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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-(Difluoromethoxy)-3-(cyclopropylmethoxy)benzaldehyde Manufacturer/High quality/Best price/In stock

Cas:151103-09-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzaldehyde supplier in China

Cas:151103-09-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

The company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:White or off-white Solid Storage:Sealed

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE

Cas:151103-09-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzaldehyde

Cas:151103-09-2

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-(Difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldehyde

Cas:151103-09-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE

Cas:151103-09-2

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--151103-09-2--High purity 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in Ch

TIANFUCHEM--151103-09-2--High purity 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE factory price

Cas:151103-09-2

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 151103-09-2 with competitive price

Cas:151103-09-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

4-(Difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldehyde

Cas:151103-09-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Products: 4-(Difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldehyde Cas No.: 151103-09-2 Molecular Formula:

4-(Difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldehyde CAS: 151103-09-2

Cas:151103-09-2

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzaldehyde,3-(cyclopropylmethoxy)-4-(difluoromethoxy)- 151103-09-2

Cas:151103-09-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Benzaldehyde,3-(cyclopropylmethoxy)-4-(difluoromethoxy)-/ LIDE PHARMA- Factory supply / Best price

Cas:151103-09-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE CAS:151103-09-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, spec

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE CAS:151103-09-2

Cas:151103-09-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzaldehyde,3-(cyclopropylmethoxy)-4-(difluoromethoxy)-

Cas:151103-09-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde

Cas:151103-09-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

RofluMilast interMediate CAS:151103-09-2 Specification:in-house Stock:Fresh Purity:97% min Application:151103-09-2

4-(Difluoromethoxy)-3-(cyclopropylmethoxy)benzaldehyde

Cas:151103-09-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-(Difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldehyde

Cas:151103-09-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ROFLUMILAST INTERMEDIATE CAS 151103-09-2

Cas:151103-09-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE

Cas:151103-09-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzaldehyde,3-(cyclopropylmethoxy)-4-(difluoromethoxy)-

Cas:151103-09-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE

Cas:151103-09-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Hangyu CAS:151103-09-2

Cas:151103-09-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

4-(Difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldehyde

Cas:151103-09-2

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediate

3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyd

Cas:151103-09-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 4-(Difluoromethoxy)-3-(Cyclopropylmethoxy)-Benzaldehyde CAS No.:151103-09-2 Molecule Formula:C12H12F2O3 Molecule Weight:242.22 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

High Quality 4-(Difluoromethoxy)-3-(Cyclopropylmethoxy)-Benzaldehyde in stock

Cas:151103-09-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

4-(Difluoromethoxy)-3-(cyclopropylmethoxy)benzaldehyde

Cas:151103-09-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE Chemical Properties Boiling point 331.3±37.0 °C(Predicted) density 1.277±0.06 g/cm3(Predicted) storage temp. Inert atmosphere,2-8°C

4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE

Cas:151103-09-2

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4-(Difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldehyde

Cas:151103-09-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Hangzhou Fandachem Co.,Ltd, a China-based chemical company, specialize in exporting 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde,cas:151103-09-2, Please contact us by email freely. We are leading exporter in China. If you rea

3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde,cas:151103-09-2 from fandachem

Cas:151103-09-2

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-(Difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldehyde

Cas:151103-09-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

cyclopropylcarbinyl bromide
7051-34-5

cyclopropylcarbinyl bromide

4-difluoromethoxy-3-hydroxybenzaldehyde
151103-08-1

4-difluoromethoxy-3-hydroxybenzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

Conditions
ConditionsYield
Stage #1: 4-difluoromethoxy-3-hydroxybenzaldehyde With potassium carbonate; potassium iodide In dimethyl sulfoxide at 70℃; for 1h;
Stage #2: cyclopropylcarbinyl bromide In dimethyl sulfoxide at 70℃; for 4h;
99%
With trimethylbenzylammonium bromide; potassium carbonate; potassium iodide In tetrahydrofuran at 0℃; Concentration; Reflux;98.5%
With potassium carbonate In tetrahydrofuran at 0℃; for 14h; Heating / reflux;97%
Cyclopropylmethanol
2516-33-8

Cyclopropylmethanol

4-(difluoromethoxy)-3-fluorobenzaldehyde

4-(difluoromethoxy)-3-fluorobenzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

Conditions
ConditionsYield
With potassium tert-butylate In 1,4-dioxane at 70 - 75℃; for 4h; Reagent/catalyst; Solvent; Temperature;96.6%
3-(cyclopropylmethoxy)-4-hydroxybenzaldehyde
25934-52-5

