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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

4-Difluoromethoxy-3-hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Difluoromethoxy-3-Hydroxybenzaldehyde supplier in China

Cas:151103-08-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

Roflumilast Intermediate Bromomethyl-Cyclopropane[CAS:7051-34-5] 4-Difluoromethoxy-3-Hydroxybenzaldehyde[CAS:151103-08-1] PRODUCT NAME 4-DifluoroMethoxy-3-hydroxybenzaldehyde

4-Difluoromethoxy-3-Hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Difluoromethoxy-3-Hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:1

Negotiable

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

4-Difluoromethoxy-3-hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 4-Difluoromethoxy-3-hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-(Difluoromethoxy)-3-hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1039.html Product Name 4-Difluoromethoxy-3-hydroxybenzaldehyde CAS No.

4-Difluoromethoxy-3-hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Difluoromethoxy-3-hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 151103-08-1 with best quality

Cas:151103-08-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

Benzaldehyde,4-(difluoromethoxy)-3-hydroxy-CAS NO.: 151103-08-1

Cas:151103-08-1

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzaldehyde,4-(difluoromethoxy)-3-hydroxy- 151103-08-1

Cas:151103-08-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Benzaldehyde,4-(difluoromethoxy)-3-hydroxy-/ LIDE PHARMA- Factory supply / Best price

Cas:151103-08-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 4-Difluoromethoxy-3-hydroxybenzaldehyde CAS: 151103-08-1 MF: C8H6F2O3 MW: 188.13 EINECS: 687-745-0 Mol File: 151103-08-1.mol 4-Difluoromethoxy-3-hydroxybenzaldehyde Structure 4-Difluoromethoxy-3-hydroxybenzaldehyde C

4-Difluoromethoxy-3-hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, 4-Difluoromethoxy-3-hydroxybenzaldehyde CAS:151103-08-1

Cas:151103-08-1

Min.Order:1 Kilogram

FOB Price: $64.0 / 68.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

4-Difluoromethoxy-3-hydroxybenzaldehyde CAS:151103-08-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high

4-Difluoromethoxy-3-hydroxybenzaldehyde CAS:151103-08-1

Cas:151103-08-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzaldehyde,4-(difluoromethoxy)-3-hydroxy-

Cas:151103-08-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

4-DifluoroMethoxy-3-hydroxybenzaldehyde cas151103-08-1

Cas:151103-08-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-DifluoroMethoxy-3-hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE 151103-08-1

Cas:151103-08-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Difluoromethoxy-3-hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

4-(difluoromethoxy)-3-hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 4-DifluoroMethoxy-3-hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE/High quality/Best price

Cas:151103-08-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Hangyu CAS:151103-08-1

Cas:151103-08-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

151103-08-1 99%Appearance:white powder Storage:keep cold Package:according to customers' requirements Application:Pharmaceutical intermediates 151103-08-1 Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or

151103-08-1 99%

Cas:151103-08-1

Min.Order:1 Gram

Negotiable

Type:Other

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

4-DifluoroMethoxy-3-hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

4-Difluoromethoxy-3-hydroxybenzaldehyde Basic information Product Name: 4-Difluoromethoxy-3-hydroxybenzaldehyde Synonyms: 2-(Difluoromethoxy)-5-formylphenol, alpha,alpha-Difluoro-4-formyl-2-hydroxyanisole;Benzaldehyde,4-(difluoroMethoxy)-3-hydrox

Tianfu Chem 4-Difluoromethoxy-3-hydroxybenzaldehyde

Cas:151103-08-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 4-Difluoromethoxy-3-Hydroxybenzaldehyde CAS No.:151103-08-1 Molecule Formula:C8H6F2O3 Molecule Weight:188.13 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard

High Quality 4-Difluoromethoxy-3-Hydroxybenzaldehyde in stock

Cas:151103-08-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-(Difluoromethoxy)-3-hydroxybenzaldehyde97%

