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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Cas:76041-71-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

The company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:White or o

3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE

Cas:76041-71-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFUCHEM-3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE

Cas:76041-71-9

Min.Order:1 Kilogram

FOB Price: $2000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 76041-71-9 with fast shipping

Cas:76041-71-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE

Cas:76041-71-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine 76041-71-9

Cas:76041-71-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2(1H)-Pyridinone,3-chloro-5-(trifluoromethyl)-

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Send Pharmaceutical Technology Co., Ltd.

PreView CBNumber: CB5391268 3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE

3-Chloro-5-trifluoromethyl-pyridin-2-ol

Cas:76041-71-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED intermediates (Flu

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridineCAS NO.: 76041-71-9

Cas:76041-71-9

Min.Order:1 Gram

FOB Price: $9.0 / 10.0

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE

Cas:76041-71-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech bar

3-Chloro-2-Hydroxy-5-(Trifluoromethyl)Pyridine china manufacture

Cas:76041-71-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

3-chloro-5-(trifluoromethyl)-2-hydroxypyridine

Cas:76041-71-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-chloro-5-(trifluoromethyl)pyridin-2-ol cas no. 76041-71-9 97%

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3-chloro-5-(trifluoromethyl)-2-pyridinol

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Other

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine CAS 76041-71-9

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

3-Chloro-2-hydroxy-5-(trifluoroMethyl)pyridine

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary a

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine cas 76041-71-9Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine cas 76041-71-9

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine 76041-71-9

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Application:Medical or chemical

76041-71-9

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.Appearance:White powder Storage:keep sealed and keep from direct light Package:According client's requirements Application:pharmaceutica

3-Chloro-2-Hydroxy-5-(Trifluoromethyl)Pyridine manufacturer

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shenzhen Foris Technology Co. LTD

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine 76041-71-9

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-CHLORO-2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE

Cas:76041-71-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

2-hydroxy-5-(trifluoromethyl)pyridine
33252-63-0

2-hydroxy-5-(trifluoromethyl)pyridine

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With N-chloro-succinimide In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide at 20℃; for 8h; Solvent;92%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With potassium hydroxide In tert-butyl alcohol for 1h; Heating;75.2%
2,3-dichloro-5-(trichloromethyl)pyridine
69045-83-6

2,3-dichloro-5-(trichloromethyl)pyridine

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80.4 percent / antimony trifluoride / 0.17 h / Heating; Irradiation
2: 75.2 percent / potassium hydroxide / 2-methyl-propan-2-ol / 1 h / Heating
View Scheme
6-hydroxy-3-pyridinecarboxylic acid
5006-66-6

6-hydroxy-3-pyridinecarboxylic acid

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen fluoride; sulfur tetrafluoride / 12 h / 100 °C / 1125.11 Torr / Autoclave
2: N-chloro-succinimide / N,N-dimethyl-formamide; 1-methyl-pyrrolidin-2-one / 8 h / 20 °C
View Scheme
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

ethyl 2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)acetate

ethyl 2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)acetate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile Reflux;94%
tris(3-(diethoxymethyl)phenyl)bismuthine

tris(3-(diethoxymethyl)phenyl)bismuthine

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

3-chloro-1-(3-(diethoxymethyl)phenyl)-5-(trifluoromethyl)-2(1H)-pyridinone
1613033-18-3

3-chloro-1-(3-(diethoxymethyl)phenyl)-5-(trifluoromethyl)-2(1H)-pyridinone

Conditions
ConditionsYield
With pyridine; copper diacetate In dichloromethane at 50℃; for 16h;89%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

3-chloro-5-(trifluoromethyl)-2-pyridinyl tosylate
1174281-15-2

3-chloro-5-(trifluoromethyl)-2-pyridinyl tosylate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 1h;84%
2-(chloromethyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole
50677-30-0

2-(chloromethyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;78%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-(chloromethyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole
350672-14-9

2-(chloromethyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;77%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

5-(2,4-dichloro-5-fluorophenyl)-2-(chloromethyl)-1,3,4-oxadiazole
497182-11-3

5-(2,4-dichloro-5-fluorophenyl)-2-(chloromethyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;75%
methyl (E)-3-methoxy-2-(2-chloromethylphenyl)acrylate
117428-51-0

methyl (E)-3-methoxy-2-(2-chloromethylphenyl)acrylate

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

methyl (E)-2-(2-(((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)phenyl)-3-methoxyacrylate

methyl (E)-2-(2-(((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)phenyl)-3-methoxyacrylate

Conditions
ConditionsYield
Stage #1: 3-chloro-5-(trifluoromethyl)-2-hydroxypyridine With potassium carbonate In N,N-dimethyl-formamide for 0.5h;
Stage #2: methyl (E)-3-methoxy-2-(2-chloromethylphenyl)acrylate In N,N-dimethyl-formamide at 80℃; for 3h;
74.8%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-chloromethyl-5-(4-ethyl-phenyl)-[1,3,4]oxadiazole
350672-18-3

2-chloromethyl-5-(4-ethyl-phenyl)-[1,3,4]oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-ethylphenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-ethylphenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;74%
{[2-(trifluoromethyl)benzoyl]amino}methyl acetate
895525-72-1

{[2-(trifluoromethyl)benzoyl]amino}methyl acetate

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

N-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-2-(trifluoromethyl)benzamide