3-(cyclopropylmethoxy)-4-hydroxybenzaldehyde

sodium chlorodifluoroacetate
1895-39-2

sodium chlorodifluoroacetate

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide at 120℃; for 2h;84%
3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / N,N-dimethyl-formamide; water / 2 h / 120 °C
2: potassium carbonate / tetrahydrofuran / 14 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 85 °C
1.2: 8 - 10 h / Inert atmosphere
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 6 h / 75 - 80 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / N,N-dimethyl-formamide; water / 2 h / 120 °C
2: caesium carbonate / N,N-dimethyl-formamide / 1 h / 65 °C
View Scheme
4-benzyloxy-3-hydroxy-benzaldehyde
4049-39-2

4-benzyloxy-3-hydroxy-benzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 65 °C
2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C
3: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
4-(benzyloxy)-3-(cyclopropylmethoxy)benzaldehyde
1381886-14-1

4-(benzyloxy)-3-(cyclopropylmethoxy)benzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C
2: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
vanillin
121-33-5

vanillin

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 90 °C
2: lithium chloride / N,N-dimethyl-formamide / Reflux
3: potassium carbonate / tetrahydrofuran / 1 h / 20 °C
View Scheme
4-(difluoromethoxy)-3-methoxybenzaldehyde
162401-70-9

4-(difluoromethoxy)-3-methoxybenzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium chloride / N,N-dimethyl-formamide / Reflux
2: potassium carbonate / tetrahydrofuran / 1 h / 20 °C
View Scheme
3-fluoro-4-hydroxybenzaldehyde
405-05-0

3-fluoro-4-hydroxybenzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / N,N-dimethyl-formamide; water / 2 h / 95 - 100 °C
2: potassium tert-butylate / 1,4-dioxane / 4 h / 70 - 75 °C
View Scheme
(R)-2-methylpropane-2-sulfinamide
196929-78-9

(R)-2-methylpropane-2-sulfinamide

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

(R)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide
1367625-78-2

(R)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide

Conditions
ConditionsYield
With titanium(IV) tetraethanolate In tetrahydrofuran at 20℃; for 12h;99.8%
(S)-2-methylpropane-2-sulfinamide
343338-28-3

(S)-2-methylpropane-2-sulfinamide

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

(S)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide
1367625-79-3

(S)-2-methyl-2-propanesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide

Conditions
ConditionsYield
With titanium(IV) tetraethanolate In tetrahydrofuran at 20℃; for 12h;98.8%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid
162401-62-9

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

Conditions
ConditionsYield
With sodium chlorite; aminosulfonic acid In water; acetic acid at 20℃; for 1h;97%
With dihydrogen peroxide; potassium hydroxide In methanol at 65℃; for 1h;97%
With sodium chlorite; aminosulfonic acid In water; acetic acid at 20℃; for 1h; Concentration;97.3%
ethyl (triphenylphosphoranylidene)acetate
1099-45-2

ethyl (triphenylphosphoranylidene)acetate

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

ethyl (E)-3-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)acrylate

ethyl (E)-3-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)acrylate

Conditions
ConditionsYield
In dichloromethane at 20℃; Wittig Olefination; Inert atmosphere;97%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

(R)-4-methylbenzenesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide

(R)-4-methylbenzenesulfinic acid 3-cyclopropylmethoxy-4-(difluoromethoxy)benzylideneamide

Conditions
ConditionsYield
Stage #1: (1S,2R,5S)-2-isopropyl-5-methylcyclohexyl (R)-4-methylbenzenesulfinate With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 0℃; for 2h;
Stage #2: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde In tetrahydrofuran at 0 - 20℃; for 12h;
95.8%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3-cyclopropylmethoxy-4-difluoromethoxy-benzaldehyde oxime
888012-88-2

3-cyclopropylmethoxy-4-difluoromethoxy-benzaldehyde oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; triethylamine In acetonitrile at 20℃; for 20h; Heating / reflux;95%
With hydroxylamine hydrochloride; sodium carbonate In dimethyl sulfoxide at 20℃;
methylmagnesium bromide
75-16-1

methylmagnesium bromide

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]ethanol

1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]ethanol

Conditions
ConditionsYield
Stage #1: methylmagnesium bromide; 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde In tetrahydrofuran at -78℃;
Stage #2: With water; ammonium chloride In tetrahydrofuran
94%
dimedone
126-81-8

dimedone

para-bromophenacyl bromide
99-73-0

para-bromophenacyl bromide

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

2-[(4-bromophenyl)carbonyl]-3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-6,6-dimethyl-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

