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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Deacetamide linezolid phthalimide

Cas:168828-89-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

DeacetaMide Linezolid PhthaliMide CAS 168828-89-5

Cas:168828-89-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

2-[[(5S)-3-(3-Fluoro-4-morpholino-phenyl)-2-oxo-oxazolidin-5-yl]methyl]isoindoline-1,3-dione

Cas:168828-89-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Triumph International Development Limilted

Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio

168828-89-5

Cas:168828-89-5

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1H-Isoindole-1,3(2H)-dione,2-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-

Cas:168828-89-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(R)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide

Cas:168828-89-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package: 1g/bag, 5g/bag, 10g/bag, 100g/bag, 1kg/bag or as per your request Application:It

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

DeacetaMide Linezolid PhthaliMide

Cas:168828-89-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

Antimex Chemical Limied

factory?direct?sale Application:healing drugs

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Deacetamide Linezolid Phthalimide CAS No.168828-89-5

Cas:168828-89-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

(S)-2-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)isoindoline-1,3-dione

Cas:168828-89-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

2-[[(5S)-3-(3-Fluoro-4-morpholino-phenyl)-2-oxo-oxazolidin-5-yl]methyl]isoindoline-1,3-dione cas 168828-89-5Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

DeacetaMide Linezolid PhthaliMide

Cas:168828-89-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

DeacetaMide Linezolid PhthaliMide

Cas:168828-89-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

(S)-N-3-3-Fluoro-4-4-morpholinylphenyl-2-oxo-5-oxazolidinylmethylphthalimide

Cas:168828-89-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

DeacetaMide Linezolid PhthaliMide

Cas:168828-89-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

(R)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide

Cas:168828-89-5

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jusheng Technology Co., Ltd.,

1,Best Quality: Our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other countries, and we have got very good feedback from our customers.so you can trust us. 2, Payment method: for e

Shanghai AngewChem Co., Ltd.

Shanghai AngewChemCo., Ltd. is an innovative enterprise on fine chemicals and pharmaceuticals. Based on Shanghai R&D center and Hunan chemical manufacturing plant, we offer chemical research, process development, and large-scale production. Com

(S)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide

Cas:168828-89-5

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei youze Biotechnology Co.,Ltd

What's our company advantages 1.Government support guarantees good company credibility and finance safe. 2.Place of Origin China with Super quality by reasonable price. 3.Fast delivery by safe express way to all the country. 4.We

Linezolid Impurity 13 CAS NO.168828-89-5 high purity best price spot goods

Cas:168828-89-5

Min.Order:1 Kilogram

FOB Price: $7.6

Type:Trading Company

inquiry

Synthetic route

3-fluoro-4-(morpholin-4-yl)-phenyl isocyanate
224323-51-7

3-fluoro-4-(morpholin-4-yl)-phenyl isocyanate

(S)-N-glycidylphthalimide
161596-47-0

(S)-N-glycidylphthalimide

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
With lithium bromide at 120℃; for 4h; Temperature; Solvent;96.51%
With lithium bromide In N,N-dimethyl-formamide at 60℃; for 4h; Reagent/catalyst; Solvent;90.11%
2-[(5R)-(2-oxo-5-oxazolidinyl)-methyl]-1H-isoindole-1,3(2H)-dione
352524-58-4

2-[(5R)-(2-oxo-5-oxazolidinyl)-methyl]-1H-isoindole-1,3(2H)-dione

4-(2-fluoro-4-bromophenyl)morpholine
513068-89-8

4-(2-fluoro-4-bromophenyl)morpholine

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
With copper(l) iodide; N,N-dimethyl-ethanamine; potassium carbonate In dichloromethane at 110℃; for 20h; Reagent/catalyst; Solvent; Temperature;92.8%
With copper(l) iodide; (S,S)-1,2-diaminocyclohexane; potassium carbonate In 1,4-dioxane at 110℃; for 20h; Goldberg Reaction; Inert atmosphere;76%
(5R)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone

(5R)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone

potassium phtalimide
1074-82-4

potassium phtalimide

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
at 140 - 145℃; for 2h;92%
In N,N-dimethyl-formamide for 5h; Reflux;62%
In N,N-dimethyl-formamide for 5h; Heating / reflux;
potassium phtalimide
1074-82-4

potassium phtalimide

(R)-methyl methanesulfonate
174649-09-3

(R)-methyl methanesulfonate

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80℃; for 3h;87.7%
In N,N-dimethyl-formamide at 120℃; for 2h;
In N,N-dimethyl-formamide at 120℃; for 2h;27 g
(S)-3-Chloro-1-(1,3-dioxoisoindolin-2-yl)propan-2-yl-3-fluoro-4-morpholinophenylcarbamate
1373348-82-3

