Diethyl acetamidomalonate supplier

Name
Diethyl acetamidomalonate
EINECS 213-952-9
CAS No. 1068-90-2
Article Data33
CAS DataBase
Density 1.141 g/cm³
Solubility Soluble in chloroform and methanol. Slightly soluble in water.
Melting Point 93 - 96 ºC
Formula C₉H₁₅NO₅
Boiling Point 311.4 ºC at 760 mmHg
Molecular Weight 217.222
Flash Point 145.2ºC
Transport Information
Appearance White crystalline powder
Safety 39-36-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Diethyl acetamido malonate;Malonicacid, acetamido-, diethyl ester (6CI,7CI,8CI);Propanedioic acid,(acetylamino)-, diethyl ester (9CI);(Acetylamino)malonic acid diethyl ester;(Acetylamino)propanedioic acid diethyl ester;2-(Acetylamino)propanedioic aciddiethyl ester;2-Acetylamino-malonic acid diethyl ester;Acetamidomalonic aciddiethyl ester;Diethyl (N-acetylamino)malonate;Diethyl (acetylamino)malonate;Diethyl 2-acetamidomalonate;Diethyl 2-acetylaminomalonate;Diethylacetamidomalonate;Diethyl a-(acetylamino)malonate;NSC 7645;Acetamidomalonic acid diethyl ester;
PSA 81.70000
LogP 0.00820

Synthetic route

: 13433-00-6
diethyl aminomalonate hydrochloride

: 108-24-7
acetic anhydride

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%
With triethylamine In dichloromethane at 0 - 20℃;	99%

: diethyl 2-aminopropanedioate hydrochloride

: 108-24-7
acetic anhydride

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%

: 13433-00-6
diethyl aminomalonate hydrochloride

: 75-36-5
acetyl chloride

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	96%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	96%

: diethyl 2-aminopropanedioate hydrochloride

: 75-36-5
acetyl chloride

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	96%

: 60-35-5
acetamide

: 105-53-3
diethyl malonate

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With 2,2′-biquinoline-4,4'-dicarboxylic acid disodium salt; acetic acid; copper(l) chloride at 80 - 110℃; for 8h;	93%

: 6829-41-0
diethyl oximinomalonate

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With zinc In water	90%
Multi-step reaction with 2 steps 1: H2 / 10percent Pd/C / ethanol / 20520 Torr 2: ethanol View Scheme
Multi-step reaction with 2 steps 1: palladium coal; ethanol / 2280 - 3040 Torr / Hydrogenation 2: ethanol View Scheme

: 64-19-7
acetic acid

: 105-53-3
diethyl malonate

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With sodium nitrite Addition; Isonitrosoylation; N-acetylation;	87%

: 6829-40-9
aminomalonic acid diethyl ester

: 78-39-7
Triethyl orthoacetate

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
for 2h; Reflux;	87%

: 105-53-3
diethyl malonate

A: 123-91-1
1,4-dioxane

B: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With acetic acid; sodium nitrite In water	A n/a B 86%

: 570-08-1
diethyl acetylmalonate

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With chloroform; tris-(2-chloro-ethyl)-amine; sulfuric acid

: 570-08-1
diethyl acetylmalonate

A: 15129-21-2
methylcarbamoyl-malonic acid diethyl ester

B: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With hydrogen azide; chloroform; sulfuric acid
With sodium azide; chloroform; sulfuric acid

: 6829-40-9
aminomalonic acid diethyl ester

: 108-24-7
acetic anhydride

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With ethanol
With pyridine
In ethanol Yield given;
With triethylamine In tetrahydrofuran at 23℃; for 1h;

: 6829-41-0
diethyl oximinomalonate

: 108-24-7
acetic anhydride

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With nickel
With acetic acid; zinc

: 603-67-8
diethyl nitromalonate

: 108-24-7
acetic anhydride

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With nickel Hydrogenation;
With palladium on activated charcoal at 60℃; under 58840.6 Torr; Hydrogenation;

