The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryAppearance: Powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Courier Dan
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryWuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma
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inquiryJinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
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inquiry1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiry(R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinoneAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by ex
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inquirybulk?production Application:Pharmaceutical intermediates
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryBest Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP
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inquiry1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
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inquiryChangzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa
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inquiryWhat's our company advantages 1.Government support guarantees good company credibility and finance safe. 2.Place of Origin China with Super quality by reasonable price. 3.Fast delivery by safe express way to all the country. 4.We
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inquiry1. Subsidiary of Institute of Chemistry, Henan Academy of Sciences, national research platform;2. About 30 years’ experience in this field since 1983;3. An experienced R&D team consisting of Doctors and Masters;4. Various types of analytical instrume
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inquiry(R)-methyl methanesulfonate
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With sodium azide In N,N-dimethyl-formamide at 85℃; | 97.23% |
With sodium azide In N,N-dimethyl-formamide at 60℃; Reflux; | 95% |
With sodium azide In tetrahydrofuran; water for 8h; Reflux; | 93% |
(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With fluorosulfonyl azide; potassium hydrogencarbonate In tert-butyl methyl ether; water; N,N-dimethyl-formamide at 20℃; for 0.0833333h; | 92% |
(R)-[N-3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl 4-methylbenzenesulfonate
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With sodium azide In N,N-dimethyl-formamide at 80 - 85℃; for 4h; | 90% |
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With sodium azide In N,N-dimethyl-formamide at 85℃; for 12h; | 87% |
With sodium azide In N,N-dimethyl-formamide at 85℃; for 12h; | 86% |
(R)-5-azidomethyl-1,3-oxazolidin-2-one
4-(2-fluoro-4-bromophenyl)morpholine
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With copper(l) iodide; potassium carbonate; rac-diaminocyclohexane In 1,4-dioxane at 110℃; for 23h; | 84% |
(S)-3-azido-1-chloropropan-2-yl 3-fluoro-4-morpholinophenylcarbamate
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 20℃; for 8h; | 83% |
(R)-5-azidomethyl-1,3-oxazolidin-2-one
4-(2-fluoro-4-iodophenyl)morpholine
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With trans-1,2-Diaminocyclohexane; potassium carbonate; copper(l) chloride In 1,4-dioxane at 110℃; for 15h; Inert atmosphere; Darkness; | 82% |
With potassium carbonate; trans-1,2-Diaminocyclohexane; copper(l) chloride In 1,4-dioxane at 110℃; for 15h; Inert atmosphere; Darkness; Sealed vessel; | 82% |
(S)-3-azido-1-chloropropan-2-yl chloroformate
3-fluoro-4-(morpholinyl)aniline
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 20℃; | 82% |
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Stage #1: (R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol With methanesulfonyl chloride; triethylamine In dichloromethane at 0 - 20℃; Stage #2: With sodium azide In N,N-dimethyl-formamide at 80℃; Further stages.; | 79% |
