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Pregnenolone Compitive price DELTA5-PREGNEN-3BETA-OL-20-ONE;DELTA5-PREGNEN-3B-OL-20-ONE;DELTA-5-PREGNENE-3B-OL-20-ONE;DELTA5-PREGNENOLONE;1-((3S,8S,9S,10R,13S,14S,17S)-3-HYDROXY-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H

Pregnenolone

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $15.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

High quality pure natural 98% antiinflammatory drugs PregnenoloneCAS:145-13-1

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $335.0 / 349.0

Type:Trading Company

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HANGZHOU CLAKE BIOTECH CO.,LTD

1. ISO AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Micro powder / Crude powder can be made to order EP/USP both ok Appearance:WHITE POWDER Storage:in cool Package:as request Application:active phar

Pregnenolone

Cas:145-13-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Pregnenolone Manufacturer/High quality/Best price/In stock

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White crystalline powder White crystalline powder Melting Point

High quality 145-13-1 Pregnenolone

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $1300.0 / 1600.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product Description

Pregnenolone

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $5.0 / 30.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Pregnenolone CAS 145-13-1 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:Refrigerator Package:1kg/foil bag, 25kg/drum or as you req

Factory low price Pregnenolone CAS 145-13-1 supplied by manufacturer

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $500.0

Type:Trading Company

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Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Lab supply 99% Pregnenolone Powder price cas:145-13-1

Cas:145-13-1

Min.Order:100 Gram

FOB Price: $0.29 / 0.32

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:White

Pregnenolone

Cas:145-13-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Pregnenolone

Cas:145-13-1

Min.Order:1

Negotiable

Type:Other

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Kono Chem Co.,Ltd

From the very beginning, we strictly manage our production according to the demand of ISO9000、ISO14001, now has received the recogonition from costomers all over the world and has passed the audit by authoritative labs. At present, our products are

High quality Pregnenolone CAS 145-13-1 with best price

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $1500.0

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% Pregnenolone 145-13-1 Producer

Cas:145-13-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Pregnenolone

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3β-Hydroxy-5-pregnen-20-one

Cas:145-13-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

1 Factory price 2 High quality 3 Good service 4 Prompt serviceQuick Details ProName: API-Pregnenolone cas:145-13-1 CasNo: 145-13-1 Appearance: white powder Application: Pharmaceutical intermediates DeliveryTim

API-Pregnenolone

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:Pregnenolone CAS:145-13-1 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability Pr

Pregnenolone Manufacturer/High quality/Best price/In stock

Cas:145-13-1

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM Pregnenolone

Cas:145-13-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Superiority As a reliable partner for Chinese market, we are specialized in chemical raw materials; consolidate sourcing, marketing, sales, distribution and after-sale services, providing our partners with sourcing evaluation, technology supports, to

Pregnenolone 145-13-1

Cas:145-13-1

Min.Order:1 Gram

FOB Price: $5.0 / 15.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 145-13-1 with best quality

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Pregnenolon99%

Cas:145-13-1

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

Pregnenolone CAS145-13-1

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name:Pregnenolone Cas No:145-13-1 Molecular formula:C21H32O2 Molecular weight:316.4776 Appearance: White or white crystalline powder Assay: 99% Appearance:White powder Storage:Store in cool and dry place, away from sun light. P

Pregnenolone

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

99%min Pregnenolone Acetate Manufacturer

Cas:145-13-1

Min.Order:0 Metric Ton

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Pharmaceutical Female Hormone Powder Pregnenolone CAS 145-13-1

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

Top supplier Pregnenolone 99%

Cas:145-13-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

99% Pregnenolone powder High Quality API Steroids Hormone Raw Pregnenolone Powder

Cas:145-13-1

Min.Order:10 Gram

FOB Price: $1.5

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Pregnenolone/ LIDE PHARMA- Factory supply / Best price

Cas:145-13-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply Pregnenolone CAS 145-13-1 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and exported to m

High quality Pregnenolone CAS 145-13-1

Cas:145-13-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the safe delivery o

Factory Supply Pharmaceutical Grade CAS 145-13-1 Pregnenolone Powder

Cas:145-13-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shanxi Ankesi Biotechnology Co., Ltd

Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual

Pregnenolone CAS 145-13-1 AKS

Cas:145-13-1

Min.Order:100 Metric Ton

Negotiable

Type:Trading Company

inquiry

Synthetic route

Pregnenolone acetate
1778-02-5

Pregnenolone acetate

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With methanol; sodium In tetrahydrofuran at 20℃; for 4h; Inert atmosphere;100%
With potassium hydroxide; water In methanol at 30℃; for 2h;97%
With potassium hydroxide In water; tert-butyl alcohol at 30℃; for 12h;96%
3β-Hydroxy-5-pregnen-20-one 1,2-Ethanediyl Dithioacetal
2722-98-7

3β-Hydroxy-5-pregnen-20-one 1,2-Ethanediyl Dithioacetal

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With (1,1',1''-[nitrilotri(4,1-phenylene)]tri(ethan-1-one)); lithium perchlorate; silica gel; sodium hydrogencarbonate In dichloromethane; water; acetonitrile for 2h; electrolysis;100%
(3β)-3-(sulfooxy)pregn-5-en-20-one sodium salt

(3β)-3-(sulfooxy)pregn-5-en-20-one sodium salt

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With toluene-4-sulfonic acid In 1,4-dioxane at 20℃; Hydrolysis;97%
3β-t-butyldimethylsilyloxy-pregn-5-en-20-one
58701-45-4

3β-t-butyldimethylsilyloxy-pregn-5-en-20-one

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With chloro-methylsulfanyl-methane; water; potassium iodide In 1,4-dioxane at 50℃; for 3.3h;97%
Multi-step reaction with 5 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 2.17 h / -78 - -20 °C / Inert atmosphere
1.2: Cooling; Inert atmosphere
2.1: mercury(II) oxide; water; mercury dichloride / acetonitrile / 2.5 h / Reflux
3.1: tetrahydrofuran; diethyl ether / 1.5 h / Cooling
4.1: hydrogenchloride / dichloromethane; methanol; water / 0.25 h
5.1: human P450 11A1; yeast alcohol dehydrogenase; oxygen-18 / aq. phosphate buffer / 37 °C / Microbiological reaction
View Scheme
16-dehydropregnenolone acetate
979-02-2

16-dehydropregnenolone acetate

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
Stage #1: 16-dehydropregnenolone acetate With hydrogen at 0 - 25℃; for 1h;
Stage #2: With potassium hydroxide for 2h; Reflux;
92.8%
Multi-step reaction with 2 steps
1: 98 percent / H2 / Pd/C / ethyl acetate / 12 h / 30 °C / 2327.23 Torr
2: 97 percent / potassium hydroxide; H2O / methanol / 2 h / 30 °C
View Scheme
Multi-step reaction with 2 steps
1: 97 percent / H2 / Pd/C / 15 h / 30 °C / 2327.17 Torr
2: 96 percent / KOH / 2-methyl-propan-2-ol; H2O / 16 h / 30 °C
View Scheme
3β-formyloxypregn-5-en-20-one
18843-28-2

3β-formyloxypregn-5-en-20-one

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With lipase from Candida cylindracea; octanol In various solvent(s) at 37℃; for 144h;90%
With bis(tri-n-butyltin)oxide In benzene at 80℃; for 1.5h;90%
Acetic acid (3S,8S,9S,10R,13S,14S,17S)-17-((R)-1-hydroxy-1,5-dimethyl-3-oxo-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Acetic acid (3S,8S,9S,10R,13S,14S,17S)-17-((R)-1-hydroxy-1,5-dimethyl-3-oxo-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With bis(tri-n-butyltin)oxide In toluene at 110℃; for 0.5h;90%
Pregnenolone hemisuccinate methyl ester

Pregnenolone hemisuccinate methyl ester

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With bis(tri-n-butyltin)oxide In toluene at 110℃; for 17h;85%
16α,17α-cyclobutenopregnenolone acetate

16α,17α-cyclobutenopregnenolone acetate

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With sodium hydroxide; dihydrogen peroxide In methanol at 5℃; for 24h; other reagent: lithium, NH3(liquid);78%
(20R)-3β,20,26-trihydroxy-27-norcholest-5-en-22-one
136634-01-0

