Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) W
Cas:446292-10-0
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryhigh quality Appearance:Colorless liquid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiry3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- Manufacturer Factory CAS 446292-10-0 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- Manufacturer High quality Best price In stock factory CAS 44629
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inquiryOur company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:446292-10-0
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inquiryCAS NO.: 446292-10-0 Molecular formula: C14H17N3O4 Molecular weight: 291.3025 Structure: Appearance:White powder Storage:RT. Package:drum App
Cas:446292-10-0
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:446292-10-0
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inquiryTop Supplier for Rivaroxaban intermediates Appearance:white or off-white powder Storage:store in well closed container Package:25kgs/fiber drum Application:Rivaroxaban intermediates Port:any port in China
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryWuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides
Cas:446292-10-0
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inquiry3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- CAS:446292-10-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical int
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:446292-10-0
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:446292-10-0
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiry1. We can provide customers with "one-stop"packaging service,from research,development,production,export and so on 2. Powerful R&D strength let our technology in a leading level,forever,in turn,to provide customers with better service .
Cas:446292-10-0
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:446292-10-0
Min.Order:10 Gram
FOB Price: $100.0
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inquiry1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m
Cas:446292-10-0
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inquiryProduct name: (S)-4-(4-(5-(Aminomethyl)-2-Oxooxazolidin-3-yl)phenyl)morpholin-2-one CAS No.: 446292-10-0 Molecule Formula:C14H17N3O4 Molecule Weight:291.30 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufac
Cas:446292-10-0
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Negotiable
Type:Trading Company
inquiryHuarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.
Cas:446292-10-0
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FOB Price: $1.0 / 2.0
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:446292-10-0
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:446292-10-0
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FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryHangzhou Fandachem Co.,Ltd, a China-based chemical company, specialize in exporting (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one,cas:446292-10-0, Please contact us by email freely. We are leading exporter in China.
Cas:446292-10-0
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:446292-10-0
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:446292-10-0
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inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
Cas:446292-10-0
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inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
Cas:446292-10-0
Min.Order:0
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Type:Manufacturers
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:446292-10-0
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inquiry4-{4-[(5S)-5-((dibenzylamino)methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol at 40 - 50℃; under 37503.8 Torr; for 20h; Solvent; Reagent/catalyst; | 100% |
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 50℃; for 18h; Inert atmosphere; | 92.6% |
With palladium 10% on activated carbon; hydrogen; acetic acid In methanol at 50℃; under 4200.42 Torr; | 2.56 g |
4-{4-[(S)-5-[(((4-chlorophenyl)methylene)amino)methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
With isobutylamine In toluene for 3h; Product distribution / selectivity; Reflux; | 99.7% |
With isobutylamine In toluene for 3h; Concentration; Solvent; Time; Temperature; Reagent/catalyst; Heating; Reflux; | 99.7% |
With hydrogenchloride; triethylamine In ethanol; water at 22 - 65℃; for 1h; | 95% |
With hydrogenchloride In water for 0.333333h; Time; |
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
In dichloromethane; water pH=8; Concentration; | 96.7% |
With potassium carbonate In methanol at 25 - 30℃; for 0.5h; | 56% |
With potassium carbonate In methanol at 25 - 30℃; for 0.5h; | 56% |
With potassium carbonate In water at 20℃; for 2h; |
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
With hydrazine hydrate In methanol at 80℃; for 2.5h; | 96.1% |
With ethanolamine In toluene at 75 - 85℃; for 2h; Solvent; Temperature; | 95.87% |
With hydrazine hydrate In ethanol for 2h; Reflux; | 95.4% |
4-{4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In ethanol at 40℃; for 24h; | 96% |
With 5%-palladium/activated carbon; hydrogen In ethyl acetate for 12h; | 91% |
With palladium 10% on activated carbon; hydrogen In methanol under 1500.15 - 3000.3 Torr; for 4h; | 90.9% |
With 5%-palladium/activated carbon; hydrogen In ethyl acetate at 45℃; under 3750.38 - 6000.6 Torr; for 8h; Autoclave; | 80% |
With water; triphenylphosphine In tetrahydrofuran at 10 - 65℃; | 18 g |
2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione
methylamine
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Stage #1: 2-((2S)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran for 12h; Reflux; Stage #2: methylamine In ethanol; water for 8h; Reflux; | 92.2% |
