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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Chlorodifluoroacetic acid Manufacturer/High quality/Best price/In stock

Cas:76-04-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Chlorodifluoroacetic Acid supplier in China

Cas:76-04-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Aceticacid, 2-chloro-2,2-difluoro-

Cas:76-04-0

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

76-04-0 Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 76-04-0 with best quality

Cas:76-04-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Chlorodifluoroacetic acid CAS76-04-0

Cas:76-04-0

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name Chlorodifluoroacetic acid CAS No 76-04-0 Formula C2HClF2O2 Molecular Weight

Chlorodifluoroacetic acid CAS: 76-04-0

Cas:76-04-0

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Aceticacid, 2-chloro-2,2-difluoro- 76-04-0

Cas:76-04-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Chlorodifluoroacetic acid fatty acid

Cas:76-04-0

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Chlorodifluoroacetic acid CAS:76-04-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in

Chlorodifluoroacetic acid CAS:76-04-0

Cas:76-04-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Aceticacid, 2-chloro-2,2-difluoro-

Cas:76-04-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Aceticacid, 2-chloro-2,2-difluoro-

Cas:76-04-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Kanbei Chemical Co.,LTD

1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E

hot sale Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Chlorodifluoroacetic Acid

Cas:76-04-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Chlorodifluoroacetic Acid CAS No.:76-04-0 Molecule Formula:C2ClF2O2 Molecule Weight:129.47 Purity: 99.0% Package: 250kg/drum Description:Colorless transparent liquid Manufacture Standards:Enterprise Standard

High Quality Chlorodifluoroacetic Acid

Cas:76-04-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

Chlorodifluoroacetic acid 76-04-0

Cas:76-04-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Chlorodifluoroacetic acid Basic information Product Name: Chlorodifluoroacetic acid Synonyms: DIFLUOROCHLOROACETIC ACID;CHLORODIFLUOROACETIC ACID;2-chloro-2,2-difluoroacetic acid;RARECHEM AL BO 1535;Aceticacid,chlorodifluoro-;chlorodifluoro-ac

Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:1 Gram

Negotiable

Type:Other

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Hangzhou ZeErRui Chemical Co., Ltd.

Product Name:Chlorodifluoroacetic acid Synonym:Acetic acid, chlorodifluoro-;2-chloro-2,2-difluoroacetic acid; CAS No.:76-04-0 Molecular formula:C2HClF2O2 Molecular weight:130.47800 Appearance:Colorless transparent liquid Purity:Content

Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Chlorodifluoroacetic acid cas no. 76-04-0 97%

Cas:76-04-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:0

Negotiable

Type:Other

inquiry

Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

Best price Chlorodifluoroacetic Acid 76-04-0

Cas:76-04-0

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Chlorodifluoroacetic acid

Cas:76-04-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

ethyl 2-chloro-2,2-difluoroacetate
383-62-0

ethyl 2-chloro-2,2-difluoroacetate

A

carbon monoxide
201230-82-2

carbon monoxide

B

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With oxygen; chlorine at 24.84℃; under 760.051 Torr; Kinetics; Temperature; Irradiation;A 34%
B 88%
1,1-difluorotetrachloroethane
76-11-9

1,1-difluorotetrachloroethane

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With ammonium peroxydisulfate; sodium formate In N,N-dimethyl-formamide at 30℃; for 4h;66.5%
ethyl 2-chloro-2,2-difluoroacetate
383-62-0

ethyl 2-chloro-2,2-difluoroacetate

A

Difluoroacetic acid
381-73-7

Difluoroacetic acid

B

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

C

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With ethanol; zinc for 1 - 3h; Product distribution / selectivity; Heating / reflux;A 9.7%
B 61.6%
C 0.4%
1,1,2-Trichloro-1,2,2-trifluoroethane
76-13-1

