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Hangzhou Think Chemical Co. Ltd

Bortezomib CAS:179324-69-7 API and Bortezomib intermediates HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marke

High purity Bortezomib supplier at best price

Cas:179324-69-7

Min.Order:10 Gram

Negotiable

Type:Other

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ACHIEVER SYSTEAM BIOCHEM CO., LTD.

Bortezomib(We are one of a few suppliers that can offer custom synthesis service of this product) We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We

Bortezomib

Cas:179324-69-7

Min.Order:10 Gram

FOB Price: $1.0 / 111.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Bortezomib Manufacturer/High quality/Best price/In stock

Cas:179324-69-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Description White or off-white powder white powder Specific rotation -

High quality Bortezomib with best price and good quality cas: 179324-69-7

Cas:179324-69-7

Min.Order:1 Kilogram

FOB Price: $45.0 / 55.0

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory Supply Bortezomib powder CAS: 179324-69-7

Cas:179324-69-7

Min.Order:1 Gram

FOB Price: $10.0

Type:Trading Company

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Kono Chem Co.,Ltd

Item Specifications Results Appearance White or almost white Pass Purity ≥99.0%

CAS:179324-69-7 Bortezomib

Cas:179324-69-7

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Bortezomib CAS NO.179324-69-7

Cas:179324-69-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Bortezomib Cas 179324-69-7 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:?20°C Package:1kg/foil bag, 25kg/drum or as you requi

Factory supply Bortezomib Cas 179324-69-7 with high quality low price

Cas:179324-69-7

Min.Order:1 Gram

FOB Price: $130.0

Type:Trading Company

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Hubei Vanz Pharm Co.,Ltd

We are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical

CAS 179324-69-7 Bortezomib Anti-Cancer

Cas:179324-69-7

Min.Order:1 Gram

FOB Price: $10.0

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Bortezomib

Cas:179324-69-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Bortezomib

Cas:179324-69-7

Min.Order:1

Negotiable

Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Bortezomib manufacturer with low price

Cas:179324-69-7

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Bortezomib 179324-69-7 ISO Manufacturer

Cas:179324-69-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Bortezomib

Cas:179324-69-7

Min.Order:1 Kilogram

FOB Price: $50.0 / 55.0

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Bortezomib

Cas:179324-69-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Bortezomib

Cas:179324-69-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Bortezomib CAS:179324-69-7 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability P

Good qualitly Bortezomib API and intermediates

Cas:179324-69-7

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Bortezomib Basic information Drug for Cancer treatment Product Name: Bortezomib Synonyms: VELCADE;dpba;BORTEZOMIB;[(1r)-3-methyl-1-[[(2s)-1-oxo-3-phenyl-2-[(pyrazinylcarbon

TIANFU-CHEM CAS:179324-69-7 Bortezomib

Cas:179324-69-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

High Quality 99% Pharmaceutical CAS 179324-69-7 Bortezomib

Cas:179324-69-7

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 179324-69-7 with best quality

Cas:179324-69-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Bortezomib Bortezomib is the first therapeutic proteasome inhibitor to be tested in humans. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete c

High purity Bortezomib 179324-69-7

Cas:179324-69-7

Min.Order:100 Gram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

High purity Bortezomib API USP CAS 179324-69-7 Raw Pharmaceutical Material

Cas:179324-69-7

Min.Order:10 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Antineoplastic Drug Bortezomib powder CAS 179324-69-7

Cas:179324-69-7

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr

Hotsale Bortezomib 179324-69-7

Cas:179324-69-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

High Quality API Bortezomib powder Anti-cancer raw materials

Cas:179324-69-7

Min.Order:10 Gram

FOB Price: $1.8

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Bortezomib/ LIDE PHARMA- Factory supply / Best price

Cas:179324-69-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Antineoplastic Agents, Bortezomib CAS:179324-69-7

Cas:179324-69-7

Min.Order:1 Kilogram

FOB Price: $51.8 / 54.2

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Bortezomib CAS: 179324-69-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Bortezomib CAS: 179324-69-7

Cas:179324-69-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

High purity Bortezomib 179324-69-7

Cas:179324-69-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifi

Bortezomib CAS 179324-69-7

Cas:179324-69-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

bortezomib pinacol ester
1029701-48-1

bortezomib pinacol ester

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With hydrogenchloride In water; acetone at 20℃;94%
N-[(1S)-1[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-2-benzyl]2-pyrazine carboxamide
205393-22-2

