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inquiryRoflumilast Intermediate Bromomethyl-Cyclopropane[CAS:7051-34-5] 4-Difluoromethoxy-3-Hydroxybenzaldehyde[CAS:151103-08-1] PRODUCT NAME 4-DifluoroMethoxy-3-hydroxybenzaldehyde
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1039.html Product Name 4-Difluoromethoxy-3-hydroxybenzaldehyde CAS No.
Cas:151103-08-1
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWe are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
Cas:151103-08-1
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inquiryProduct Name: 4-Difluoromethoxy-3-hydroxybenzaldehyde CAS: 151103-08-1 MF: C8H6F2O3 MW: 188.13 EINECS: 687-745-0 Mol File: 151103-08-1.mol 4-Difluoromethoxy-3-hydroxybenzaldehyde Structure 4-Difluoromethoxy-3-hydroxybenzaldehyde C
Cas:151103-08-1
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:151103-08-1
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inquiry4-Difluoromethoxy-3-hydroxybenzaldehyde CAS:151103-08-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high
Cas:151103-08-1
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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Cas:151103-08-1
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:151103-08-1
Min.Order:1 Gram
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:151103-08-1
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Cas:151103-08-1
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:151103-08-1
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inquiry151103-08-1 99%Appearance:white powder Storage:keep cold Package:according to customers' requirements Application:Pharmaceutical intermediates 151103-08-1 Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or
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Cas:151103-08-1
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inquiry4-Difluoromethoxy-3-hydroxybenzaldehyde Basic information Product Name: 4-Difluoromethoxy-3-hydroxybenzaldehyde Synonyms: 2-(Difluoromethoxy)-5-formylphenol, alpha,alpha-Difluoro-4-formyl-2-hydroxyanisole;Benzaldehyde,4-(difluoroMethoxy)-3-hydrox
Cas:151103-08-1
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inquiryProduct name: 4-Difluoromethoxy-3-Hydroxybenzaldehyde CAS No.:151103-08-1 Molecule Formula:C8H6F2O3 Molecule Weight:188.13 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard
Cas:151103-08-1
Min.Order:1 Kilogram
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquirymethyl bromodifluoroacetate
3,4-dihydroxybenzaldehyde
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With hydroxylamine In water; acetonitrile at 45℃; Concentration; Reagent/catalyst; | 90.3% |
4-(difluoromethoxy)-3-methoxybenzaldehyde
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In 1-methyl-pyrrolidin-2-one | 88.3% |
With lithium chloride In N,N-dimethyl-formamide Reagent/catalyst; Reflux; | 28% |
Multi-step reaction with 2 steps 1.1: orthoformic acid triethyl ester / boron trifluoride diethyl etherate / diethyl ether / 24 h / Heating / reflux 2.1: lithium diphenylphosphide / tetrahydrofuran / 3 - 4 h 2.2: pH 3 - 4 View Scheme |
C11H12F2O4
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
Stage #1: C11H12F2O4 With lithium diphenylphosphide In tetrahydrofuran for 3 - 4h; Stage #2: With hydrogenchloride; water pH=3 - 4; | 83% |
metyhyl chlorodifluoroacetate
3,4-dihydroxybenzaldehyde
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With tetrabutylammonium hydrogen sulfide; sodium hydroxide at 60 - 65℃; for 3h; Concentration; | 79.4% |
With caesium carbonate In N,N-dimethyl-formamide at 20 - 90℃; for 0.5h; Reagent/catalyst; Time; Microwave irradiation; Green chemistry; | 57% |
With caesium carbonate In N,N-dimethyl-formamide at 90℃; for 0.5h; Microwave irradiation; | 57% |
sodium chlorodifluoroacetate
3,4-dihydroxybenzaldehyde
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With sodium carbonate In water; N,N-dimethyl-formamide at 80℃; for 6h; | 57.5% |
With sodium hydroxide In water; N,N-dimethyl-formamide at 120℃; for 2h; | 46% |
Stage #1: sodium chlorodifluoroacetate; 3,4-dihydroxybenzaldehyde With sodium hydroxide In water; N,N-dimethyl-formamide at 120℃; for 2h; Stage #2: With hydrogenchloride In water | 44% |
potassium 2-bromo-2,2-difluoroacetate
3,4-dihydroxybenzaldehyde
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With sodium hydroxide In water; N,N-dimethyl-formamide at 70℃; for 2h; | 53% |
metyhyl chlorodifluoroacetate
3,4-dihydroxybenzaldehyde