(20R)-3β,20,26-trihydroxy-27-norcholest-5-en-22-one

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
Stage #1: (20R)-3β,20,26-trihydroxy-27-norcholest-5-en-22-one With hydrazine hydrate In 2,2'-[1,2-ethanediylbis(oxy)]bisethanol at 165 - 195℃; for 2.5h;
Stage #2: With sodium periodate; sulfuric acid In ethanol for 0.0833333h;
37%
bromethyl methyl ether
13057-17-5

bromethyl methyl ether

3β,20-diacetoxy-5,17(20)pregnadien
73465-46-0

3β,20-diacetoxy-5,17(20)pregnadien

A

Pregnenolone
145-13-1

Pregnenolone

B

3β-hydroxy-17-methoxymethyl-5-pregnen-20-one
82989-16-0

3β-hydroxy-17-methoxymethyl-5-pregnen-20-one

Conditions
ConditionsYield
With methyllithium In tetrahydrofuran at 0℃; for 0.0833333h;A 1.8 g
B 36%
Pregnenolone acetate
1778-02-5

Pregnenolone acetate

difluoromethyl-diphenyl-phosphine oxide
129932-29-2

difluoromethyl-diphenyl-phosphine oxide

A

Pregnenolone
145-13-1

Pregnenolone

B

21,21-difluoro-20-methylpregna-5,20-dien-3β-ol

21,21-difluoro-20-methylpregna-5,20-dien-3β-ol

C

21,21-difluoro-20-methylpregna-5,20-dien-3β-ol acetate

21,21-difluoro-20-methylpregna-5,20-dien-3β-ol acetate

Conditions
ConditionsYield
Stage #1: difluoromethyl-diphenyl-phosphine oxide With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.833333h;
Stage #2: Pregnenolone acetate In tetrahydrofuran for 1.5h; Wittig reaction; Heating;
A 30.2%
B 20%
C 13.7%
22(R)-Hydroxycholesterol
17954-98-2

22(R)-Hydroxycholesterol

A

Pregnenolone
145-13-1

Pregnenolone

B

(22R)-20α,22-dihydroxycholesterol

(22R)-20α,22-dihydroxycholesterol

Conditions
ConditionsYield
In ethanol for 0.5h; mitochondria from the human placenta;A n/a
B 10%
16-dehydropregnenolone
1162-53-4

16-dehydropregnenolone

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With sodium hydroxide; nickel Hydrogenation;
With Pd-BaSO4; diethyl ether Hydrogenation;
methyl magnesium iodide
917-64-6

methyl magnesium iodide

3β-hydroxy-androstene-(5)-carboxylic acid-(17β)-nitrile
57764-90-6

3β-hydroxy-androstene-(5)-carboxylic acid-(17β)-nitrile

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With diethyl ether; benzene Behandeln des eigeengten Reaktionsgemisches mit wss.Saeure,zuletzt unter Erhitzen;
sodium diethylmalonate
996-82-7, 34727-00-9, 73177-21-6

sodium diethylmalonate

3β-acetoxy-5-etienic acid chloride
7429-97-2

3β-acetoxy-5-etienic acid chloride

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With benzene anschliessend Behandeln mit Wasser und Erwaermen des Reaktionsprodukts mit methanol.KOH und anschliessend mit wss.-methanol.H2SO4;
pregn-5-ene-3,20-dione
1236-09-5

pregn-5-ene-3,20-dione

A

Pregnenolone
145-13-1

Pregnenolone

B

(3α)-3-hydroxypregn-5-en-20-one
19037-28-6

(3α)-3-hydroxypregn-5-en-20-one

Conditions
ConditionsYield
With ethanol; nickel Hydrogenation;
6β-hydroxy-3α,5α-cyclo-pregnan-20-one
465-53-2, 15387-47-0, 68138-60-3, 115225-84-8

6β-hydroxy-3α,5α-cyclo-pregnan-20-one

A

Pregnenolone
145-13-1

Pregnenolone

B

3β-fluoro-pregn-5-en-20-one
474-43-1

3β-fluoro-pregn-5-en-20-one

Conditions
ConditionsYield
With hydrogen fluoride
3β-hydroxypregn-5-ene-16,20-dione
911442-53-0

3β-hydroxypregn-5-ene-16,20-dione

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With hydrogenchloride; ethanol; zinc
(20S)-3β-acetoxy-5-pregnen-20-amine
60534-25-0

