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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-phenyl-3-Morpholinone

Cas:29518-11-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-phenylmorpholin-3-one

Cas:29518-11-4

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Phenyl-3-morpholinone

Cas:29518-11-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-Morpholinone, 4-phenyl- CAS:29518-11-4

Cas:29518-11-4

Min.Order:1 Kilogram

FOB Price: $5.0 / 20.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Discount price CAS 29518-11-4 with best quality

Cas:29518-11-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

3-Morpholinone,4-phenyl-/ LIDE PHARMA- Factory supply / Best price

Cas:29518-11-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

3-Morpholinone,4-phenyl-

Cas:29518-11-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Morpholinone,4-phenyl-

Cas:29518-11-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:Off-White solid Storage:Sealed in dry,Room Temperature Application:4-Phenyl-3-morpholinone is used in studies to evaluate the bactericidal activity Port:QINGDAO

3-Morpholinone, 4-phenyl-

Cas:29518-11-4

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Morpholinone, 4-phenyl-

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

3-Morpholinone, 4-phenyl-

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

29518-11-4 CAS NO.29518-11-4

Cas:29518-11-4

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Suzhou Lipin chemical Co., Ltd.

high quality ,iso , cgmp . accept the supplier audit . in stock now ,capacity is flexible support the documents Appearance:Purple to white powder Storage: protect from light seal room temperature Package:DRUM Application:impurity key interm

3-Morpholinone, 4-phenyl

Cas:29518-11-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-Phenyl-3-morpholinone

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediate

4-Phenyl-3-morpholinone

Cas:29518-11-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-phenyl-morpholin-3-one Cas.no 29518-11-4 98%

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, in

Enke 4-Phenyl-3-morpholinone

Cas:29518-11-4

Min.Order:1 Kilogram

FOB Price: $300.0 / 400.0

Type:Lab/Research institutions

inquiry

Suzhou Sibian Chemical Technology Co., Ltd

The process is mature and can be mass produced to 100 kg, with good quality and purity up to 99%.The product has a large stock and can be supplied stably. Package:bottle Application:Drug R&D Transportation:Sealed drying(25℃) Port:ShangHai

3-Morpholinone, 4-phenyl-

Cas:29518-11-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

4-phenyl-3-Morpholinone

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-phenylmorpholin-3-one

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

3-Morpholinone, 4-phenyl-

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high qualityAppearance:white crystalline powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Methyl thiazole-5-carboxylate

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

3-Morpholinone,4-phenyl-

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

3-Morpholinone,4-phenyl-

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

3-Morpholinone, 4-phenyl-

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

4-Phenylmorpholin-3-one

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

29518-11-4

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

4-Phenyl-3-morpholinoneAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

4-Phenyl-3-morpholinone

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-Morpholinone, 4-phenyl-

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

29518-11-4 Application:intermediate

4-phenylmorpholin-3-one

Cas:29518-11-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-(2-chloroethoxy)-N-phenylacetamide

2-(2-chloroethoxy)-N-phenylacetamide

4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 6h; Solvent; Reflux;97%
4-Phenylmorpholine
92-53-5

4-Phenylmorpholine

4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

Conditions
ConditionsYield
Stage #1: 4-Phenylmorpholine With sodium dihydrogenphosphate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In acetonitrile at 0℃; for 0.0833333h;
Stage #2: With sodium hypochlorite; sodium chlorite In water; acetonitrile
90%
With potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane for 6h; phase transfer oxidation; Heating;45%
chloroacetyl chloride
79-04-9

chloroacetyl chloride

2-Anilinoethanol
122-98-5

2-Anilinoethanol

4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 0 - 38℃; for 2h; pH=12 - 12.5;89%
With sodium hydroxide In ethanol; water at 2 - 43℃; pH=12 - 12.5;80%
With sodium hydroxide In ethanol; water at 38 - 45℃; for 0.5h; pH=10 - 13; Industry scale;68%
2-(2-((methylsulfonyl)oxy)ethoxy)-N-phenylacetamide

2-(2-((methylsulfonyl)oxy)ethoxy)-N-phenylacetamide

4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 8h;85%
morpholine-3-one
109-11-5

morpholine-3-one

iodobenzene
591-50-4

iodobenzene

4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

Conditions
ConditionsYield
With caesium carbonate at 120℃; for 14h; Goldberg Reaction; Schlenk technique; Inert atmosphere;85%
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

2-Anilinoethanol
122-98-5

2-Anilinoethanol

4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 38℃; for 16h; Inert atmosphere;83%
With potassium 2-methylpropan-2-olate In tetrahydrofuran at 25℃; for 16h;62%
2-(2-((benzenesulfonyl)oxy)ethoxy)-N-phenylacetamide

