonic acid diethyl ester
diethyl 2-acetamido-2-((2-isopropylthiazol-4-yl)methyl)malonate
Conditions | Yield |
---|---|
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; Stage #2: 2-isopropyl-4-chloromethylthiazole In N,N-dimethyl-formamide at 20℃; | 100% |
Conditions | Yield |
---|---|
In water at 20℃; for 4h; | 100% |
3-(Dimethylaminomethyl)indole
2-acetylaminomalonic acid diethyl ester
acetylamino-indol-3-ylmethyl-malonic acid diethyl ester
Conditions | Yield |
---|---|
With tributylphosphine In acetonitrile for 4h; Heating; | 99.5% |
With sodium hydroxide; toluene | |
With sodium hydroxide; xylene | |
With sodium ethanolate; ethyl iodide | |
With ethanol; dimethyl sulfate |
N,N-dimethyl-formamide
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With caesium carbonate | 99.4% |
4-Fluorobenzyl bromide
2-acetylaminomalonic acid diethyl ester
diethyl α-acetamido, α-(4-fluorobenzyl)malonate
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile Alkylation; Heating; | 99% |
With potassium hydroxide; Aliquat 336 for 0.25h; Ambient temperature; | 71% |
With caesium carbonate In acetonitrile at 130℃; Microwave irradiation; |
propargyl p-toluenesulfonate
2-acetylaminomalonic acid diethyl ester
diethyl α-acetamido-α-propargylmalonate
Conditions | Yield |
---|---|
Stage #1: 2-acetylaminomalonic acid diethyl ester With potassium tert-butylate In 1,4-dioxane at 20 - 50℃; for 4h; Inert atmosphere; Stage #2: propargyl p-toluenesulfonate In 1,4-dioxane at 50℃; Concentration; Solvent; Inert atmosphere; Reflux; | 99% |
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.333333h; Inert atmosphere; Stage #2: {4-(bromomethyl)-2-[(2-nitrobenzyl)oxy]phenoxy}(tert-butyl)dimethylsilane In N,N-dimethyl-formamide; mineral oil at 20℃; for 4h; Inert atmosphere; | 99% |
4-bromomethyl-2(1H)-quinolinone
2-acetylaminomalonic acid diethyl ester
2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester
Conditions | Yield |
---|---|
With sodium ethanolate; tetra-(n-butyl)ammonium iodide In ethanol at 60℃; for 8h; Reagent/catalyst; Temperature; | 98.44% |
With sodium In ethanol for 2h; | 69% |
With sodium hydroxide In water; dimethyl sulfoxide at 20 - 30℃; for 2h; Reagent/catalyst; Solvent; Large scale; |
5-methoxygramine
2-acetylaminomalonic acid diethyl ester
acetylamino-(5-methoxy-indol-3-ylmethyl)-malonic acid diethyl ester
Conditions | Yield |
---|---|
With sodium hydroxide In toluene for 18h; Reflux; | 98% |
With ethanol; sodium ethanolate; dimethyl sulfate |
1-bromomethyl-3-nitrobenzene
2-acetylaminomalonic acid diethyl ester
diethyl 2-(acetylamino)-2-(3-nitrobenzyl)malonate
Conditions | Yield |
---|---|
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.0833333h; Inert atmosphere; Stage #2: 1-bromomethyl-3-nitrobenzene In N,N-dimethyl-formamide; mineral oil at 0℃; for 16h; Inert atmosphere; | 98% |
With ethanol; sodium ethanolate |
2-acetylaminomalonic acid diethyl ester
2-acetamido-3-ethoxy-3-oxopropanoic acid
Conditions | Yield |
---|---|
With sodium hydroxide; phosphate buffer; α-chymotrypsin for 5.25h; Product distribution; Ambient temperature; var. pH; | 98% |
With sodium hydroxide In 1,4-dioxane; water at 20℃; for 17h; | 81% |
With sodium hydroxide In 1,4-dioxane at 20℃; for 15h; | 76% |
1-Bromo-3-phenylpropane
2-acetylaminomalonic acid diethyl ester