: 108-24-7
acetic anhydride

: 13636-61-8
α-Benzolazo-malonsaeure-diethylester

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With acetic acid; zinc

: (1-ethoxy-ethylidenamino)-malonic acid diethyl ester

: 64-19-7
acetic acid

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
beim Kochen der Kalium-Verbindung;

: 6829-40-9
aminomalonic acid diethyl ester

: 75-36-5
acetyl chloride

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With pyridine
With sodium carbonate In dichloromethane; water for 2h; Acetylation;
With benzothiazole-2-sulphonic acid In diethyl ether at 0 - 25℃; for 1h;

: 67-56-1
methanol

: 74-85-1
ethene

: 201230-82-2
carbon monoxide

: 30412-43-2
sodium diethyl (acetylamino)malonate

A: 74090-40-7
1-acetamidopropanetricarboxylic acid 1,1-diethyl-3-methyl ester

B: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 91011-83-5
acetylamino-bromomethyl-malonic acid diethyl ester

A: 1069-38-1
diethyl 2-acetylaminobutanedioate

B: 55166-91-1
diethyl α-acetamido, α-methylmalonate

C: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
carbon-skeleton rearrangement mediated by hydrophobic Vitamin B12 covalent bound to a lipid species in a bilayer membrane; 1.) NaBH4, complex 1, 2.) N,N-bis(hexadecyl)-Nα-(6-sulfohexanoyl)-L-alaninamide, irradiation; other medium for irradiation;	A 2 % Chromat. B 57 % Chromat. C 25 % Chromat.

...Expand

acetylhydroxyimino-malonic acid diethyl ester: acetylhydroxyimino-malonic acid diethyl ester

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With diethyl ether; aluminium amalgam

: 75-36-5
acetyl chloride

sodium compound of aminomalonic acid diethyl ester: sodium compound of aminomalonic acid diethyl ester

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
With pyridine

: 90713-04-5
acetoxyimino-malonic acid diethyl ester

amalgamated aluminium: amalgamated aluminium

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
Reduktion;

: 105-53-3
diethyl malonate

Me3SiCH2C(Me)=CH(CH2)2CH(Me)-X: Me3SiCH2C(Me)=CH(CH2)2CH(Me)-X

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: NaH / tetrahydrofuran / 0.25 h / 23 °C 1.2: O-(4-nitrobenzoyl)-hydroxylamine / tetrahydrofuran / 23 °C 2.1: Et3N / tetrahydrofuran / 1 h / 23 °C View Scheme

: 91469-69-1
ethylesters of amino malonic acid

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 5 h / Reflux 2: 2 h / Reflux View Scheme

: 100-44-7
benzyl chloride

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 3235-26-5
2-(N-acetylamino)-2-benzylpropanedioic diethyl ester

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In dichloromethane at 100 - 110℃; for 0.8h; Product distribution; var. solvents, var. time, other reaction partners;	100%
With 18-crown-6 ether; potassium carbonate In N,N-dimethyl-formamide at 100 - 110℃; for 0.8h;	100%
With ethanol; sodium ethanolate
With ethanol; sodium ethanolate

: 106-95-6
allyl bromide

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 14109-62-7
ethyl 2-acetamido-2-(ethoxycarbonyl)-4-pentenoate

Conditions

Conditions	Yield
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol for 5h; Reflux; Stage #2: allyl bromide In ethanol for 15h; Reflux;	100%
With caesium carbonate In acetonitrile Heating;	99%
With ethanol; sodium	97%

: 106-96-7
propargyl bromide

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 61172-60-9
diethyl α-acetamido-α-propargylmalonate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 20℃; for 18h;	100%
With caesium carbonate In acetonitrile at 20℃; for 18h;	99%
With sodium hydride In N,N-dimethyl-formamide at 60℃; for 3h;	95%

: 96-34-4
methyl chloroacetate

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 2-Acetylamino-2-ethoxycarbonyl-succinic acid 1-ethyl ester 4-methyl ester

