Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryAppearance:Off-White solid Storage:Sealed in dry,Room Temperature Application:4-Phenyl-3-morpholinone is used in studies to evaluate the bactericidal activity Port:QINGDAO
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediate
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inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquirySupply top quality products with a reasonable price Application:api
4-Phenyl-3-morpholinoneAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiry4-phenyl-3-morpholinone
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 6h; Solvent; Reflux; | 97% |
4-Phenylmorpholine
4-phenyl-3-morpholinone
Conditions | Yield |
---|---|
Stage #1: 4-Phenylmorpholine With sodium dihydrogenphosphate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In acetonitrile at 0℃; for 0.0833333h; Stage #2: With sodium hypochlorite; sodium chlorite In water; acetonitrile | 90% |
With potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane for 6h; phase transfer oxidation; Heating; | 45% |
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 0 - 38℃; for 2h; pH=12 - 12.5; | 89% |
With sodium hydroxide In ethanol; water at 2 - 43℃; pH=12 - 12.5; | 80% |
With sodium hydroxide In ethanol; water at 38 - 45℃; for 0.5h; pH=10 - 13; Industry scale; | 68% |
4-phenyl-3-morpholinone
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 8h; | 85% |
Conditions | Yield |
---|---|
With caesium carbonate at 120℃; for 14h; Goldberg Reaction; Schlenk technique; Inert atmosphere; | 85% |
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran at 38℃; for 16h; Inert atmosphere; | 83% |
With potassium 2-methylpropan-2-olate In tetrahydrofuran at 25℃; for 16h; | 62% |
4-phenyl-3-morpholinone
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 8h; | 81% |
4-Phenylmorpholine
A
4-phenyl-3-morpholinone
B
2-(N-phenylformamido)ethyl formate
Conditions | Yield |
---|---|
With ozone In acetonitrile at 25℃; for 24h; Mechanism; Solvent; Temperature; regioselective reaction; | A 46% B 8% |
chloroacetic acid ethyl ester
4-phenyl-3-morpholinone
Conditions | Yield |
---|---|
With toluene |
Acetanilid
4-phenyl-3-morpholinone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: nitric acid; acetic acid; sulfuric acid / 2 h / 0 - 25 °C 2: potassium carbonate / tetrahydrofuran / 4 h / 0 - 55 °C 3: potassium carbonate / acetonitrile / 6 h / Reflux View Scheme |
4-nitro-aniline
4-phenyl-3-morpholinone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / tetrahydrofuran / 4 h / 0 - 55 °C 2: potassium carbonate / acetonitrile / 6 h / Reflux View Scheme |
aniline
4-phenyl-3-morpholinone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 4 h / 0 - 25 °C 2: potassium carbonate / acetonitrile / 6 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 4 h / 0 - 5 °C 2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / tert-butyl methyl ether / 4 h / 0 - 5 °C 2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium acetate; acetic acid / 0.5 h / 20 °C / Large scale 2: nitric acid; acetic acid; sulfuric acid / 2 h / 0 - 25 °C 3: potassium carbonate / tetrahydrofuran / 4 h / 0 - 55 °C 4: potassium carbonate / acetonitrile / 6 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: acetone / 15 h / Cooling with ice 2: potassium tert-butylate / tetrahydrofuran / 16 h / 38 °C / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
Stage #1: oxirane; aniline Stage #2: With potassium carbonate In N,N-dimethyl-formamide at 0 - 60℃; for 4h; |
4-phenyl-3-morpholinone
4-(4-nitrophenyl)-3-morpholinone
Conditions | Yield |
---|---|
With nitric acid; acetic anhydride at 0 - 25℃; for 5h; | 85% |
With sulfuric acid; nitric acid at -10℃; for 1h; | 83% |
With sulfuric acid; nitric acid at -10℃; for 1h; | 83% |
4-phenyl-3-morpholinone
4-(4-bromophenyl)morpholin-3-one
Conditions | Yield |
---|---|
With bis-[(trifluoroacetoxy)iodo]benzene; sodium bromide In ethanol at 25℃; for 12h; Green chemistry; regioselective reaction; | 60% |
4-phenyl-3-morpholinone
ethyl 4-methoxybenzoate
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane In tetrahydrofuran at 0 - 20℃; Claisen Condensation; Inert atmosphere; | 42% |
4-phenyl-3-morpholinone
benzaldehyde
2-<1-hydroxy-1-phenylmethyl>-4-phenyl-3-morpholinone
Conditions | Yield |
---|---|
With lithium diisopropyl amide 1.) 30 min., -78 deg C, THF, 2.) 1 h, -78 to -30 deg C; Yield given. Multistep reaction; |
4-phenyl-3-morpholinone
benzaldehyde
Conditions | Yield |
---|---|
Stage #1: 4-phenylmorpholin-3-one With lithium diisopropyl amide In tetrahydrofuran; hexane at -80℃; for 0.25h; Metallation; Stage #2: benzaldehyde In tetrahydrofuran at -80℃; for 0.25h; α-hydroxyalkylation; Title compound not separated from byproducts; |
4-phenyl-3-morpholinone
4-(4-aminophenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C 2: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C View Scheme | |