N-[(1S)-1[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-2-benzyl]2-pyrazine carboxamide

dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With hydrogenchloride In water; acetone at 20℃; for 40h;92%
C24H33BN4O4

C24H33BN4O4

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With hydrogenchloride; 2-methyl-propan-1-ol In methanol; pentane at 0 - 20℃; for 12h; Large scale;86%
C26H37BN4O4

C26H37BN4O4

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With hydrogenchloride; 2-methyl-propan-1-ol In methanol; pentane at 0 - 20℃; for 12h; Large scale;86%
(2S)-N-[(1R)-1-(1,3,6,2-dioxazaborocan-2-yl)-3-methylbutyl]-3-phenyl-2-(pyrazin-2-ylformamido)propanamide

(2S)-N-[(1R)-1-(1,3,6,2-dioxazaborocan-2-yl)-3-methylbutyl]-3-phenyl-2-(pyrazin-2-ylformamido)propanamide

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 20℃;82.3%
C25H35BN4O4

C25H35BN4O4

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With hydrogenchloride; 2-methyl-propan-1-ol In methanol; pentane at 0 - 20℃; for 12h; Large scale;82%
N-[(1S)-1[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-2-benzyl]2-pyrazine carboxamide
205393-22-2

N-[(1S)-1[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-2-benzyl]2-pyrazine carboxamide

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With hydrogenchloride; Dihydroxy-isobutyl-boran In water at 20℃; Solvent; Temperature;77%
With hydrogenchloride; Dihydroxy-isobutyl-boran In methanol; n-heptane; water at 25 - 30℃; for 1 - 2h; Product distribution / selectivity;70%
With hydrogenchloride; Dihydroxy-isobutyl-boran; water In methanol; hexane at 20℃; for 18h;56.4%
Dihydroxy-isobutyl-boran
84110-40-7

Dihydroxy-isobutyl-boran

C29H39BN4O4

C29H39BN4O4

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With hydrogenchloride In methanol; n-heptane; water at 0 - 25℃; for 2h;71.5%
2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

N-benzyl-L-phenylalanine
19461-04-2

N-benzyl-L-phenylalanine

(R)-1-amino-3-methylbutylboronic acid pinanediol ester hydrochloride

(R)-1-amino-3-methylbutylboronic acid pinanediol ester hydrochloride

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Stage #1: N-benzyl-L-phenylalanine; (R)-1-amino-3-methylbutylboronic acid pinanediol ester hydrochloride With 4-methyl-morpholine; N-ethyl-N,N-diisopropylamine; isobutyryl chloride In tetrahydrofuran at 55℃; for 2h; pH=10; Inert atmosphere;
Stage #2: With palladium on activated charcoal; hydrogen In tetrahydrofuran at 68℃; under 4560.31 Torr; for 2h;
Stage #3: 2-pyrazylcarboxylic acid Concentration; Temperature; Solvent; pH-value; Pressure; Further stages;
67%
2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

C23H27BNO5Pol

C23H27BNO5Pol

N-Fmoc L-Phe
35661-40-6

N-Fmoc L-Phe

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Stage #1: C23H27BNO5Pol With piperidine In N,N-dimethyl-formamide for 0.333333h; 1-glycerol polystyrene resin;
Stage #2: N-Fmoc L-Phe With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide for 2h; 1-glycerol polystyrene resin;
Stage #3: 2-pyrazylcarboxylic acid Further stages;
54%
(S)-N-(1-(isopentylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide

(S)-N-(1-(isopentylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide

phenylboronic acid
98-80-6

phenylboronic acid

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Stage #1: (S)-N-(1-(isopentylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide With [Rh(OH)(cod)]2; 4-((2'-((triisopropylsilyl)oxy)-[1,1'-binaphthalen]-2-yl)oxy)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine; bis(pinacol)diborane In acetonitrile at 80℃; for 36h; Inert atmosphere; Sealed tube;
Stage #2: phenylboronic acid With hydrogenchloride In methanol; water; pentane at 20℃; for 12h; Inert atmosphere; stereoselective reaction;
53%
bortezomib pinacol ester
1029701-48-1

bortezomib pinacol ester

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With hydrogenchloride; 2-methyl-propan-1-ol In methanol; pentane at 0 - 20℃; for 12h;52%
With hydrogenchloride In methanol; pentane for 20h;93.4 mg
Stage #1: bortezomib pinacol ester With hydrogenchloride; Dihydroxy-isobutyl-boran In methanol; n-heptane; water at 20℃;
Stage #2: With sodium hydroxide In water
With hydrogenchloride; Dihydroxy-isobutyl-boran
2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

