Chlorodifluoroacetic acid supplier

Name
Chlorodifluoroacetic acid
EINECS 200-928-8
CAS No. 76-04-0
Article Data24
CAS DataBase
Density 1.48 g/cm³
Solubility soluble in water
Melting Point 20-23 °C(lit.)
Formula C₂HClF₂O₂
Boiling Point 119.239 °C at 760 mmHg
Molecular Weight 130.479
Flash Point 25.915 °C
Transport Information UN 3261 8/PG 2
Appearance clear colorless to pale brown liquid after melting
Safety 26-36/37/39-45
Risk Codes 35
Molecular Structure
Hazard Symbols C
Synonyms Aceticacid, chlorodifluoro- (6CI,7CI,8CI,9CI);Monochlorodifluoroacetic acid;NSC 60298;
PSA 37.30000
LogP 0.90260

Synthetic route

: 383-62-0
ethyl 2-chloro-2,2-difluoroacetate

A: 201230-82-2
carbon monoxide

B: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With oxygen; chlorine at 24.84℃; under 760.051 Torr; Kinetics; Temperature; Irradiation;	A 34% B 88%

: 76-11-9
1,1-difluorotetrachloroethane

: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With ammonium peroxydisulfate; sodium formate In N,N-dimethyl-formamide at 30℃; for 4h;	66.5%

: 383-62-0
ethyl 2-chloro-2,2-difluoroacetate

A: 381-73-7
Difluoroacetic acid

B: 454-31-9
ethyl difluoroacetate

C: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With ethanol; zinc for 1 - 3h; Product distribution / selectivity; Heating / reflux;	A 9.7% B 61.6% C 0.4%

...Expand

: 76-13-1
1,1,2-Trichloro-1,2,2-trifluoroethane

: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With ammonium peroxydisulfate; sodium formate In N,N-dimethyl-formamide at 20℃; for 10h;	55.6%

: 89740-32-9
sodium 2-chloro-1,1,2,2-tetrafluoroethanesulfinate

: 106-95-6
allyl bromide

A: 354-53-0
1,1,2,2-tetrafluoro-1-bromo-2-chloroethane

B: 103780-92-3
5-chloro-4,4,5,5-tetrafluoro-1-pentene

C: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With ammonium peroxydisulfate In N,N-dimethyl-formamide at 40℃; for 4h;	A 22% B 53% C 14%

...Expand

: 1514-87-0
metyhyl chlorodifluoroacetate

A: 201230-82-2
carbon monoxide

B: formic difluorochloroacetic anhydride

C: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With oxygen; chlorine at 24.84℃; under 760.051 Torr; Kinetics; Temperature; Irradiation;	A 26% B n/a C 34%

...Expand

: 89740-32-9
sodium 2-chloro-1,1,2,2-tetrafluoroethanesulfinate

: 106-96-7
propargyl bromide

A: 354-53-0
1,1,2,2-tetrafluoro-1-bromo-2-chloroethane

B: 132673-96-2
5-chloro-4,4,5,5-tetrafluoro-1,2-pentadiene

C: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With ammonium peroxydisulfate In N,N-dimethyl-formamide at 40℃; for 4h;	A 30% B 32% C 12%

...Expand

: 67-56-1
methanol

: 354-24-5
chlordifluoroacetyl chloride

A: 381-73-7
Difluoroacetic acid

B: 433-53-4
difluoroacetic acid methyl ester

C: 1514-87-0
metyhyl chlorodifluoroacetate

D: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With zinc at 20℃; for 1 - 3h; Product distribution / selectivity; Heating / reflux;	A 2.6% B 16.7% C 0% D 28.6%

...Expand

: 1514-87-0
metyhyl chlorodifluoroacetate

A: 381-73-7
Difluoroacetic acid

B: 433-53-4
difluoroacetic acid methyl ester

C: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With methanol; zinc at 50℃; for 1 - 4h; Product distribution / selectivity; Heating / reflux;	A 0.3% B 26.8% C 0%

...Expand

: 381-73-7
Difluoroacetic acid

: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With chlorine im direkten Sonnenlicht;

: 79-52-7
1,1,3-trichloro-1,3,3-trifluoroacetone

: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With alkali hydroxide; benzene
With alkaline solution; benzene
With ammonium hydroxide