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In N,N-dimethyl-formamide at 100 - 110℃; for 0.5h;	100%

: 5324-30-1
diethyl 2-bromoethylphosphonate

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 107257-47-6
(N-acetylamino-3 bis-ethoxycarbonyl-3,3)-propylphosphonate de diethyle

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In acetonitrile for 8h; Heating;	100%
With sodium hydride In toluene at 110℃; for 24h;	100%
With sodium hydride; Diethyl carbonate In hexane; toluene; mineral oil at 110℃; for 24h;	33.3 g

: 6294-34-4
bis(2-chloroethyl) 2-chloroethylphosphonate

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: (N-acetylamino-3 bis-ethoxycarbonyl-3,3)-propylphosphonate de di(chloro-2 ethyle)

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In acetonitrile for 8h; Heating;	100%

: 82420-34-6
4-bromo-1-(bromomethyl)-2-nitrobenzene

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 82420-36-8
Ethyl 2-Acetamido-2-(4'-bromo-2'-nitrobenzyl)malonate

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide	100%
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol at 20℃; for 0.5h; Stage #2: 4-bromo-1-(bromomethyl)-2-nitrobenzene In ethanol	74%
	68%

: 15017-52-4
4-(bromomethyl)-1-fluoro-2-nitrobenzene

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 20367-99-1
ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-3-(4'-fluoro-3'-nitrophenyl)propanoate

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide for 4h; Ambient temperature;	100%
With sodium hydride In N,N-dimethyl-formamide; mineral oil; pentane at 20℃; for 4h;	100%
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium hydride In tetrahydrofuran; mineral oil for 3h; Reflux; Stage #2: 4-(bromomethyl)-1-fluoro-2-nitrobenzene In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil Reflux;	100%
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium hydride In N,N-dimethyl-formamide; mineral oil Stage #2: 4-(bromomethyl)-1-fluoro-2-nitrobenzene In N,N-dimethyl-formamide; mineral oil at 20℃; for 24h;	74%
With sodium hydride In hexanes; N,N-dimethyl-formamide; mineral oil at 20℃; for 4h;

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 205386-16-9
6'-(bromomethyl)-3',4'-dihydro-4,4-dimethyl-7'-nitrospiro(cyclohexane-1,1'(2H)-naphthalene)

: 205386-17-0
C27H38N2O7

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide for 2.5h; Ambient temperature;	100%

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 270921-39-6
(4-methoxyphenyl)methyl methyl carbonate

: 53612-87-6
2-acetylamino-2-(4-methoxybenzyl)malonic acid diethyl ester

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; N,O-bis-(trimethylsilyl)-acetamide; {(η4-1,5-cyclooctadiene)Pd(η3-allyl)}BF4; potassium acetate In tetrahydrofuran at 80℃; for 24h;	100%
With 1,1'-bis(diisopropylphosphino)ferrocene; {(η4-1,5-cyclooctadiene)Pd(η3-allyl)}BF4; caesium carbonate In N,N-dimethyl-formamide at 30℃; for 72h; Inert atmosphere;	95%
With 1,1'-bis-(diphenylphosphino)ferrocene; 1,5-cis,cis-cyclooctadiene; [PdCp(η3-C3H5)] In tetrahydrofuran at 80℃;	92%

: 40516-57-2
2-isopropyl-4-chloromethylthiazole

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 1187649-36-0
diethyl 2-acetamido-2-((2-isopropylthiazol-4-yl)methyl)malonate

Conditions

Conditions	Yield
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; Stage #2: 2-isopropyl-4-chloromethylthiazole In N,N-dimethyl-formamide at 20℃;	100%

: 50-00-0
formaldehyd

: 103-67-3
benzyl-methyl-amine

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: C18H26N2O5

Conditions

Conditions	Yield
In water at 20℃; for 4h;	100%

...Expand

: 87-52-5
3-(Dimethylaminomethyl)indole

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 5379-97-5
acetylamino-indol-3-ylmethyl-malonic acid diethyl ester

