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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid Manufacturer/High quality/Best price/In stock

Cas:162401-62-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Item Quality Standard Test Result Appearance colorless clear liquid colorless clear liquid Assay %

high purity 162401-62-9 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid

Cas:162401-62-9

Min.Order:1 Kilogram

FOB Price: $1.9 / 2.5

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-Cyclopropylmethoxy-4-Difluoromethoxy-Benzoic Acid supplier in China

Cas:162401-62-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

The company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:White or off-white Solid Storage:Sealed

3-CyclopropylMethoxy-4-difluoroMethoxy-benzoic acid

Cas:162401-62-9

Min.Order:100 Gram

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid CAS No.:162401-62-9 Name: 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid Molecular Structure Molecular Formula: C12H12F2O4 Molecula

High purity 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid CAS No.:162401-62-9

Cas:162401-62-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-Cyclopropylmethoxy-4-Difluoromethoxy-Benzoic Acid

Cas:162401-62-9

Min.Order:1

Negotiable

Type:Other

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

Cas:162401-62-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Cas:162401-62-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-Cyclopropylmethoxy-4-Difluoromethoxy-Benzoic Acid CAS 162401-62-9

Cas:162401-62-9

Min.Order:1 Kilogram

FOB Price: $10.0 / 16.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--162401-62-9--High purity 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China

TIANFUCHEM--162401-62-9--High purity 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid factory price

Cas:162401-62-9

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 162401-62-9 with competitive price

Cas:162401-62-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid CAS162401-62-9

Cas:162401-62-9

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Products: 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Cas No.: 162401-62-9 Molecular Formula: C12H12F2O4 Molecular Weight: 258.219 Assay:

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid CAS: 162401-62-9

Cas:162401-62-9

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 162401-62-9

Cas:162401-62-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid/ LIDE PHARMA- Factory supply / Best price

Cas:162401-62-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid CAS:162401-62-9

Cas:162401-62-9

Min.Order:1 Kilogram

FOB Price: $81.4 / 86.2

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid CAS:162401-62-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializ

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid CAS:162401-62-9

Cas:162401-62-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

Cas:162401-62-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

Cas:162401-62-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

Cas:162401-62-9

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

RofluMilast InterMediate II CAS:162401-62-9 Specification:in-house Stock:Fresh Purity:97% min Application:162401-62-9

3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid

Cas:162401-62-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

Cas:162401-62-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

3-(CYCLOPROPYLMETHOXY-4-(DIFLUORO METHOXY)BENZOIC ACID

Cas:162401-62-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid

Cas:162401-62-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

Cas:162401-62-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Hangyu CAS:162401-62-9

Cas:162401-62-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

Factory 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid CAS 162401-62-9Appearance:White powder Storage:Store in Cool and dry .place, keep away from incompatible substances Package:according to customers' requirements Application:Pharmaceutical int

Factory 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid CAS 162401-62-9

Cas:162401-62-9

Min.Order:1 Gram

Negotiable

Type:Other

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:White or off-white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide inter

3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid

Cas:162401-62-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Product Product name 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid CAS No. 162401-62-9 Molecular formula

Lowest price and high quality 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

Cas:162401-62-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

Cas:162401-62-9

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

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Synthetic route

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid methyl ester

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid methyl ester

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol at 50℃; for 3h;99%
With hydrogenchloride; water at 20 - 55℃; pH=3 - 4;
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
With sodium chlorite; aminosulfonic acid In water; acetic acid at 20℃; for 1h;97%
With dihydrogen peroxide; potassium hydroxide In methanol at 65℃; for 1h;97%
With sodium chlorite; aminosulfonic acid In water; acetic acid at 20℃; for 1h; Concentration;97.3%
4-bromo-2-(cyclopropylmethoxy)-1-(difluoromethoxy)benzene
680184-55-8

4-bromo-2-(cyclopropylmethoxy)-1-(difluoromethoxy)benzene

carbon dioxide
124-38-9

carbon dioxide

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Stage #1: 4-bromo-2-(cyclopropylmethoxy)-1-(difluoromethoxy)benzene With ethylmagnesium chloride In tetrahydrofuran; 1,2-dimethoxyethane for 1h; Reflux;
Stage #2: carbon dioxide In tetrahydrofuran; 1,2-dimethoxyethane
Stage #3: With hydrogenchloride In tetrahydrofuran; 1,2-dimethoxyethane; water Temperature; Solvent; Reagent/catalyst; Acidic conditions;
95%
3-cyclopropylmethoxy-4-hydroxybenzoic acid methyl ester

