As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryItem Quality Standard Test Result Appearance colorless clear liquid colorless clear liquid Assay %
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiry3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid CAS No.:162401-62-9 Name: 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid Molecular Structure Molecular Formula: C12H12F2O4 Molecula
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryTIANFUCHEM--162401-62-9--High purity 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
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inquiryProducts: 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Cas No.: 162401-62-9 Molecular Formula: C12H12F2O4 Molecular Weight: 258.219 Assay:
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
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inquiry3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid CAS:162401-62-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializ
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryRofluMilast InterMediate II CAS:162401-62-9 Specification:in-house Stock:Fresh Purity:97% min Application:162401-62-9
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryFactory 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid CAS 162401-62-9Appearance:White powder Storage:Store in Cool and dry .place, keep away from incompatible substances Package:according to customers' requirements Application:Pharmaceutical int
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inquirySuperior quality, moderate price & quick delivery. Appearance:White or off-white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide inter
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inquiryProduct Product name 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid CAS No. 162401-62-9 Molecular formula
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inquiryHuarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.
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inquiry3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
With sodium hydroxide In methanol at 50℃; for 3h; | 99% |
With hydrogenchloride; water at 20 - 55℃; pH=3 - 4; |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
With sodium chlorite; aminosulfonic acid In water; acetic acid at 20℃; for 1h; | 97% |
With dihydrogen peroxide; potassium hydroxide In methanol at 65℃; for 1h; | 97% |
With sodium chlorite; aminosulfonic acid In water; acetic acid at 20℃; for 1h; Concentration; | 97.3% |
4-bromo-2-(cyclopropylmethoxy)-1-(difluoromethoxy)benzene
carbon dioxide
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Stage #1: 4-bromo-2-(cyclopropylmethoxy)-1-(difluoromethoxy)benzene With ethylmagnesium chloride In tetrahydrofuran; 1,2-dimethoxyethane for 1h; Reflux; Stage #2: carbon dioxide In tetrahydrofuran; 1,2-dimethoxyethane Stage #3: With hydrogenchloride In tetrahydrofuran; 1,2-dimethoxyethane; water Temperature; Solvent; Reagent/catalyst; Acidic conditions; | 95% |
sodium chlorodifluoroacetate
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Stage #1: 3-cyclopropylmethoxy-4-hydroxybenzoic acid methyl ester; sodium chlorodifluoroacetate With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 0.5h; Stage #2: With water; sodium hydroxide In methanol at 50℃; for 2h; | 81.4% |
3-hydroxy-4-iodobenzoic acid
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: thionyl chloride / 3 h / 50 °C 2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Large scale 3: potassium hydroxide; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 30 h / 100 °C / Inert atmosphere; Large scale 4: thionyl chloride / 3 h / 50 °C 5: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 95 °C 6: sodium hydroxide / methanol / 3 h / 50 °C View Scheme | |
Multi-step reaction with 6 steps 1: thionyl chloride / 3 h / 50 °C 2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Large scale 3: potassium hydroxide; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 30 h / 100 °C / Inert atmosphere; Large scale 4: thionyl chloride / 3 h / 50 °C 5: N,N-dimethyl-formamide / Heating 6: sodium hydroxide / methanol / 3 h / 50 °C View Scheme |
methyl 3-hydroxy-4-iodobenzoate
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Large scale 2: potassium hydroxide; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 30 h / 100 °C / Inert atmosphere; Large scale 3: thionyl chloride / 3 h / 50 °C 4: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 95 °C 5: sodium hydroxide / methanol / 3 h / 50 °C View Scheme | |
Multi-step reaction with 5 steps 1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Large scale 2: potassium hydroxide; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 30 h / 100 °C / Inert atmosphere; Large scale 3: thionyl chloride / 3 h / 50 °C 4: N,N-dimethyl-formamide / Heating 5: sodium hydroxide / methanol / 3 h / 50 °C View Scheme |
methyl 3-(cyclopropylmethoxy)-4-iodobenzoate
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium hydroxide; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 30 h / 100 °C / Inert atmosphere; Large scale 2: thionyl chloride / 3 h / 50 °C 3: N,N-dimethyl-formamide / Heating 4: sodium hydroxide / methanol / 3 h / 50 °C View Scheme | |
