1. GMP AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Micro powder / Crude powder can be made to order EP/USP both ok Package:25kg/drum Application:active pharmaceutical ingredient Transportation:as request P
We can provide high quality,cheap price,spot supply and good service. If you have any questions,pls do not hesitate to contact us. Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&am
Cas:366789-02-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHubei Lidu New Materials Technology Co. , Ltd. is located in No. 12,3C Industrial Park, Zhongxiang Economic Development Zone, Hubei Province. The company is committed to fine chemical raw materials, pharmaceutical intermediates and other production,
high quality ,iso , cgmp . accept the supplier audit . in stock now ,capacity is flexible support the documents Appearance:white powder Storage: protect from light seal room temperature Package:DRUM Application:API Port:SHANGHAI
Senova supply high quality Rivaroxaban with competitive prices ~ The main specification Application:Anticoagulation
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:366789-02-8
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:366789-02-8
Min.Order:1 Kilogram
FOB Price: $1.0 / 999.0
Type:Trading Company
inquiryTEST ITEMS STANDARD RESULTS Appearance White to off-white crystalline powder Off-White crystalline powder
Cas:366789-02-8
Min.Order:1 Kilogram
FOB Price: $1.0 / 5.0
Type:Manufacturers
inquiryBasic Information of Rivaroxaban Powder Product Name Rivaroxaban Powder Other Name BAY-59-7939
Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shangha
Cas:366789-02-8
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryUnique advantages for Rivaroxaban Cas 366789-02-8 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Refrigerator Package:100g,1kg/foil bag;25kg/drum
Cas:366789-02-8
Min.Order:100 Gram
FOB Price: $2.0 / 3.0
Type:Trading Company
inquiryHebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. Main products are Titanium dioxide(CAS13463-67-7). Lead a
Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
Cas:366789-02-8
Min.Order:10 Gram
FOB Price: $29.0 / 33.9
Type:Manufacturers
inquirySpecifications Rivaroxaban 1.GMP Manufacturer 2.High Quality and Competitive Price. 3.Prompt Shipment Appearance:White crystal powder Storage:dry environment Package:25kg/drum or as your needs Application:Blood System Agents, Cardiovasc
Cas:366789-02-8
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiryRivaroxaban[CAS:366789-02-8] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, think
Cas:366789-02-8
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:366789-02-8
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryOur products are of good quality, exquisite workmanship and reasonable price, and our after-sales service is good, which can be guaranteed. Our chief line is the export of API. We have been in this line of API since 2005. Many of our products are be
Basic information Product Name: Rivaroxaban Synonyms: (S)-Rivaroxaban;(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiophene-2-carbox;RIVAROXABAN STAGE-IV [5-CHLORO-N-({5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLIN
Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:366789-02-8
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryName:Rivaroxaban The alias:Rivaroxaban intermediate CAS NO: 366789-02-8 Molecular formula:C19H18ClN3O5S Molecular weight:435.8813 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data
Cas:366789-02-8
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryTIANFUCHEM--366789-02-8-- Rivaroxaban in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationship
Cas:366789-02-8
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:366789-02-8
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:366789-02-8
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Name: 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide CAS: 366789-02-8 MF: C19H18ClN3O5S Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25kg Ap
Cas:366789-02-8
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:366789-02-8
Min.Order:10 Gram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:366789-02-8
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:366789-02-8
Min.Order:10 Gram
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Type:Trading Company
inquiry4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
5-chlorothiophene-2-carbonyl chloride
Rivaroxaban