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 4 h / 0 °C 2: NaN3 / dimethylformamide / 75 °C View Scheme | |
Multi-step reaction with 2 steps 1: Et3N / tetrahydrofuran / 2 h / 20 °C 2: sodium azide / dimethylformamide / 6 h / 65 °C View Scheme |
(R)-N-(3-fluoro-4-morpholinylphenyl)oxiranylmethyl carbamic acid ethyl ester
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With sodium azide; ammonium chloride In methanol; water at 80 - 85℃; for 4h; | 76% |
3-chloro-2-((phenoxycarbonyl)oxy)propyl azide
3-fluoro-4-(morpholinyl)aniline
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In N,N-dimethyl-formamide at 80℃; for 12h; |
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: aq. NaHCO3 / acetone 2.1: 95 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - -60 °C 3.1: nitrosobenzene; D-proline / acetonitrile / 24 h / -20 °C 3.2: NaBH4 / methanol 3.3: 86 percent / CuSO4 / methanol 4.1: 96 percent / sodium hydride / tetrahydrofuran / 0 °C 5.1: Et3N / CH2Cl2 / 4 h / 0 °C 6.1: NaN3 / dimethylformamide / 75 °C View Scheme |
(3-fluoro-4-morpholin-4-yl-phenyl)-(3-oxo-propyl)-carbamic acid benzyl ester
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: nitrosobenzene; D-proline / acetonitrile / 24 h / -20 °C 1.2: NaBH4 / methanol 1.3: 86 percent / CuSO4 / methanol 2.1: 96 percent / sodium hydride / tetrahydrofuran / 0 °C 3.1: Et3N / CH2Cl2 / 4 h / 0 °C 4.1: NaN3 / dimethylformamide / 75 °C View Scheme |
(3-fluoro-4-morpholin-4-yl-phenyl)-(3-hydroxy-propyl)-carbamic acid benzyl ester
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 95 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - -60 °C 2.1: nitrosobenzene; D-proline / acetonitrile / 24 h / -20 °C 2.2: NaBH4 / methanol 2.3: 86 percent / CuSO4 / methanol 3.1: 96 percent / sodium hydride / tetrahydrofuran / 0 °C 4.1: Et3N / CH2Cl2 / 4 h / 0 °C 5.1: NaN3 / dimethylformamide / 75 °C View Scheme |
((S)-2,3-Dihydroxy-propyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-carbamic acid benzyl ester
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 96 percent / sodium hydride / tetrahydrofuran / 0 °C 2: Et3N / CH2Cl2 / 4 h / 0 °C 3: NaN3 / dimethylformamide / 75 °C View Scheme |
3-fluoro-4-(morpholinyl)aniline
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: NaI; Na2CO3 / dimethylformamide / 65 °C 2.1: aq. NaHCO3 / acetone 3.1: 95 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - -60 °C 4.1: nitrosobenzene; D-proline / acetonitrile / 24 h / -20 °C 4.2: NaBH4 / methanol 4.3: 86 percent / CuSO4 / methanol 5.1: 96 percent / sodium hydride / tetrahydrofuran / 0 °C 6.1: Et3N / CH2Cl2 / 4 h / 0 °C 7.1: NaN3 / dimethylformamide / 75 °C View Scheme | |
Multi-step reaction with 3 steps 1: Et3N / tetrahydrofuran / 2 h / 20 °C 2: sodium azide / dimethylformamide / 6 h / 65 °C View Scheme | |
Multi-step reaction with 4 steps 1: 70 percent / sodium bicarbonate / acetone; H2O 2: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 35 min, 2.) THF, hexane, -78 deg C, 1 h 3: 35.423 g / triethylamine / CH2Cl2 / 20 h 4: sodium azide / dimethylformamide / 16 h / 75 °C View Scheme |
3,4-difluoronitrobenzene
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: N,N-diisopropylethylamine / acetonitrile / 17 h / Heating 2: H2 / PtO2 / methanol / 3 h / 20 °C / 1471.02 Torr 3: Et3N / tetrahydrofuran / 2 h / 20 °C 4: sodium azide / dimethylformamide / 6 h / 65 °C View Scheme | |
Multi-step reaction with 6 steps 1: 98 percent / N,N-diisopropylethylamine / ethyl acetate 2: ammonium formate / 10percent Pd/C 3: 70 percent / sodium bicarbonate / acetone; H2O 4: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 35 min, 2.) THF, hexane, -78 deg C, 1 h 5: 35.423 g / triethylamine / CH2Cl2 / 20 h 6: sodium azide / dimethylformamide / 16 h / 75 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: methanol / 25 - 30 °C 2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 - 30 °C / Autoclave 3.1: sodium carbonate / toluene; acetone / 0 - 5 °C 4.1: butan-1-ol; n-butyllithium / hexane; tetrahydrofuran / -15 - 30 °C / Inert atmosphere 4.2: -10 - 15 °C 5.1: triethylamine / dichloromethane / 20 - 30 °C 6.1: sodium azide / N,N-dimethyl-formamide / 60 °C / Reflux View Scheme |