(20S)-3β-acetoxy-5-pregnen-20-amine

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With diethyl ether; hypochloric acid; sodium sulfate Erwaermen des gebildeten Chloramins mit Natriumaethylat in Aethanol und Behandeln des Reaktiongemisches mit Wasser;
With diethyl ether; hypochloric acid; sodium sulfate Erwaermen des gebildeten Chloramins mit Natriumaethylat in Aethanol und Behandeln des Reaktiongemisches mit Wasser;
With diethyl ether; hypochloric acid; sodium sulfate Erwaermen des gebildeten Chloramins mit Natriumaethylat in Aethanol und Behandeln des Reaktiongemisches mit Wasser;
Hyodeoxycholic Acid
83-49-8

Hyodeoxycholic Acid

Pregnenolone
145-13-1

Pregnenolone

3β-acetoxy-5-chloro-5α-pregnan-20-one
112790-35-9

3β-acetoxy-5-chloro-5α-pregnan-20-one

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With methanol; potassium carbonate
21-diazo-3β-hydroxy-pregn-5-en-20-one
33769-71-0

21-diazo-3β-hydroxy-pregn-5-en-20-one

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With hydrogenchloride; ethanol; sodium iodide
3β-acetoxy-24,24-diphenyl-chola-5,20(22)ξ,23-triene
108516-75-2

3β-acetoxy-24,24-diphenyl-chola-5,20(22)ξ,23-triene

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With chromium(VI) oxide; chloroform; acetic acid at 0℃; Erwaermen des Reaktionsprodukts mit K2CO3 und wss.Methanol;
3β-acetoxybisnor-5-cholenic acid
1474-14-2

3β-acetoxybisnor-5-cholenic acid

lead(IV) tetraacetate
546-67-8

lead(IV) tetraacetate

acetic acid
64-19-7

acetic acid

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
Erwaermen des Reaktionsprod. mit meth. Kalilauge unter Stickstoff und Behandeln der danach isolierten Saeure mit Blei(IV)-acetat in Essigsaeure;
methyl 5-androsten-3β-ol-17β-carboxylate
85541-82-8, 95119-09-8, 7254-03-7

methyl 5-androsten-3β-ol-17β-carboxylate

ethyl acetate
141-78-6

ethyl acetate

Pregnenolone
145-13-1

Pregnenolone

Conditions
ConditionsYield
With sodium Behandeln des Reaktionsgemisches mit Eis und wss.HCl und Erhitzen des Reaktionsprodukts mit wss.-aethanol.NaOH;
diethyl ether
60-29-7

diethyl ether

dehydroepiandrosterone
53-43-0

dehydroepiandrosterone

sodium ethanolate
141-52-6

sodium ethanolate

2-chloro-propanoic acid, ethyl ester
535-13-7

2-chloro-propanoic acid, ethyl ester

A

Pregnenolone
145-13-1

Pregnenolone

C

3β-hydroxy-17α-pregn-5-en-20-one
566-63-2

3β-hydroxy-17α-pregn-5-en-20-one

Conditions
ConditionsYield
Erhitzen des Reaktionsprodukts mit wss.-aethanol.NaOH;
dehydroepiandrosterone
53-43-0

dehydroepiandrosterone

2-chloro-propanoic acid, ethyl ester
535-13-7

2-chloro-propanoic acid, ethyl ester

A

Pregnenolone
145-13-1

Pregnenolone

B

3β-hydroxy-17α-pregn-5-en-20-one
566-63-2

3β-hydroxy-17α-pregn-5-en-20-one

Conditions
ConditionsYield
With diethyl ether; sodium ethanolate Erhitzen des Reaktionsprodukts mit wss.-aethanol.NaOH;
quinoline
91-22-5

quinoline

17,20-epoxy-3-hydroxy-23,24-dinor-chol-5-en-21-oic acid

17,20-epoxy-3-hydroxy-23,24-dinor-chol-5-en-21-oic acid

A

Pregnenolone
145-13-1

Pregnenolone

B

3β-hydroxy-17aβ-methyl-D-homo-androst-5-en-17-one

3β-hydroxy-17aβ-methyl-D-homo-androst-5-en-17-one

Conditions
ConditionsYield
at 200℃; Erhitzen des Stereoisomeren-Gemisches; stereoisomer(ic) of mp: 248 degree;
at 200℃; Erhitzen des Steroisomeren-Gemisches; stereoisomer(ic) of mp: 187 degree;
Pregnenolone
145-13-1