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid / 1 h / -10 °C 2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid / water 2: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C View Scheme |
4-phenyl-3-morpholinone
Rivaroxaban
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C 2.1: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C 3.1: water / ethanol / 36 h / 60 °C / Industry scale 4.1: toluene / 3 h / Industry scale; Reflux 5.1: methylamine / ethanol / 4 h / 65 °C / Industry scale 5.2: 58 - 60 °C / pH 2.7 / Industry scale 6.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Industry scale 6.2: 2.5 h / 0 - 25 °C View Scheme | |
Multi-step reaction with 8 steps 1.1: nitric acid; sulfuric acid / 1 h / -10 °C 2.1: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr 3.1: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C 4.1: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C 5.1: triethylamine / dichloromethane / 4 h / 20 °C 6.1: isopropyl alcohol / 12 h / 120 °C 7.1: triethylamine / dichloromethane / 24 h / 20 °C 8.1: hydrogenchloride / ethyl acetate / 2 h / 55 °C 8.2: pH 9 View Scheme | |
Multi-step reaction with 7 steps 1.1: nitric acid; sulfuric acid / 1 h / -10 °C 2.1: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr 3.1: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C 4.1: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C 5.1: triethylamine / dichloromethane / 4 h / 20 °C 6.1: isopropyl alcohol / 12 h / 120 °C 7.1: triethylamine / toluene / 2 h / 120 °C 7.2: 4 h / 55 °C 7.3: 20 °C / pH 9 View Scheme |
4-phenyl-3-morpholinone
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C 2.1: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C 3.1: water / ethanol / 36 h / 60 °C / Industry scale 4.1: toluene / 3 h / Industry scale; Reflux 5.1: methylamine / ethanol / 4 h / 65 °C / Industry scale 5.2: 58 - 60 °C / pH 2.7 / Industry scale View Scheme | |
Multi-step reaction with 6 steps 1: sulfuric acid; nitric acid / water 2: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C 3: toluene / 20 °C / Reflux 4: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere 5: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C 6: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h View Scheme |
4-phenyl-3-morpholinone
2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C 2: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C 3: water / ethanol / 36 h / 60 °C / Industry scale View Scheme | |
Multi-step reaction with 3 steps 1: sulfuric acid; nitric acid / 2.5 h / 0 - 5 °C 2: hydrogen; palladium on activated charcoal / dichloromethane / 25 - 80 °C / Inert atmosphere; Autoclave 3: 18 h / 75 - 80 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sulfuric acid / 0.25 h / 0 - 5 °C 1.2: 2.5 h / 0 - 5 °C 2.1: palladium on activated charcoal; hydrogen / dichloromethane / 75 - 80 °C / 3750.38 Torr / Autoclave; Inert atmosphere 3.1: ethanol / 18 h / 75 - 80 °C View Scheme |
4-phenyl-3-morpholinone
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C 2: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C 3: water / ethanol / 36 h / 60 °C / Industry scale 4: toluene / 3 h / Industry scale; Reflux View Scheme | |
Multi-step reaction with 4 steps 1: sulfuric acid; nitric acid / 2.5 h / 0 - 5 °C 2: hydrogen; palladium on activated charcoal / dichloromethane / 25 - 80 °C / Inert atmosphere; Autoclave 3: 18 h / 75 - 80 °C 4: dmap / dichloromethane / 40 - 45 °C View Scheme | |
Multi-step reaction with 7 steps 1: sulfuric acid; nitric acid / 2.5 h / 0 - 5 °C 2: hydrogen; palladium on activated charcoal / dichloromethane / 25 - 80 °C / Inert atmosphere; Autoclave 3: ethanol / 12 h / 75 - 80 °C 4: dmap / dichloromethane / 40 - 45 °C 5: water; sodium hydroxide / methanol / 1 h / 60 - 65 °C 6: triethylamine / dichloromethane / 24 h / 25 - 35 °C 7: potassium carbonate / N,N-dimethyl-formamide / 10 h / 25 - 45 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sulfuric acid / 0.25 h / 0 - 5 °C 1.2: 2.5 h / 0 - 5 °C 2.1: palladium on activated charcoal; hydrogen / dichloromethane / 75 - 80 °C / 3750.38 Torr / Autoclave; Inert atmosphere 3.1: ethanol / 18 h / 75 - 80 °C 4.1: dmap / dichloromethane / 40 - 45 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: sulfuric acid / 0.25 h / 0 - 5 °C 1.2: 2.5 h / 0 - 5 °C 2.1: palladium on activated charcoal; hydrogen / dichloromethane / 75 - 80 °C / 3750.38 Torr / Autoclave; Inert atmosphere 3.1: water; ethanol / 12 h / 25 - 80 °C 4.1: dmap / dichloromethane / 25 - 45 °C 5.1: sodium hydroxide; water / methanol / 1 h / 25 - 65 °C 6.1: triethylamine / dichloromethane / 24 h / 25 - 35 °C 7.1: hydrogenchloride; potassium carbonate / N,N-dimethyl-formamide / 10 h / 25 - 45 °C View Scheme |
4-phenyl-3-morpholinone
[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: nitric acid; sulfuric acid / 1 h / -10 °C 2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr 3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C View Scheme |
4-phenyl-3-morpholinone