tert-butyl {(5S)-3-[4-(3-oxo-4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methylcarbamate
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
With hydrogenchloride; water In ethanol at 20℃; for 24h; Solvent; | 90% |
With hydrogenchloride In ethanol; water at 20℃; for 24h; Solvent; | 90% |
(S)-4-(4-{5-[(benzylidene-amino)-methyl]-2-oxo-oxazolidine-3-yl}-phenyl)-morpholin-3-one
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
With hydrogenchloride; water In ethanol at 20℃; for 24h; Solvent; | 90% |
With hydrogenchloride In ethanol; water at 20℃; for 24h; Solvent; Time; | 90% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Stage #1: C14H14N2O5 With ammonium hydroxide In methanol for 0.5h; Stage #2: With methanol; sodium tetrahydroborate at 0 - 20℃; for 2.5h; | 87.5% |
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
methylamine
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
In methanol; water for 2h; Reflux; | 85% |
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
A
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
B
2,3-dihydrophthalazine-1,4-dione
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol at 65℃; for 3h; | A 73% B 12.7% |
2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 87 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 24 h / 60 °C 2: aq. MeNH2 / ethanol / 1 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene / 3 h / Industry scale; Reflux 2.1: methylamine / ethanol / 4 h / 65 °C / Industry scale 2.2: 58 - 60 °C / pH 2.7 / Industry scale View Scheme | |
Multi-step reaction with 2 steps 1: dichloromethane / 20 h / 30 °C 2: hydrazine hydrate / methanol / 1 h / Reflux View Scheme |
4-(4-aminophenyl)morpholin-3-one
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 92 percent / ethanol; H2O / 27 h / Heating 2: 87 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 24 h / 60 °C 3: aq. MeNH2 / ethanol / 1 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: water / ethanol / 36 h / 60 °C / Industry scale 2.1: toluene / 3 h / Industry scale; Reflux 3.1: methylamine / ethanol / 4 h / 65 °C / Industry scale 3.2: 58 - 60 °C / pH 2.7 / Industry scale View Scheme | |
Multi-step reaction with 4 steps 1: toluene / 20 °C / Reflux 2: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere 3: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C 4: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h View Scheme |
2-Anilinoethanol
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium hydroxide / ethanol; water / 0.5 h / 38 - 45 °C / pH 10 - 13 / Industry scale 2.1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C 3.1: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C 4.1: water / ethanol / 36 h / 60 °C / Industry scale 5.1: toluene / 3 h / Industry scale; Reflux 6.1: methylamine / ethanol / 4 h / 65 °C / Industry scale 6.2: 58 - 60 °C / pH 2.7 / Industry scale View Scheme | |
Multi-step reaction with 7 steps 1: sodium hydroxide / ethanol; water 2: sulfuric acid; nitric acid / water 3: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C 4: toluene / 20 °C / Reflux 5: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere 6: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C 7: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h View Scheme |
4-(4-nitrophenyl)-3-morpholinone
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C 2.1: water / ethanol / 36 h / 60 °C / Industry scale 3.1: toluene / 3 h / Industry scale; Reflux 4.1: methylamine / ethanol / 4 h / 65 °C / Industry scale 4.2: 58 - 60 °C / pH 2.7 / Industry scale View Scheme | |
Multi-step reaction with 5 steps 1: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C 2: toluene / 20 °C / Reflux 3: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere 4: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C 5: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h View Scheme | |
Multi-step reaction with 4 steps 1: ammonium formate / water / 30 - 90 °C 2: water / 8 h / 80 °C 3: dmap / 6 h / 80 - 85 °C 4: methylamine / water / 5 h / 35 °C View Scheme |
4-phenyl-3-morpholinone
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C 2.1: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C 3.1: water / ethanol / 36 h / 60 °C / Industry scale 4.1: toluene / 3 h / Industry scale; Reflux 5.1: methylamine / ethanol / 4 h / 65 °C / Industry scale 5.2: 58 - 60 °C / pH 2.7 / Industry scale View Scheme | |
Multi-step reaction with 6 steps 1: sulfuric acid; nitric acid / water 2: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C 3: toluene / 20 °C / Reflux 4: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere 5: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C 6: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h View Scheme |
4-{4-[(5R)-5-(chloromethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C 2: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h View Scheme | |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 5 h / Reflux 2: hydrazine hydrate / methanol / 1 h / Reflux View Scheme |
4-(4-isocyanatophenyl)morpholin-3-one
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere 2: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C 3: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h View Scheme | |
Multi-step reaction with 2 steps 1: lithium bromide; Triphenylphosphine oxide / 1-methyl-pyrrolidin-2-one / 7 h / 90 - 95 °C 2: potassium hydroxide / water / Reflux View Scheme |
4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)amino)phenyl]morpholin-3-one