Pregnenolone

isopregnanolone
516-55-2

isopregnanolone

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen; acetic acid In tetrahydrofuran at 60℃; under 3102.97 Torr;100%
With palladium 10% on activated carbon; hydrogen In ethanol for 5h; Inert atmosphere;97%
palladium-carbon In ethanol96%
Pregnenolone
145-13-1

Pregnenolone

1-((3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one oxime
6192-84-3

1-((3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride In pyridine100%
With pyridine; hydroxylamine hydrochloride In ethanol at 130℃; for 1h; Inert atmosphere;95%
With hydroxylamine hydrochloride; sodium acetate In ethanol; water Reflux;62%
Pregnenolone
145-13-1

Pregnenolone

acetic anhydride
108-24-7

acetic anhydride

Pregnenolone acetate
1778-02-5

Pregnenolone acetate

Conditions
ConditionsYield
With pyridine at 37℃; Inert atmosphere;100%
With pyridine for 60h; Ambient temperature;99%
With dmap; triethylamine at 25℃; for 0.916667h;99%
Pregnenolone
145-13-1

Pregnenolone

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

3β-methoxymethylether-pregnane-5-ene-20-one
23328-05-4

3β-methoxymethylether-pregnane-5-ene-20-one

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane for 2h; Ambient temperature;100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Cooling with ice;98%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Inert atmosphere; Cooling with ice;95%
Pregnenolone
145-13-1

Pregnenolone

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

3β-t-butyldimethylsilyloxy-pregn-5-en-20-one
58701-45-4

3β-t-butyldimethylsilyloxy-pregn-5-en-20-one

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide for 25h; Ambient temperature;100%
With 1H-imidazole In dichloromethane100%
With 1H-imidazole In N,N-dimethyl-formamide100%
Pregnenolone
145-13-1

Pregnenolone

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
1526930-28-8

1-((3S,10R,13S,17S)-3-((tert-butyldiphenylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 50℃;100%
With 1H-imidazole In dichloromethane at 0 - 20℃; for 4h;85%
Pregnenolone
145-13-1

Pregnenolone

3-Methylbenzoyl chloride
1711-06-4

3-Methylbenzoyl chloride

pregne-3-m-methylbenzoate

pregne-3-m-methylbenzoate

Conditions
ConditionsYield
With pyridine at 40℃; for 24h;99.9%
Pregnenolone
145-13-1

Pregnenolone

3β,20-dihydroxypregn-5-ene
59042-34-1

3β,20-dihydroxypregn-5-ene

Conditions
ConditionsYield
With hydrogen In ethanol at 100℃; under 15001.5 Torr; Autoclave;99%
With sodium tetrahydroborate In tetrahydrofuran; methanol at 0℃; for 0.666667h;28 g
With sodium tetrahydroborate; cerium(III) chloride heptahydrate In methanol Luche Cerium Reduction;
4-methoxy-trans-cinnamaldehyde
24680-50-0, 71277-11-7, 1963-36-6

4-methoxy-trans-cinnamaldehyde

Pregnenolone
145-13-1

Pregnenolone

(2E)-1-((10R,13S)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3(β)-hydroxy-10,13-dimethyl-1H-cyclopenta[α]phenanthren-17(β)-yl)-3-(4-methoxyphenyl)prop-2-en-1-one
1246397-34-1

(2E)-1-((10R,13S)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3(β)-hydroxy-10,13-dimethyl-1H-cyclopenta[α]phenanthren-17(β)-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 20℃; for 12h; Aldol condensation;99%
Pregnenolone
145-13-1

Pregnenolone

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

(E)-3β-hydroxy-21-(4-nitrobenzal)pregn-5-en-20-one
1569482-86-5

(E)-3β-hydroxy-21-(4-nitrobenzal)pregn-5-en-20-one

Conditions
ConditionsYield
With Aliquat 336; sodium hydroxide In water at 80℃; for 2h; Reagent/catalyst; Time; Aldol Condensation;99%
Pregnenolone
145-13-1

Pregnenolone

Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

(3S,8S,9S,10R,13S,14S,17R)-10,13-dimethyl-17-(prop-1-en-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
17879-91-3