2-[(4-bromophenyl)carbonyl]-3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-6,6-dimethyl-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

Conditions
ConditionsYield
Stage #1: dimedone; para-bromophenacyl bromide; 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde With pyridine In acetonitrile for 3h; Reflux;
Stage #2: With triethylamine In acetonitrile Reflux;
89%
dimedone
126-81-8

dimedone

para-bromophenacyl bromide
99-73-0

para-bromophenacyl bromide

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

2-[(4-bromophenyl)carbonyl]-3-(3-cyclopropylmethoxy,4-difluoromethoxyphenyl)-6,6-dimethyl-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

2-[(4-bromophenyl)carbonyl]-3-(3-cyclopropylmethoxy,4-difluoromethoxyphenyl)-6,6-dimethyl-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

Conditions
ConditionsYield
Stage #1: dimedone; para-bromophenacyl bromide; 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde With pyridine In acetonitrile at 70℃; for 3h;
Stage #2: With triethylamine In acetonitrile at 70℃; for 16h; Temperature; stereospecific reaction;
89%
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-methanol
151450-20-3

(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-methanol

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran; water at 0℃; for 0.166667h;87%
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde With sodium tetrahydroborate In tetrahydrofuran; methanol at 0 - 20℃; for 24h;
Stage #2: With sodium hydroxide; water
81%
With sodium tetrahydroborate In tetrahydrofuran; methanol at 20℃;
4-Nitrophenacyl bromide
99-81-0

4-Nitrophenacyl bromide

dimedone
126-81-8

dimedone

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-6,6-dimethyl-2-(4-nitrophenylcarbonyl)-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-6,6-dimethyl-2-(4-nitrophenylcarbonyl)-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

Conditions
ConditionsYield
Stage #1: 4-Nitrophenacyl bromide; dimedone; 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde With pyridine In acetonitrile for 3h; Reflux;
Stage #2: With triethylamine In acetonitrile Reflux;
86%
4-Nitrophenacyl bromide
99-81-0

4-Nitrophenacyl bromide

dimedone
126-81-8

dimedone

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3-(3-cyclopropylmethoxy,4-difluoromethoxyphenyl)-6,6-dimethyl-2-(4-nitrophenylcarbonyl)-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

3-(3-cyclopropylmethoxy,4-difluoromethoxyphenyl)-6,6-dimethyl-2-(4-nitrophenylcarbonyl)-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

Conditions
ConditionsYield
Stage #1: 4-Nitrophenacyl bromide; dimedone; 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde With pyridine In acetonitrile at 70℃; for 3h;
Stage #2: With triethylamine In acetonitrile at 70℃; for 14h; Temperature; stereospecific reaction;
86%
dimedone
126-81-8

dimedone

2-bromo-1-(3,4-dichlorophenyl)ethanone
2632-10-2

2-bromo-1-(3,4-dichlorophenyl)ethanone

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-[(3,4-dichlorophenyl)carbonyl]-6,6-dimethyl-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-[(3,4-dichlorophenyl)carbonyl]-6,6-dimethyl-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

Conditions
ConditionsYield
Stage #1: dimedone; 2-bromo-1-(3,4-dichlorophenyl)ethanone; 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde With pyridine In acetonitrile for 3h; Reflux;
Stage #2: With triethylamine In acetonitrile Reflux;
85%
dimedone
126-81-8

dimedone

2-Bromo-4'-methoxyacetophenone
2632-13-5

2-Bromo-4'-methoxyacetophenone

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-6,6-dimethyl-2-(4-methoxyphenylcarbonyl)-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-6,6-dimethyl-2-(4-methoxyphenylcarbonyl)-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

Conditions
ConditionsYield
Stage #1: dimedone; 2-Bromo-4'-methoxyacetophenone; 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde With pyridine In acetonitrile for 3h; Reflux;
Stage #2: With triethylamine In acetonitrile Reflux;
84%
dimedone
126-81-8

dimedone

2-Bromo-4'-methoxyacetophenone
2632-13-5

2-Bromo-4'-methoxyacetophenone

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-6,6-dimethyl-2-(4-methoxyphenylcarbonyl)-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-6,6-dimethyl-2-(4-methoxyphenylcarbonyl)-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-one

Conditions
ConditionsYield
Stage #1: dimedone; 2-Bromo-4'-methoxyacetophenone; 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde With pyridine In acetonitrile at 70℃; for 3h;
Stage #2: With triethylamine In acetonitrile at 70℃; for 15h; Temperature; stereospecific reaction;
84%
acetic anhydride
108-24-7

acetic anhydride

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3-cyclopropylmethoxy-4-difluoromethoxycinnamic acid