(S)-3-Chloro-1-(1,3-dioxoisoindolin-2-yl)propan-2-yl-3-fluoro-4-morpholinophenylcarbamate

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 8h;86%
methyl (3-fluoro-4-morpholinophenyl)carbamate
212325-40-1

methyl (3-fluoro-4-morpholinophenyl)carbamate

(S)-N-glycidylphthalimide
161596-47-0

(S)-N-glycidylphthalimide

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
With lithium tert-butoxide In N,N-dimethyl-formamide at 25 - 85℃; Temperature; Solvent; Reagent/catalyst;85%
With lithium tert-butoxide In ethyl acetate at 25 - 75℃; Solvent; Temperature; Reagent/catalyst;70%
benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate
168828-81-7, 1027135-00-7

benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate

(S)-N-glycidylphthalimide
161596-47-0

(S)-N-glycidylphthalimide

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Stage #1: benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate With lithium tert-butoxide In tetrahydrofuran; N,N-dimethyl-formamide at 5℃; for 0.5h; Inert atmosphere;
Stage #2: (S)-N-glycidylphthalimide In tetrahydrofuran; N,N-dimethyl-formamide at 5 - 20℃; for 24h; Reagent/catalyst; Temperature; Inert atmosphere;
84%
(R)-(-)-epichlorohydrin
51594-55-9

(R)-(-)-epichlorohydrin

potassium phtalimide
1074-82-4

potassium phtalimide

methyl chloroformate
79-22-1

methyl chloroformate

3-fluoro-4-(morpholinyl)aniline
93246-53-8

3-fluoro-4-(morpholinyl)aniline

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Stage #1: (R)-(-)-epichlorohydrin; 3-fluoro-4-(morpholinyl)aniline In butan-1-ol at 20℃; Cooling;
Stage #2: methyl chloroformate With sodium hydrogencarbonate In butan-1-ol at 0 - 5℃;
Stage #3: potassium phtalimide In N,N-dimethyl-formamide at 95 - 100℃; for 3h;
83%
C21H22FN3O4

C21H22FN3O4

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
With dmap In acetonitrile at 80℃; for 1.5h; Inert atmosphere;70.51%
N-[3-phthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(4-morpholinyl)aniline
874340-08-6

N-[3-phthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(4-morpholinyl)aniline

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
In dichloromethane at 20℃; for 20h;
In dichloromethane
phthalimide
136918-14-4

phthalimide

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / isopropyl alcohol / 5 h / Reflux
2: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere
3: potassium carbonate / dichloromethane / 20 °C
4: potassium carbonate / acetone / 8 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: methylamine / isopropyl alcohol / 5 h / 60 °C
1.2: 10 - 30 °C
2.1: lithium tert-butoxide / N,N-dimethyl-formamide / 25 - 85 °C
View Scheme
Multi-step reaction with 3 steps
1: methylamine / isopropyl alcohol / 5 h / 60 °C
2: sodium methylate / methanol / 10 - 30 °C
3: lithium tert-butoxide / ethyl acetate / 25 - 75 °C
View Scheme
(S)-3-chloro-1-(1,3-dioxoisoindolin-2-yl)propan-2-yl chloroformate
1373348-79-8

(S)-3-chloro-1-(1,3-dioxoisoindolin-2-yl)propan-2-yl chloroformate

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / dichloromethane / 20 °C
2: potassium carbonate / acetone / 8 h / 20 °C
View Scheme
2-((S)-3-chloro-2-hydroxypropyl)isoindoline-1,3-dione
148857-42-5

2-((S)-3-chloro-2-hydroxypropyl)isoindoline-1,3-dione

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere
2: potassium carbonate / dichloromethane / 20 °C
3: potassium carbonate / acetone / 8 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium methylate / methanol / 10 - 30 °C
2: lithium tert-butoxide / ethyl acetate / 25 - 75 °C
View Scheme
N-[3-chloro-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholin-4-yl)aniline
868405-66-7

N-[3-chloro-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholin-4-yl)aniline