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dichloromethane / 20 h / 30 °C 2: N,N-dimethyl-formamide / 5 h / Reflux 3: hydrazine hydrate / methanol / 1 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: chloroform / 20 h / 30 °C 2: N,N-dimethyl-formamide / 5 h / Reflux 3: hydrazine hydrate / methanol / 1 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 5 h / Reflux 2: dichloromethane / 20 h / 30 °C 3: hydrazine hydrate / methanol / 1 h / Reflux View Scheme |
[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium tert-butoxide / dichloromethane / 24 h / Reflux 2: isobutylamine / toluene / 3 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 0 °C 1.2: 18 h / 30 °C 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C 4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 0 °C 1.2: 18 h / 30 °C 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C 4.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr View Scheme |
dodecyl (4-(3-oxomorpholin)phenyl)carbamate
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium tert-butoxide / dichloromethane / 36 h / Reflux 2: isobutylamine / toluene / 3 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: n-butyllithium / dichloromethane / 36 h / Heating; Reflux 2: isobutylamine / toluene / 3 h / Heating; Reflux View Scheme |
4-{4-[(5S)-5-(N-benzylaminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morphoIin-3-one
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen; acetic acid In methanol at 45℃; under 3750.38 - 6000.6 Torr; for 8h; Autoclave; | 15.5 g |
4-[4-{(R)-2,3-dihydroxy-propylamino}phenyl]morpholin-3-one
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: methanol / 48 h / 30 °C 1.2: 2 h / Reflux 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C 4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: methanol / 48 h / 30 °C 1.2: 2 h / Reflux 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C 4.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine / chloroform / 1 h / -5 °C 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 10 h / 80 °C 3: sodium azide / water; N,N-dimethyl-formamide / 10 h / 0 - 40 °C 4: 5%-palladium/activated carbon; hydrogen / ethanol / 24 h / 40 °C View Scheme |
butyric acid-2(R)-2-hydroxy-3-[4-(3-oxo-morpholin-4-yl)phenylamino]-propyl ester
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: methanol / 48 h / 30 °C 1.2: 2 h / Reflux 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C 4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: methanol / 48 h / 30 °C 1.2: 2 h / Reflux 2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C 4.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr View Scheme | |
Multi-step reaction with 5 steps 1: dichloromethane / 48 h / 30 °C 2: sodium methylate; methanol / 1 h / 30 °C 3: triethylamine / dichloromethane / 18 h / 0 - 20 °C 4: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C 5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: dichloromethane / 48 h / 30 °C 2: sodium methylate; methanol / 1 h / 30 °C 3: triethylamine / dichloromethane / 18 h / 0 - 20 °C 4: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C 5: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr View Scheme |
butyric acid-2-oxo-5(R)-3-[4-(3-oxomorpholin-4-yl)-phenyl]oxazolidin-5-yl-methyl ester
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium methylate; methanol / 1 h / 30 °C 2: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C 4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: sodium methylate; methanol / 1 h / 30 °C 2: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C 4: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr View Scheme |
4-(4-((R)-5-benzyloxymethyl-2-oxo-oxazolidin-3-yl)phenyl)morpholin-3-one
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave 2: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C 4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave 2: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C 4: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr View Scheme |
4-(4-(R)-3-benzyloxy-2-hydroxy-propylamino)phenyl-morpholin-3-one
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: dichloromethane / 44 h / 30 °C 2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave 3: triethylamine / dichloromethane / 18 h / 0 - 20 °C 4: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C 5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: dichloromethane / 44 h / 30 °C 2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave 3: triethylamine / dichloromethane / 18 h / 0 - 20 °C 4: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C 5: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr View Scheme |
acetic acid-1-benzyloxymethyl-2-[(R)-4-(3-oxo-morpholin-4-yl)phenylamino]-ethylester
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: chloroform / 2 h / 50 °C 2: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 °C 3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave 4: triethylamine / dichloromethane / 18 h / 0 - 20 °C 5: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C 6: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 6 steps 1: chloroform / 2 h / 50 °C 2: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 °C 3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave 4: triethylamine / dichloromethane / 18 h / 0 - 20 °C 5: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C 6: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr View Scheme |
acetic acid-1-benzyloxymethyl-2-{[(R)-(3-oxo-morpholin-4-yl)-phenyl]-chlorocarbonyl-amino} ethyl ester
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 °C 2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave 3: triethylamine / dichloromethane / 18 h / 0 - 20 °C 4: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C 5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 °C 2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave 3: triethylamine / dichloromethane / 18 h / 0 - 20 °C 4: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C 5: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr View Scheme |