: 354-27-8
chlorodifluoroacetyl fluoride

: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With water

: 758-41-8
1,1,1,3-tetrachloro-3,3-difluoro-propan-2-one

: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With alkali hydroxide; benzene
With alkaline solution; benzene
With ammonium hydroxide

: 127-21-9
1,3-dichloro-1,1,3,3-tetrafluoro-propan-2-one

: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With alkali hydroxide; benzene
With alkaline solution; benzene

3.3.-difluoro-1.1.2.3-tetrachloro-propene-(1): 3.3.-difluoro-1.1.2.3-tetrachloro-propene-(1)

: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With alkaline KMNO4 at 70℃;
With alkaline KMNO4 at 70℃;

difluorochloroacetyl chloride: difluorochloroacetyl chloride

: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With water

: 79-52-7
1,1,3-trichloro-1,3,3-trifluoroacetone

: 71-43-2
benzene

potassium hydroxide: potassium hydroxide

A: 75-43-4
Dichlorofluoromethane

B: 76-04-0
2-chloro-2,2-difluoroacetic acid

...Expand

: 758-41-8
1,1,1,3-tetrachloro-3,3-difluoro-propan-2-one

aqueous NaOH-solution: aqueous NaOH-solution

A: 67-66-3
chloroform

B: 76-04-0
2-chloro-2,2-difluoroacetic acid

...Expand

: 75-69-4
trichlorofluoromethane

: 383-62-0
ethyl 2-chloro-2,2-difluoroacetate

A: 1,1,3-trichloro-2-ethoxy-1,3,3-trifluoro-propan-2-ol

B: 56753-83-4
1,3-dichloro-1,3,3-trifluoroacetone

C: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
Stage #1: trichlorofluoromethane; ethyl 2-chloro-2,2-difluoroacetate With aluminium; mercury dichloride In N,N-dimethyl-formamide Stage #2: With hydrogenchloride In N,N-dimethyl-formamide Title compound not separated from byproducts;

...Expand

: 2-chloro-2,2-difluoronitroethane

: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With sulfuric acid

chlorodifluoroacetic anhydride (ClF2CO)2O: chlorodifluoroacetic anhydride (ClF2CO)2O

: 2-chlorodifluoroethyl-4,5-dicyanoimidazol3

: 5329-14-6
aminosulfonic acid

: 1187-42-4
diaminomaleonitrile

: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With sodium carbonate In diethylene glycol dimethyl ether; water

...Expand

: chlorodifluoroselenoacetic acid

: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With water

: 354-24-5
chlordifluoroacetyl chloride

: 76-04-0
2-chloro-2,2-difluoroacetic acid

Conditions

Conditions	Yield
With water at 20 - 100℃;

: 106-44-5
p-cresol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 207803-79-0
difluoro-(4-methylphenoxy)acetic acid

Conditions

Conditions	Yield
With sodium hydride In 1,4-dioxane for 3h; Heating;	100%

: 5390-04-5
pent-1-yn-5-ol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: C7H7ClF2O2

Conditions

Conditions	Yield
With sulfuric acid In toluene at 110℃; for 10h;	98.3%

: 821-41-0
5-Hexen-1-ol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 2-chloro-2,2-difluoroacetic acid allylhexyl ester

Conditions

Conditions	Yield
With dodecatungstosilic acid In 5,5-dimethyl-1,3-cyclohexadiene at 130℃; for 5h;	98.2%

: 928-90-5
5-hexyl-1-ol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: C8H9ClF2O2

Conditions

Conditions	Yield
With sulfuric acid In toluene at 110℃; for 10h;	98.1%

: 627-27-0
homoalylic alcohol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 881903-10-2
2-chloro-2,2-difluoroethylene butyl acetate

Conditions

Conditions	Yield
With dodecatungstosilic acid In toluene at 110℃; for 10h;	97.8%
With toluene-4-sulfonic acid In hexane for 3h; Heating / reflux;	85%

: 821-09-0
n-Pent-4-enyl alcohol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 2-chloro-2,2-difluoroacetate allyl pentyl ester

Conditions

Conditions	Yield
With phosphotungstic acid In toluene at 100℃; for 10h; Temperature; Solvent;	97.6%