(3S,8S,9S,10R,13S,14S,17R)-10,13-dimethyl-17-(prop-1-en-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

Conditions
ConditionsYield
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 15 - 50℃; Inert atmosphere;
Stage #2: Pregnenolone In tetrahydrofuran at 50 - 65℃; for 1h; Inert atmosphere;
99%
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20 - 50℃; for 0.5h; Inert atmosphere;
Stage #2: Pregnenolone In tetrahydrofuran at 50℃; for 1h;
99%
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 0℃; for 1h; Heck Reaction; Sealed tube; Inert atmosphere;
Stage #2: Pregnenolone In tetrahydrofuran at 0 - 20℃; for 16h; Sealed tube; Reflux;
97%
Pregnenolone
145-13-1

Pregnenolone

methyl triphenylphosphonium bromide
27200-84-6

methyl triphenylphosphonium bromide

(3S,8S,9S,10R,13S,14S,17R)-10,13-dimethyl-17-(prop-1-en-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
17879-91-3

(3S,8S,9S,10R,13S,14S,17R)-10,13-dimethyl-17-(prop-1-en-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

Conditions
ConditionsYield
Stage #1: methyl triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 15 - 50℃; for 0.5h; Inert atmosphere;
Stage #2: Pregnenolone In tetrahydrofuran at 50 - 65℃; for 1h; Inert atmosphere;
99%
(E)-3-phenylpropenal
14371-10-9

(E)-3-phenylpropenal

Pregnenolone
145-13-1

Pregnenolone

(2E,4E)-1-((8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-phenylpenta-2,4-dien-1-one

(2E,4E)-1-((8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-phenylpenta-2,4-dien-1-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water for 1h; Inert atmosphere;99%
Pregnenolone
145-13-1

Pregnenolone

1,3-dioxolan-2-ylethylmagnesium bromide
37610-80-3

1,3-dioxolan-2-ylethylmagnesium bromide

24,24-ethylenedioxy-Δ5-chol-3β,20-diol
86476-21-3

24,24-ethylenedioxy-Δ5-chol-3β,20-diol

Conditions
ConditionsYield
In tetrahydrofuran for 1h; Ambient temperature;98.2%
Pregnenolone
145-13-1

Pregnenolone

benzaldehyde
100-52-7

benzaldehyde

(2E)-1-((10R,13S)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3(β)-hydroxy-10,13-dimethyl-1H-cyclopenta[α]phenanthren-17(β)-yl)-3-phenylprop-2-en-1-one
120793-61-5

(2E)-1-((10R,13S)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3(β)-hydroxy-10,13-dimethyl-1H-cyclopenta[α]phenanthren-17(β)-yl)-3-phenylprop-2-en-1-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 20℃; for 0.333333h;98%
With potassium hydroxide In ethanol at 20℃; Claisen Schmidt condensation;92%
With aluminum oxide; potassium fluoride In ethanol for 2h; Reflux;90%
Pregnenolone
145-13-1

Pregnenolone

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

3β-toluene-4-sulfonyloxy-pregn-5-en-20-one
6885-40-1

3β-toluene-4-sulfonyloxy-pregn-5-en-20-one

Conditions
ConditionsYield
With pyridine for 14h;98%
With pyridine; dmap at 20℃; for 12h;98%
With pyridine at 30℃; for 4h; Tosylation;94%
Pregnenolone
145-13-1

Pregnenolone

1-((3S,8S,9S,10R,13S,14S,17S)-3-Hydroxy-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[5,6]cyclopenta[a]phenanthren-17-yl)-ethanone
85552-32-5

1-((3S,8S,9S,10R,13S,14S,17S)-3-Hydroxy-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[5,6]cyclopenta[a]phenanthren-17-yl)-ethanone

Conditions
ConditionsYield
With sodium carbonate; 3-chloro-benzenecarboperoxoic acid In dichloromethane98%
With methyl hexanoate; CpLIP2 Y179F (ipase/acyltransferase) from Candida parapsilosis; dihydrogen peroxide In aq. phosphate buffer; water at 20℃; pH=6.5; Enzymatic reaction;39%
With magnesium bis(monoperoxyphthalate)hexahydrate In acetone at 57℃; for 0.5h;
Pregnenolone
145-13-1