A
3,4-bis-(difluoromethoxy)-benzaldehyde
B
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 65℃; for 3h; Inert atmosphere; | A 20% B 45% |
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 16h; | A 13% B 21% |
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 16h; | A 13% B 21% |
3-(benzyloxy)-4-(difluoromethoxy)benzaldehyde
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In ethyl acetate under 760.051 Torr; for 1h; | 43.7% |
Chlorodifluoromethane
3,4-dihydroxybenzaldehyde
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In N,N-dimethyl-formamide for 0.166667h; | 37% |
With potassium carbonate In N,N-dimethyl-formamide at 80 - 85℃; for 4.5h; | 25% |
With potassium carbonate In N,N-dimethyl-formamide at 75 - 80℃; | 25.3% |
Stage #1: 3,4-dihydroxybenzaldehyde With potassium carbonate In N,N-dimethyl-formamide at 20 - 85℃; Stage #2: Chlorodifluoromethane In N,N-dimethyl-formamide for 8 - 10h; Inert atmosphere; |
3,4-dihydroxybenzaldehyde
2-chloro-2,2-difluoroacetic acid
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
Stage #1: 3,4-dihydroxybenzaldehyde; 2-chloro-2,2-difluoroacetic acid With sodium hydroxide In N,N-dimethyl-formamide at 55℃; for 16h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide pH=1.0; | 24% |
water
3,4-dihydroxybenzaldehyde
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide In 1,4-dioxane | 19% |
3,4-dihydroxybenzaldehyde
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With potassium carbonate | 18% |
Chlorodifluoromethane
3,4-dihydroxybenzaldehyde
A
3,4-bis-(difluoromethoxy)-benzaldehyde
B
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
Stage #1: Chlorodifluoromethane; 3,4-dihydroxybenzaldehyde With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In DMF (N,N-dimethyl-formamide); water for 0.05h; Stage #2: With hydrogenchloride In DMF (N,N-dimethyl-formamide); water |
vanillin
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: potassium carbonate / 1-methyl-pyrrolidin-2-one View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 90 °C 2: lithium chloride / N,N-dimethyl-formamide / Reflux View Scheme |
Ethyl bromodifluoroacetate
3,4-dihydroxybenzaldehyde
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With sodium hydroxide In water; N,N-dimethyl-formamide at 70℃; for 2h; | 3.43 g |
Conditions | Yield |
---|---|
With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate In acetonitrile at 23℃; for 12h; Irradiation; Overall yield = 60 %Spectr.; | |
With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate In acetonitrile at 23℃; for 12h; Irradiation; Glovebox; Sealed tube; Inert atmosphere; Overall yield = 60 percentSpectr.; | |
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; lithium carbonate In 1,2-dichloro-ethane; acetonitrile at 60℃; for 20h; Sealed tube; Overall yield = 68 percentSpectr.; |
isovanillin
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 25 °C 2: ethanethiol; sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 70 °C / Cooling with ice 3: potassium carbonate / N,N-dimethyl-formamide; water / 120 °C 4: hydrogen; 5%-palladium/activated carbon / ethyl acetate / 1 h / 760.05 Torr View Scheme |
3-benzyloxy-4-methoxybenzaldehyde
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethanethiol; sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 70 °C / Cooling with ice 2: potassium carbonate / N,N-dimethyl-formamide; water / 120 °C 3: hydrogen; 5%-palladium/activated carbon / ethyl acetate / 1 h / 760.05 Torr View Scheme |
3-benzyloxy-4-hydroxybenzaldehyde
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide; water / 120 °C 2: hydrogen; 5%-palladium/activated carbon / ethyl acetate / 1 h / 760.05 Torr View Scheme |
benzyl bromide
4-difluoromethoxy-3-hydroxybenzaldehyde
3-(benzyloxy)-4-(difluoromethoxy)benzaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 20℃; for 3h; | 100% |
With potassium carbonate In acetonitrile at 20 - 30℃; for 4h; | 99.4% |
With potassium carbonate In acetonitrile at 80℃; for 3h; Inert atmosphere; | 95% |
With potassium carbonate In acetonitrile at 20℃; for 4h; |
Cyclopentyl bromide
4-difluoromethoxy-3-hydroxybenzaldehyde
3-Cyclopentyloxy-4-difluoromethoxybenzaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In DMF (N,N-dimethyl-formamide) | 100% |
With potassium carbonate In N-methyl-acetamide | 89% |
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 65℃; for 22h; | 87% |
propargyl bromide
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 16h; Reflux; | 100% |
