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Cas:168828-82-8
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryLinezolid Intermediate:(R)-N-[[3-(3-fluoro-4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methanol[CAS:168828-82-8] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. Wit
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:168828-82-8
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1486.html Product Name (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl -2-oxazolidione
Cas:168828-82-8
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inquiryOur advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity 鈮 9% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package can
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam
Cas:168828-82-8
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inquiryProduct name:(R)-(3-(3-flouro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl methanesulfonate Structural formula: CAS:168828-82-8 Molecular formula: C14H17FN2O4 Molecular weight: 296.29 Appearance:white crystalline powder Storage:Store in c
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:168828-82-8
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inquiryBeluga chemical professional supply High quality (R)-3-(3-Fluoro-4-morpholinophenyl)-5-(hydroxymethyl)oxazolidin-2-one 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support an
Cas:168828-82-8
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:168828-82-8
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inquiryAppearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Courie
Cas:168828-82-8
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inquiryproduct name :(R)-N-[[3-(3-Fluoro-4-Morpholinyl)Phenyl]-2-Oxo-5-Oxazolidinyl]Methanol CAS:168828-82-8 Appearance:Off-white powder Storage:keep from moisture,sealed in container container,room temperature. Package:25kgs/drum Application:linezolid
Cas:168828-82-8
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiry99%Suzhou Jingye Medicine & Chemical Co., Ltd (Former: Suzhou Daxin Chemical Agent Factory) is a Hi-tech private enterprise, which is a professional manufacturer of hydrogenous products. It is located in Suzhou New District Chemical Area, about
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:168828-82-8
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:168828-82-8
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediates Tr
Cas:168828-82-8
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inquiryProduct name: (R)-(3-(3-Fluoro-4-Morpholinophenyl)-2-Oxo-5-Oxazolidinyl)Methyl Methanesulfonate CAS No.: 168828-82-8 Molecule Formula:C14H17FN2O4 Molecule Weight:296.29 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Man
Cas:168828-82-8
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:168828-82-8
Min.Order:1 Gram
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inquiryProduct Name: (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione Synonyms: (R)-3-(3-FLUORO-4-MORPHOLINOPHENYL)-5-(HYDROXYMETHYL…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton
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inquiryWe are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
Cas:168828-82-8
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inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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inquiry((S)-2,3-Dihydroxy-propyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-carbamic acid benzyl ester
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 0℃; | 96% |
(R)-glycidyl butyrate
benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Stage #1: benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; Stage #3: With ammonium chloride In tetrahydrofuran; hexane; water | 85.1% |
Stage #1: benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate With n-butyllithium; butan-1-ol In tetrahydrofuran; hexane at -15 - 30℃; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -10 - 15℃; Stage #3: With water In tetrahydrofuran; hexane; ethyl acetate | 85% |
Stage #1: benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1.63333h; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; for 22.1h; | 83% |
carbon dioxide
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
With dmap; C20H14AlNO3 In dichloromethane at 25℃; under 760.051 Torr; for 60h; Sealed tube; stereoselective reaction; | 85% |
N-ethoxycarbonyl-3-fluoro-4-morpholinyl aniline
(R)-glycidyl butyrate
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Stage #1: N-ethoxycarbonyl-3-fluoro-4-morpholinyl aniline With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 3.5h; Inert atmosphere; Stage #2: (R)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃; Stage #3: With ammonium chloride In tetrahydrofuran; hexane; water at 20℃; for 0.5h; Product distribution / selectivity; | 80% |
N-[4(R)-(2,2-dimethyl-1,3-dioxolane-4-yl)methyl]-3-fluoro-4-morpholinylaniline
bis(trichloromethyl) carbonate
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Stage #1: N-[4(R)-(2,2-dimethyl-1,3-dioxolane-4-yl)methyl]-3-fluoro-4-morpholinylaniline With hydrogenchloride; water In methanol at 20℃; for 8h; Stage #2: bis(trichloromethyl) carbonate With sodium carbonate at 20℃; for 24h; Further stages.; | 56% |