Cas:151103-08-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

methyl bromodifluoroacetate
683-98-7

methyl bromodifluoroacetate

3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
With hydroxylamine In water; acetonitrile at 45℃; Concentration; Reagent/catalyst;90.3%
4-(difluoromethoxy)-3-methoxybenzaldehyde
162401-70-9

4-(difluoromethoxy)-3-methoxybenzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
With potassium carbonate In 1-methyl-pyrrolidin-2-one88.3%
With lithium chloride In N,N-dimethyl-formamide Reagent/catalyst; Reflux;28%
Multi-step reaction with 2 steps
1.1: orthoformic acid triethyl ester / boron trifluoride diethyl etherate / diethyl ether / 24 h / Heating / reflux
2.1: lithium diphenylphosphide / tetrahydrofuran / 3 - 4 h
2.2: pH 3 - 4
View Scheme
C11H12F2O4
773093-32-6

C11H12F2O4

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
Stage #1: C11H12F2O4 With lithium diphenylphosphide In tetrahydrofuran for 3 - 4h;
Stage #2: With hydrogenchloride; water pH=3 - 4;
83%
metyhyl chlorodifluoroacetate
1514-87-0

metyhyl chlorodifluoroacetate

3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
With tetrabutylammonium hydrogen sulfide; sodium hydroxide at 60 - 65℃; for 3h; Concentration;79.4%
With caesium carbonate In N,N-dimethyl-formamide at 20 - 90℃; for 0.5h; Reagent/catalyst; Time; Microwave irradiation; Green chemistry;57%
With caesium carbonate In N,N-dimethyl-formamide at 90℃; for 0.5h; Microwave irradiation;57%
sodium chlorodifluoroacetate
1895-39-2

sodium chlorodifluoroacetate

3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
With sodium carbonate In water; N,N-dimethyl-formamide at 80℃; for 6h;57.5%
With sodium hydroxide In water; N,N-dimethyl-formamide at 120℃; for 2h;46%
Stage #1: sodium chlorodifluoroacetate; 3,4-dihydroxybenzaldehyde With sodium hydroxide In water; N,N-dimethyl-formamide at 120℃; for 2h;
Stage #2: With hydrogenchloride In water
44%
potassium 2-bromo-2,2-difluoroacetate
87189-16-0

potassium 2-bromo-2,2-difluoroacetate

3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
With sodium hydroxide In water; N,N-dimethyl-formamide at 70℃; for 2h;53%
metyhyl chlorodifluoroacetate
1514-87-0

metyhyl chlorodifluoroacetate

3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

A

3,4-bis-(difluoromethoxy)-benzaldehyde
127842-54-0

3,4-bis-(difluoromethoxy)-benzaldehyde

B

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 65℃; for 3h; Inert atmosphere;A 20%
B 45%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 16h;A 13%
B 21%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 16h;A 13%
B 21%
3-(benzyloxy)-4-(difluoromethoxy)benzaldehyde
577968-58-2

3-(benzyloxy)-4-(difluoromethoxy)benzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In ethyl acetate under 760.051 Torr; for 1h;43.7%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In N,N-dimethyl-formamide for 0.166667h;37%
With potassium carbonate In N,N-dimethyl-formamide at 80 - 85℃; for 4.5h;25%
With potassium carbonate In N,N-dimethyl-formamide at 75 - 80℃;25.3%
Stage #1: 3,4-dihydroxybenzaldehyde With potassium carbonate In N,N-dimethyl-formamide at 20 - 85℃;
Stage #2: Chlorodifluoromethane In N,N-dimethyl-formamide for 8 - 10h; Inert atmosphere;
3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
Stage #1: 3,4-dihydroxybenzaldehyde; 2-chloro-2,2-difluoroacetic acid With sodium hydroxide In N,N-dimethyl-formamide at 55℃; for 16h;
Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide pH=1.0;
24%
water
7732-18-5

water

3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In 1,4-dioxane19%
3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
With potassium carbonate18%
Chlorodifluoromethane
75-45-6

