Bortezomib CAS:179324-69-7 API and Bortezomib intermediates HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marke
Cas:179324-69-7
Min.Order:10 Gram
Negotiable
Type:Other
inquiryBortezomib(We are one of a few suppliers that can offer custom synthesis service of this product) We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We
Cas:179324-69-7
Min.Order:10 Gram
FOB Price: $1.0 / 111.0
Type:Lab/Research institutions
inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:179324-69-7
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryItems Standard Result Description White or off-white powder white powder Specific rotation -
Cas:179324-69-7
Min.Order:1 Kilogram
FOB Price: $45.0 / 55.0
Type:Manufacturers
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:179324-69-7
Min.Order:1 Gram
FOB Price: $10.0
Type:Trading Company
inquiryItem Specifications Results Appearance White or almost white Pass Purity ≥99.0%
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:179324-69-7
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryUnique advantages for Bortezomib Cas 179324-69-7 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:?20°C Package:1kg/foil bag, 25kg/drum or as you requi
Cas:179324-69-7
Min.Order:1 Gram
FOB Price: $130.0
Type:Trading Company
inquiryWe are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical
Cas:179324-69-7
Min.Order:1 Gram
FOB Price: $10.0
Type:Manufacturers
inquiryhigh quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:179324-69-7
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:179324-69-7
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:179324-69-7
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Bortezomib CAS:179324-69-7 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability P
Cas:179324-69-7
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryBortezomib Basic information Drug for Cancer treatment Product Name: Bortezomib Synonyms: VELCADE;dpba;BORTEZOMIB;[(1r)-3-methyl-1-[[(2s)-1-oxo-3-phenyl-2-[(pyrazinylcarbon
Cas:179324-69-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:179324-69-7
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:179324-69-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryBortezomib Bortezomib is the first therapeutic proteasome inhibitor to be tested in humans. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete c
Cas:179324-69-7
Min.Order:100 Gram
FOB Price: $1.0
Type:Other
inquiryOur Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua
Cas:179324-69-7
Min.Order:10 Gram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:179324-69-7
Min.Order:1 Kilogram
FOB Price: $20.0 / 40.0
Type:Trading Company
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White powder Storage:storage in a dr
Cas:179324-69-7
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:179324-69-7
Min.Order:10 Gram
FOB Price: $1.8
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:179324-69-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:179324-69-7
Min.Order:1 Kilogram
FOB Price: $51.8 / 54.2
Type:Trading Company
inquiryBortezomib CAS: 179324-69-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:179324-69-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:179324-69-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifi
Cas:179324-69-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
With hydrogenchloride In water; acetone at 20℃; | 94% |
N-[(1S)-1[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-2-benzyl]2-pyrazine carboxamide
dihydroxy-methyl-borane
velcade
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetone at 20℃; for 40h; | 92% |
velcade
Conditions | Yield |
---|---|
With hydrogenchloride; 2-methyl-propan-1-ol In methanol; pentane at 0 - 20℃; for 12h; Large scale; | 86% |
velcade
Conditions | Yield |
---|---|
With hydrogenchloride; 2-methyl-propan-1-ol In methanol; pentane at 0 - 20℃; for 12h; Large scale; | 86% |
velcade
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 20℃; | 82.3% |
velcade
Conditions | Yield |
---|---|
With hydrogenchloride; 2-methyl-propan-1-ol In methanol; pentane at 0 - 20℃; for 12h; Large scale; | 82% |
N-[(1S)-1[[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]carbonyl]-2-benzyl]2-pyrazine carboxamide
velcade
Conditions | Yield |
---|---|
With hydrogenchloride; Dihydroxy-isobutyl-boran In water at 20℃; Solvent; Temperature; | 77% |
With hydrogenchloride; Dihydroxy-isobutyl-boran In methanol; n-heptane; water at 25 - 30℃; for 1 - 2h; Product distribution / selectivity; | 70% |
With hydrogenchloride; Dihydroxy-isobutyl-boran; water In methanol; hexane at 20℃; for 18h; | 56.4% |
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; n-heptane; water at 0 - 25℃; for 2h; | 71.5% |
Conditions | Yield |
---|---|
Stage #1: N-benzyl-L-phenylalanine; (R)-1-amino-3-methylbutylboronic acid pinanediol ester hydrochloride With 4-methyl-morpholine; N-ethyl-N,N-diisopropylamine; isobutyryl chloride In tetrahydrofuran at 55℃; for 2h; pH=10; Inert atmosphere; Stage #2: With palladium on activated charcoal; hydrogen In tetrahydrofuran at 68℃; under 4560.31 Torr; for 2h; Stage #3: 2-pyrazylcarboxylic acid Concentration; Temperature; Solvent; pH-value; Pressure; Further stages; | 67% |