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide
2: dichloromethane
View Scheme
Multi-step reaction with 5 steps
1: 1,1'-carbonyldiimidazole / dichloromethane / 24 h / 20 - 30 °C
2: N,N-dimethyl-formamide / 120 °C
3: water; sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 - 15 °C
4: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Cooling with ice
5: N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
Multi-step reaction with 5 steps
1: dichloromethane / 24 h / 25 - 30 °C
2: N,N-dimethyl-formamide / 120 °C
3: sodium t-butanolate; water / tetrahydrofuran / 0.5 h / 0 - 15 °C
4: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C
5: N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
Multi-step reaction with 2 steps
1: dichloromethane / 20 h / 20 °C
2: N,N-dimethyl-formamide / 5 h / Reflux
View Scheme
3-fluoro-4-(morpholinyl)aniline
93246-53-8

3-fluoro-4-(morpholinyl)aniline

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: methanol
2: N,N-dimethyl-formamide
3: dichloromethane
View Scheme
Multi-step reaction with 6 steps
1: tert-butyl alcohol / 16 h / Reflux
2: 1,1'-carbonyldiimidazole / dichloromethane / 24 h / 20 - 30 °C
3: N,N-dimethyl-formamide / 120 °C
4: water; sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 - 15 °C
5: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Cooling with ice
6: N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / water; toluene / 1 h / 0 - 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -80 - -78 °C / Inert atmosphere
2.2: 20 °C / Cooling
3.1: triethylamine / dichloromethane / 45 °C
4.1: N,N-dimethyl-formamide / 3 h / 80 °C
View Scheme
3-fluoro-4-(morpholinyl)aniline
93246-53-8

3-fluoro-4-(morpholinyl)aniline

(S)-N-glycidylphthalimide
161596-47-0

(S)-N-glycidylphthalimide

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide
2: dichloromethane
View Scheme
Multi-step reaction with 2 steps
1: ethanol / 16 h / 60 °C / Inert atmosphere
2: dmap / acetonitrile / 1.5 h / 80 °C / Inert atmosphere
View Scheme
3,4-difluoronitrobenzene
369-34-6

3,4-difluoronitrobenzene

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: triethylamine / acetonitrile / 6 h / 40 - 50 °C / Reflux
2: hydrogen / Raney nickel / methanol / 8 h / 45 - 50 °C / 2942.29 Torr / Autoclave
3: tert-butyl alcohol / 16 h / Reflux
4: 1,1'-carbonyldiimidazole / dichloromethane / 24 h / 20 - 30 °C
5: N,N-dimethyl-formamide / 120 °C
6: water; sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 - 15 °C
7: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Cooling with ice
8: N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 4 h / 10 - 20 °C
2.1: hydrogen / methanol / 10 h / 20 °C / 3750.38 Torr / Inert atmosphere; Autoclave
3.1: sodium hydrogencarbonate / water; toluene / 1 h / 0 - 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -80 - -78 °C / Inert atmosphere
4.2: 20 °C / Cooling
5.1: triethylamine / dichloromethane / 45 °C
6.1: N,N-dimethyl-formamide / 3 h / 80 °C
View Scheme
Multi-step reaction with 8 steps
1: triethylamine / acetonitrile / 6 h / 40 °C / Reflux
2: hydrogen / methanol / 8 h / 45 - 50 °C / 3000.3 Torr / Autoclave; Inert atmosphere
3: tert-butyl alcohol / 16 h / Reflux
4: dichloromethane / 24 h / 25 - 30 °C
5: N,N-dimethyl-formamide / 120 °C
6: sodium t-butanolate; water / tetrahydrofuran / 0.5 h / 0 - 15 °C
7: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C
8: N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / ethyl acetate / 25 - 80 °C
2.1: 5%-palladium/activated carbon; hydrogen / methanol / 22 - 35 °C / 225.02 - 1500.15 Torr
3.1: isopropyl alcohol / 28 - 88 °C
3.2: 35 - 38 °C
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / ethyl acetate / 24 h / 20 °C
2.1: palladium 10% on activated carbon; ammonium formate / acetone / 8 h / 50 °C
3.1: sodium hydrogencarbonate / acetone; water / 0 - 20 °C
4.1: lithium tert-butoxide / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 5 °C / Inert atmosphere
4.2: 24 h / 5 - 20 °C / Inert atmosphere
View Scheme
3-fluoro-4-(4-morpholinyl)nitrobenzene
2689-39-6