Chlorodifluoromethane

3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

A

3,4-bis-(difluoromethoxy)-benzaldehyde
127842-54-0

3,4-bis-(difluoromethoxy)-benzaldehyde

B

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
Stage #1: Chlorodifluoromethane; 3,4-dihydroxybenzaldehyde With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In DMF (N,N-dimethyl-formamide); water for 0.05h;
Stage #2: With hydrogenchloride In DMF (N,N-dimethyl-formamide); water
vanillin
121-33-5

vanillin

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: potassium carbonate / 1-methyl-pyrrolidin-2-one
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 90 °C
2: lithium chloride / N,N-dimethyl-formamide / Reflux
View Scheme
Ethyl bromodifluoroacetate
667-27-6

Ethyl bromodifluoroacetate

3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
With sodium hydroxide In water; N,N-dimethyl-formamide at 70℃; for 2h;3.43 g
1-(difluoromethoxy)-3-methyl-6-nitro-4-(trifluoromethyl)-1H-benzo[d][1,2,3]triazol-3-ium trifluoromethanesulfonate

1-(difluoromethoxy)-3-methyl-6-nitro-4-(trifluoromethyl)-1H-benzo[d][1,2,3]triazol-3-ium trifluoromethanesulfonate

meta-hydroxybenzaldehyde
100-83-4

meta-hydroxybenzaldehyde

A

2-(difluoromethoxy)-3-hydroxybenzaldehyde

2-(difluoromethoxy)-3-hydroxybenzaldehyde

B

2-(difluoromethoxy)-5-hydroxybenzaldehyde

2-(difluoromethoxy)-5-hydroxybenzaldehyde

C

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate In acetonitrile at 23℃; for 12h; Irradiation; Overall yield = 60 %Spectr.;
With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate In acetonitrile at 23℃; for 12h; Irradiation; Glovebox; Sealed tube; Inert atmosphere; Overall yield = 60 percentSpectr.;
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; lithium carbonate In 1,2-dichloro-ethane; acetonitrile at 60℃; for 20h; Sealed tube; Overall yield = 68 percentSpectr.;
isovanillin
621-59-0

isovanillin

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 25 °C
2: ethanethiol; sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 70 °C / Cooling with ice
3: potassium carbonate / N,N-dimethyl-formamide; water / 120 °C
4: hydrogen; 5%-palladium/activated carbon / ethyl acetate / 1 h / 760.05 Torr
View Scheme
3-benzyloxy-4-methoxybenzaldehyde
6346-05-0

3-benzyloxy-4-methoxybenzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanethiol; sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 70 °C / Cooling with ice
2: potassium carbonate / N,N-dimethyl-formamide; water / 120 °C
3: hydrogen; 5%-palladium/activated carbon / ethyl acetate / 1 h / 760.05 Torr
View Scheme
3-benzyloxy-4-hydroxybenzaldehyde
50773-56-3

3-benzyloxy-4-hydroxybenzaldehyde

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide; water / 120 °C
2: hydrogen; 5%-palladium/activated carbon / ethyl acetate / 1 h / 760.05 Torr
View Scheme
benzyl bromide
100-39-0

benzyl bromide

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

3-(benzyloxy)-4-(difluoromethoxy)benzaldehyde
577968-58-2

3-(benzyloxy)-4-(difluoromethoxy)benzaldehyde

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃; for 3h;100%
With potassium carbonate In acetonitrile at 20 - 30℃; for 4h;99.4%
With potassium carbonate In acetonitrile at 80℃; for 3h; Inert atmosphere;95%
With potassium carbonate In acetonitrile at 20℃; for 4h;
Cyclopentyl bromide
137-43-9