1,1,2-Trichloro-1,2,2-trifluoroethane

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With ammonium peroxydisulfate; sodium formate In N,N-dimethyl-formamide at 20℃; for 10h;55.6%
sodium 2-chloro-1,1,2,2-tetrafluoroethanesulfinate
89740-32-9

sodium 2-chloro-1,1,2,2-tetrafluoroethanesulfinate

allyl bromide
106-95-6

allyl bromide

A

1,1,2,2-tetrafluoro-1-bromo-2-chloroethane
354-53-0

1,1,2,2-tetrafluoro-1-bromo-2-chloroethane

B

5-chloro-4,4,5,5-tetrafluoro-1-pentene
103780-92-3

5-chloro-4,4,5,5-tetrafluoro-1-pentene

C

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With ammonium peroxydisulfate In N,N-dimethyl-formamide at 40℃; for 4h;A 22%
B 53%
C 14%
metyhyl chlorodifluoroacetate
1514-87-0

metyhyl chlorodifluoroacetate

A

carbon monoxide
201230-82-2

carbon monoxide

B

formic difluorochloroacetic anhydride

formic difluorochloroacetic anhydride

C

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With oxygen; chlorine at 24.84℃; under 760.051 Torr; Kinetics; Temperature; Irradiation;A 26%
B n/a
C 34%
sodium 2-chloro-1,1,2,2-tetrafluoroethanesulfinate
89740-32-9

sodium 2-chloro-1,1,2,2-tetrafluoroethanesulfinate

propargyl bromide
106-96-7

propargyl bromide

A

1,1,2,2-tetrafluoro-1-bromo-2-chloroethane
354-53-0

1,1,2,2-tetrafluoro-1-bromo-2-chloroethane

B

5-chloro-4,4,5,5-tetrafluoro-1,2-pentadiene
132673-96-2

5-chloro-4,4,5,5-tetrafluoro-1,2-pentadiene

C

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With ammonium peroxydisulfate In N,N-dimethyl-formamide at 40℃; for 4h;A 30%
B 32%
C 12%
methanol
67-56-1

methanol

chlordifluoroacetyl chloride
354-24-5

chlordifluoroacetyl chloride

A

Difluoroacetic acid
381-73-7

Difluoroacetic acid

B

difluoroacetic acid methyl ester
433-53-4

difluoroacetic acid methyl ester

C

metyhyl chlorodifluoroacetate
1514-87-0

metyhyl chlorodifluoroacetate

D

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With zinc at 20℃; for 1 - 3h; Product distribution / selectivity; Heating / reflux;A 2.6%
B 16.7%
C 0%
D 28.6%
metyhyl chlorodifluoroacetate
1514-87-0

metyhyl chlorodifluoroacetate

A

Difluoroacetic acid
381-73-7

Difluoroacetic acid

B

difluoroacetic acid methyl ester
433-53-4

difluoroacetic acid methyl ester

C

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With methanol; zinc at 50℃; for 1 - 4h; Product distribution / selectivity; Heating / reflux;A 0.3%
B 26.8%
C 0%
Difluoroacetic acid
381-73-7

Difluoroacetic acid

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With chlorine im direkten Sonnenlicht;
1,1,3-trichloro-1,3,3-trifluoroacetone
79-52-7

1,1,3-trichloro-1,3,3-trifluoroacetone

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With alkali hydroxide; benzene
With alkaline solution; benzene
With ammonium hydroxide
chlorodifluoroacetyl fluoride
354-27-8

chlorodifluoroacetyl fluoride

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With water
1,1,1,3-tetrachloro-3,3-difluoro-propan-2-one
758-41-8

1,1,1,3-tetrachloro-3,3-difluoro-propan-2-one

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With alkali hydroxide; benzene
With alkaline solution; benzene
With ammonium hydroxide
1,3-dichloro-1,1,3,3-tetrafluoro-propan-2-one
127-21-9

1,3-dichloro-1,1,3,3-tetrafluoro-propan-2-one

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With alkali hydroxide; benzene
With alkaline solution; benzene
3.3.-difluoro-1.1.2.3-tetrachloro-propene-(1)