(CH3)2CHCH2CH(BO2C2(CH3)4)NHCOCH(CH2C6H5)NH3(1+)*Cl(1-)=(CH3)2CHCH2CH(BO2C2(CH3)4)NHCOCH(CH2C6H5)NH3Cl
1029701-41-4

(CH3)2CHCH2CH(BO2C2(CH3)4)NHCOCH(CH2C6H5)NH3(1+)*Cl(1-)=(CH3)2CHCH2CH(BO2C2(CH3)4)NHCOCH(CH2C6H5)NH3Cl

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In not given 1. (2-pyrazine)CO2H, TBTU, i-Pr2EtN, 0°C - room temp.; 2. i-BuB(OH)2, pentane, MeOH, 1 N HCl;
(2S)-N-[1-(1,3,6,2-dioxazaborocan-2-yl)-3-methylbutyl]-3-phenyl-2-(pyrazin-2-ylformamido)propanamide

(2S)-N-[1-(1,3,6,2-dioxazaborocan-2-yl)-3-methylbutyl]-3-phenyl-2-(pyrazin-2-ylformamido)propanamide

A

[(1S)-1-[[(2S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]-1-oxopropyl]amino]-3-methylbutyl]boronic acid
1132709-14-8

[(1S)-1-[[(2S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]-1-oxopropyl]amino]-3-methylbutyl]boronic acid

B

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 20℃;
C32H43BN2O5

C32H43BN2O5

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide
2: N-ethyl-N,N-diisopropylamine / dichloromethane
3: methanol / Acidic conditions
View Scheme
N-{(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}phenylalanine amide
789472-91-9

N-{(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}phenylalanine amide

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane
2: methanol / Acidic conditions
View Scheme
N-Cbz-L-Phe
1161-13-3

N-Cbz-L-Phe

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane
2: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide
3: N-ethyl-N,N-diisopropylamine / dichloromethane
4: methanol / Acidic conditions
View Scheme
2-pyrazylcarboxylic acid
98-97-5

2-pyrazylcarboxylic acid

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / toluene / 75 °C
2.1: sodium carbonate / toluene; water / 10 - 25 °C
3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / -40 - -11 °C
4.1: hydrogenchloride; Dihydroxy-isobutyl-boran / water; methanol; n-heptane / 20 °C
4.2: 20 °C
5.1: hydrogenchloride / water; methanol / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.67 h / 0 °C
1.2: 3 h / 0 - 20 °C
2.1: sodium hydroxide / water; acetone / 2 h / 0 °C
3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -10 - -5 °C
4.1: hydrogenchloride / water; acetone / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.67 h / 0 °C
1.2: 3 h / 0 - 20 °C
2.1: sodium hydroxide / water; acetone / 2 h / 0 °C
3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -10 - -5 °C
4.1: hydrogenchloride / water; acetone / 40 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride
2: hydrogenchloride; Dihydroxy-isobutyl-boran
View Scheme
Multi-step reaction with 4 steps
1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C
2: sodium hydroxide / methanol; water / 20 °C
3: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C
4: Dihydroxy-isobutyl-boran; hydrogenchloride / water; methanol; ethyl acetate
View Scheme
(3aS,4S,6S,7aR)-2-(1-chloro-3-methylbutyl)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborole

(3aS,4S,6S,7aR)-2-(1-chloro-3-methylbutyl)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborole

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: hexane / -70 - 20 °C / Large scale
2: di-isopropyl ether / 2 h / -10 - 0 °C / Large scale
3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale
4: hydrogenchloride / toluene / 1 h / 0 °C / Large scale
5: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale
6: hydrogenchloride; Dihydroxy-isobutyl-boran / hexane; 1,1,1-trideuteromethanol; water / 0 - 20 °C / Large scale
View Scheme
1,1,1-trimethyl-N-{(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}-N-(trimethylsilyl)silanamine
514820-48-5

1,1,1-trimethyl-N-{(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}-N-(trimethylsilyl)silanamine