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; for 3h; Product distribution / selectivity; | 100% |
With triethylamine In tetrahydrofuran at 20℃; for 3h; Reagent/catalyst; Solvent; Time; Concentration; Temperature; | 100% |
With sodium carbonate In water; acetone; toluene at 8 - 53℃; for 0.5h; | 98.7% |
5-chlorothiophene-2-carbonyl chloride
Rivaroxaban
Conditions | Yield |
---|---|
With sodium carbonate In water; acetone at 10 - 50℃; for 0.5h; | 97.5% |
Rivaroxaban
Conditions | Yield |
---|---|
With potassium carbonate In methanol at 20℃; for 2h; | 97% |
Conditions | Yield |
---|---|
In ethanol at 36℃; for 7h; Solvent; | 96.4% |
5-Chlorothiophene-2-carboxylic acid
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Rivaroxaban
Conditions | Yield |
---|---|
Stage #1: 5-Chlorothiophene-2-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 25℃; for 0.5h; Stage #2: 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride In N,N-dimethyl-formamide at 34℃; for 4h; | 96.3% |
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 2.83333h; Reagent/catalyst; Cooling with ice; | 95.2% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 24h; pH=8 - 9; Large scale; | 94.7% |
5-chlorothiophene-2-carbonyl chloride
4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one methanesulfonic acid salt
Rivaroxaban
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In ethanol; water; butanone at 20 - 35℃; for 0.75h; Large scale; | 96% |
With triethylamine In 1-methyl-pyrrolidin-2-one; toluene at 50 - 60℃; for 0.25h; | 81% |
5-chlorothiophene-2-carbonyl chloride
Rivaroxaban
Conditions | Yield |
---|---|
Stage #1: 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride With sodium carbonate In water; acetone at 8 - 12℃; Stage #2: 5-chlorothiophene-2-carbonyl chloride In water; acetone at 50 - 53℃; for 0.5h; Temperature; | 95.6% |
With triethylamine In N,N-dimethyl-formamide at 30 - 40℃; for 5h; | 150.1 g |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
5-Chlorothiophene-2-carboxylic acid
Rivaroxaban
Conditions | Yield |
---|---|
With 4-methyl-morpholine; hydrogenchloride In water; N,N-dimethyl-formamide at 20℃; for 2.83333h; | 95.2% |
With ortho-iodophenylboronic acid In dichloromethane at 30℃; for 48h; Reagent/catalyst; Time; Concentration; Temperature; Solvent; Dean-Stark; | 85% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; | 68.9% |
5-chloro-N-{(R)‐2‐hydroxy‐3‐[4‐(3-oxo-4-morpholinyl)phenylamino]-propyl}thiophene-2-carboxamide
1,1'-carbonyldiimidazole
Rivaroxaban
Conditions | Yield |
---|---|
With dmap In acetone at 100℃; for 6h; | 95.1% |
In 1-methyl-pyrrolidin-2-one; toluene at 20 - 115℃; for 1.33333h; | 91.5% |
In 1-methyl-pyrrolidin-2-one; toluene at 20 - 110℃; for 3.5h; Inert atmosphere; | 90% |
5-chlorothiophene-2-carbonyl chloride
Rivaroxaban
Conditions | Yield |
---|---|
With sodium carbonate In water; acetone at 10 - 50℃; for 0.5h; | 95% |
With triethylamine In ethyl acetate at 10 - 20℃; for 1h; | 10 g |
5-chloro-N-{(R)‐2‐hydroxy‐3‐[4‐(3-oxo-4-morpholinyl)phenylamino]-propyl}thiophene-2-carboxamide
bis(trichloromethyl) carbonate
Rivaroxaban
Conditions | Yield |
---|---|
With potassium carbonate In water; acetonitrile at 5 - 40℃; Solvent; Temperature; | 95% |
5-Chlorothiophene-2-carboxylic acid
Rivaroxaban
Conditions | Yield |
---|---|
Stage #1: 5-Chlorothiophene-2-carboxylic acid; 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate at 10 - 25℃; for 12.5h; Stage #2: With water In ethyl acetate for 1h; | 94% |
5-chlorothiophene-2-carbonyl chloride
Rivaroxaban
Conditions | Yield |
---|---|
Stage #1: (S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one hydrobromide With sodium carbonate In dichloromethane at 20℃; for 1h; Stage #2: 5-chlorothiophene-2-carbonyl chloride In dichloromethane at 0 - 20℃; for 5h; Reagent/catalyst; | 93.4% |
5-chlorothiophene-2-carboxylic acid chloride
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Rivaroxaban
Conditions | Yield |
---|---|
With triethylamine In water; acetone; toluene at 30 - 35℃; for 2h; Temperature; Concentration; | 93.3% |
5-chlorothiophene-2-carbonyl chloride
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
Rivaroxaban
Conditions | Yield |
---|---|
With sodium carbonate In water; acetone; toluene at 8 - 53℃; | 93.12% |
With sodium carbonate In water; acetone; toluene at 10 - 53℃; for 0.5h; High pressure; | 90% |
With potassium carbonate In dichloromethane at 25 - 30℃; for 5h; | 88% |
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide for 6h; Reflux; | 93.1% |