3-cyclopropylmethoxy-4-hydroxybenzoic acid methyl ester

sodium chlorodifluoroacetate
1895-39-2

sodium chlorodifluoroacetate

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Stage #1: 3-cyclopropylmethoxy-4-hydroxybenzoic acid methyl ester; sodium chlorodifluoroacetate With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 0.5h;
Stage #2: With water; sodium hydroxide In methanol at 50℃; for 2h;
81.4%
3-hydroxy-4-iodobenzoic acid
58123-77-6

3-hydroxy-4-iodobenzoic acid

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: thionyl chloride / 3 h / 50 °C
2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Large scale
3: potassium hydroxide; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 30 h / 100 °C / Inert atmosphere; Large scale
4: thionyl chloride / 3 h / 50 °C
5: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 95 °C
6: sodium hydroxide / methanol / 3 h / 50 °C
View Scheme
Multi-step reaction with 6 steps
1: thionyl chloride / 3 h / 50 °C
2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Large scale
3: potassium hydroxide; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 30 h / 100 °C / Inert atmosphere; Large scale
4: thionyl chloride / 3 h / 50 °C
5: N,N-dimethyl-formamide / Heating
6: sodium hydroxide / methanol / 3 h / 50 °C
View Scheme
methyl 3-hydroxy-4-iodobenzoate
157942-12-6

methyl 3-hydroxy-4-iodobenzoate

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Large scale
2: potassium hydroxide; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 30 h / 100 °C / Inert atmosphere; Large scale
3: thionyl chloride / 3 h / 50 °C
4: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 95 °C
5: sodium hydroxide / methanol / 3 h / 50 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Large scale
2: potassium hydroxide; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 30 h / 100 °C / Inert atmosphere; Large scale
3: thionyl chloride / 3 h / 50 °C
4: N,N-dimethyl-formamide / Heating
5: sodium hydroxide / methanol / 3 h / 50 °C
View Scheme
methyl 3-(cyclopropylmethoxy)-4-iodobenzoate
1392191-29-5

methyl 3-(cyclopropylmethoxy)-4-iodobenzoate

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium hydroxide; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 30 h / 100 °C / Inert atmosphere; Large scale
2: thionyl chloride / 3 h / 50 °C
3: N,N-dimethyl-formamide / Heating
4: sodium hydroxide / methanol / 3 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium hydroxide; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 30 h / 100 °C / Inert atmosphere; Large scale
2: thionyl chloride / 3 h / 50 °C
3: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 95 °C
4: sodium hydroxide / methanol / 3 h / 50 °C
View Scheme
3-(cyclopropylmethoxy)-4-hydroxybenzoic acid
1243391-44-7

3-(cyclopropylmethoxy)-4-hydroxybenzoic acid

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: thionyl chloride / 3 h / 50 °C
2: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 95 °C
3: sodium hydroxide / methanol / 3 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: thionyl chloride / 3 h / 50 °C
2: N,N-dimethyl-formamide / Heating
3: sodium hydroxide / methanol / 3 h / 50 °C
View Scheme
3-cyclopropylmethoxy-4-hydroxybenzoic acid methyl ester

3-cyclopropylmethoxy-4-hydroxybenzoic acid methyl ester

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 95 °C
2: sodium hydroxide / methanol / 3 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / Heating
2: sodium hydroxide / methanol / 3 h / 50 °C
View Scheme
4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate; potassium iodide / acetone / 0.5 h / Inert atmosphere; Reflux
1.2: 12.5 h / 20 °C / Inert atmosphere; Reflux
2.1: aminosulfonic acid; sodium chlorite / water; acetonitrile / 5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / tetrahydrofuran / 14 h / 0 °C / Reflux
2: acetic acid; aminosulfonic acid; sodium chlorite / water / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate; potassium iodide / dimethyl sulfoxide / 1 h / 70 °C
1.2: 4 h / 70 °C
2.1: acetic acid; aminosulfonic acid / 5 - 20 °C
View Scheme
3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / N,N-dimethyl-formamide; water / 2 h / 120 °C
2: potassium carbonate / tetrahydrofuran / 14 h / 0 °C / Reflux
3: acetic acid; aminosulfonic acid; sodium chlorite / water / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 85 °C
1.2: 8 - 10 h / Inert atmosphere
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 6 h / 75 - 80 °C
3.1: aminosulfonic acid; acetic acid / water / 5 - 10 °C
3.2: 1 h / 5 - 10 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / N,N-dimethyl-formamide; water / 2 h / 120 °C
2: caesium carbonate / N,N-dimethyl-formamide / 1 h / 65 °C
3: potassium hydroxide; dihydrogen peroxide / methanol / 1 h / 20 °C
View Scheme
4-benzyloxy-3-hydroxy-benzaldehyde
4049-39-2

4-benzyloxy-3-hydroxy-benzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 65 °C
2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C
3: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 120 °C
4: potassium hydroxide; dihydrogen peroxide / methanol / 1 h / 65 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C
2.1: N-iodo-succinimide; potassium carbonate / 24 h / 20 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 18 h
4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 100 °C
4.2: 2 h / 50 °C
View Scheme
4-(benzyloxy)-3-(cyclopropylmethoxy)benzaldehyde
1381886-14-1