Conditions | Yield |
---|---|
Stage #1: C23H27BNO5Pol With piperidine In N,N-dimethyl-formamide for 0.333333h; 1-glycerol polystyrene resin; Stage #2: N-Fmoc L-Phe With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide for 2h; 1-glycerol polystyrene resin; Stage #3: 2-pyrazylcarboxylic acid Further stages; | 54% |
phenylboronic acid
velcade
Conditions | Yield |
---|---|
Stage #1: (S)-N-(1-(isopentylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide With [Rh(OH)(cod)]2; 4-((2'-((triisopropylsilyl)oxy)-[1,1'-binaphthalen]-2-yl)oxy)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine; bis(pinacol)diborane In acetonitrile at 80℃; for 36h; Inert atmosphere; Sealed tube; Stage #2: phenylboronic acid With hydrogenchloride In methanol; water; pentane at 20℃; for 12h; Inert atmosphere; stereoselective reaction; | 53% |
bortezomib pinacol ester
velcade
Conditions | Yield |
---|---|
With hydrogenchloride; 2-methyl-propan-1-ol In methanol; pentane at 0 - 20℃; for 12h; | 52% |
With hydrogenchloride In methanol; pentane for 20h; | 93.4 mg |
Stage #1: bortezomib pinacol ester With hydrogenchloride; Dihydroxy-isobutyl-boran In methanol; n-heptane; water at 20℃; Stage #2: With sodium hydroxide In water | |
With hydrogenchloride; Dihydroxy-isobutyl-boran |
2-pyrazylcarboxylic acid
(CH3)2CHCH2CH(BO2C2(CH3)4)NHCOCH(CH2C6H5)NH3(1+)*Cl(1-)=(CH3)2CHCH2CH(BO2C2(CH3)4)NHCOCH(CH2C6H5)NH3Cl
velcade
Conditions | Yield |
---|---|
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In not given 1. (2-pyrazine)CO2H, TBTU, i-Pr2EtN, 0°C - room temp.; 2. i-BuB(OH)2, pentane, MeOH, 1 N HCl; |
A
[(1S)-1-[[(2S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]-1-oxopropyl]amino]-3-methylbutyl]boronic acid
B
velcade
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 20℃; |
velcade
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide 2: N-ethyl-N,N-diisopropylamine / dichloromethane 3: methanol / Acidic conditions View Scheme |
N-{(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}phenylalanine amide
velcade
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane 2: methanol / Acidic conditions View Scheme |
N-Cbz-L-Phe
velcade
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane 2: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide 3: N-ethyl-N,N-diisopropylamine / dichloromethane 4: methanol / Acidic conditions View Scheme |
2-pyrazylcarboxylic acid
velcade
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: thionyl chloride / toluene / 75 °C 2.1: sodium carbonate / toluene; water / 10 - 25 °C 3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / -40 - -11 °C 4.1: hydrogenchloride; Dihydroxy-isobutyl-boran / water; methanol; n-heptane / 20 °C 4.2: 20 °C 5.1: hydrogenchloride / water; methanol / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.67 h / 0 °C 1.2: 3 h / 0 - 20 °C 2.1: sodium hydroxide / water; acetone / 2 h / 0 °C 3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -10 - -5 °C 4.1: hydrogenchloride / water; acetone / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.67 h / 0 °C 1.2: 3 h / 0 - 20 °C 2.1: sodium hydroxide / water; acetone / 2 h / 0 °C 3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -10 - -5 °C 4.1: hydrogenchloride / water; acetone / 40 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride 2: hydrogenchloride; Dihydroxy-isobutyl-boran View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C 2: sodium hydroxide / methanol; water / 20 °C 3: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C 4: Dihydroxy-isobutyl-boran; hydrogenchloride / water; methanol; ethyl acetate View Scheme |
velcade
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: hexane / -70 - 20 °C / Large scale 2: di-isopropyl ether / 2 h / -10 - 0 °C / Large scale 3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale 4: hydrogenchloride / toluene / 1 h / 0 °C / Large scale 5: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale 6: hydrogenchloride; Dihydroxy-isobutyl-boran / hexane; 1,1,1-trideuteromethanol; water / 0 - 20 °C / Large scale View Scheme |
1,1,1-trimethyl-N-{(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}-N-(trimethylsilyl)silanamine
velcade
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: di-isopropyl ether / 2 h / -10 - 0 °C / Large scale 2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale 3: hydrogenchloride / toluene / 1 h / 0 °C / Large scale 4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale 5: hydrogenchloride; Dihydroxy-isobutyl-boran / hexane; 1,1,1-trideuteromethanol; water / 0 - 20 °C / Large scale View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogenchloride / tert-butyl methyl ether / -40 - 20 °C / Inert atmosphere 2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / -40 - -11 °C 3.1: hydrogenchloride; Dihydroxy-isobutyl-boran / water; methanol; n-heptane / 20 °C 3.2: 20 °C 4.1: hydrogenchloride / water; methanol / 20 °C View Scheme |
velcade