3.3.-difluoro-1.1.2.3-tetrachloro-propene-(1)

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With alkaline KMNO4 at 70℃;
With alkaline KMNO4 at 70℃;
difluorochloroacetyl chloride

difluorochloroacetyl chloride

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With water
1,1,3-trichloro-1,3,3-trifluoroacetone
79-52-7

1,1,3-trichloro-1,3,3-trifluoroacetone

benzene
71-43-2

benzene

potassium hydroxide

potassium hydroxide

A

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

B

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

1,1,1,3-tetrachloro-3,3-difluoro-propan-2-one
758-41-8

1,1,1,3-tetrachloro-3,3-difluoro-propan-2-one

aqueous NaOH-solution

aqueous NaOH-solution

A

chloroform
67-66-3

chloroform

B

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

trichlorofluoromethane
75-69-4

trichlorofluoromethane

ethyl 2-chloro-2,2-difluoroacetate
383-62-0

ethyl 2-chloro-2,2-difluoroacetate

A

1,1,3-trichloro-2-ethoxy-1,3,3-trifluoro-propan-2-ol

1,1,3-trichloro-2-ethoxy-1,3,3-trifluoro-propan-2-ol

B

1,3-dichloro-1,3,3-trifluoroacetone
56753-83-4

1,3-dichloro-1,3,3-trifluoroacetone

C

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
Stage #1: trichlorofluoromethane; ethyl 2-chloro-2,2-difluoroacetate With aluminium; mercury dichloride In N,N-dimethyl-formamide
Stage #2: With hydrogenchloride In N,N-dimethyl-formamide Title compound not separated from byproducts;
2-chloro-2,2-difluoronitroethane

2-chloro-2,2-difluoronitroethane

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With sulfuric acid
chlorodifluoroacetic anhydride (ClF2CO)2O

chlorodifluoroacetic anhydride (ClF2CO)2O

2-chlorodifluoroethyl-4,5-dicyanoimidazol3

2-chlorodifluoroethyl-4,5-dicyanoimidazol3

aminosulfonic acid
5329-14-6

aminosulfonic acid

diaminomaleonitrile
1187-42-4

diaminomaleonitrile

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With sodium carbonate In diethylene glycol dimethyl ether; water
chlorodifluoroselenoacetic acid

chlorodifluoroselenoacetic acid

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With water
chlordifluoroacetyl chloride
354-24-5

chlordifluoroacetyl chloride

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Conditions
ConditionsYield
With water at 20 - 100℃;
p-cresol
106-44-5

p-cresol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

difluoro-(4-methylphenoxy)acetic acid
207803-79-0

difluoro-(4-methylphenoxy)acetic acid

Conditions
ConditionsYield
With sodium hydride In 1,4-dioxane for 3h; Heating;100%
pent-1-yn-5-ol
5390-04-5

pent-1-yn-5-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C7H7ClF2O2

C7H7ClF2O2

Conditions
ConditionsYield
With sulfuric acid In toluene at 110℃; for 10h;98.3%
5-Hexen-1-ol
821-41-0

5-Hexen-1-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-chloro-2,2-difluoroacetic acid allylhexyl ester

2-chloro-2,2-difluoroacetic acid allylhexyl ester

Conditions
ConditionsYield
With dodecatungstosilic acid In 5,5-dimethyl-1,3-cyclohexadiene at 130℃; for 5h;98.2%
5-hexyl-1-ol
928-90-5

5-hexyl-1-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C8H9ClF2O2

C8H9ClF2O2

Conditions
ConditionsYield
With sulfuric acid In toluene at 110℃; for 10h;98.1%
homoalylic alcohol
627-27-0

homoalylic alcohol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-chloro-2,2-difluoroethylene butyl acetate
881903-10-2