3-cyclopropylmethoxy-4-difluoromethoxycinnamic acid

Conditions
ConditionsYield
With potassium carbonate at 140 - 150℃; for 3.5h; Perkin Carboxylic Acid Synthesis;84%
3,5-dichloro-4-picoline
100868-46-0

3,5-dichloro-4-picoline

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloro-1-pyridin-4-yl)ethanone
1113061-20-3, 1239278-70-6, 1246537-42-7

1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloro-1-pyridin-4-yl)ethanone

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -30 - -20℃; for 1h;75%
Stage #1: 3,5-dichloro-4-picoline; 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde With potassium tert-butylate In tetrahydrofuran at -30 - -20℃;
Stage #2: With water; ammonium chloride In tetrahydrofuran at -10 - -5℃;
pyridin-4-yl-acetic acid ethyl ester
54401-85-3

pyridin-4-yl-acetic acid ethyl ester

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)acrylic acid ethyl ester
1041846-46-1

3-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(pyridin-4-yl)acrylic acid ethyl ester

Conditions
ConditionsYield
With ammonium acetate In acetic acid for 18h; Reflux;75%
1-propynylmagnesium bromide
16466-97-0, 13254-27-8

1-propynylmagnesium bromide

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)but-2-yn-1-ol

1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)but-2-yn-1-ol

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 16h; Inert atmosphere;74%
3,5-dichloro-4-aminopyridine
22889-78-7

3,5-dichloro-4-aminopyridine

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3,5-dichloro-N-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzylidene)pyridin-4-amine
1454574-39-0

3,5-dichloro-N-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzylidene)pyridin-4-amine

Conditions
ConditionsYield
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde With trifluoroacetic acid; trimethyl orthoformate In toluene at 20 - 30℃; Inert atmosphere; Reflux;
Stage #2: 3,5-dichloro-4-aminopyridine With trifluoroacetic acid In toluene at 40 - 110℃;
73%
Stage #1: 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde With toluene-4-sulfonic acid; trimethyl orthoformate In toluene for 3h; Reflux;
Stage #2: 3,5-dichloro-4-aminopyridine With toluene-4-sulfonic acid In toluene at 70 - 80℃; for 30h; Reflux;
23%
With N,O-Bis(trimethylsilyl)trifluoroacetamide; toluene-4-sulfonic acid In acetonitrile for 48h; Reagent/catalyst; Reflux;70 %Chromat.
Nitroethane
79-24-3

Nitroethane

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

2-(cyclopropylmethoxy)-1-(difluoromethoxy)-4-(2-nitroprop-1-en-1-yl)benzene

2-(cyclopropylmethoxy)-1-(difluoromethoxy)-4-(2-nitroprop-1-en-1-yl)benzene

Conditions
ConditionsYield
With ammonium acetate; acetic acid at 90℃; for 9h; Inert atmosphere;54%
methanol
67-56-1

methanol

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid methyl ester

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid methyl ester

Conditions
ConditionsYield
With Oxone at 55 - 60℃; for 3h;52%
With Oxone at 55 - 60℃; for 3h;52%
3,5-dichloro-4-methylpyridin-1-ium-1-olate
1026899-06-8

3,5-dichloro-4-methylpyridin-1-ium-1-olate

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

(R/S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloro-1-oxypyridin-4-yl)ethanol
1113061-31-6

(R/S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloro-1-oxypyridin-4-yl)ethanol

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -35℃; for 0.666667h; Inert atmosphere;42%
With potassium tert-butylate In tetrahydrofuran at -35℃; for 1.16667h;
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

3-cyclopropylmethoxy-4-difluoromethoxybenzyl chloride
153587-18-9

3-cyclopropylmethoxy-4-difluoromethoxybenzyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaBH4 / methanol; tetrahydrofuran / 20 °C
2: SOCl2; DMF / toluene
View Scheme
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)acetonitrile
153276-22-3

(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)acetonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaBH4 / methanol; tetrahydrofuran / 20 °C
2: SOCl2; DMF / toluene
3: ethanol; H2O; dimethylformamide / 2 h / 60 °C
View Scheme
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde
151103-09-2

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

A

C25H26F2N2O3S

C25H26F2N2O3S

B

C25H26F2N2O3S

C25H26F2N2O3S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - 0 °C
1.2: 12 h / 0 - 20 °C
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - 0 °C
2.2: -78 °C
View Scheme

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