4-(benzyloxy)-3-(cyclopropylmethoxy)benzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C
2: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 120 °C
3: potassium hydroxide; dihydrogen peroxide / methanol / 1 h / 65 °C
View Scheme
Multi-step reaction with 3 steps
1.1: N-iodo-succinimide; potassium carbonate / 24 h / 20 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol / 18 h
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 100 °C
3.2: 2 h / 50 °C
View Scheme
3-(cyclopropylmethoxy)-4-hydroxybenzaldehyde
25934-52-5

3-(cyclopropylmethoxy)-4-hydroxybenzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 120 °C
2: potassium hydroxide; dihydrogen peroxide / methanol / 1 h / 65 °C
View Scheme
vanillin
121-33-5

vanillin

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 90 °C
2.1: lithium chloride / N,N-dimethyl-formamide / Reflux
3.1: potassium carbonate / tetrahydrofuran / 1 h / 20 °C
4.1: acetic acid / 0.5 h / 20 °C
4.2: 5 - 20 °C
View Scheme
4-(difluoromethoxy)-3-methoxybenzaldehyde
162401-70-9

4-(difluoromethoxy)-3-methoxybenzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium chloride / N,N-dimethyl-formamide / Reflux
2.1: potassium carbonate / tetrahydrofuran / 1 h / 20 °C
3.1: acetic acid / 0.5 h / 20 °C
3.2: 5 - 20 °C
View Scheme
3-fluoro-4-hydroxybenzaldehyde
405-05-0

3-fluoro-4-hydroxybenzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / N,N-dimethyl-formamide; water / 2 h / 95 - 100 °C
2: potassium tert-butylate / 1,4-dioxane / 4 h / 70 - 75 °C
3: aminosulfonic acid; sodium chlorite; acetic acid / water / 0.5 h / 0 - 10 °C
View Scheme
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyl chloride
672883-68-0

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyl chloride

Conditions
ConditionsYield
With thionyl chloride In toluene for 2h; Heating / reflux;100%
With thionyl chloride In toluene for 2h; Reflux;100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 25℃; for 3h;100%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

methyl iodide
74-88-4

methyl iodide

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid methyl ester

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide at 75 - 85℃; for 1h;98.1%
With potassium carbonate In N,N-dimethyl acetamide at 75 - 85℃; for 1h;98.1%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

3,5-dichloro-4-aminopyridine
22889-78-7

3,5-dichloro-4-aminopyridine

roflumilast
162401-32-3

roflumilast

Conditions
ConditionsYield
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With pyridine; 2,4,6-trinitrochlorobenzene In 1,4-dioxane at 20 - 35℃; for 3h; Industrial scale;
Stage #2: 3,5-dichloro-4-aminopyridine In 1,4-dioxane for 2h; Reagent/catalyst; Solvent; Temperature; Industrial scale;
95%
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In dichloromethane at 0 - 20℃; for 3h;
Stage #2: 3,5-dichloro-4-aminopyridine In dichloromethane for 2h; Concentration;
91%
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With pivaloyl chloride; sodium carbonate In tetrahydrofuran at 25℃; for 2h;
Stage #2: 3,5-dichloro-4-aminopyridine In tetrahydrofuran at 50℃; for 4h; Temperature; Solvent; Reagent/catalyst;
64%
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With thionyl chloride In toluene Heating / reflux;
Stage #2: 3,5-dichloro-4-aminopyridine With sodium hydride In tetrahydrofuran for 1h; Cooling;
58.6%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

roflumilast
162401-32-3

roflumilast

Conditions
ConditionsYield
Large scale;93%
Multi-step reaction with 2 steps
1.1: dimethyl sulfoxide / 3 h / 20 °C
2.1: cesium fluoride / dimethyl sulfoxide / 3 h / 90 °C
2.2: 6.5 h / 90 - 95 °C
View Scheme
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

glycine ethyl ester hydrochloride
5680-79-5

glycine ethyl ester hydrochloride

2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamido)acetic acid methyl ester

2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamido)acetic acid methyl ester

Conditions
ConditionsYield
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h;
Stage #2: glycine ethyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 10h;
87%
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h;
Stage #2: glycine ethyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 10h;
87%
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Inert atmosphere;
Stage #2: glycine ethyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Cooling with ice;
86.1%
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h;
Stage #2: glycine ethyl ester hydrochloride With N-ethyl-N,N-diisopropylamine at 20℃; Cooling with ice;
86.1%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyl fluoride