: 107-19-7
propargyl alcohol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 118373-19-6
propargyl 2-chloro-2,2-difluoroacetate

Conditions

Conditions	Yield
With sulfuric acid; toluene-4-sulfonic acid In cyclohexane at 60℃; for 15h;	97.6%

: 90-15-3
α-naphthol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 2,2-difluoro-2-(naphthalen-1-yloxy)acetic acid

Conditions

Conditions	Yield
Stage #1: α-naphthol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux; Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;	97%

: 81028-03-7
(Z)-4-benzyloxy-but-2-en-1-ol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 807378-02-5
chlorodifluoroacetic acid (Z)-5-benzyloxy-pent-2-enyl ester

Conditions

Conditions	Yield
With sulfuric acid In toluene for 7h; Heating;	96%

: 150-76-5
4-methoxy-phenol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 2,2-difluoro-2-(4-methoxyphenoxy)acetic acid

Conditions

Conditions	Yield
Stage #1: 4-methoxy-phenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux; Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;	96%

: 92-69-3
4-Phenylphenol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 2-([1,1'-biphenyl]-4-yloxy)-2,2-difluoroacetic acid

Conditions

Conditions	Yield
Stage #1: 4-Phenylphenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux; Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;	96%

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 76-05-1
trifluoroacetic acid

Conditions

Conditions	Yield
With potassium fluoride In water at 140℃; for 1h;	95%

: 18269-90-4
(+/-)-1-trimethylsilyl-1-pentyn-3-ol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: C10H15ClF2O2Si

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere;	95%

: 1484-12-4
N-methylcarbazole

: 2834-23-3
chlorodifluoroacetic anhydride

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: C15H10Cl2FNO

Conditions

Conditions	Yield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation; Schlenk technique;	95%

...Expand

: 2834-23-3
chlorodifluoroacetic anhydride

: 66294-86-8
3,6,9-trimethyl-9H-carbazole

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: C17H14Cl2FNO

Conditions

Conditions	Yield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation; Schlenk technique;	94%

...Expand

: 106-54-7
p-Chlorothiophenol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 16503-81-4
2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid

Conditions

Conditions	Yield
Stage #1: p-Chlorothiophenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux; Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;	92%

: 927-74-2
1-butyn-4-ol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: C6H5ClF2O2

Conditions

Conditions	Yield
With phosphoric acid; sulfuric acid In toluene at 110℃; for 10h;	90.2%

: 917-64-6
methyl magnesium iodide

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 88257-33-4
1-chloro-1,1-difluoroacetone monohydrate

Conditions

Conditions	Yield
In diethyl ether at 10℃; for 0.5h;	90%
In diethyl ether

: 371-42-6
4-Fluorothiophenol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 911360-86-6
α,α-difluoro(4-fluorophenylthio)acetic acid

Conditions

Conditions	Yield
Stage #1: 4-Fluorothiophenol; 2-chloro-2,2-difluoroacetic acid With sodium hydride In 1,4-dioxane at 0 - 100℃; for 3h; Stage #2: With hydrogenchloride In 1,4-dioxane; ethanol; water at 0℃;	90%

: C21H24O4

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: C21H21ClF2O4

Conditions

Conditions	Yield
Stage #1: C21H24O4 With diisobutylaluminium hydride In dichloromethane at -78℃; Stage #2: 2-chloro-2,2-difluoroacetic acid In dichloromethane; chloroform Reflux;	90%

: 106-53-6
para-bromobenzenethiol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: α,α-difluoro(4-bromophenylthio)acetic acid

Conditions

Conditions	Yield
Stage #1: para-bromobenzenethiol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux; Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;	90%

: 2521-13-3
5-methoxy-N-methylindole

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 1620097-97-3
2-chloro-2,2-difluoro-1-(5-methoxy-1-methyl-1H-indol-3-yl)-ethan-1-one

Conditions

Conditions	Yield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation;	89%

: 576-26-1
2.6-dimethylphenol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 2-(2,6-dimethylphenoxy)-2,2-difluoroacetic acid

Conditions

Conditions	Yield
Stage #1: 2.6-dimethylphenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux; Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;	89%