3-fluoro-4-(4-morpholinyl)nitrobenzene
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: H2 / PtO2 / methanol / 3 h / 20 °C / 1471.02 Torr 2: Et3N / tetrahydrofuran / 2 h / 20 °C 3: sodium azide / dimethylformamide / 6 h / 65 °C View Scheme | |
Multi-step reaction with 5 steps 1: ammonium formate / 10percent Pd/C 2: 70 percent / sodium bicarbonate / acetone; H2O 3: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 35 min, 2.) THF, hexane, -78 deg C, 1 h 4: 35.423 g / triethylamine / CH2Cl2 / 20 h 5: sodium azide / dimethylformamide / 16 h / 75 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: hydrogen / palladium 10% on activated carbon / methanol / 20 - 30 °C / Autoclave 2.1: sodium carbonate / toluene; acetone / 0 - 5 °C 3.1: butan-1-ol; n-butyllithium / hexane; tetrahydrofuran / -15 - 30 °C / Inert atmosphere 3.2: -10 - 15 °C 4.1: triethylamine / dichloromethane / 20 - 30 °C 5.1: sodium azide / N,N-dimethyl-formamide / 60 °C / Reflux View Scheme |
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NaBH4 / methanol / 0 °C 2: Et3N 3: NaN3 / dimethylsulfoxide / 80 °C View Scheme |
(R)-2-(3-Fluoro-4-morpholin-4-yl-phenylamino)-1-{(4R,5R)-5-[(R)-2-(3-fluoro-4-morpholin-4-yl-phenylamino)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethanol
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: CH2Cl2 / Ambient temperature 2: 2N HCl / Ambient temperature 3: lead tetraacetate (LTA) / tetrahydrofuran / 0 °C 4: NaBH4 / methanol / 0 °C 5: Et3N 6: NaN3 / dimethylsulfoxide / 80 °C View Scheme |
C28H32F2N4O8
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: lead tetraacetate (LTA) / tetrahydrofuran / 0 °C 2: NaBH4 / methanol / 0 °C 3: Et3N 4: NaN3 / dimethylsulfoxide / 80 °C View Scheme |
C31H36F2N4O8
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 2N HCl / Ambient temperature 2: lead tetraacetate (LTA) / tetrahydrofuran / 0 °C 3: NaBH4 / methanol / 0 °C 4: Et3N 5: NaN3 / dimethylsulfoxide / 80 °C View Scheme |
benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 35 min, 2.) THF, hexane, -78 deg C, 1 h 2: 35.423 g / triethylamine / CH2Cl2 / 20 h 3: sodium azide / dimethylformamide / 16 h / 75 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: butan-1-ol; n-butyllithium / hexane; tetrahydrofuran / -15 - 30 °C / Inert atmosphere 1.2: -10 - 15 °C 2.1: triethylamine / dichloromethane / 20 - 30 °C 3.1: sodium azide / N,N-dimethyl-formamide / 60 °C / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere 1.2: -78 - 20 °C 1.3: 0.17 h / 20 °C 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran / -78 °C 1.2: -78 - 20 °C 2.1: triethylamine / dichloromethane 3.1: sodium azide / N,N-dimethyl-formamide / 70 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran / -30 - -20 °C 1.2: -30 - 50 °C 2.1: triethylamine / dichloromethane / 0 - 5 °C 3.1: sodium azide / N,N-dimethyl-formamide / 2 h / 25 - 85 °C View Scheme |
C8H10FNO3S
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: bis(1,5-cyclooctadiene)nickel(0); sodium t-butanolate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere 2.1: N-iodo-succinimide; trifluoroacetic acid / 14 h / 23 °C / Inert atmosphere 2.2: 23 °C 3.1: trans-1,2-Diaminocyclohexane; potassium carbonate; copper(l) chloride / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere; Darkness View Scheme | |
Multi-step reaction with 3 steps 1: sodium t-butanolate / bis(1,5-cyclooctadiene)nickel (0); 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere; Sealed vessel 2: trifluoroacetic acid; N-iodo-succinimide / 14 h / 23 °C / Inert atmosphere; Sealed vessel 3: potassium carbonate / trans-1,2-Diaminocyclohexane; copper(l) chloride / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere; Darkness; Sealed vessel View Scheme |
