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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) W

99% up Rivaroxaban Impurity 9 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL] 446292-10-0

Cas:446292-10-0

Min.Order:1 Kilogram

FOB Price: $825.0 / 1100.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one Manufacturer/High quality/Best price/In stock

Cas:446292-10-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Colorless liquid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

(S)-4-(4-(5-(AMinoMethyl)-2-oxooxazolidin-3-yl)phenyl)Morpholin-3-one

Cas:446292-10-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- Manufacturer Factory CAS 446292-10-0 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- Manufacturer High quality Best price In stock factory CAS 44629

3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- Manufacturer Factory CAS 446292-10-0

Cas:446292-10-0

Min.Order:5 Kiloliter

FOB Price: $3.5 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-

Cas:446292-10-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 446292-10-0 with best quality

Cas:446292-10-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

CAS NO.: 446292-10-0 Molecular formula: C14H17N3O4 Molecular weight: 291.3025 Structure: Appearance:White powder Storage:RT. Package:drum App

(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one

Cas:446292-10-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99%min Rivaroxaban Intermediate Manufacturer CAS 446292-10-0

Cas:446292-10-0

Min.Order:10 Gram

Negotiable

Type:Other

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Hangzhou Maytime Bio-Tech Co.,Ltd.

Top Supplier for Rivaroxaban intermediates Appearance:white or off-white powder Storage:store in well closed container Package:25kgs/fiber drum Application:Rivaroxaban intermediates Port:any port in China

Rivaroxaban intermediate 446292-10-0

Cas:446292-10-0

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Morpholinone,4-[4-[(5S)-5-(aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]- 446292-10-0

Cas:446292-10-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Rivaroxaban Intermediate CAS 446292-10-0

Cas:446292-10-0

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- CAS:446292-10-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical int

3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- CAS:446292-10-0

Cas:446292-10-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Morpholinone,4-[4-[(5S)-5-(aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-

Cas:446292-10-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-Morpholinone,4-[4-[(5S)-5-(aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-

Cas:446292-10-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM--3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-

Cas:446292-10-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

4-{4-[(5S)-5-AMINOMETHYL)-2-OXO-1,3-OXAZOLIDIN-3-YL} MORPHOLIN-3-ONE

Cas:446292-10-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Morpholinone,4-[4-[(5S)-5-(aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-

Cas:446292-10-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Xinhao Biotechnology Co., Ltd.

1. We can provide customers with "one-stop"packaging service,from research,development,production,export and so on 2. Powerful R&D strength let our technology in a leading level,forever,in turn,to provide customers with better service .

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(S)-4-(4-(5-(AMinoMethyl)-2-oxooxazolidin-3-yl)phenyl)Morpholin-3-one

Cas:446292-10-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

CAS 446292-10-0 (s)-4-(4-(5-aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one

Cas:446292-10-0

Min.Order:1 Kilogram

FOB Price: $8.2 / 8.8

Type:Trading Company

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Siwei Development Group Ltd.

Product name: (S)-4-(4-(5-(Aminomethyl)-2-Oxooxazolidin-3-yl)phenyl)morpholin-2-one CAS No.: 446292-10-0 Molecule Formula:C14H17N3O4 Molecule Weight:291.30 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufac

Lower Price (S)-4-(4-(5-(Aminomethyl)-2-Oxooxazolidin-3-yl)phenyl)morpholin-2-one

Cas:446292-10-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-

Cas:446292-10-0

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-

Cas:446292-10-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFUCHEM--3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-

Cas:446292-10-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Hangzhou Fandachem Co.,Ltd, a China-based chemical company, specialize in exporting (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one,cas:446292-10-0, Please contact us by email freely. We are leading exporter in China.

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-

Cas:446292-10-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFUCHEM--3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-

Cas:446292-10-0

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one

Cas:446292-10-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFUCHEM--3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-

Cas:446292-10-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Synthetic route

4-{4-[(5S)-5-((dibenzylamino)methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one
1372665-04-7

4-{4-[(5S)-5-((dibenzylamino)methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In methanol at 40 - 50℃; under 37503.8 Torr; for 20h; Solvent; Reagent/catalyst;100%
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 50℃; for 18h; Inert atmosphere;92.6%
With palladium 10% on activated carbon; hydrogen; acetic acid In methanol at 50℃; under 4200.42 Torr;2.56 g
4-{4-[(S)-5-[(((4-chlorophenyl)methylene)amino)methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one
1414932-72-1