Multi-step reaction with 4 steps 1: potassium hydroxide; copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 30 h / 100 °C / Inert atmosphere; Large scale 2: thionyl chloride / 3 h / 50 °C 3: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 95 °C 4: sodium hydroxide / methanol / 3 h / 50 °C View Scheme |
3-(cyclopropylmethoxy)-4-hydroxybenzoic acid
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: thionyl chloride / 3 h / 50 °C 2: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 95 °C 3: sodium hydroxide / methanol / 3 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: thionyl chloride / 3 h / 50 °C 2: N,N-dimethyl-formamide / Heating 3: sodium hydroxide / methanol / 3 h / 50 °C View Scheme |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 95 °C 2: sodium hydroxide / methanol / 3 h / 50 °C View Scheme | |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / Heating 2: sodium hydroxide / methanol / 3 h / 50 °C View Scheme |
4-difluoromethoxy-3-hydroxybenzaldehyde
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate; potassium iodide / acetone / 0.5 h / Inert atmosphere; Reflux 1.2: 12.5 h / 20 °C / Inert atmosphere; Reflux 2.1: aminosulfonic acid; sodium chlorite / water; acetonitrile / 5 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / tetrahydrofuran / 14 h / 0 °C / Reflux 2: acetic acid; aminosulfonic acid; sodium chlorite / water / 1 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium carbonate; potassium iodide / dimethyl sulfoxide / 1 h / 70 °C 1.2: 4 h / 70 °C 2.1: acetic acid; aminosulfonic acid / 5 - 20 °C View Scheme |
3,4-dihydroxybenzaldehyde
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / N,N-dimethyl-formamide; water / 2 h / 120 °C 2: potassium carbonate / tetrahydrofuran / 14 h / 0 °C / Reflux 3: acetic acid; aminosulfonic acid; sodium chlorite / water / 1 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 85 °C 1.2: 8 - 10 h / Inert atmosphere 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 6 h / 75 - 80 °C 3.1: aminosulfonic acid; acetic acid / water / 5 - 10 °C 3.2: 1 h / 5 - 10 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / N,N-dimethyl-formamide; water / 2 h / 120 °C 2: caesium carbonate / N,N-dimethyl-formamide / 1 h / 65 °C 3: potassium hydroxide; dihydrogen peroxide / methanol / 1 h / 20 °C View Scheme |
4-benzyloxy-3-hydroxy-benzaldehyde
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 65 °C 2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C 3: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 120 °C 4: potassium hydroxide; dihydrogen peroxide / methanol / 1 h / 65 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C 2.1: N-iodo-succinimide; potassium carbonate / 24 h / 20 °C 3.1: palladium 10% on activated carbon; hydrogen / methanol / 18 h 4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 100 °C 4.2: 2 h / 50 °C View Scheme |
4-(benzyloxy)-3-(cyclopropylmethoxy)benzaldehyde
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C 2: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 120 °C 3: potassium hydroxide; dihydrogen peroxide / methanol / 1 h / 65 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: N-iodo-succinimide; potassium carbonate / 24 h / 20 °C 2.1: palladium 10% on activated carbon; hydrogen / methanol / 18 h 3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 100 °C 3.2: 2 h / 50 °C View Scheme |
3-(cyclopropylmethoxy)-4-hydroxybenzaldehyde
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 120 °C 2: potassium hydroxide; dihydrogen peroxide / methanol / 1 h / 65 °C View Scheme |
vanillin
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 90 °C 2.1: lithium chloride / N,N-dimethyl-formamide / Reflux 3.1: potassium carbonate / tetrahydrofuran / 1 h / 20 °C 4.1: acetic acid / 0.5 h / 20 °C 4.2: 5 - 20 °C View Scheme |
4-(difluoromethoxy)-3-methoxybenzaldehyde
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: lithium chloride / N,N-dimethyl-formamide / Reflux 2.1: potassium carbonate / tetrahydrofuran / 1 h / 20 °C 3.1: acetic acid / 0.5 h / 20 °C 3.2: 5 - 20 °C View Scheme |
3-fluoro-4-hydroxybenzaldehyde
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / N,N-dimethyl-formamide; water / 2 h / 95 - 100 °C 2: potassium tert-butylate / 1,4-dioxane / 4 h / 70 - 75 °C 3: aminosulfonic acid; sodium chlorite; acetic acid / water / 0.5 h / 0 - 10 °C View Scheme |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyl chloride
Conditions | Yield |
---|---|
With thionyl chloride In toluene for 2h; Heating / reflux; | 100% |
With thionyl chloride In toluene for 2h; Reflux; | 100% |
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 25℃; for 3h; | 100% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
methyl iodide
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl acetamide at 75 - 85℃; for 1h; | 98.1% |
With potassium carbonate In N,N-dimethyl acetamide at 75 - 85℃; for 1h; | 98.1% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
3,5-dichloro-4-aminopyridine
roflumilast
Conditions | Yield |
---|---|