cyclopropylcarbinyl bromide
4-difluoromethoxy-3-hydroxybenzaldehyde
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
Conditions | Yield |
---|---|
Stage #1: 4-difluoromethoxy-3-hydroxybenzaldehyde With potassium carbonate; potassium iodide In dimethyl sulfoxide at 70℃; for 1h; Stage #2: cyclopropylcarbinyl bromide In dimethyl sulfoxide at 70℃; for 4h; | 99% |
With trimethylbenzylammonium bromide; potassium carbonate; potassium iodide In tetrahydrofuran at 0℃; Concentration; Reflux; | 98.5% |
With potassium carbonate In tetrahydrofuran at 0℃; for 14h; Heating / reflux; | 97% |
2-bromo-1-fluoro-4-nitrobenzene
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With potassium fluoride In dimethyl sulfoxide at 90℃; for 2h; | 97.9% |
With potassium fluoride In dimethyl sulfoxide at 100 - 120℃; | 66% |
1-Bromo-2-butyne
4-difluoromethoxy-3-hydroxybenzaldehyde
3-(but-2-ynyloxy)-4-difluoromethoxybenzaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 16h; Heating / reflux; | 97% |
trityl chloride
4-difluoromethoxy-3-hydroxybenzaldehyde
3-trityloxy-4-difluoromethoxybenzaldehyde
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran for 1h; | 91% |
4-difluoromethoxy-3-hydroxybenzaldehyde
4-difluoromethoxy-3-hydroxybenzoic acid
Conditions | Yield |
---|---|
With sodium chlorite; aminosulfonic acid In water; acetonitrile at 0 - 30℃; | 90.4% |
With sodium chlorite; aminosulfonic acid In water; acetic acid at 10 - 20℃; | 77% |
1-acetyl-2-thiohydantoin
4-difluoromethoxy-3-hydroxybenzaldehyde
5-(4-(difluoromethoxy)-3-hydroxybenzylidene)-2-thioxoimidazolidin-4-one
Conditions | Yield |
---|---|
With sodium acetate; acetic acid for 5h; Reflux; | 84.8% |
3-Hydroxytetrahydrofuran
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; Mitsunobu reaction; | 84% |
4-difluoromethoxy-3-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl acetamide at 75℃; for 3h; | 83% |
1,3-dibromo-propane
4-difluoromethoxy-3-hydroxybenzaldehyde
3-(3-bromopropoxy)-4-(difluoromethoxy)benzaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 1.5h; Reflux; Inert atmosphere; | 81% |
1,4-dibromo-butane
4-difluoromethoxy-3-hydroxybenzaldehyde
3-(4-bromobutoxy)-4-(difluoromethoxy)benzaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 1.5h; Reflux; Inert atmosphere; | 75.8% |
With potassium carbonate In acetonitrile for 4h; Reflux; |
methanol
4-difluoromethoxy-3-hydroxybenzaldehyde
3-hydroxy-4-(difluoromethoxy)-benzoic acid methyl ester
Conditions | Yield |
---|---|
With Oxone at 50 - 55℃; for 3h; | 70% |
With Oxone at 50 - 55℃; for 3h; | 70% |
2-bromo-1-fluoro-4-nitrobenzene
4-difluoromethoxy-3-hydroxybenzaldehyde
4-(difluoromethoxy)-8-nitrodibenzo[b,d]furan-1-carbaldehyde
Conditions | Yield |
---|---|
Stage #1: 2-bromo-1-fluoro-4-nitrobenzene; 4-difluoromethoxy-3-hydroxybenzaldehyde With sodium carbonate In N,N-dimethyl-formamide at 90℃; for 2h; Stage #2: With sodium acetate; palladium diacetate In N,N-dimethyl-formamide at 90 - 130℃; for 2h; Product distribution / selectivity; | 67% |
4-methoxycarbonylphenylboronic acid
4-difluoromethoxy-3-hydroxybenzaldehyde
methyl 4-(2-(difluoromethoxy)-5-formylphenoxy)benzoate
Conditions | Yield |
---|---|
With pyridine; copper diacetate In dichloromethane at 20℃; for 15h; | 67% |
3-bromo-4-chloropyridine-1-oxide
4-difluoromethoxy-3-hydroxybenzaldehyde
3-[(3-bromo-pyridin-N-oxide-4-yl)oxyl]-4-(difluoromethoxy)benzaldehyde
Conditions | Yield |
---|---|
Stage #1: 4-difluoromethoxy-3-hydroxybenzaldehyde With potassium fluoride In dimethyl sulfoxide at 100 - 110℃; for 0.5 - 1h; Stage #2: 3-bromo-4-chloropyridine-1-oxide In dimethyl sulfoxide at 20 - 110℃; for 16 - 18h; | 65% |
propyl 5-bromopentanoate
4-difluoromethoxy-3-hydroxybenzaldehyde
propyl 5-[2-(difluoromethoxy)-5-formylphenoxy]pentanoate
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 4h; Inert atmosphere; Reflux; | 60.8% |
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol at 20℃; Claisen-Schmidt Condensation; | 60% |
t-butyl 4-hydroxy piperidine-1-carboxylate
4-difluoromethoxy-3-hydroxybenzaldehyde
4-(2-difluoromethoxy-5-formylphenoxy)piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; Mitsunobu reaction; | 54% |
Tetrahydro-pyran-4-ol
4-difluoromethoxy-3-hydroxybenzaldehyde
4-difluoromethoxy-3-(tetrahydropyran-4-yloxy)benzaldehydehyde
Conditions | Yield |
---|---|
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; Mitsunobu reaction; | 28% |
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