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale 2: hydrogenchloride / toluene / 1 h / 0 °C / Large scale 3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale 4: hydrogenchloride; Dihydroxy-isobutyl-boran / hexane; 1,1,1-trideuteromethanol; water / 0 - 20 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1.1: dichloromethane / 0.08 h / 0 °C / Inert atmosphere 1.2: 1 h / -3 - 2 °C 1.3: 0.25 h / 15 - 27 °C 2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / toluene / 0.17 h / Inert atmosphere 2.2: 3 h / 25 °C 3.1: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; n-heptane / 12 h / 20 °C View Scheme |
velcade
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / toluene / 1 h / 0 °C / Large scale 2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale 3: hydrogenchloride; Dihydroxy-isobutyl-boran / hexane; 1,1,1-trideuteromethanol; water / 0 - 20 °C / Large scale View Scheme |
velcade
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Large scale 2: hydrogenchloride; Dihydroxy-isobutyl-boran / hexane; 1,1,1-trideuteromethanol; water / 0 - 20 °C / Large scale View Scheme |
velcade
Conditions | Yield |
---|---|
With hydrogenchloride; Dihydroxy-isobutyl-boran In hexane; 1,1,1-trideuteromethanol; water at 0 - 20℃; Concentration; Temperature; Large scale; |
N-tert-butoxycarbonyl-L-phenylalanine
velcade
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dichloromethane / 0.08 h / 0 °C / Inert atmosphere 1.2: 1 h / -3 - 2 °C 1.3: 0.25 h / 15 - 27 °C 2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / toluene / 0.17 h / Inert atmosphere 2.2: 3 h / 25 °C 3.1: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; n-heptane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: N-isopropylethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 2 h / -10 - 5 °C 2: dichloromethane / 25 - 35 °C 3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 0 - 10 °C 4: Dihydroxy-isobutyl-boran; hydrogenchloride / water / 20 °C View Scheme |
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
velcade
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / 0.33 h / 20 °C / Inert atmosphere 1.2: 4 h / 20 °C / Inert atmosphere 2.1: hydrogenchloride; Dihydroxy-isobutyl-boran / n-heptane; water; methanol / 1.5 h / 20 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / -40 - -11 °C 2.1: hydrogenchloride; Dihydroxy-isobutyl-boran / water; methanol; n-heptane / 20 °C 2.2: 20 °C 3.1: hydrogenchloride / water; methanol / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -10 - -5 °C 2: hydrogenchloride / water; acetone / 20 °C View Scheme |
velcade
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / 0.33 h / 20 °C / Inert atmosphere 1.2: 4 h / 20 °C / Inert atmosphere 2.1: hydrogenchloride; Dihydroxy-isobutyl-boran / n-heptane; water; methanol / 1.5 h / 20 - 30 °C View Scheme |
velcade
Conditions | Yield |
---|---|
With hydrogenchloride; Dihydroxy-isobutyl-boran In methanol; n-heptane; water at 20 - 30℃; for 1.5h; | 4.2 g |
Conditions | Yield |
---|---|
With hydrogenchloride In hexane; acetonitrile |
velcade
Pyrazine-2-carboxylic acid [(S)-1-((R)-1-hydroxy-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]-amide
Conditions | Yield |
---|---|
With dihydrogen peroxide In ethanol; water at 20℃; for 1h; Oxidation; hydrolysis; | 100% |
With hydrogenchloride; oxygen In ethanol; water at 25℃; for 336h; pH=2.8; Kinetics; Product distribution; Further Variations:; with/without ascorbic acid; Oxidation; hydrolysis; | |
With oxygen In ethanol; water at 25℃; for 5844h; pH=6.9; Kinetics; Product distribution; Further Variations:; with/without EDTA; Oxidation; hydrolysis; |
Conditions | Yield |
---|---|
In chloroform-d1 at 45℃; | 95% |
Conditions | Yield |
---|---|
In toluene for 3h; Inert atmosphere; Reflux; | 91.2% |
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 25℃; | 80% |
velcade
bortezomib
Conditions | Yield |
---|---|
In isopropyl alcohol; acetonitrile at 20℃; for 4h; Product distribution / selectivity; | 76.9% |
citric acid
velcade
Conditions | Yield |
---|---|
In ethyl acetate at 20 - 74℃; for 3h; | 71.1% |
Conditions | Yield |
---|---|
In chloroform-d1 | 70% |
velcade
B
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With sodium hydroxide; oxygen In dimethyl sulfoxide at 70℃; for 250h; pH=12.0; Kinetics; Product distribution; Oxidation; hydrolysis; | |
With sodium hydroxide; oxygen at 70℃; for 48h; pH=12; Oxidation; hydrolysis; |
velcade
B
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
C
Pyrazine-2-carboxylic acid [(S)-1-((R)-1-hydroxy-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]-amide
Conditions | Yield |
---|---|
With dihydrogen peroxide In water at 20℃; for 1h; Kinetics; Product distribution; Further Variations:; Solvents; Oxidation; hydrolysis; |
velcade
(S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]propanoic acid
Conditions | Yield |
---|---|
With hydrogenchloride; oxygen In dimethyl sulfoxide at 70℃; for 250h; pH=1.0; Kinetics; Product distribution; Oxidation; hydrolysis; | |
With hydrogenchloride; oxygen at 70℃; for 120h; pH=1.0; Oxidation; hydrolysis; |
Conditions | Yield |
---|---|
With sodium dihydrogenphosphate; sodium hydroxide In dimethylsulfoxide-d6; water-d2 for 1h; pH=7.4; |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View