phenyl N,N-dimethylsulfamate
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: Inert atmosphere 2.1: bis(1,5-cyclooctadiene)nickel(0); sodium t-butanolate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere 3.1: N-iodo-succinimide; trifluoroacetic acid / 14 h / 23 °C / Inert atmosphere 3.2: 23 °C 4.1: trans-1,2-Diaminocyclohexane; potassium carbonate; copper(l) chloride / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere; Darkness View Scheme |
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: N-iodo-succinimide; trifluoroacetic acid / 14 h / 23 °C / Inert atmosphere 1.2: 23 °C 2.1: trans-1,2-Diaminocyclohexane; potassium carbonate; copper(l) chloride / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere; Darkness View Scheme | |
Multi-step reaction with 2 steps 1: trifluoroacetic acid; N-iodo-succinimide / 14 h / 23 °C / Inert atmosphere; Sealed vessel 2: potassium carbonate / trans-1,2-Diaminocyclohexane; copper(l) chloride / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere; Darkness; Sealed vessel View Scheme |
phenol
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: Inert atmosphere 2.1: Inert atmosphere 3.1: bis(1,5-cyclooctadiene)nickel(0); sodium t-butanolate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere 4.1: N-iodo-succinimide; trifluoroacetic acid / 14 h / 23 °C / Inert atmosphere 4.2: 23 °C 5.1: trans-1,2-Diaminocyclohexane; potassium carbonate; copper(l) chloride / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere; Darkness View Scheme |
N-ethoxycarbonyl-3-fluoro-4-morpholinyl aniline
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium / hexane; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere 1.2: -78 - 20 °C 1.3: 0.5 h / 20 °C 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C View Scheme |
2-fluorophenol
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 15 h / 23 °C / Inert atmosphere 2: sodium t-butanolate / bis(1,5-cyclooctadiene)nickel (0); 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere 3: trifluoroacetic acid; N-iodo-succinimide / 14 h / 23 °C / Inert atmosphere; Sealed vessel 4: potassium carbonate / trans-1,2-Diaminocyclohexane; copper(l) chloride / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere; Darkness; Sealed vessel View Scheme |
2-fluorophenyl diethylcarbamate
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium t-butanolate / bis(1,5-cyclooctadiene)nickel (0); 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere 2: trifluoroacetic acid; N-iodo-succinimide / 14 h / 23 °C / Inert atmosphere; Sealed vessel 3: potassium carbonate / trans-1,2-Diaminocyclohexane; copper(l) chloride / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere; Darkness; Sealed vessel View Scheme |
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine
Conditions | Yield |
---|---|
With water; triphenylphosphine In tetrahydrofuran at 70℃; | 100% |
With hydrogen In methanol at 40 - 60℃; under 3750.38 Torr; for 3h; Temperature; Pressure; Reagent/catalyst; Autoclave; | 98% |
With palladium on activated charcoal; hydrogen; acetic acid In methanol for 2h; | 81% |
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
thioacetic acid
linezolid
Conditions | Yield |
---|---|
Stage #1: (R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one; tiolacetic acid at 23℃; for 7h; Stage #2: With potassium hydroxide In water at 23℃; | 90% |
at 23℃; for 7h; Inert atmosphere; | 90% |
Ambient temperature; | 86% |
at 20℃; for 15h; | 85% |
at 20℃; for 15h; |
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With copper(l) iodide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 4h; | 86% |
acetic anhydride
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
linezolid
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol at 20℃; under 1034.32 Torr; for 3h; | 85% |