2-acetylamino-2-(3-phenyl-propyl)malonic acid diethyl ester
Conditions | Yield |
---|---|
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol at 20℃; for 1.5h; Stage #2: 1-Bromo-3-phenylpropane In ethanol for 16h; Heating; | 98% |
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol at 20℃; for 1.5h; Stage #2: 1-Bromo-3-phenylpropane In ethanol for 16.25h; Heating / reflux; | 98% |
(i) Na, EtOH, (ii) /BRN= 2205527/; Multistep reaction; | |
With sodium ethanolate; sodium In ethanol; nitrogen | |
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol at 20℃; for 2h; Stage #2: 1-Bromo-3-phenylpropane In ethanol at 20 - 73℃; for 28.25h; |
benzyl bromide
2-acetylaminomalonic acid diethyl ester
2-(N-acetylamino)-2-benzylpropanedioic diethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile Alkylation; Heating; | 98% |
With potassium hydroxide; Aliquat 336 for 0.25h; Ambient temperature; | 84% |
With caesium carbonate In acetonitrile at 130℃; for 0.166667h; Microwave irradiation; | 82% |
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol at 0℃; for 0.0833333h; Inert atmosphere; Stage #2: benzyl bromide In ethanol for 2h; Inert atmosphere; Reflux; | |
With caesium carbonate In acetonitrile at 130℃; Microwave irradiation; |
rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide; potassium acetate; chiral (phosphinoaryldihydrooxazole)allyl-Pd(II) In dichloromethane at 23℃; | 98% |
With bis(η3-allyl-μ-chloropalladium(II)); C2-symmetric chiral P; potassium acetate; bis-(trimethylsilyl)acetamide In dichloromethane for 0.5h; Ambient temperature; | 98% |
4-(bromomethyl)-3-nitrobenzaldehyde
2-acetylaminomalonic acid diethyl ester
ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-3-(4-formyl-2-nitrophenyl)propanoate
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide for 2.5h; Ambient temperature; | 98% |
With sodium hydride In N,N-dimethyl-formamide |
rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene
2-acetylaminomalonic acid diethyl ester
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide; bis(η3-allyl-μ-chloropalladium(II)); (S)-7-(diphenylphosphino)-2′-isopropyl-2,3-dihydro-5′H-spiro[indene-1,4′-oxazole]; potassium acetate In toluene at 0℃; for 5h; Inert atmosphere; Schlenk technique; enantioselective reaction; | 98% |
With bis(η3-allyl-μ-chloropalladium(II)); potassium acetate; (1R,2R)-2-[N-(2-diphenylphosphanylbenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester In diethyl ether at 25℃; for 6h; enantioselective reaction; | 98% |
With benzenesulfonamide; potassium acetate; (1R,2S,4R,5S)-(+)-2,5-dimethyl-7-phenyl-7-phosphabicyclo[2.2.1]heptane; bis(η3-allyl-μ-chloropalladium(II)) In toluene for 2h; | 95% |
With benzenesulfonamide; potassium acetate; (S,S)-N,N'-1,2-bis(S-cyclopentyl-S-phenyl-sulfonimidoyl)-ethane; bis(η3-allyl-μ-chloropalladium(II)) In dichloromethane at 45℃; for 96h; | 89% |
2-acetylaminomalonic acid diethyl ester
2-ethylsulfanyl-3-(ethylsulfanyl-trimethylsilanyl-methyl)-1H-indole
Conditions | Yield |
---|---|
With tributylphosphine In acetonitrile at 80℃; for 9h; Alkylation; | 98% |
2-acetylaminomalonic acid diethyl ester
diethyl (N-acetylamino)[(1-naphthyl)methyl]malonate
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; [PdCp(η3-C3H5)] In tetrahydrofuran at 80℃; for 1h; | 98% |
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