: 108-98-5
thiophenol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 46207-56-1
2,2-difluoro-2-(phenylthio)acetic acid

Conditions

Conditions	Yield
Stage #1: thiophenol With sodium hydride In 1,4-dioxane Inert atmosphere; Schlenk technique; Reflux; Stage #2: 2-chloro-2,2-difluoroacetic acid at 0℃; Inert atmosphere; Schlenk technique; Reflux;	88%

: 3761-92-0
n-hexylmagnesium bromide

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 86340-68-3
Chlorodifluoromethyl n-hexyl ketone

Conditions

Conditions	Yield
In diethyl ether at -20℃; for 12h;	87%
In diethyl ether at -78 - 0℃;

: 100-58-3
phenylmagnesium bromide

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 384-67-8
2-chloro-2,2-difluoroacetophenone

Conditions

Conditions	Yield
With sodium hydroxide	87%

: 1001273-06-8
(S,E)-4,5-bis(benzyloxy)pent-2-en-1-ol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 1001273-08-0
(S,E)-4,5-bis(benzyloxy)pent-2-enyl 2-chloro-2,2-difluoroacetate

Conditions

Conditions	Yield
In chloroform for 10h; Heating;	87%

: 5621-15-8
1,6-dimethyl-1H-indole

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 2-chloro-1-(1,6-dimethyl-1H-indol-3-yl)-2,2-difluoroethan-1-one

Conditions

Conditions	Yield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation;	87%

: 617-86-7
triethylsilane

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: C14H31ClF2O2Si2

Conditions

Conditions	Yield
With tris(pentafluorophenyl)borate In dichloromethane at 23℃; for 1h;	87%

Chlorodifluoroacetic acid Chemical Properties

The Molecular formula of Chlorodifluoroacetic acid (76-04-0): C₂HClF₂O₂
The Molecular Weight of Chlorodifluoroacetic acid (76-04-0): 130.48 g/mol
Molecular Structure:
EINECS: 200-928-8
Flash Point: 25.9 °C
Refractive index: 1.3545-1.3565
Molar Refractivity: 18.02 cm³
Molar Volume: 78.5 cm³
Polarizability: 7.14 10^-24 cm³
Surface Tension: 31.5 dyne/cm
Density: 1.48 g/cm³
Melting point: 24-26 °C
Boiling point: 122 °C
Enthalpy of Vaporization: 39.44 kJ/mol
Vapour Pressure: 10.3 mmHg at 25 °C
Water Solubility: soluble
Sensitive: Lachrymatory
BRN: 956625
Appearance: clear colorless to pale brown liquid after melting
IUPAC Name: 2-chloro-2,2-difluoroacetate
Synonyms: Chlorodifluoroacetic acid ; 2-chloro-2,2-difluoroacetic acid ; Rarechem al bo 1535 ; chlorodifluoro-aceticaci ; Chlorodifluoroaceticacid 98%

Chlorodifluoroacetic acid Toxicity Data With Reference

Chlorodifluoroacetic acid (76-04-0) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated.

Chlorodifluoroacetic acid Safety Profile

The Hazard Codes of Chlorodifluoroacetic acid (76-04-0): C
HazardClass: 8
Hazard Note: Corrosive/Lachrymatory
The Risk Statements information of Chlorodifluoroacetic acid (76-04-0):
35: Causes severe burns
The Safety Statements information of Chlorodifluoroacetic acid (76-04-0):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
F: 19
TSCA: T
PackingGroup: II
HS Code: 29159080
RIDADR: UN 3261 8/PG 2
WGK Germany: 3

Chlorodifluoroacetic acid Specification

In addition, Chlorodifluoroacetic acid (76-04-0) could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, strong bases, and you must not take it with incompatible materials. It should avoid the condition that incompatible materials, moisture, heat And also prevent it to broken down into hazardous decomposition products: hydrogen chloride, carbon monoxide, carbon dioxide, hydrogen fluoride gas. Its hazardous polymerization has not been reported.

Product Name

Chlorodifluoroacetic acid

Synthetic route

Chlorodifluoroacetic acid Chemical Properties

Chlorodifluoroacetic acid Toxicity Data With Reference

Chlorodifluoroacetic acid Safety Profile

Chlorodifluoroacetic acid Specification

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