Cyclopentyl bromide

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

3-Cyclopentyloxy-4-difluoromethoxybenzaldehyde
153587-14-5

3-Cyclopentyloxy-4-difluoromethoxybenzaldehyde

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide)100%
With potassium carbonate In N-methyl-acetamide89%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 65℃; for 22h;87%
propargyl bromide
106-96-7

propargyl bromide

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

4-difluoromethoxy-3-propargyloxybenzaldehyde

4-difluoromethoxy-3-propargyloxybenzaldehyde

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 16h; Reflux;100%
cyclopropylcarbinyl bromide
7051-34-5

cyclopropylcarbinyl bromide

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

Conditions
ConditionsYield
Stage #1: 4-difluoromethoxy-3-hydroxybenzaldehyde With potassium carbonate; potassium iodide In dimethyl sulfoxide at 70℃; for 1h;
Stage #2: cyclopropylcarbinyl bromide In dimethyl sulfoxide at 70℃; for 4h;
99%
With trimethylbenzylammonium bromide; potassium carbonate; potassium iodide In tetrahydrofuran at 0℃; Concentration; Reflux;98.5%
With potassium carbonate In tetrahydrofuran at 0℃; for 14h; Heating / reflux;97%
2-bromo-1-fluoro-4-nitrobenzene
701-45-1

2-bromo-1-fluoro-4-nitrobenzene

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

3-(2-bromo-4-nitrophenoxy)-4-(difluoromethoxy)benzaldehyde

3-(2-bromo-4-nitrophenoxy)-4-(difluoromethoxy)benzaldehyde

Conditions
ConditionsYield
With potassium fluoride In dimethyl sulfoxide at 90℃; for 2h;97.9%
With potassium fluoride In dimethyl sulfoxide at 100 - 120℃;66%
1-Bromo-2-butyne
3355-28-0

1-Bromo-2-butyne

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

3-(but-2-ynyloxy)-4-difluoromethoxybenzaldehyde
1164145-11-2

3-(but-2-ynyloxy)-4-difluoromethoxybenzaldehyde

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 16h; Heating / reflux;97%
trityl chloride
76-83-5

trityl chloride

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

3-trityloxy-4-difluoromethoxybenzaldehyde
959860-02-7

3-trityloxy-4-difluoromethoxybenzaldehyde

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 1h;91%
4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

4-difluoromethoxy-3-hydroxybenzoic acid
913985-07-6

4-difluoromethoxy-3-hydroxybenzoic acid

Conditions
ConditionsYield
With sodium chlorite; aminosulfonic acid In water; acetonitrile at 0 - 30℃;90.4%
With sodium chlorite; aminosulfonic acid In water; acetic acid at 10 - 20℃;77%
1-acetyl-2-thiohydantoin
584-26-9

1-acetyl-2-thiohydantoin

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

5-(4-(difluoromethoxy)-3-hydroxybenzylidene)-2-thioxoimidazolidin-4-one
1447755-95-4

5-(4-(difluoromethoxy)-3-hydroxybenzylidene)-2-thioxoimidazolidin-4-one

Conditions
ConditionsYield
With sodium acetate; acetic acid for 5h; Reflux;84.8%
3-Hydroxytetrahydrofuran
453-20-3

3-Hydroxytetrahydrofuran

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]benzaldehyde

4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]benzaldehyde

Conditions
ConditionsYield
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; Mitsunobu reaction;84%
[2H2]bromomethyl-[1-2H]cyclopropane

[2H2]bromomethyl-[1-2H]cyclopropane

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

3-([1-2H]cyclopropyl[2H2]methoxy)-4-difluoromethoxybenzaldehyde

3-([1-2H]cyclopropyl[2H2]methoxy)-4-difluoromethoxybenzaldehyde

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide at 75℃; for 3h;83%
1,3-dibromo-propane
109-64-8

1,3-dibromo-propane

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

3-(3-bromopropoxy)-4-(difluoromethoxy)benzaldehyde
1422361-81-6

3-(3-bromopropoxy)-4-(difluoromethoxy)benzaldehyde

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 1.5h; Reflux; Inert atmosphere;81%
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