With hydrogen; palladium 10% on activated carbon In dichloromethane under 1103.36 Torr; for 6h; | 80% |
Stage #1: acetic anhydride; (R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one With hydrogen; acetic acid; palladium 10% on activated carbon In ethyl acetate at 25 - 35℃; under 1551.49 Torr; for 3h; Stage #2: With sodium carbonate In water; ethyl acetate for 0.166667h; Product distribution / selectivity; | 78% |
ethylenesulfonyl fluoride
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
In ethyl acetate at 100℃; for 16h; Sealed tube; | 85% |
C40H69NO13
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; copper(l) iodide In tetrahydrofuran at 20℃; for 2h; | 80% |
N-(3,6,9,12-tetraoxapentadec-14-ynyl)-2,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-isoindol
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
(R)-1-(1-(1-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)-2,5,8,11-tetraoxatridecan-13-yl)-2,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methanoisoindole
Conditions | Yield |
---|---|
With copper(l) iodide; triethylamine In acetonitrile at 20℃; for 2h; Inert atmosphere; | 75% |
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
acetylene
Conditions | Yield |
---|---|
In 1,2-dimethoxyethane at 90℃; for 12h; | 74% |
dimethyl acetylenedicarboxylate
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
1-[3-(3-fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-1H-[1,2,3]triazole-4,5-dicarboxylic acid dimethyl ester
Conditions | Yield |
---|---|
In 1,2-dimethoxyethane at 90℃; for 24h; | 73% |
3-butyn-1-yl p-toluenesulfonate
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
C25H28FN5O6S
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; copper(l) iodide In tetrahydrofuran at 20℃; for 2h; | 63% |
methyl ethynyl ketone
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
B
(R)-5-(4-Acetyl-[1,2,3]triazol-1-ylmethyl)-3-(3-fluoro-4-morpholin-4-yl-phenyl)-oxazolidin-2-one
Conditions | Yield |
---|---|
In 1,2-dimethoxyethane at 90℃; for 24h; | A 5% B 62% |
C33H57NO10
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; copper(l) iodide In tetrahydrofuran at 20℃; for 15h; | 56% |
3,6,9,12-tetraoxapentadec-14-yn-1-ol
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
(R)-3-(3-fluoro-4-morpholinophenyl)-5-((4-(13-hydroxy-2,5,8,11-tetraoxatridecyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With copper(l) iodide; triethylamine In acetonitrile at 20℃; for 2h; Inert atmosphere; | 54% |
2-(N-methyl-N-prop-2-yn-1-ylamino)ethanol
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; copper(l) iodide In tetrahydrofuran at 20℃; for 16h; | 50.6% |
C43H78N2O12
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; copper(l) iodide In tetrahydrofuran at 20℃; for 4h; | 50% |
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; copper(l) iodide In tetrahydrofuran at 20℃; for 4h; | 50% |
C42H76N2O13
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; copper(l) iodide In tetrahydrofuran at 20℃; for 4h; | 50% |
pent-1-yn-5-ol
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; copper(l) iodide In tetrahydrofuran at 20℃; for 16h; | 48.7% |
1,11-bis(2-propyn-1-oxy)-3,6,9-trioxaundecane
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
C42H54F2N10O11
Conditions | Yield |
---|---|
With copper(l) iodide; triethylamine In acetonitrile at 20℃; for 2h; Inert atmosphere; | 47% |
4-amino-1-(3,6,9,12-tetraoxapentadec-14-ynyl)pyrimidin-2(1H)-one
(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one
(R)-5-((4-(13-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,5,8,11-tetraoxatridecyl)-1H-1,2,3-triazol-1-yl)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one
Conditions | Yield |
---|---|
With copper(l) iodide; triethylamine In acetonitrile at 20℃; for 2h; Inert atmosphere; | 46% |
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