Conditions

Conditions	Yield
With tributylphosphine In acetonitrile for 4h; Heating;	99.5%
With sodium hydroxide; toluene
With sodium hydroxide; xylene
With sodium ethanolate; ethyl iodide
With ethanol; dimethyl sulfate

: [1-(5-bromomethyl-isoxazol-3-yl)-3-methyl-butyl]-carbamic acid tert-butyl ester

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 2-acetylamino-2-[3-(1-tert-butoxycarbonylamino-3-methyl-butyl)-isoxazol-5-ylmethyl]-malonic acid diethyl ester

Conditions

Conditions	Yield
With caesium carbonate	99.4%

...Expand

: 459-46-1
4-Fluorobenzyl bromide

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 380-71-2
diethyl α-acetamido, α-(4-fluorobenzyl)malonate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile Alkylation; Heating;	99%
With potassium hydroxide; Aliquat 336 for 0.25h; Ambient temperature;	71%
With caesium carbonate In acetonitrile at 130℃; Microwave irradiation;

: 6165-76-0
propargyl p-toluenesulfonate

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 61172-60-9
diethyl α-acetamido-α-propargylmalonate

Conditions

Conditions	Yield
Stage #1: 2-acetylaminomalonic acid diethyl ester With potassium tert-butylate In 1,4-dioxane at 20 - 50℃; for 4h; Inert atmosphere; Stage #2: propargyl p-toluenesulfonate In 1,4-dioxane at 50℃; Concentration; Solvent; Inert atmosphere; Reflux;	99%

: {4-(bromomethyl)-2-[(2-nitrobenzyl)oxy]phenoxy}(tert-butyl)dimethylsilane

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: diethyl 2-acetamido-2-{4-[(tert-butyldimethylsilyl)oxy]-3-[(2-nitrobenzyl)oxy]benzyl}malonate

Conditions

Conditions	Yield
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.333333h; Inert atmosphere; Stage #2: {4-(bromomethyl)-2-[(2-nitrobenzyl)oxy]phenoxy}(tert-butyl)dimethylsilane In N,N-dimethyl-formamide; mineral oil at 20℃; for 4h; Inert atmosphere;	99%

: 4876-10-2
4-bromomethyl-2(1H)-quinolinone

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 4900-38-3
2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester

Conditions

Conditions	Yield
With sodium ethanolate; tetra-(n-butyl)ammonium iodide In ethanol at 60℃; for 8h; Reagent/catalyst; Temperature;	98.44%
With sodium In ethanol for 2h;	69%
With sodium hydroxide In water; dimethyl sulfoxide at 20 - 30℃; for 2h; Reagent/catalyst; Solvent; Large scale;

: 16620-52-3
5-methoxygramine

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 54744-69-3
acetylamino-(5-methoxy-indol-3-ylmethyl)-malonic acid diethyl ester

Conditions

Conditions	Yield
With sodium hydroxide In toluene for 18h; Reflux;	98%
With ethanol; sodium ethanolate; dimethyl sulfate

: 3958-57-4
1-bromomethyl-3-nitrobenzene

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 5432-19-9
diethyl 2-(acetylamino)-2-(3-nitrobenzyl)malonate

Conditions

Conditions	Yield
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.0833333h; Inert atmosphere; Stage #2: 1-bromomethyl-3-nitrobenzene In N,N-dimethyl-formamide; mineral oil at 0℃; for 16h; Inert atmosphere;	98%
With ethanol; sodium ethanolate

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 54681-67-3, 187868-53-7
2-acetamido-3-ethoxy-3-oxopropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide; phosphate buffer; α-chymotrypsin for 5.25h; Product distribution; Ambient temperature; var. pH;	98%
With sodium hydroxide In 1,4-dioxane; water at 20℃; for 17h;	81%
With sodium hydroxide In 1,4-dioxane at 20℃; for 15h;	76%