4-{4-[(S)-5-[(((4-chlorophenyl)methylene)amino)methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
With isobutylamine In toluene for 3h; Product distribution / selectivity; Reflux;99.7%
With isobutylamine In toluene for 3h; Concentration; Solvent; Time; Temperature; Reagent/catalyst; Heating; Reflux;99.7%
With hydrogenchloride; triethylamine In ethanol; water at 22 - 65℃; for 1h;95%
With hydrogenchloride In water for 0.333333h; Time;
4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride
898543-06-1

4-{4-[(5S)-5-(amino methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one hydrochloride

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
In dichloromethane; water pH=8; Concentration;96.7%
With potassium carbonate In methanol at 25 - 30℃; for 0.5h;56%
With potassium carbonate In methanol at 25 - 30℃; for 0.5h;56%
With potassium carbonate In water at 20℃; for 2h;
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
446292-08-6

2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
With hydrazine hydrate In methanol at 80℃; for 2.5h;96.1%
With ethanolamine In toluene at 75 - 85℃; for 2h; Solvent; Temperature;95.87%
With hydrazine hydrate In ethanol for 2h; Reflux;95.4%
4-{4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one
1349248-79-8

4-{4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In ethanol at 40℃; for 24h;96%
With 5%-palladium/activated carbon; hydrogen In ethyl acetate for 12h;91%
With palladium 10% on activated carbon; hydrogen In methanol under 1500.15 - 3000.3 Torr; for 4h;90.9%
With 5%-palladium/activated carbon; hydrogen In ethyl acetate at 45℃; under 3750.38 - 6000.6 Torr; for 8h; Autoclave;80%
With water; triphenylphosphine In tetrahydrofuran at 10 - 65℃;18 g
2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione
446292-07-5

2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione

methylamine
74-89-5

methylamine

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Stage #1: 2-((2S)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran for 12h; Reflux;
Stage #2: methylamine In ethanol; water for 8h; Reflux;
92.2%
tert-butyl {(5S)-3-[4-(3-oxo-4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methylcarbamate
1416129-92-4

tert-butyl {(5S)-3-[4-(3-oxo-4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methylcarbamate

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
With hydrogenchloride; water In ethanol at 20℃; for 24h; Solvent;90%
With hydrogenchloride In ethanol; water at 20℃; for 24h; Solvent;90%
(S)-4-(4-{5-[(benzylidene-amino)-methyl]-2-oxo-oxazolidine-3-yl}-phenyl)-morpholin-3-one
1414932-73-2

(S)-4-(4-{5-[(benzylidene-amino)-methyl]-2-oxo-oxazolidine-3-yl}-phenyl)-morpholin-3-one

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
With hydrogenchloride; water In ethanol at 20℃; for 24h; Solvent;90%
With hydrogenchloride In ethanol; water at 20℃; for 24h; Solvent; Time;90%
C14H14N2O5

C14H14N2O5

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Stage #1: C14H14N2O5 With ammonium hydroxide In methanol for 0.5h;
Stage #2: With methanol; sodium tetrahydroborate at 0 - 20℃; for 2.5h;
87.5%
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
446292-08-6

2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

methylamine
74-89-5

methylamine

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
In methanol; water for 2h; Reflux;85%
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
446292-08-6

2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

A

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

B

2,3-dihydrophthalazine-1,4-dione
1445-69-8

2,3-dihydrophthalazine-1,4-dione

Conditions
ConditionsYield
With hydrazine hydrate In ethanol at 65℃; for 3h;A 73%
B 12.7%
2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione
446292-07-5

2-((2R)-2-hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 87 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 24 h / 60 °C
2: aq. MeNH2 / ethanol / 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: toluene / 3 h / Industry scale; Reflux
2.1: methylamine / ethanol / 4 h / 65 °C / Industry scale
2.2: 58 - 60 °C / pH 2.7 / Industry scale
View Scheme
Multi-step reaction with 2 steps
1: dichloromethane / 20 h / 30 °C
2: hydrazine hydrate / methanol / 1 h / Reflux
View Scheme
4-(4-aminophenyl)morpholin-3-one
438056-69-0

4-(4-aminophenyl)morpholin-3-one

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / ethanol; H2O / 27 h / Heating
2: 87 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 24 h / 60 °C
3: aq. MeNH2 / ethanol / 1 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: water / ethanol / 36 h / 60 °C / Industry scale
2.1: toluene / 3 h / Industry scale; Reflux
3.1: methylamine / ethanol / 4 h / 65 °C / Industry scale
3.2: 58 - 60 °C / pH 2.7 / Industry scale
View Scheme
Multi-step reaction with 4 steps
1: toluene / 20 °C / Reflux
2: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere
3: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C
4: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h
View Scheme
2-Anilinoethanol
122-98-5