Pregnenolone

cyclohexylamine
108-91-8

cyclohexylamine

20-cyclohexyliminopregn-5-en-3β-ol
317841-08-0

20-cyclohexyliminopregn-5-en-3β-ol

Conditions
ConditionsYield
With trifluoroacetic acid for 20h; Heating;98%
trifluoromethane sulfonyl chloride
421-83-0

trifluoromethane sulfonyl chloride

Pregnenolone
145-13-1

Pregnenolone

3β-t-butyldimethylsilyloxy-pregn-5-en-20-one
58701-45-4

3β-t-butyldimethylsilyloxy-pregn-5-en-20-one

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 12h;98%
oxalyl dichloride
79-37-8

oxalyl dichloride

Pregnenolone
145-13-1

Pregnenolone

Pregnenolone hemioxylate

Pregnenolone hemioxylate

Conditions
ConditionsYield
Stage #1: oxalyl dichloride; Pregnenolone In diethyl ether at 20℃; for 18h;
Stage #2: With water In diethyl ether at 20℃; for 1h;
98%
With triethylamine; N,N-dimethyl-formamide In dichloromethane at 0 - 10℃; for 2h;36%
Pregnenolone
145-13-1

Pregnenolone

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

1-((3S,8S,9S,10R,13S,14S,17S)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3-[(1,1-dimethylethyl)dimethylsilyloxy]-10,13-dimethyl-1H-cyclopenta[a]phenanthren-17-yl)ethanone
58701-45-4

1-((3S,8S,9S,10R,13S,14S,17S)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3-[(1,1-dimethylethyl)dimethylsilyloxy]-10,13-dimethyl-1H-cyclopenta[a]phenanthren-17-yl)ethanone

Conditions
ConditionsYield
Stage #1: Pregnenolone With 1H-imidazole In N,N-dimethyl-formamide for 0.333333h;
Stage #2: tert-butyldimethylsilyl chloride In N,N-dimethyl-formamide at 20℃; for 12h;
98%
Pregnenolone
145-13-1

Pregnenolone

4-(Methylthio)benzaldehyde
3446-89-7

4-(Methylthio)benzaldehyde

(2E)-3-(4-(methylthio)phenyl)-1-((10R,13S)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3(β)-hydroxy-10,13-dimethyl-1H-cyclopenta[a]phenanthren-17(β)-yl)prop-2-en-1-one

(2E)-3-(4-(methylthio)phenyl)-1-((10R,13S)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3(β)-hydroxy-10,13-dimethyl-1H-cyclopenta[a]phenanthren-17(β)-yl)prop-2-en-1-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water for 1h; Inert atmosphere;98%
(E)-3-(2-furanyl)-2-propenal
39511-08-5

(E)-3-(2-furanyl)-2-propenal

Pregnenolone
145-13-1

Pregnenolone

(2E,4E)-5-(furan-2-yl)-1-((8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)penta-2,4-dien-1-one

(2E,4E)-5-(furan-2-yl)-1-((8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)penta-2,4-dien-1-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water for 1h; Inert atmosphere;98%
Pregnenolone
145-13-1

Pregnenolone

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

3β-methanesulfonyloxypregn-5-en-20-one
38759-50-1

3β-methanesulfonyloxypregn-5-en-20-one

Conditions
ConditionsYield
With pyridine at 20 - 25℃; for 4h; Inert atmosphere;97.2%
With pyridine at 20℃; for 23h;
With pyridine
With triethylamine In toluene
triisopropylsilyl chloride
13154-24-0

triisopropylsilyl chloride

Pregnenolone
145-13-1

Pregnenolone

3β-((triisopropylsilyl)oxy)pregn-5-en-20-one
241139-90-2

3β-((triisopropylsilyl)oxy)pregn-5-en-20-one

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane; N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;97%
With 1H-imidazole In dichloromethane; N,N-dimethyl-formamide at 25℃; for 24h;74%
Pregnenolone
145-13-1

Pregnenolone

(E)-1-((3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone oxime
60562-58-5

(E)-1-((3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium acetate In methanol; water at 20℃; for 6h; Inert atmosphere; Reflux;97%
With hydroxylamine hydrochloride; sodium acetate In methanol; water for 6h; Reflux;97%
With hydroxylamine hydrochloride; sodium acetate In methanol; water for 6h; Reflux;97%
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