3-(4-bromobutoxy)-4-(difluoromethoxy)benzaldehyde
1422361-77-0

3-(4-bromobutoxy)-4-(difluoromethoxy)benzaldehyde

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 1.5h; Reflux; Inert atmosphere;75.8%
With potassium carbonate In acetonitrile for 4h; Reflux;
methanol
67-56-1

methanol

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

3-hydroxy-4-(difluoromethoxy)-benzoic acid methyl ester
1159429-52-3

3-hydroxy-4-(difluoromethoxy)-benzoic acid methyl ester

Conditions
ConditionsYield
With Oxone at 50 - 55℃; for 3h;70%
With Oxone at 50 - 55℃; for 3h;70%
2-bromo-1-fluoro-4-nitrobenzene
701-45-1

2-bromo-1-fluoro-4-nitrobenzene

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

4-(difluoromethoxy)-8-nitrodibenzo[b,d]furan-1-carbaldehyde
685873-93-2

4-(difluoromethoxy)-8-nitrodibenzo[b,d]furan-1-carbaldehyde

Conditions
ConditionsYield
Stage #1: 2-bromo-1-fluoro-4-nitrobenzene; 4-difluoromethoxy-3-hydroxybenzaldehyde With sodium carbonate In N,N-dimethyl-formamide at 90℃; for 2h;
Stage #2: With sodium acetate; palladium diacetate In N,N-dimethyl-formamide at 90 - 130℃; for 2h; Product distribution / selectivity;
67%
4-methoxycarbonylphenylboronic acid
99768-12-4

4-methoxycarbonylphenylboronic acid

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

methyl 4-(2-(difluoromethoxy)-5-formylphenoxy)benzoate
1422361-86-1

methyl 4-(2-(difluoromethoxy)-5-formylphenoxy)benzoate

Conditions
ConditionsYield
With pyridine; copper diacetate In dichloromethane at 20℃; for 15h;67%
3-bromo-4-chloropyridine-1-oxide
99839-30-2

3-bromo-4-chloropyridine-1-oxide

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

3-[(3-bromo-pyridin-N-oxide-4-yl)oxyl]-4-(difluoromethoxy)benzaldehyde
1086277-95-3

3-[(3-bromo-pyridin-N-oxide-4-yl)oxyl]-4-(difluoromethoxy)benzaldehyde

Conditions
ConditionsYield
Stage #1: 4-difluoromethoxy-3-hydroxybenzaldehyde With potassium fluoride In dimethyl sulfoxide at 100 - 110℃; for 0.5 - 1h;
Stage #2: 3-bromo-4-chloropyridine-1-oxide In dimethyl sulfoxide at 20 - 110℃; for 16 - 18h;
65%
propyl 5-bromopentanoate
13931-37-8

propyl 5-bromopentanoate

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

propyl 5-[2-(difluoromethoxy)-5-formylphenoxy]pentanoate
1422361-74-7

propyl 5-[2-(difluoromethoxy)-5-formylphenoxy]pentanoate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 4h; Inert atmosphere; Reflux;60.8%
C30H21N15O3

C30H21N15O3

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

C54H33F6N15O9

C54H33F6N15O9

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 20℃; Claisen-Schmidt Condensation;60%
t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

4-(2-difluoromethoxy-5-formylphenoxy)piperidine-1-carboxylic acid tert-butyl ester
1093411-52-9

4-(2-difluoromethoxy-5-formylphenoxy)piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; Mitsunobu reaction;54%
Tetrahydro-pyran-4-ol
2081-44-9

Tetrahydro-pyran-4-ol

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

4-difluoromethoxy-3-(tetrahydropyran-4-yloxy)benzaldehydehyde
1093411-51-8

4-difluoromethoxy-3-(tetrahydropyran-4-yloxy)benzaldehydehyde

Conditions
ConditionsYield
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; Mitsunobu reaction;28%
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