: 637-59-2
1-Bromo-3-phenylpropane

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 52161-73-6
2-acetylamino-2-(3-phenyl-propyl)malonic acid diethyl ester

Conditions

Conditions	Yield
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol at 20℃; for 1.5h; Stage #2: 1-Bromo-3-phenylpropane In ethanol for 16h; Heating;	98%
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol at 20℃; for 1.5h; Stage #2: 1-Bromo-3-phenylpropane In ethanol for 16.25h; Heating / reflux;	98%
(i) Na, EtOH, (ii) /BRN= 2205527/; Multistep reaction;
With sodium ethanolate; sodium In ethanol; nitrogen
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol at 20℃; for 2h; Stage #2: 1-Bromo-3-phenylpropane In ethanol at 20 - 73℃; for 28.25h;

: 100-39-0
benzyl bromide

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 3235-26-5
2-(N-acetylamino)-2-benzylpropanedioic diethyl ester

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile Alkylation; Heating;	98%
With potassium hydroxide; Aliquat 336 for 0.25h; Ambient temperature;	84%
With caesium carbonate In acetonitrile at 130℃; for 0.166667h; Microwave irradiation;	82%
Stage #1: 2-acetylaminomalonic acid diethyl ester With sodium ethanolate In ethanol at 0℃; for 0.0833333h; Inert atmosphere; Stage #2: benzyl bromide In ethanol for 2h; Inert atmosphere; Reflux;
With caesium carbonate In acetonitrile at 130℃; Microwave irradiation;

: 87751-69-7
rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: diethyl (R)-(acetylamino)[(E)-1,3-diphenylprop-2-en-1-yl]malonate

Conditions

Conditions	Yield
With N,O-bis-(trimethylsilyl)-acetamide; potassium acetate; chiral (phosphinoaryldihydrooxazole)allyl-Pd(II) In dichloromethane at 23℃;	98%
With bis(η3-allyl-μ-chloropalladium(II)); C2-symmetric chiral P; potassium acetate; bis-(trimethylsilyl)acetamide In dichloromethane for 0.5h; Ambient temperature;	98%

: 155526-65-1
4-(bromomethyl)-3-nitrobenzaldehyde

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 168965-43-3
ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-3-(4-formyl-2-nitrophenyl)propanoate

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide for 2.5h; Ambient temperature;	98%
With sodium hydride In N,N-dimethyl-formamide

: 87751-69-7
rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: diethyl (S)-(acetylamino)[(E)-1,3-diphenylprop-2-en-1-yl]malonate

Conditions

Conditions	Yield
With N,O-bis-(trimethylsilyl)-acetamide; bis(η3-allyl-μ-chloropalladium(II)); (S)-7-(diphenylphosphino)-2′-isopropyl-2,3-dihydro-5′H-spiro[indene-1,4′-oxazole]; potassium acetate In toluene at 0℃; for 5h; Inert atmosphere; Schlenk technique; enantioselective reaction;	98%
With bis(η3-allyl-μ-chloropalladium(II)); potassium acetate; (1R,2R)-2-[N-(2-diphenylphosphanylbenzoyl)amino]cyclohexylcarbamic acid tert-butyl ester In diethyl ether at 25℃; for 6h; enantioselective reaction;	98%
With benzenesulfonamide; potassium acetate; (1R,2S,4R,5S)-(+)-2,5-dimethyl-7-phenyl-7-phosphabicyclo[2.2.1]heptane; bis(η3-allyl-μ-chloropalladium(II)) In toluene for 2h;	95%
With benzenesulfonamide; potassium acetate; (S,S)-N,N'-1,2-bis(S-cyclopentyl-S-phenyl-sulfonimidoyl)-ethane; bis(η3-allyl-μ-chloropalladium(II)) In dichloromethane at 45℃; for 96h;	89%

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 247222-86-2
2-ethylsulfanyl-3-(ethylsulfanyl-trimethylsilanyl-methyl)-1H-indole