2-(2-((benzenesulfonyl)oxy)ethoxy)-N-phenylacetamide

4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 8h;81%
4-Phenylmorpholine
92-53-5

4-Phenylmorpholine

A

4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

B

2-(N-phenylformamido)ethyl formate
13238-43-2

2-(N-phenylformamido)ethyl formate

Conditions
ConditionsYield
With ozone In acetonitrile at 25℃; for 24h; Mechanism; Solvent; Temperature; regioselective reaction;A 46%
B 8%
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

sodium-<2-anilino ethylate>

sodium-<2-anilino ethylate>

4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

Conditions
ConditionsYield
With toluene
Acetanilid
103-84-4

Acetanilid

4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: nitric acid; acetic acid; sulfuric acid / 2 h / 0 - 25 °C
2: potassium carbonate / tetrahydrofuran / 4 h / 0 - 55 °C
3: potassium carbonate / acetonitrile / 6 h / Reflux
View Scheme
4-nitro-aniline
100-01-6

4-nitro-aniline

4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / tetrahydrofuran / 4 h / 0 - 55 °C
2: potassium carbonate / acetonitrile / 6 h / Reflux
View Scheme
aniline
62-53-3

aniline

4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 4 h / 0 - 25 °C
2: potassium carbonate / acetonitrile / 6 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 4 h / 0 - 5 °C
2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / tert-butyl methyl ether / 4 h / 0 - 5 °C
2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium acetate; acetic acid / 0.5 h / 20 °C / Large scale
2: nitric acid; acetic acid; sulfuric acid / 2 h / 0 - 25 °C
3: potassium carbonate / tetrahydrofuran / 4 h / 0 - 55 °C
4: potassium carbonate / acetonitrile / 6 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: acetone / 15 h / Cooling with ice
2: potassium tert-butylate / tetrahydrofuran / 16 h / 38 °C / Inert atmosphere
View Scheme
oxirane
75-21-8

oxirane

aniline
62-53-3

aniline

4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

Conditions
ConditionsYield
Stage #1: oxirane; aniline
Stage #2: With potassium carbonate In N,N-dimethyl-formamide at 0 - 60℃; for 4h;
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

4-(4-nitrophenyl)-3-morpholinone
446292-04-2

4-(4-nitrophenyl)-3-morpholinone

Conditions
ConditionsYield
With nitric acid; acetic anhydride at 0 - 25℃; for 5h;85%
With sulfuric acid; nitric acid at -10℃; for 1h;83%
With sulfuric acid; nitric acid at -10℃; for 1h;83%
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

4-(4-bromophenyl)morpholin-3-one
634905-12-7

4-(4-bromophenyl)morpholin-3-one

Conditions
ConditionsYield
With bis-[(trifluoroacetoxy)iodo]benzene; sodium bromide In ethanol at 25℃; for 12h; Green chemistry; regioselective reaction;60%
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

ethyl 4-methoxybenzoate
94-30-4

ethyl 4-methoxybenzoate

2-(4-methoxybenzoyl)-4-phenylmorpholin-3-one

2-(4-methoxybenzoyl)-4-phenylmorpholin-3-one

Conditions
ConditionsYield
With lithium hexamethyldisilazane In tetrahydrofuran at 0 - 20℃; Claisen Condensation; Inert atmosphere;42%
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

benzaldehyde
100-52-7

benzaldehyde

2-<1-hydroxy-1-phenylmethyl>-4-phenyl-3-morpholinone
353268-54-9

2-<1-hydroxy-1-phenylmethyl>-4-phenyl-3-morpholinone

Conditions
ConditionsYield
With lithium diisopropyl amide 1.) 30 min., -78 deg C, THF, 2.) 1 h, -78 to -30 deg C; Yield given. Multistep reaction;
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

benzaldehyde
100-52-7

benzaldehyde

anti-2-(1-hydroxy-1-phenylmethyl)-4-phenyl-3-morpholinone

anti-2-(1-hydroxy-1-phenylmethyl)-4-phenyl-3-morpholinone

syn-2-(1-hydroxy-1-phenylmethyl)-4-phenyl-3-morpholinone

syn-2-(1-hydroxy-1-phenylmethyl)-4-phenyl-3-morpholinone

Conditions
ConditionsYield
Stage #1: 4-phenylmorpholin-3-one With lithium diisopropyl amide In tetrahydrofuran; hexane at -80℃; for 0.25h; Metallation;
Stage #2: benzaldehyde In tetrahydrofuran at -80℃; for 0.25h; α-hydroxyalkylation; Title compound not separated from byproducts;
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

4-(4-aminophenyl)morpholin-3-one
438056-69-0

4-(4-aminophenyl)morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C
2: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C
View Scheme
Multi-step reaction with 2 steps
1: nitric acid; sulfuric acid / 1 h / -10 °C
2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid; nitric acid / water
2: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