3-fluoro-4-(4-morpholinyl)nitrobenzene

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: hydrogen / Raney nickel / methanol / 8 h / 45 - 50 °C / 2942.29 Torr / Autoclave
2: tert-butyl alcohol / 16 h / Reflux
3: 1,1'-carbonyldiimidazole / dichloromethane / 24 h / 20 - 30 °C
4: N,N-dimethyl-formamide / 120 °C
5: water; sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 - 15 °C
6: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Cooling with ice
7: N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogen / methanol / 10 h / 20 °C / 3750.38 Torr / Inert atmosphere; Autoclave
2.1: sodium hydrogencarbonate / water; toluene / 1 h / 0 - 20 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -80 - -78 °C / Inert atmosphere
3.2: 20 °C / Cooling
4.1: triethylamine / dichloromethane / 45 °C
5.1: N,N-dimethyl-formamide / 3 h / 80 °C
View Scheme
Multi-step reaction with 7 steps
1: hydrogen / methanol / 8 h / 45 - 50 °C / 3000.3 Torr / Autoclave; Inert atmosphere
2: tert-butyl alcohol / 16 h / Reflux
3: dichloromethane / 24 h / 25 - 30 °C
4: N,N-dimethyl-formamide / 120 °C
5: sodium t-butanolate; water / tetrahydrofuran / 0.5 h / 0 - 15 °C
6: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C
7: N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 5%-palladium/activated carbon; hydrogen / methanol / 22 - 35 °C / 225.02 - 1500.15 Torr
2.1: isopropyl alcohol / 28 - 88 °C
2.2: 35 - 38 °C
View Scheme
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; ammonium formate / acetone / 8 h / 50 °C
2.1: sodium hydrogencarbonate / acetone; water / 0 - 20 °C
3.1: lithium tert-butoxide / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 5 °C / Inert atmosphere
3.2: 24 h / 5 - 20 °C / Inert atmosphere
View Scheme
(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol
168828-82-8

(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Cooling with ice
2: N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 45 °C
2: N,N-dimethyl-formamide / 3 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C
2: N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
(5R)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone

(5R)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N,N-dimethyl-formamide / 120 °C
2: water; sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 - 15 °C
3: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Cooling with ice
4: N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
Multi-step reaction with 4 steps
1: N,N-dimethyl-formamide / 120 °C
2: sodium t-butanolate; water / tetrahydrofuran / 0.5 h / 0 - 15 °C
3: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C
4: N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
(R)-(3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl acetate
496031-56-2

(R)-(3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl acetate

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 - 15 °C
2: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Cooling with ice
3: N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium t-butanolate; water / tetrahydrofuran / 0.5 h / 0 - 15 °C
2: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C
3: N,N-dimethyl-formamide / 2 h / 120 °C
View Scheme
benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate
168828-81-7, 1027135-00-7

benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -80 - -78 °C / Inert atmosphere
1.2: 20 °C / Cooling
2.1: triethylamine / dichloromethane / 45 °C
3.1: N,N-dimethyl-formamide / 3 h / 80 °C
View Scheme
(R)-(-)-epichlorohydrin
51594-55-9

(R)-(-)-epichlorohydrin

potassium phtalimide
1074-82-4

potassium phtalimide

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

3-fluoro-4-(morpholinyl)aniline
93246-53-8

3-fluoro-4-(morpholinyl)aniline

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Stage #1: (R)-(-)-epichlorohydrin; 3-fluoro-4-(morpholinyl)aniline In isopropyl alcohol at 28 - 88℃;
Stage #2: N,N-dimethyl-formamide at 35 - 38℃;
Stage #3: potassium phtalimide Further stages;
234 g
N-ethoxycarbonyl-3-fluoro-4-morpholinyl aniline
565176-83-2

N-ethoxycarbonyl-3-fluoro-4-morpholinyl aniline

(S)-N-glycidylphthalimide
161596-47-0

(S)-N-glycidylphthalimide

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
With triethylamine at 90 - 95℃; for 6h; Reagent/catalyst; Concentration;40 g
methyl (3-fluoro-4-morpholinophenyl)carbamate
212325-40-1

methyl (3-fluoro-4-morpholinophenyl)carbamate

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1.17 h / -10 °C
1.2: 4.67 h / -10 - 55 °C
2.1: 2 h / 140 - 145 °C
View Scheme
potassium phtalimide
1074-82-4

potassium phtalimide

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide / 3 h / 80 °C
2: sodium azide; (Dichloroiodo)benzene / ethyl acetate / 12 h / 0 - 80 °C / Inert atmosphere
3: potassium carbonate; N,N-dimethyl-ethanamine; copper(l) iodide / dichloromethane / 20 h / 110 °C
View Scheme
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide / 5 h / 70 °C
2: sodium azide; (Dichloroiodo)benzene / ethyl acetate / 12 h / 0 - 80 °C / Inert atmosphere
3: potassium carbonate; N,N-dimethyl-ethanamine; copper(l) iodide / dichloromethane / 20 h / 110 °C
View Scheme
C12H13NO4