2-chloro-2,2-difluoroethylene butyl acetate

Conditions
ConditionsYield
With dodecatungstosilic acid In toluene at 110℃; for 10h;97.8%
With toluene-4-sulfonic acid In hexane for 3h; Heating / reflux;85%
n-Pent-4-enyl alcohol
821-09-0

n-Pent-4-enyl alcohol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-chloro-2,2-difluoroacetate allyl pentyl ester

2-chloro-2,2-difluoroacetate allyl pentyl ester

Conditions
ConditionsYield
With phosphotungstic acid In toluene at 100℃; for 10h; Temperature; Solvent;97.6%
propargyl alcohol
107-19-7

propargyl alcohol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

propargyl 2-chloro-2,2-difluoroacetate
118373-19-6

propargyl 2-chloro-2,2-difluoroacetate

Conditions
ConditionsYield
With sulfuric acid; toluene-4-sulfonic acid In cyclohexane at 60℃; for 15h;97.6%
α-naphthol
90-15-3

α-naphthol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2,2-difluoro-2-(naphthalen-1-yloxy)acetic acid

2,2-difluoro-2-(naphthalen-1-yloxy)acetic acid

Conditions
ConditionsYield
Stage #1: α-naphthol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
97%
(Z)-4-benzyloxy-but-2-en-1-ol
81028-03-7

(Z)-4-benzyloxy-but-2-en-1-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

chlorodifluoroacetic acid (Z)-5-benzyloxy-pent-2-enyl ester
807378-02-5

chlorodifluoroacetic acid (Z)-5-benzyloxy-pent-2-enyl ester

Conditions
ConditionsYield
With sulfuric acid In toluene for 7h; Heating;96%
4-methoxy-phenol
150-76-5

4-methoxy-phenol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2,2-difluoro-2-(4-methoxyphenoxy)acetic acid

2,2-difluoro-2-(4-methoxyphenoxy)acetic acid

Conditions
ConditionsYield
Stage #1: 4-methoxy-phenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
96%
4-Phenylphenol
92-69-3

4-Phenylphenol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-([1,1'-biphenyl]-4-yloxy)-2,2-difluoroacetic acid

2-([1,1'-biphenyl]-4-yloxy)-2,2-difluoroacetic acid

Conditions
ConditionsYield
Stage #1: 4-Phenylphenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
96%
2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

trifluoroacetic acid
76-05-1

trifluoroacetic acid

Conditions
ConditionsYield
With potassium fluoride In water at 140℃; for 1h;95%
(+/-)-1-trimethylsilyl-1-pentyn-3-ol
18269-90-4

(+/-)-1-trimethylsilyl-1-pentyn-3-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C10H15ClF2O2Si

C10H15ClF2O2Si

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere;95%
N-methylcarbazole
1484-12-4

N-methylcarbazole

chlorodifluoroacetic anhydride
2834-23-3

chlorodifluoroacetic anhydride

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C15H10Cl2FNO

C15H10Cl2FNO

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation; Schlenk technique;95%
chlorodifluoroacetic anhydride
2834-23-3

chlorodifluoroacetic anhydride

3,6,9-trimethyl-9H-carbazole
66294-86-8

3,6,9-trimethyl-9H-carbazole

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C17H14Cl2FNO

C17H14Cl2FNO

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation; Schlenk technique;94%
p-Chlorothiophenol
106-54-7

p-Chlorothiophenol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid
16503-81-4

2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid

Conditions
ConditionsYield
Stage #1: p-Chlorothiophenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
92%
1-butyn-4-ol
927-74-2

1-butyn-4-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C6H5ClF2O2

C6H5ClF2O2

Conditions
ConditionsYield
With phosphoric acid; sulfuric acid In toluene at 110℃; for 10h;90.2%
methyl magnesium iodide
917-64-6

methyl magnesium iodide

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

1-chloro-1,1-difluoroacetone monohydrate
88257-33-4

1-chloro-1,1-difluoroacetone monohydrate

Conditions
ConditionsYield
In diethyl ether at 10℃; for 0.5h;90%
In diethyl ether
4-Fluorothiophenol
371-42-6