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With pyridine; 2,4,6-trinitrochlorobenzene In 1,4-dioxane at 20 - 35℃; for 3h; Industrial scale; Stage #2: 3,5-dichloro-4-aminopyridine In 1,4-dioxane for 2h; Reagent/catalyst; Solvent; Temperature; Industrial scale; | 95% |
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In dichloromethane at 0 - 20℃; for 3h; Stage #2: 3,5-dichloro-4-aminopyridine In dichloromethane for 2h; Concentration; | 91% |
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With pivaloyl chloride; sodium carbonate In tetrahydrofuran at 25℃; for 2h; Stage #2: 3,5-dichloro-4-aminopyridine In tetrahydrofuran at 50℃; for 4h; Temperature; Solvent; Reagent/catalyst; | 64% |
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With thionyl chloride In toluene Heating / reflux; Stage #2: 3,5-dichloro-4-aminopyridine With sodium hydride In tetrahydrofuran for 1h; Cooling; | 58.6% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
roflumilast
Conditions | Yield |
---|---|
Large scale; | 93% |
Multi-step reaction with 2 steps 1.1: dimethyl sulfoxide / 3 h / 20 °C 2.1: cesium fluoride / dimethyl sulfoxide / 3 h / 90 °C 2.2: 6.5 h / 90 - 95 °C View Scheme |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
glycine ethyl ester hydrochloride
Conditions | Yield |
---|---|
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Stage #2: glycine ethyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 10h; | 87% |
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Stage #2: glycine ethyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 10h; | 87% |
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Inert atmosphere; Stage #2: glycine ethyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Cooling with ice; | 86.1% |
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Stage #2: glycine ethyl ester hydrochloride With N-ethyl-N,N-diisopropylamine at 20℃; Cooling with ice; | 86.1% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
With diethylamino-sulfur trifluoride In dichloromethane at 0℃; for 0.5h; | 80% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloro-1-pyridin-4-yl)ethanone
1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoate
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 72h; | 77% |
2-hydroxypyridin
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere; | 76% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
ethyl Bromopyruvate
Conditions | Yield |
---|---|
With dipotassium hydrogenphosphate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) acetate In 2,2,2-trifluoroethanol at 140℃; for 24h; | 75% |
With dipotassium hydrogenphosphate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; 1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; silver(I) acetate; XPhos In 2,2,2-trifluoroethanol at 140℃; for 24h; Sealed tube; | 75% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; | 71% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
3-bromo-1,1,1-trifluoroacetone
Conditions | Yield |
---|---|
With dipotassium hydrogenphosphate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) acetate In 2,2,2-trifluoroethanol at 140℃; for 24h; | 71% |
With dipotassium hydrogenphosphate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; 1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; silver(I) acetate; XPhos In 2,2,2-trifluoroethanol at 140℃; for 24h; Sealed tube; | 71% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
(S)-(-)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoate
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h; | 70% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
N-(p-toluenesulfonyl)aziridine
Conditions | Yield |
---|---|
With mesitylenecarboxylic acid; palladium diacetate; caesium carbonate at 50℃; for 24h; Sealed tube; | 67% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
1-(4-nitro-benzenesulfonyl)-aziridine
Conditions | Yield |
---|---|
With mesitylenecarboxylic acid; palladium diacetate; caesium carbonate at 50℃; for 24h; Sealed tube; | 64% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
2,2,2-trifluoroethanol
Conditions | Yield |
---|---|
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium carbonate In 1,2-dichloro-ethane at 60℃; for 24h; | 61% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
methyl iodide
Conditions | Yield |
---|---|
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid With rhodium(III) chloride trihydrate; tetrabutylammonium acetate In N,N-dimethyl-formamide at 80℃; for 20h; Electrolysis; Stage #2: methyl iodide | 56% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 2h; | 55% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
1-tosyl-2-methylaziridine
Conditions | Yield |
---|---|
With mesitylenecarboxylic acid; palladium diacetate; caesium carbonate at 50℃; for 24h; Sealed tube; | 52% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) acetate In 2,2,2-trifluoroethanol at 20℃; for 24h; | 44% |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
Conditions | Yield |
---|---|
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; Trimethylacetic acid In methanol at 80℃; for 24h; | 40% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 1.5h; | 38% |
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