C12H13NO4

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium azide; (Dichloroiodo)benzene / ethyl acetate / 12 h / 0 - 80 °C / Inert atmosphere
2: potassium carbonate; N,N-dimethyl-ethanamine; copper(l) iodide / dichloromethane / 20 h / 110 °C
View Scheme
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine
168828-90-8

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 4h; Solvent; Reflux;95.4%
With hydrazine hydrate In methanol for 1h; Reflux;90%
With hydrazine hydrate In methanol for 1h; Reflux;71%
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

acetic anhydride
108-24-7

acetic anhydride

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
Stage #1: 2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione With hydrazine In methanol; water at 60℃; for 1h;
Stage #2: acetic anhydride With triethylamine at 0 - 20℃; for 2h;
89.1%
Stage #1: 2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione With hydrazine hydrate In methanol at 30 - 70℃;
Stage #2: acetic anhydride at 10 - 30℃; Concentration;
145 g
Stage #1: 2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione With hydrazine hydrate In methanol for 1h; Reflux;
Stage #2: acetic anhydride With triethylamine at 10 - 30℃; for 1h;
9 g
Stage #1: 2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione With hydrazine hydrate In methanol for 2h; Reflux;
Stage #2: acetic anhydride In dichloromethane at 0 - 10℃;
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

methylamine
74-89-5

methylamine

N-[[3-(3-fluoro-4-morphol-4-ylphenyl)-2-oxazolone-5-yl]methyl]-2-methylaminobenzamide

N-[[3-(3-fluoro-4-morphol-4-ylphenyl)-2-oxazolone-5-yl]methyl]-2-methylaminobenzamide

Conditions
ConditionsYield
In water; acetone for 6h; Reagent/catalyst; Solvent; Reflux;66.39%
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrazine hydrate / methanol / 1 h / Reflux
2: toluene / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrazine hydrate / methanol / 1 h / Reflux
2: triethylamine / dichloromethane / 1 h / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrazine hydrate / methanol / 1 h / Reflux
2: ethyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrazine hydrate / methanol / 1 h / Reflux
2: ethyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrazine hydrate / ethanol / 4 h / Reflux
2: triethylamine / ethyl acetate / 2 h / 20 °C
View Scheme
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

(S)-5-chloro-N-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]thiophen-2-carboxamide

(S)-5-chloro-N-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]thiophen-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrazine hydrate / methanol
2: triethylamine / toluene / 12 h / 20 - 45 °C
View Scheme
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

(S)-N-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]benzamide
1390617-34-1

(S)-N-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]benzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrazine hydrate / methanol
2: triethylamine / toluene / 12 h / 20 - 45 °C
View Scheme
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

4-amino-5-(ethylsulfonyl)-N-(S)-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]-2-methoxybenzamide
1390617-35-2

4-amino-5-(ethylsulfonyl)-N-(S)-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]-2-methoxybenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrazine hydrate / methanol
2.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
2.2: 4 h / 0 - 20 °C
View Scheme
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

4-amino-5-chloro-2-ethoxy-N-(S)-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]benzamide

4-amino-5-chloro-2-ethoxy-N-(S)-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]benzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrazine hydrate / methanol
2.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
2.2: 4 h / 0 - 20 °C
View Scheme
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

5-(aminosulfonyl)-N-(S)-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]-2-methoxy benzamide
1390617-37-4

5-(aminosulfonyl)-N-(S)-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]-2-methoxy benzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrazine hydrate / methanol
2.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
2.2: 4 h / 0 - 20 °C
View Scheme
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

(S)-N-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]-3,4-dimethoxybenzamide
1390617-32-9

(S)-N-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]-3,4-dimethoxybenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrazine hydrate / methanol
2: triethylamine / toluene / 12 h / 20 - 45 °C
View Scheme
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

2-benzyl-(S)-N-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]acrylamide
1390617-33-0

2-benzyl-(S)-N-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]acrylamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrazine hydrate / methanol
2: triethylamine / toluene / 12 h / 20 - 45 °C
View Scheme
2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione
168828-89-5

2-({(5S)-2-oxo-3-[(4-morpholino-3-fluorophenyl)]-4,5-dihydro-1,3-oxazole-5-yl}methyl)-isoindole-1,3-dione

2-chloro-(S)-N-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]acetamide

2-chloro-(S)-N-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrazine hydrate / methanol
2: triethylamine / toluene / 12 h / 20 - 45 °C
View Scheme

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