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: di-isopropyl ether / 2 h / -10 - 0 °C / Large scale
2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale
3: hydrogenchloride / toluene / 1 h / 0 °C / Large scale
4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale
5: hydrogenchloride; Dihydroxy-isobutyl-boran / hexane; 1,1,1-trideuteromethanol; water / 0 - 20 °C / Large scale
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogenchloride / tert-butyl methyl ether / -40 - 20 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / -40 - -11 °C
3.1: hydrogenchloride; Dihydroxy-isobutyl-boran / water; methanol; n-heptane / 20 °C
3.2: 20 °C
4.1: hydrogenchloride / water; methanol / 20 °C
View Scheme
(aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate

(aR,3aS,4S,6S,7aR)-hexahydro-3a,8,8-trimethyl-α-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale
2: hydrogenchloride / toluene / 1 h / 0 °C / Large scale
3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale
4: hydrogenchloride; Dihydroxy-isobutyl-boran / hexane; 1,1,1-trideuteromethanol; water / 0 - 20 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1.1: dichloromethane / 0.08 h / 0 °C / Inert atmosphere
1.2: 1 h / -3 - 2 °C
1.3: 0.25 h / 15 - 27 °C
2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / toluene / 0.17 h / Inert atmosphere
2.2: 3 h / 25 °C
3.1: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; n-heptane / 12 h / 20 °C
View Scheme
tert-butyl [1-({3-methyl-1-[(3aS,4S,6S)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-1-oxo-3-phenylpropan-2-yl]carbamate

tert-butyl [1-({3-methyl-1-[(3aS,4S,6S)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-1-oxo-3-phenylpropan-2-yl]carbamate

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / toluene / 1 h / 0 °C / Large scale
2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale
3: hydrogenchloride; Dihydroxy-isobutyl-boran / hexane; 1,1,1-trideuteromethanol; water / 0 - 20 °C / Large scale
View Scheme
N-{3-methyl-1-[(3aS,4S,6S)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}phenylalanine amide

N-{3-methyl-1-[(3aS,4S,6S)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}phenylalanine amide

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale
2: hydrogenchloride; Dihydroxy-isobutyl-boran / hexane; 1,1,1-trideuteromethanol; water / 0 - 20 °C / Large scale
View Scheme
N-{(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide

N-{(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With hydrogenchloride; Dihydroxy-isobutyl-boran In hexane; 1,1,1-trideuteromethanol; water at 0 - 20℃; Concentration; Temperature; Large scale;
N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dichloromethane / 0.08 h / 0 °C / Inert atmosphere
1.2: 1 h / -3 - 2 °C
1.3: 0.25 h / 15 - 27 °C
2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / toluene / 0.17 h / Inert atmosphere
2.2: 3 h / 25 °C
3.1: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; n-heptane / 12 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: N-isopropylethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 2 h / -10 - 5 °C
2: dichloromethane / 25 - 35 °C
3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 0 - 10 °C
4: Dihydroxy-isobutyl-boran; hydrogenchloride / water / 20 °C
View Scheme
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
114457-94-2

(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / 0.33 h / 20 °C / Inert atmosphere
1.2: 4 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride; Dihydroxy-isobutyl-boran / n-heptane; water; methanol / 1.5 h / 20 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / -40 - -11 °C
2.1: hydrogenchloride; Dihydroxy-isobutyl-boran / water; methanol; n-heptane / 20 °C
2.2: 20 °C
3.1: hydrogenchloride / water; methanol / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -10 - -5 °C
2: hydrogenchloride / water; acetone / 20 °C
View Scheme
(R)-boroleu-(+)-pinanediol trifluoroacetic acid

(R)-boroleu-(+)-pinanediol trifluoroacetic acid

velcade
179324-69-7

velcade

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / 0.33 h / 20 °C / Inert atmosphere
1.2: 4 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride; Dihydroxy-isobutyl-boran / n-heptane; water; methanol / 1.5 h / 20 - 30 °C
View Scheme
N-((2S)-1-((3-methyl-1-((3aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide

N-((2S)-1-((3-methyl-1-((3aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With hydrogenchloride; Dihydroxy-isobutyl-boran In methanol; n-heptane; water at 20 - 30℃; for 1.5h;4.2 g
acetone
67-64-1

acetone

phenylboronic acid
98-80-6

phenylboronic acid

velcade
179324-69-7

velcade

Conditions
ConditionsYield
With hydrogenchloride In hexane; acetonitrile
velcade
179324-69-7

velcade

Pyrazine-2-carboxylic acid [(S)-1-((R)-1-hydroxy-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]-amide
289472-78-2