N-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-2-(trifluoromethyl)benzamide

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 14h;74%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate
133409-72-0

methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate

methyl (E)-2-(2-(((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)phenyl)-2-(methoxyimino)acetate

methyl (E)-2-(2-(((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)phenyl)-2-(methoxyimino)acetate

Conditions
ConditionsYield
Stage #1: 3-chloro-5-(trifluoromethyl)-2-hydroxypyridine With potassium carbonate In butanone for 0.5h;
Stage #2: methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate In butanone at 80℃; for 5h;
73.5%
2-(chloromethyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole
24023-71-0

2-(chloromethyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;73%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole
33575-83-6

2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-phenyl-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-phenyl-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;71%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-chloromethyl-5-(2-fluoro-phenyl)-[1,3,4]oxadiazole
350672-17-2

2-chloromethyl-5-(2-fluoro-phenyl)-[1,3,4]oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(2-fluorophenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(2-fluorophenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;70%
2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole
24068-15-3

2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;69%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-bromo-3-chloro-5-(trifluoromethyl)pyridine
75806-84-7

2-bromo-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With phosphorus(V) oxybromide at 150℃; for 6h; Temperature;58%
8-chloro-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-one
1217539-63-3

8-chloro-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-one

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

8-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-one
1217539-65-5

8-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-one

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 180℃; for 0.5h; microwave irradiation;33%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

3-methyl-1-{[methyl(phenyl)amino]carbonyl}-1H-imidazol-3-ium iodide

3-methyl-1-{[methyl(phenyl)amino]carbonyl}-1H-imidazol-3-ium iodide

methyl-phenyl-carbamic acid 3-chloro-5-trifluoromethyl-pyridin-2-yl ester
548766-54-7

methyl-phenyl-carbamic acid 3-chloro-5-trifluoromethyl-pyridin-2-yl ester

Conditions
ConditionsYield
With triethylamine In acetonitrile15%
2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-(trifluoromethyl)oxirane
271587-47-4

2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-(trifluoromethyl)oxirane

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

3-chloro-1-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-5-trifluoromethyl-1H-pyridin-2-one
727375-79-3

3-chloro-1-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-5-trifluoromethyl-1H-pyridin-2-one

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 85℃;
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

cyanomethyl bromide
590-17-0

cyanomethyl bromide

N-cyanomethyl-3-chloro-5-(trifluoromethyl)-2-pyridinone

N-cyanomethyl-3-chloro-5-(trifluoromethyl)-2-pyridinone

Conditions
ConditionsYield
With potassium carbonate In water; dimethyl sulfoxide
1-[3-chloro-5-(3,3-dichloroallyloxy)-2-methoxyphenyl]ethanone O-(2-hydroxyethyl)-oxime
918311-09-8

1-[3-chloro-5-(3,3-dichloroallyloxy)-2-methoxyphenyl]ethanone O-(2-hydroxyethyl)-oxime

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

1-[3-chloro-5-(3,3-dichloroallyloxy)-2-methoxyphenyl]ethanone O-[2-(3-chloro-5-trifluoromethylpyridin-2-yloxy)ethyl]oxime
918311-11-2

1-[3-chloro-5-(3,3-dichloroallyloxy)-2-methoxyphenyl]ethanone O-[2-(3-chloro-5-trifluoromethylpyridin-2-yloxy)ethyl]oxime

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

(RS,SR)-8-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-ol

(RS,SR)-8-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 0.5 h / 180 °C / microwave irradiation
2.1: titanium tetrachloride / dichloromethane / 0.5 h / -30 °C
2.2: 14 h / -30 - 20 °C
View Scheme
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

(RR,SS)-8-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-ol

(RR,SS)-8-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 0.5 h / 180 °C / microwave irradiation
2: sodium tetrahydroborate; methanol / 14 h / 0 - 20 °C
View Scheme
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate
133409-72-0

methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate

(E)-2-(2-(((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)phenyl)-2-(methoxyimino)-N-methylacetamide

(E)-2-(2-(((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)phenyl)-2-(methoxyimino)-N-methylacetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / butanone / 0.5 h
1.2: 5 h / 80 °C
2.1: methanol / 3 h / 20 °C
View Scheme
methyl (1s,4s)-4-hydroxy-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-5'-carboxylate

methyl (1s,4s)-4-hydroxy-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-5'-carboxylate

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

(1r,4r)-4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-5'-carboxylic acid

(1r,4r)-4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-5'-carboxylic acid

Conditions
ConditionsYield
Stage #1: methyl (1s,4s)-4-hydroxy-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-5'-carboxylate; 3-chloro-5-(trifluoromethyl)-2-hydroxypyridine With di-isopropyl azodicarboxylate In toluene at 80℃; for 3h;
Stage #2: With water; sodium hydroxide In tetrahydrofuran; methanol at 50℃; for 3h;
12.1 mg
methyl (1r,4r)-4-hydroxy-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-pyrrolo[3,2-b]pyridine]-5'-carboxylate

methyl (1r,4r)-4-hydroxy-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-pyrrolo[3,2-b]pyridine]-5'-carboxylate

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

C20H17ClF3N3O4

C20H17ClF3N3O4

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 10 - 35℃; for 16h;
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

3-chloro-4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)aniline
76471-06-2

3-chloro-4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C
2: ammonium chloride; iron / ethanol; water / 6 h / Reflux
View Scheme

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