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol at 0℃; Yield given; |
(R)-glycidyl butyrate
3-fluoro-4-(morpholinyl)aniline
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multistep reaction; |
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: aq. NaHCO3 / acetone 2.1: 95 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - -60 °C 3.1: nitrosobenzene; D-proline / acetonitrile / 24 h / -20 °C 3.2: NaBH4 / methanol 3.3: 86 percent / CuSO4 / methanol 4.1: 96 percent / sodium hydride / tetrahydrofuran / 0 °C View Scheme |
(3-fluoro-4-morpholin-4-yl-phenyl)-(3-oxo-propyl)-carbamic acid benzyl ester
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: nitrosobenzene; D-proline / acetonitrile / 24 h / -20 °C 1.2: NaBH4 / methanol 1.3: 86 percent / CuSO4 / methanol 2.1: 96 percent / sodium hydride / tetrahydrofuran / 0 °C View Scheme |
(3-fluoro-4-morpholin-4-yl-phenyl)-(3-hydroxy-propyl)-carbamic acid benzyl ester
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 95 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - -60 °C 2.1: nitrosobenzene; D-proline / acetonitrile / 24 h / -20 °C 2.2: NaBH4 / methanol 2.3: 86 percent / CuSO4 / methanol 3.1: 96 percent / sodium hydride / tetrahydrofuran / 0 °C View Scheme |
3-fluoro-4-(morpholinyl)aniline
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: NaI; Na2CO3 / dimethylformamide / 65 °C 2.1: aq. NaHCO3 / acetone 3.1: 95 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - -60 °C 4.1: nitrosobenzene; D-proline / acetonitrile / 24 h / -20 °C 4.2: NaBH4 / methanol 4.3: 86 percent / CuSO4 / methanol 5.1: 96 percent / sodium hydride / tetrahydrofuran / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: NaHCO3 2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 2.2: hexane; tetrahydrofuran / -78 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 70 percent / sodium bicarbonate / acetone; H2O 2: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 35 min, 2.) THF, hexane, -78 deg C, 1 h View Scheme |
3,4-difluoronitrobenzene
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N,N-diisopropylethylamine 2.1: ammonium formate / 10 percent Pd/C / methanol; tetrahydrofuran 3.1: NaHCO3 4.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 4.2: hexane; tetrahydrofuran / -78 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: N,N-diisopropylethylamine / acetonitrile / 17 h / Heating 2: H2 / PtO2 / methanol / 3 h / 20 °C / 1471.02 Torr View Scheme | |
Multi-step reaction with 4 steps 1: 98 percent / N,N-diisopropylethylamine / ethyl acetate 2: ammonium formate / 10percent Pd/C 3: 70 percent / sodium bicarbonate / acetone; H2O 4: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 35 min, 2.) THF, hexane, -78 deg C, 1 h View Scheme |
3-fluoro-4-(4-morpholinyl)nitrobenzene
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ammonium formate / 10 percent Pd/C / methanol; tetrahydrofuran 2.1: NaHCO3 3.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 3.2: hexane; tetrahydrofuran / -78 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: H2 / PtO2 / methanol / 3 h / 20 °C / 1471.02 Torr View Scheme | |
Multi-step reaction with 3 steps 1: ammonium formate / 10percent Pd/C 2: 70 percent / sodium bicarbonate / acetone; H2O 3: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 35 min, 2.) THF, hexane, -78 deg C, 1 h View Scheme |
(R)-2-(3-Fluoro-4-morpholin-4-yl-phenylamino)-1-{(4R,5R)-5-[(R)-2-(3-fluoro-4-morpholin-4-yl-phenylamino)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethanol
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: CH2Cl2 / Ambient temperature 2: 2N HCl / Ambient temperature 3: lead tetraacetate (LTA) / tetrahydrofuran / 0 °C 4: NaBH4 / methanol / 0 °C View Scheme |
C28H32F2N4O8
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lead tetraacetate (LTA) / tetrahydrofuran / 0 °C 2: NaBH4 / methanol / 0 °C View Scheme |
C31H36F2N4O8
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 2N HCl / Ambient temperature 2: lead tetraacetate (LTA) / tetrahydrofuran / 0 °C 3: NaBH4 / methanol / 0 °C View Scheme |
N-[3-chloro-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholin-4-yl)aniline
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1,1'-carbonyldiimidazole / dichloromethane / 24 h / 20 - 30 °C 2: N,N-dimethyl-formamide / 120 °C 3: water; sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 - 15 °C View Scheme | |
Multi-step reaction with 3 steps 1: dichloromethane / 24 h / 25 - 30 °C 2: N,N-dimethyl-formamide / 120 °C 3: sodium t-butanolate; water / tetrahydrofuran / 0.5 h / 0 - 15 °C View Scheme |
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 120 °C 2: water; sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 - 15 °C View Scheme | |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 120 °C 2: sodium t-butanolate; water / tetrahydrofuran / 0.5 h / 0 - 15 °C View Scheme |
(R)-(3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl acetate
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
With water; sodium t-butanolate In tetrahydrofuran at 0 - 15℃; for 0.5h; | |
With water; sodium t-butanolate In tetrahydrofuran at 0 - 15℃; for 0.5h; | 50 g |
(S)-3-chloropropan-1,2-diol
benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