Pyrazine-2-carboxylic acid [(S)-1-((R)-1-hydroxy-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]-amide

Conditions
ConditionsYield
With dihydrogen peroxide In ethanol; water at 20℃; for 1h; Oxidation; hydrolysis;100%
With hydrogenchloride; oxygen In ethanol; water at 25℃; for 336h; pH=2.8; Kinetics; Product distribution; Further Variations:; with/without ascorbic acid; Oxidation; hydrolysis;
With oxygen In ethanol; water at 25℃; for 5844h; pH=6.9; Kinetics; Product distribution; Further Variations:; with/without EDTA; Oxidation; hydrolysis;
C16H29N3O4

C16H29N3O4

velcade
179324-69-7

velcade

C35H50BN7O6

C35H50BN7O6

Conditions
ConditionsYield
In chloroform-d1 at 45℃;95%
pinanediol

pinanediol

velcade
179324-69-7

velcade

C29H39BN4O4

C29H39BN4O4

Conditions
ConditionsYield
In toluene for 3h; Inert atmosphere; Reflux;91.2%
dopamine folic acid

dopamine folic acid

velcade
179324-69-7

velcade

C46H49BN12O9

C46H49BN12O9

Conditions
ConditionsYield
In dimethyl sulfoxide at 25℃;80%
velcade
179324-69-7

velcade

bortezomib
390800-88-1

bortezomib

Conditions
ConditionsYield
In isopropyl alcohol; acetonitrile at 20℃; for 4h; Product distribution / selectivity;76.9%
citric acid
77-92-9

citric acid

velcade
179324-69-7

velcade

5-(carboxymethyl)-2-((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid

5-(carboxymethyl)-2-((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid

Conditions
ConditionsYield
In ethyl acetate at 20 - 74℃; for 3h;71.1%
C14H29N3O6

C14H29N3O6

velcade
179324-69-7

velcade

C33H50BN7O8

C33H50BN7O8

Conditions
ConditionsYield
In chloroform-d170%
velcade
179324-69-7

velcade

A

Pyrazine-2-carboxylic acid ((S)-1-carbamoyl-2-phenyl-ethyl)-amide

Pyrazine-2-carboxylic acid ((S)-1-carbamoyl-2-phenyl-ethyl)-amide

B

(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
114457-94-2

(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid

Conditions
ConditionsYield
With sodium hydroxide; oxygen In dimethyl sulfoxide at 70℃; for 250h; pH=12.0; Kinetics; Product distribution; Oxidation; hydrolysis;
With sodium hydroxide; oxygen at 70℃; for 48h; pH=12; Oxidation; hydrolysis;
velcade
179324-69-7

velcade

A

Pyrazine-2-carboxylic acid ((S)-1-carbamoyl-2-phenyl-ethyl)-amide

Pyrazine-2-carboxylic acid ((S)-1-carbamoyl-2-phenyl-ethyl)-amide

B

(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
114457-94-2

(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid

C

Pyrazine-2-carboxylic acid [(S)-1-((R)-1-hydroxy-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]-amide
289472-78-2

Pyrazine-2-carboxylic acid [(S)-1-((R)-1-hydroxy-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]-amide

D

Pyrazine-2-carboxylic acid [(S)-1-((S)-1-hydroxy-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]-amide

Pyrazine-2-carboxylic acid [(S)-1-((S)-1-hydroxy-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]-amide

Conditions
ConditionsYield
With dihydrogen peroxide In water at 20℃; for 1h; Kinetics; Product distribution; Further Variations:; Solvents; Oxidation; hydrolysis;
velcade
179324-69-7

velcade

(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
114457-94-2

(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid

Conditions
ConditionsYield
With hydrogenchloride; oxygen In dimethyl sulfoxide at 70℃; for 250h; pH=1.0; Kinetics; Product distribution; Oxidation; hydrolysis;
With hydrogenchloride; oxygen at 70℃; for 120h; pH=1.0; Oxidation; hydrolysis;
dopamine hydrochloride
62-31-7

dopamine hydrochloride

velcade
179324-69-7

velcade

C27H33BN5O5(1-)*H(1+)

C27H33BN5O5(1-)*H(1+)

Conditions
ConditionsYield
With sodium dihydrogenphosphate; sodium hydroxide In dimethylsulfoxide-d6; water-d2 for 1h; pH=7.4;

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