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
5-Chlorothiophene-2-carboxylic acid
Rivaroxaban
Conditions | Yield |
---|---|
Stage #1: 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione With methylamine In ethanol; water at 60℃; for 3h; Stage #2: 5-Chlorothiophene-2-carboxylic acid With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In ethanol; water at 25℃; for 12h; Solvent; Temperature; | 92.8% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Rivaroxaban
Conditions | Yield |
---|---|
With triethylamine at 10 - 25℃; | 90.3% |
5-chlorothiophene-2-carbonyl chloride
Rivaroxaban
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 10 - 20℃; for 1h; Large scale; | 90% |
Rivaroxaban
Conditions | Yield |
---|---|
With trichloroisocyanuric acid In acetic acid at 20 - 40℃; for 2h; | 90% |
5-chlorothiophene-2-carbonyl chloride
4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one oxalate
Rivaroxaban
Conditions | Yield |
---|---|
With sodium carbonate In water; acetone; toluene at 50 - 55℃; for 1h; Temperature; Time; | 89.9% |
5-Chlorothiophene-2-carboxylic acid
4-{4-[(5S)-aminomethyI-2-oxo-1,3-oxazolidine-3-yl]-phenyl}-morphoIine-3-one acetate
Rivaroxaban
Conditions | Yield |
---|---|
With potassium carbonate; 1,1'-carbonyldiimidazole In water; acetonitrile at 50 - 55℃; Product distribution / selectivity; | 89% |
Rivaroxaban
Conditions | Yield |
---|---|
With lithium tert-butoxide In tetrahydrofuran at 0℃; for 1h; | 88.5% |
toluene-4-sulfonic acid (S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-2-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyloxy]-propyl ester
Rivaroxaban
Conditions | Yield |
---|---|
With lithium tert-butoxide In tetrahydrofuran at 0℃; for 1h; Inert atmosphere; | 88.5% |
5-chlorothiophene-2-carbonyl chloride
4-{4-[(5S)-aminomethyI-2-oxo-1,3-oxazolidine-3-yl]-phenyl}-morphoIine-3-one acetate
Rivaroxaban
Conditions | Yield |
---|---|
With sodium carbonate; acetone In water; toluene at 8 - 55℃; Product distribution / selectivity; | 88% |
5-chloro-thiophene-2-carboxylic acid-1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-{methoxycarbonyl-[4-(3-oxo-morpholin-4-yl)-phenyl]-amino}-ethyl ester
Rivaroxaban
Conditions | Yield |
---|---|
With potassium carbonate; methylamine In water; isopropyl alcohol at 60℃; for 15h; Product distribution / selectivity; | 86% |
5-chlorothiophene-2-carbonyl chloride
4-{4-[5-aminomethyI-2-oxo-1,3-oxazolidine-3-yl]-phenyl}-morphoIine-3-one acetate
Rivaroxaban
Conditions | Yield |
---|---|
With sodium carbonate; acetone In water; toluene at 8 - 53℃; | 86% |
5-chlorothiophene-2-carbonyl chloride
4-{4-[(S)-5-[(((4-chlorophenyl)methylene)amino)methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one
Rivaroxaban
Conditions | Yield |
---|---|
Stage #1: 4-{4-[(S)-5-[(((4-chlorophenyl)methylene)amino)methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one With hydrogenchloride In water; ethyl acetate at 20℃; for 2h; Stage #2: 5-chlorothiophene-2-carbonyl chloride With sodium hydroxide In dichloromethane; water at 20℃; for 4h; pH=7 - 8; | 83% |
Stage #1: 4-{4-[(S)-5-[(((4-chlorophenyl)methylene)amino)methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one With hydrogenchloride In water; ethyl acetate at 20℃; for 2h; Stage #2: 5-chlorothiophene-2-carbonyl chloride With sodium hydroxide In dichloromethane at 20℃; for 4h; pH=7 - 8; | 83% |
Stage #1: 4-{4-[(S)-5-[(((4-chlorophenyl)methylene)amino)methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one With hydrogenchloride; water In dichloromethane for 1.5h; Stage #2: With sodium hydroxide In dichloromethane; water pH=9 - 10; Cooling with ice; Stage #3: 5-chlorothiophene-2-carbonyl chloride In dichloromethane; water at 20℃; for 0.5h; Time; pH-value; Cooling with ice; | 36.0 g |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
4-nitrophenyl 5-chlorothiophene-2-carboxylate
Rivaroxaban
Conditions | Yield |
---|---|
With triethylamine In dimethyl sulfoxide at 35 - 40℃; Reagent/catalyst; Solvent; Temperature; | 82.7% |
With triethylamine In dimethyl sulfoxide; acetonitrile at 35 - 40℃; | 82.7% |
Conditions | Yield |
---|---|
at 60℃; for 2h; Temperature; | 98% |
Rivaroxaban
2-[2-({4-[(5S)-5-{[(5-chlorothiophen-2-yl)formamido]methyl}-2-oxo-1,3-oxazolidin-3-yl]phenyl}amino)ethoxy]acetic acid
Conditions | Yield |
---|---|
With hydrogenchloride; acetic acid In water at 60℃; for 5h; | 92.2% |
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