4-(4-((R)-5-((phenyloxycarbonyloxy)methyl)-2-oxo-oxazolidin-3-yl)phenyl)-morpholin-3-one
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium methylate; methanol / 4 h / 30 °C 2: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C 4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: sodium methylate; methanol / 4 h / 30 °C 2: triethylamine / dichloromethane / 18 h / 0 - 20 °C 3: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C 4: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr View Scheme |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
5-chlorothiophene-2-carbonyl chloride
Rivaroxaban
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; for 3h; Product distribution / selectivity; | 100% |
With triethylamine In tetrahydrofuran at 20℃; for 3h; Reagent/catalyst; Solvent; Time; Concentration; Temperature; | 100% |
With sodium carbonate In water; acetone; toluene at 8 - 53℃; for 0.5h; | 98.7% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
formic acid
N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)formamide
Conditions | Yield |
---|---|
In toluene at 110 - 120℃; Solvent; | 96% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
2-Thiophenecarbonyl chloride
Conditions | Yield |
---|---|
With 4-methyl-morpholine In water; acetonitrile at -5 - 20℃; for 2.5h; Reagent/catalyst; | 96% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
5-Chlorothiophene-2-carboxylic acid
Rivaroxaban
Conditions | Yield |
---|---|
With 4-methyl-morpholine; hydrogenchloride In water; N,N-dimethyl-formamide at 20℃; for 2.83333h; | 95.2% |
With ortho-iodophenylboronic acid In dichloromethane at 30℃; for 48h; Reagent/catalyst; Time; Concentration; Temperature; Solvent; Dean-Stark; | 85% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; | 68.9% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
N-(Benzyloxycarbonyl)sarcosine
C25H28N4O7
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; | 92% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Rivaroxaban
Conditions | Yield |
---|---|
With triethylamine at 10 - 25℃; | 90.3% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
4-chloro-benzoyl chloride
Conditions | Yield |
---|---|
With pyridine; aminomethylpolystyrol resin at 20℃; for 3.5h; | 89% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
O-acetylsalicyloyl chloride
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; | 73% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
2-(methylcarbamoyl)benzoic acid.
Conditions | Yield |
---|---|
Stage #1: 2-(methylcarbamoyl)benzoic acid. With sodium hydrogencarbonate In N,N-dimethyl-formamide for 0.5h; Stage #2: With isobutyl chloroformate In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #3: 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one In N,N-dimethyl-formamide for 8h; | 65% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
(S)-2-(((2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)oxazolidin-5-yl)methyl)carbamoyl)benzoic acid
N,N'-bis[{(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl]benzene-1,2-diamide
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In ethyl acetate; acetonitrile at 5℃; for 2.16667h; pH=8; | 62.8% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
4-nitrophenyl 5-chlorothiophene-2-carboxylate
Rivaroxaban
Conditions | Yield |
---|---|
With potassium carbonate In dichloromethane at 25 - 30℃; | 55.5% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
With hydrazine hydrate In methanol at 80℃; for 12h; Temperature; Solvent; | 49.5% |
With hydrazine hydrate In methanol at 80℃; for 12h; | 49.5% |
With hydrazine hydrate In methanol at 90℃; for 12h; | 49.5% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
2-thiophenylcarboxylic acid
Conditions | Yield |
---|---|
Stage #1: 2-thiophenylcarboxylic acid With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2h; Inert atmosphere; Stage #2: 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one In dichloromethane at 20℃; for 6h; Inert atmosphere; | 48% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
In water at 130℃; for 12h; Temperature; Time; Solvent; Autoclave; | 46% |
With water at 130℃; for 12h; Sealed tube; | 46% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
5-chlorothien-2-ylsulfonyl chloride
Conditions | Yield |
---|---|
With pyridine In tetrahydrofuran at 20℃; for 4h; | 43% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
bis(trichloromethyl) carbonate
N,N'-bis[{(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl]urea
Conditions | Yield |
---|---|
Stage #1: 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one; bis(trichloromethyl) carbonate With triethylamine In tetrahydrofuran at 20℃; Cooling; Stage #2: With sodium carbonate In tetrahydrofuran | 38.8% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
5-bromothiophene-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 5-bromothiophene-2-carboxylic acid With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2h; Inert atmosphere; Stage #2: 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one In dichloromethane at 20℃; for 6h; Inert atmosphere; | 37% |
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
Conditions | Yield |
---|---|
With pyridine at 0 - 23℃; for 1h; Inert atmosphere; | 37% |
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
6-chloropicolinic acid
Conditions | Yield |
---|---|
Stage #1: 6-chloropicolinic acid With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2h; Inert atmosphere; Stage #2: 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one In dichloromethane at 20℃; for 6h; Inert atmosphere; | 27% |
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