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyl fluoride

Conditions
ConditionsYield
With diethylamino-sulfur trifluoride In dichloromethane at 0℃; for 0.5h;80%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloro-1-pyridin-4-yl)ethanone
1113061-20-3, 1239278-70-6, 1246537-42-7

1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloro-1-pyridin-4-yl)ethanone

1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoate
1113061-14-5

1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 72h;77%
2-hydroxypyridin
142-08-5

2-hydroxypyridin

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

pyridin-2-yl 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoate

pyridin-2-yl 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;76%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

C17H16F2O6

C17H16F2O6

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) acetate In 2,2,2-trifluoroethanol at 140℃; for 24h;75%
With dipotassium hydrogenphosphate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; 1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; silver(I) acetate; XPhos In 2,2,2-trifluoroethanol at 140℃; for 24h; Sealed tube;75%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide
1548868-68-3

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;71%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

3-bromo-1,1,1-trifluoroacetone
431-35-6

3-bromo-1,1,1-trifluoroacetone

C15H11F5O4

C15H11F5O4

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) acetate In 2,2,2-trifluoroethanol at 140℃; for 24h;71%
With dipotassium hydrogenphosphate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; 1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; silver(I) acetate; XPhos In 2,2,2-trifluoroethanol at 140℃; for 24h; Sealed tube;71%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

(S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloro-1-pyridin-4-yl)ethanol

(S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloro-1-pyridin-4-yl)ethanol

(S)-(-)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoate
1548868-62-7

(S)-(-)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h;70%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

N-(p-toluenesulfonyl)aziridine
3634-89-7

N-(p-toluenesulfonyl)aziridine

C21H23F2NO6S

C21H23F2NO6S

Conditions
ConditionsYield
With mesitylenecarboxylic acid; palladium diacetate; caesium carbonate at 50℃; for 24h; Sealed tube;67%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

1-(4-nitro-benzenesulfonyl)-aziridine
43090-97-7

1-(4-nitro-benzenesulfonyl)-aziridine

C20H20F2N2O8S

C20H20F2N2O8S

Conditions
ConditionsYield
With mesitylenecarboxylic acid; palladium diacetate; caesium carbonate at 50℃; for 24h; Sealed tube;64%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

(3,3-difluoronon-4-yn-1-yl)benzene

(3,3-difluoronon-4-yn-1-yl)benzene

2,2,2-trifluoroethyl 5-(cyclopropylmethoxy)-4-(difluoromethoxy)-2-(6-oxo-9-phenylnon-4-en-5-yl)benzoate

2,2,2-trifluoroethyl 5-(cyclopropylmethoxy)-4-(difluoromethoxy)-2-(6-oxo-9-phenylnon-4-en-5-yl)benzoate

Conditions
ConditionsYield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium carbonate In 1,2-dichloro-ethane at 60℃; for 24h;61%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

methyl iodide
74-88-4

methyl iodide

C26H26F4O8

C26H26F4O8

Conditions
ConditionsYield
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With rhodium(III) chloride trihydrate; tetrabutylammonium acetate In N,N-dimethyl-formamide at 80℃; for 20h; Electrolysis;
Stage #2: methyl iodide
56%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

C22H25F4N3O2

C22H25F4N3O2

C34H35F6N3O5

C34H35F6N3O5

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 2h;55%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

1-tosyl-2-methylaziridine
25856-77-3

1-tosyl-2-methylaziridine

C22H25F2NO6S

C22H25F2NO6S

Conditions
ConditionsYield
With mesitylenecarboxylic acid; palladium diacetate; caesium carbonate at 50℃; for 24h; Sealed tube;52%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

(3,3-difluoronon-4-yn-1-yl)benzene

(3,3-difluoronon-4-yn-1-yl)benzene

4-butyl-7-(cyclopropylmethoxy)-3-(1,1-difluoro-3-phenylpropyl)-6-(difluoromethoxy)-1H-isochromen-1-one

4-butyl-7-(cyclopropylmethoxy)-3-(1,1-difluoro-3-phenylpropyl)-6-(difluoromethoxy)-1H-isochromen-1-one

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) acetate In 2,2,2-trifluoroethanol at 20℃; for 24h;44%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

(3,3-difluoronon-4-yn-1-yl)benzene

(3,3-difluoronon-4-yn-1-yl)benzene

(E)-4-butyl-7-(cyclopropylmethoxy)-6-(difluoromethoxy)-3-(3-phenylprop-1-en-1-yl)-1H-isochromen-1-one

(E)-4-butyl-7-(cyclopropylmethoxy)-6-(difluoromethoxy)-3-(3-phenylprop-1-en-1-yl)-1H-isochromen-1-one

Conditions
ConditionsYield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; Trimethylacetic acid In methanol at 80℃; for 24h;40%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

C18H17F4N3O3

C18H17F4N3O3

C30H27F6N3O6

C30H27F6N3O6

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 1.5h;38%
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