Rivaroxaban
366789-02-8

Rivaroxaban

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C
2.1: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C
3.1: water / ethanol / 36 h / 60 °C / Industry scale
4.1: toluene / 3 h / Industry scale; Reflux
5.1: methylamine / ethanol / 4 h / 65 °C / Industry scale
5.2: 58 - 60 °C / pH 2.7 / Industry scale
6.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Industry scale
6.2: 2.5 h / 0 - 25 °C
View Scheme
Multi-step reaction with 8 steps
1.1: nitric acid; sulfuric acid / 1 h / -10 °C
2.1: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr
3.1: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C
4.1: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C
5.1: triethylamine / dichloromethane / 4 h / 20 °C
6.1: isopropyl alcohol / 12 h / 120 °C
7.1: triethylamine / dichloromethane / 24 h / 20 °C
8.1: hydrogenchloride / ethyl acetate / 2 h / 55 °C
8.2: pH 9
View Scheme
Multi-step reaction with 7 steps
1.1: nitric acid; sulfuric acid / 1 h / -10 °C
2.1: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr
3.1: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C
4.1: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C
5.1: triethylamine / dichloromethane / 4 h / 20 °C
6.1: isopropyl alcohol / 12 h / 120 °C
7.1: triethylamine / toluene / 2 h / 120 °C
7.2: 4 h / 55 °C
7.3: 20 °C / pH 9
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C
2.1: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C
3.1: water / ethanol / 36 h / 60 °C / Industry scale
4.1: toluene / 3 h / Industry scale; Reflux
5.1: methylamine / ethanol / 4 h / 65 °C / Industry scale
5.2: 58 - 60 °C / pH 2.7 / Industry scale
View Scheme
Multi-step reaction with 6 steps
1: sulfuric acid; nitric acid / water
2: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C
3: toluene / 20 °C / Reflux
4: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere
5: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C
6: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione
446292-07-5

2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C
2: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C
3: water / ethanol / 36 h / 60 °C / Industry scale
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid; nitric acid / 2.5 h / 0 - 5 °C
2: hydrogen; palladium on activated charcoal / dichloromethane / 25 - 80 °C / Inert atmosphere; Autoclave
3: 18 h / 75 - 80 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sulfuric acid / 0.25 h / 0 - 5 °C
1.2: 2.5 h / 0 - 5 °C
2.1: palladium on activated charcoal; hydrogen / dichloromethane / 75 - 80 °C / 3750.38 Torr / Autoclave; Inert atmosphere
3.1: ethanol / 18 h / 75 - 80 °C
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
446292-08-6

2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C
2: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C
3: water / ethanol / 36 h / 60 °C / Industry scale
4: toluene / 3 h / Industry scale; Reflux
View Scheme
Multi-step reaction with 4 steps
1: sulfuric acid; nitric acid / 2.5 h / 0 - 5 °C
2: hydrogen; palladium on activated charcoal / dichloromethane / 25 - 80 °C / Inert atmosphere; Autoclave
3: 18 h / 75 - 80 °C
4: dmap / dichloromethane / 40 - 45 °C
View Scheme
Multi-step reaction with 7 steps
1: sulfuric acid; nitric acid / 2.5 h / 0 - 5 °C
2: hydrogen; palladium on activated charcoal / dichloromethane / 25 - 80 °C / Inert atmosphere; Autoclave
3: ethanol / 12 h / 75 - 80 °C
4: dmap / dichloromethane / 40 - 45 °C
5: water; sodium hydroxide / methanol / 1 h / 60 - 65 °C
6: triethylamine / dichloromethane / 24 h / 25 - 35 °C
7: potassium carbonate / N,N-dimethyl-formamide / 10 h / 25 - 45 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sulfuric acid / 0.25 h / 0 - 5 °C
1.2: 2.5 h / 0 - 5 °C
2.1: palladium on activated charcoal; hydrogen / dichloromethane / 75 - 80 °C / 3750.38 Torr / Autoclave; Inert atmosphere
3.1: ethanol / 18 h / 75 - 80 °C
4.1: dmap / dichloromethane / 40 - 45 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sulfuric acid / 0.25 h / 0 - 5 °C
1.2: 2.5 h / 0 - 5 °C
2.1: palladium on activated charcoal; hydrogen / dichloromethane / 75 - 80 °C / 3750.38 Torr / Autoclave; Inert atmosphere
3.1: water; ethanol / 12 h / 25 - 80 °C
4.1: dmap / dichloromethane / 25 - 45 °C
5.1: sodium hydroxide; water / methanol / 1 h / 25 - 65 °C
6.1: triethylamine / dichloromethane / 24 h / 25 - 35 °C
7.1: hydrogenchloride; potassium carbonate / N,N-dimethyl-formamide / 10 h / 25 - 45 °C
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester
1313613-18-1