With potassium tert-butylate; lithium diisopropyl amide |
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / dichloromethane; water / 24 h 2: dmap; C20H14AlNO3 / dichloromethane / 60 h / 25 °C / 760.05 Torr / Sealed tube View Scheme |
methanesulfonyl chloride
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
(R)-methyl methanesulfonate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; for 0.5h; | 100% |
With triethylamine In tetrahydrofuran at 8 - 15℃; for 3.75h; Cooling with ice; Inert atmosphere; | 96% |
With triethylamine In dichloromethane at 20 - 30℃; | 95% |
p-toluenesulfonyl chloride
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
(R)-[N-3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl 4-methylbenzenesulfonate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 92% |
With triethylamine In dichloromethane at 0 - 20℃; for 18.8333h; | 92% |
With triethylamine In dichloromethane at 0 - 20℃; for 18h; | 85% |
4-iodobenzenesulfonyl chloride
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 18h; | 82.5% |
4-bromobenzenesulfonyl chloride
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 26h; | 81.5% |
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
thioacetic acid
linezolid
Conditions | Yield |
---|---|
Stage #1: (R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol With methanesulfonyl chloride Stage #2: With sodium azide Stage #3: tiolacetic acid stereoselective reaction; | 81% |
4-Fluorobenzenesulfonyl chloride
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 18h; | 80.3% |
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: (R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol With methanesulfonyl chloride; triethylamine In dichloromethane at 0 - 20℃; Stage #2: With sodium azide In N,N-dimethyl-formamide at 80℃; Further stages.; | 79% |
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 4 h / 0 °C 2: NaN3 / dimethylformamide / 75 °C View Scheme | |
Multi-step reaction with 2 steps 1: Et3N / tetrahydrofuran / 2 h / 20 °C 2: sodium azide / dimethylformamide / 6 h / 65 °C View Scheme |
acetic anhydride
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
(R)-(3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl acetate
Conditions | Yield |
---|---|
With pyridine; dmap In dichloromethane at 20℃; for 4h; | 75% |
isoxazol-3-ol
diisopropyl (E)-azodicarboxylate
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
5(R)-Isoxazol-3-yloxymethyl-3-(4-morpholino-3-fluoro-phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With triphenylphosphine In tetrahydrofuran | 69% |
4-Nitrobenzenesulfonyl chloride
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
4-Nitro-benzenesulfonic acid (R)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester
Conditions | Yield |
---|---|
With triethylamine |
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Et3N / CH2Cl2 / 4 h / 0 °C 2: NaN3 / dimethylformamide / 75 °C 3: hydrogen / Pd/C / ethyl acetate / 12 h / 760 Torr View Scheme | |
Multi-step reaction with 2 steps 1: Et3N 2: NH3 / methanol View Scheme | |
Multi-step reaction with 3 steps 1: Et3N / tetrahydrofuran / 2 h / 20 °C 2: sodium azide / dimethylformamide / 6 h / 65 °C 3: triphenylphosphine; H2O / tetrahydrofuran / 11 h / 40 °C View Scheme |
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
linezolid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Et3N / CH2Cl2 / 4 h / 0 °C 2: NaN3 / dimethylformamide / 75 °C 3: hydrogen / Pd/C / ethyl acetate / 12 h / 760 Torr 4: pyridine View Scheme | |
Multi-step reaction with 3 steps 1: Et3N 2: NH3 / methanol 3: 2 h / 40 °C View Scheme | |
Multi-step reaction with 3 steps 1: Et3N 2: NaN3 / dimethylsulfoxide / 80 °C 3: 86 percent / Ambient temperature View Scheme |
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
(R)-[{N-3-(3-fluoro-4-morpholinophenyl)-2-oxo-oxazolidin-5-yl}methyl]isothiocyanate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: Et3N / tetrahydrofuran / 2 h / 20 °C 2.1: sodium azide / dimethylformamide / 6 h / 65 °C 3.1: triphenylphosphine; H2O / tetrahydrofuran / 11 h / 40 °C 4.1: Et3N / tetrahydrofuran / 4 h / 0 °C 4.2: ethyl chloroformate / tetrahydrofuran / 1 h / 0 °C View Scheme |
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
(S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]methyldithiocarbamate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Et3N / tetrahydrofuran / 2 h / 20 °C 2: sodium azide / dimethylformamide / 6 h / 65 °C 3: triphenylphosphine; H2O / tetrahydrofuran / 11 h / 40 °C 4: Et3N / tetrahydrofuran / 7 h / 0 °C 5: Et3N / tetrahydrofuran / 0.5 h / 20 °C View Scheme |
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: Et3N / tetrahydrofuran / 2 h / 20 °C 2.1: sodium azide / dimethylformamide / 6 h / 65 °C 3.1: triphenylphosphine; H2O / tetrahydrofuran / 11 h / 40 °C 4.1: Et3N / tetrahydrofuran / 4 h / 0 °C 4.2: ethyl chloroformate / tetrahydrofuran / 1 h / 0 °C 5.1: 40 percent / NH3 / methanol / 3 h / 0 °C View Scheme |
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Et3N / tetrahydrofuran / 2 h / 20 °C 2: sodium azide / dimethylformamide / 6 h / 65 °C 3: triphenylphosphine; H2O / tetrahydrofuran / 11 h / 40 °C 4: Et3N / tetrahydrofuran / 7 h / 0 °C View Scheme |
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