4-Fluorothiophenol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

α,α-difluoro(4-fluorophenylthio)acetic acid
911360-86-6

α,α-difluoro(4-fluorophenylthio)acetic acid

Conditions
ConditionsYield
Stage #1: 4-Fluorothiophenol; 2-chloro-2,2-difluoroacetic acid With sodium hydride In 1,4-dioxane at 0 - 100℃; for 3h;
Stage #2: With hydrogenchloride In 1,4-dioxane; ethanol; water at 0℃;
90%
C21H24O4

C21H24O4

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C21H21ClF2O4

C21H21ClF2O4

Conditions
ConditionsYield
Stage #1: C21H24O4 With diisobutylaluminium hydride In dichloromethane at -78℃;
Stage #2: 2-chloro-2,2-difluoroacetic acid In dichloromethane; chloroform Reflux;
90%
para-bromobenzenethiol
106-53-6

para-bromobenzenethiol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

α,α-difluoro(4-bromophenylthio)acetic acid

α,α-difluoro(4-bromophenylthio)acetic acid

Conditions
ConditionsYield
Stage #1: para-bromobenzenethiol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
90%
5-methoxy-N-methylindole
2521-13-3

5-methoxy-N-methylindole

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-chloro-2,2-difluoro-1-(5-methoxy-1-methyl-1H-indol-3-yl)-ethan-1-one
1620097-97-3

2-chloro-2,2-difluoro-1-(5-methoxy-1-methyl-1H-indol-3-yl)-ethan-1-one

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation;89%
2.6-dimethylphenol
576-26-1

2.6-dimethylphenol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-(2,6-dimethylphenoxy)-2,2-difluoroacetic acid

2-(2,6-dimethylphenoxy)-2,2-difluoroacetic acid

Conditions
ConditionsYield
Stage #1: 2.6-dimethylphenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
89%
thiophenol
108-98-5

thiophenol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2,2-difluoro-2-(phenylthio)acetic acid
46207-56-1

2,2-difluoro-2-(phenylthio)acetic acid

Conditions
ConditionsYield
Stage #1: thiophenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux;
Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;
88%
n-hexylmagnesium bromide
3761-92-0

n-hexylmagnesium bromide

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

Chlorodifluoromethyl n-hexyl ketone
86340-68-3

Chlorodifluoromethyl n-hexyl ketone

Conditions
ConditionsYield
In diethyl ether at -20℃; for 12h;87%
In diethyl ether at -78 - 0℃;
phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-chloro-2,2-difluoroacetophenone
384-67-8

2-chloro-2,2-difluoroacetophenone

Conditions
ConditionsYield
With sodium hydroxide87%
(S,E)-4,5-bis(benzyloxy)pent-2-en-1-ol
1001273-06-8

(S,E)-4,5-bis(benzyloxy)pent-2-en-1-ol

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

(S,E)-4,5-bis(benzyloxy)pent-2-enyl 2-chloro-2,2-difluoroacetate
1001273-08-0

(S,E)-4,5-bis(benzyloxy)pent-2-enyl 2-chloro-2,2-difluoroacetate

Conditions
ConditionsYield
In chloroform for 10h; Heating;87%
1,6-dimethyl-1H-indole
5621-15-8

1,6-dimethyl-1H-indole

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

2-chloro-1-(1,6-dimethyl-1H-indol-3-yl)-2,2-difluoroethan-1-one

2-chloro-1-(1,6-dimethyl-1H-indol-3-yl)-2,2-difluoroethan-1-one

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation;87%
triethylsilane
617-86-7

triethylsilane

2-chloro-2,2-difluoroacetic acid
76-04-0

2-chloro-2,2-difluoroacetic acid

C14H31ClF2O2Si2

C14H31ClF2O2Si2

Conditions
ConditionsYield
With tris(pentafluorophenyl)borate In dichloromethane at 23℃; for 1h;87%

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