[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: nitric acid; sulfuric acid / 1 h / -10 °C
2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr
3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

4-{4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one
1117893-60-3

4-{4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: nitric acid; sulfuric acid / 1 h / -10 °C
2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr
3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C
4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: sulfuric acid; nitric acid / 2.5 h / 0 - 5 °C
2: hydrogen; palladium on activated charcoal / dichloromethane / 25 - 80 °C / Inert atmosphere; Autoclave
3: ethanol / 12 h / 75 - 80 °C
4: dmap / dichloromethane / 40 - 45 °C
5: water; sodium hydroxide / methanol / 1 h / 60 - 65 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sulfuric acid / 0.25 h / 0 - 5 °C
1.2: 2.5 h / 0 - 5 °C
2.1: palladium on activated charcoal; hydrogen / dichloromethane / 75 - 80 °C / 3750.38 Torr / Autoclave; Inert atmosphere
3.1: water; ethanol / 12 h / 25 - 80 °C
4.1: dmap / dichloromethane / 25 - 45 °C
5.1: sodium hydroxide; water / methanol / 1 h / 25 - 65 °C
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

R-(2-oxo-3-((4-(3-oxo-morpholinyl)phenyl)oxazolidin-5-yl))methylmethanesulfonate
1117893-61-4

R-(2-oxo-3-((4-(3-oxo-morpholinyl)phenyl)oxazolidin-5-yl))methylmethanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: nitric acid; sulfuric acid / 1 h / -10 °C
2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr
3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C
4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C
5: triethylamine / dichloromethane / 4 h / 20 °C
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

4-(4-((S)-5-(tert-butylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one
1313613-19-2

4-(4-((S)-5-(tert-butylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: nitric acid; sulfuric acid / 1 h / -10 °C
2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr
3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C
4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C
5: triethylamine / dichloromethane / 4 h / 20 °C
6: isopropyl alcohol / 12 h / 120 °C
View Scheme
Multi-step reaction with 7 steps
1: nitric acid; sulfuric acid / 1 h / -10 °C
2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr
3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C
4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C
5: triethylamine / dichloromethane / 4 h / 20 °C
6: N,N-dimethyl-formamide / 24 h / 80 °C
7: sodium hydrogencarbonate / ethyl acetate
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

4-(4-((S)-5-(tert-octylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one
1313613-22-7

4-(4-((S)-5-(tert-octylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: nitric acid; sulfuric acid / 1 h / -10 °C
2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr
3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C
4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C
5: triethylamine / dichloromethane / 4 h / 20 °C
6: isopropyl alcohol / 0 - 120 °C
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide
1313613-21-6

5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: nitric acid; sulfuric acid / 1 h / -10 °C
2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr
3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C
4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C
5: triethylamine / dichloromethane / 4 h / 20 °C
6: isopropyl alcohol / 12 h / 120 °C
7: triethylamine / dichloromethane / 24 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1: nitric acid; sulfuric acid / 1 h / -10 °C
2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr
3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C
4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C
5: triethylamine / dichloromethane / 4 h / 20 °C
6: N,N-dimethyl-formamide / 24 h / 80 °C
7: sodium hydrogencarbonate / ethyl acetate
8: triethylamine / dichloromethane / 24 h / 20 °C
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

5-chloro-N-tert-octyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide
1313613-23-8

5-chloro-N-tert-octyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: nitric acid; sulfuric acid / 1 h / -10 °C
2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr
3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C
4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C
5: triethylamine / dichloromethane / 4 h / 20 °C
6: isopropyl alcohol / 0 - 120 °C
7: dmap; triethylamine / toluene / 10 h / Inert atmosphere; Reflux
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

4-(4-((S)-5-(tert-butylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one methanesulfonic salt
1313613-20-5

4-(4-((S)-5-(tert-butylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one methanesulfonic salt

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: nitric acid; sulfuric acid / 1 h / -10 °C
2: hydrogen / 5% Pd(II)/C(eggshell) / water; tetrahydrofuran / 6.5 h / 70 °C / 2250.23 Torr
3: sodium hydrogencarbonate / water; acetone / 4 h / 20 °C
4: lithium tert-butoxide / tetrahydrofuran / 24 h / 20 °C
5: triethylamine / dichloromethane / 4 h / 20 °C
6: N,N-dimethyl-formamide / 24 h / 80 °C
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

4-{4-[(5R)-5-(chloromethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one
1252018-28-2

4-{4-[(5R)-5-(chloromethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid; nitric acid / water
2: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C
3: toluene / 20 °C / Reflux
4: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

4-{4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one
1349248-79-8

4-{4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sulfuric acid; nitric acid / water
2: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C
3: toluene / 20 °C / Reflux
4: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere
5: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C
View Scheme

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