4-{4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: nitric acid; sulfuric acid / 1 h / -10 °C 2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr 3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C 4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: sulfuric acid; nitric acid / 2.5 h / 0 - 5 °C 2: hydrogen; palladium on activated charcoal / dichloromethane / 25 - 80 °C / Inert atmosphere; Autoclave 3: ethanol / 12 h / 75 - 80 °C 4: dmap / dichloromethane / 40 - 45 °C 5: water; sodium hydroxide / methanol / 1 h / 60 - 65 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: sulfuric acid / 0.25 h / 0 - 5 °C 1.2: 2.5 h / 0 - 5 °C 2.1: palladium on activated charcoal; hydrogen / dichloromethane / 75 - 80 °C / 3750.38 Torr / Autoclave; Inert atmosphere 3.1: water; ethanol / 12 h / 25 - 80 °C 4.1: dmap / dichloromethane / 25 - 45 °C 5.1: sodium hydroxide; water / methanol / 1 h / 25 - 65 °C View Scheme |
4-phenyl-3-morpholinone
R-(2-oxo-3-((4-(3-oxo-morpholinyl)phenyl)oxazolidin-5-yl))methylmethanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: nitric acid; sulfuric acid / 1 h / -10 °C 2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr 3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C 4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C 5: triethylamine / dichloromethane / 4 h / 20 °C View Scheme |
4-phenyl-3-morpholinone
4-(4-((S)-5-(tert-butylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: nitric acid; sulfuric acid / 1 h / -10 °C 2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr 3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C 4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C 5: triethylamine / dichloromethane / 4 h / 20 °C 6: isopropyl alcohol / 12 h / 120 °C View Scheme | |
Multi-step reaction with 7 steps 1: nitric acid; sulfuric acid / 1 h / -10 °C 2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr 3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C 4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C 5: triethylamine / dichloromethane / 4 h / 20 °C 6: N,N-dimethyl-formamide / 24 h / 80 °C 7: sodium hydrogencarbonate / ethyl acetate View Scheme |
4-phenyl-3-morpholinone
4-(4-((S)-5-(tert-octylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: nitric acid; sulfuric acid / 1 h / -10 °C 2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr 3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C 4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C 5: triethylamine / dichloromethane / 4 h / 20 °C 6: isopropyl alcohol / 0 - 120 °C View Scheme |
4-phenyl-3-morpholinone
5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: nitric acid; sulfuric acid / 1 h / -10 °C 2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr 3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C 4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C 5: triethylamine / dichloromethane / 4 h / 20 °C 6: isopropyl alcohol / 12 h / 120 °C 7: triethylamine / dichloromethane / 24 h / 20 °C View Scheme | |
Multi-step reaction with 8 steps 1: nitric acid; sulfuric acid / 1 h / -10 °C 2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr 3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C 4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C 5: triethylamine / dichloromethane / 4 h / 20 °C 6: N,N-dimethyl-formamide / 24 h / 80 °C 7: sodium hydrogencarbonate / ethyl acetate 8: triethylamine / dichloromethane / 24 h / 20 °C View Scheme |
4-phenyl-3-morpholinone
5-chloro-N-tert-octyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: nitric acid; sulfuric acid / 1 h / -10 °C 2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr 3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C 4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C 5: triethylamine / dichloromethane / 4 h / 20 °C 6: isopropyl alcohol / 0 - 120 °C 7: dmap; triethylamine / toluene / 10 h / Inert atmosphere; Reflux View Scheme |
4-phenyl-3-morpholinone
4-(4-((S)-5-(tert-butylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one methanesulfonic salt
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: nitric acid; sulfuric acid / 1 h / -10 °C 2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr 3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C 4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C 5: triethylamine / dichloromethane / 4 h / 20 °C 6: N,N-dimethyl-formamide / 24 h / 80 °C View Scheme |
4-phenyl-3-morpholinone
4-{4-[(5R)-5-(chloromethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid; nitric acid / water 2: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C 3: toluene / 20 °C / Reflux 4: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere View Scheme |
4-phenyl-3-morpholinone
4-{4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sulfuric acid; nitric acid / water 2: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C 3: toluene / 20 °C / Reflux 4: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere 5: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C View Scheme |
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