: 2-acetylamino-2-(2-ethylsulfanyl-1H-indol-3-ylmethyl)-malonic acid diethyl ester

Conditions

Conditions	Yield
With tributylphosphine In acetonitrile at 80℃; for 9h; Alkylation;	98%

: methyl (naphthalen-1-ylmethyl) carbonate

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 5440-57-3
diethyl (N-acetylamino)[(1-naphthyl)methyl]malonate

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; [PdCp(η3-C3H5)] In tetrahydrofuran at 80℃; for 1h;	98%

Diethyl acetamidomalonate Chemical Properties

IUPAC Name: Diethyl 2-acetamidopropanedioate
Synonyms of Acetamidomalonic acid diethyl ester (1068-90-2): Diethyl acetamidomalonic acid ; (Acetylamino)propanedioic acid diethyl ester ; 4-04-00-02993 (Beilstein Handbook Reference) ; AI3-52334 ; Acetamidomalonic acid diethyl ester ; BRN 0783883 ; Diethyl 2-acetamidomalonate ; Diethyl acetamidomalonate ; Diethyl acetaminomalonate ; Diethyl acetylaminomalonate ; Diethylester kyseliny acetylaminomalonove ; Diethylester kyseliny acetylaminomalonove [Czech] ; EINECS 213-952-9 ; Ethyl acetamidomalonate ; HSDB 2664 ; Malonic acid, acetamido-, diethyl ester ; NSC 7645 ; Propanedioic acid, (acetylamino)-, diethyl ester ; Propanedioic acid, 2-(acetylamino)-, 1,3-diethyl ester
CAS NO: 1068-90-2
Classification Code: Skin / Eye Irritant
Molecular Formula: C₉H₁₅NO₅
Molecular Weight: 217.2191
Molecular Structure:

Melting Point: 95-98 °C
ProductCategories: Pharmaceutical Intermediates ; Other Reagents ; Amino ester
Polar Surface Area: 72.91Å²
Index of Refraction: 1.447
Molar Refractivity: 50.87 cm³
Molar Volume: 190.3 cm³
Surface Tension: 37.1 dyne/cm
Density: 1.141 g/cm³
Flash Point: 145.2 °C
Enthalpy of Vaporization: 55.23 kJ/mol
Boiling Point: 311.4 °C at 760 mmHg
Vapour Pressure: 0.000565 mmHg at 25°C

Diethyl acetamidomalonate Uses

Acetamidomalonic acid diethyl ester (1068-90-2) can be used in the pharmaceutical industry, also used as a tryptophan intermediate.

Diethyl acetamidomalonate Production

Acetamidomalonic acid diethyl ester (1068-90-2) can be produced from diethyl malonate by nitrosation, reduction, acetylation derived.

Diethyl acetamidomalonate Consensus Reports

Reported in EPA TSCA Inventory.

Diethyl acetamidomalonate Safety Profile

An eye irritant. When heated to decomposition it emits toxic fumes of NO_x. See also ESTERS.
Hazard Codes of Acetamidomalonic acid diethyl ester

(1068-90-2): Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 39-36-26
S39: Wear eye / face protection.
S36: Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany; 3
RTECS: OO0360000
HS Code: 29241900

Diethyl acetamidomalonate Specification

Stability and Reactivity of Acetamidomalonic acid diethyl ester (1068-90-2).
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials Strong oxidizing agents, strong oxidizing agents, reducing agents, acids, bases.
Hazardous Decomposition Products Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization Has not been reported.
Handling and Storage of Acetamidomalonic acid diethyl ester (1068-90-2).
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Store in a tightly closed container.

Product Name

Diethyl acetamidomalonate

Synthetic route

Diethyl acetamidomalonate Chemical Properties

Diethyl acetamidomalonate Uses

Diethyl acetamidomalonate Production

Diethyl acetamidomalonate Consensus Reports

Diethyl acetamidomalonate Safety Profile

Diethyl acetamidomalonate Specification

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