2-Anilinoethanol

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium hydroxide / ethanol; water / 0.5 h / 38 - 45 °C / pH 10 - 13 / Industry scale
2.1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C
3.1: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C
4.1: water / ethanol / 36 h / 60 °C / Industry scale
5.1: toluene / 3 h / Industry scale; Reflux
6.1: methylamine / ethanol / 4 h / 65 °C / Industry scale
6.2: 58 - 60 °C / pH 2.7 / Industry scale
View Scheme
Multi-step reaction with 7 steps
1: sodium hydroxide / ethanol; water
2: sulfuric acid; nitric acid / water
3: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C
4: toluene / 20 °C / Reflux
5: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere
6: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C
7: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h
View Scheme
4-(4-nitrophenyl)-3-morpholinone
446292-04-2

4-(4-nitrophenyl)-3-morpholinone

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C
2.1: water / ethanol / 36 h / 60 °C / Industry scale
3.1: toluene / 3 h / Industry scale; Reflux
4.1: methylamine / ethanol / 4 h / 65 °C / Industry scale
4.2: 58 - 60 °C / pH 2.7 / Industry scale
View Scheme
Multi-step reaction with 5 steps
1: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C
2: toluene / 20 °C / Reflux
3: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere
4: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C
5: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h
View Scheme
Multi-step reaction with 4 steps
1: ammonium formate / water / 30 - 90 °C
2: water / 8 h / 80 °C
3: dmap / 6 h / 80 - 85 °C
4: methylamine / water / 5 h / 35 °C
View Scheme
4-phenyl-3-morpholinone
29518-11-4

4-phenyl-3-morpholinone

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C
2.1: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C
3.1: water / ethanol / 36 h / 60 °C / Industry scale
4.1: toluene / 3 h / Industry scale; Reflux
5.1: methylamine / ethanol / 4 h / 65 °C / Industry scale
5.2: 58 - 60 °C / pH 2.7 / Industry scale
View Scheme
Multi-step reaction with 6 steps
1: sulfuric acid; nitric acid / water
2: 5%-palladium/activated carbon; hydrogen / ethanol / 40 °C
3: toluene / 20 °C / Reflux
4: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere
5: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C
6: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h
View Scheme
4-{4-[(5R)-5-(chloromethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one
1252018-28-2

4-{4-[(5R)-5-(chloromethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C
2: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 5 h / Reflux
2: hydrazine hydrate / methanol / 1 h / Reflux
View Scheme
4-(4-isocyanatophenyl)morpholin-3-one
1325210-64-7

4-(4-isocyanatophenyl)morpholin-3-one

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: MgI2*etherate / tetrahydrofuran / 20 - 80 °C / Inert atmosphere
2: sodium azide / N,N-dimethyl-formamide / 12 h / 85 °C
3: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 12 h
View Scheme
Multi-step reaction with 2 steps
1: lithium bromide; Triphenylphosphine oxide / 1-methyl-pyrrolidin-2-one / 7 h / 90 - 95 °C
2: potassium hydroxide / water / Reflux
View Scheme
4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)amino)phenyl]morpholin-3-one
1252018-10-2

4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)amino)phenyl]morpholin-3-one

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dichloromethane / 20 h / 30 °C
2: N,N-dimethyl-formamide / 5 h / Reflux
3: hydrazine hydrate / methanol / 1 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: chloroform / 20 h / 30 °C
2: N,N-dimethyl-formamide / 5 h / Reflux
3: hydrazine hydrate / methanol / 1 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide / 5 h / Reflux
2: dichloromethane / 20 h / 30 °C
3: hydrazine hydrate / methanol / 1 h / Reflux
View Scheme
[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester
1313613-18-1

[4-(3-oxo-morpholin-4-yl)phenyl]carbamic acid benzyl ester

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium tert-butoxide / dichloromethane / 24 h / Reflux
2: isobutylamine / toluene / 3 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 0 °C
1.2: 18 h / 30 °C
2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C
3.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C
4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 0 °C
1.2: 18 h / 30 °C
2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C
3.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr
View Scheme
dodecyl (4-(3-oxomorpholin)phenyl)carbamate
1414932-71-0

dodecyl (4-(3-oxomorpholin)phenyl)carbamate

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium tert-butoxide / dichloromethane / 36 h / Reflux
2: isobutylamine / toluene / 3 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: n-butyllithium / dichloromethane / 36 h / Heating; Reflux
2: isobutylamine / toluene / 3 h / Heating; Reflux
View Scheme
4-{4-[(5S)-5-(N-benzylaminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morphoIin-3-one
1424942-78-8

4-{4-[(5S)-5-(N-benzylaminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morphoIin-3-one

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen; acetic acid In methanol at 45℃; under 3750.38 - 6000.6 Torr; for 8h; Autoclave;15.5 g
4-[4-{(R)-2,3-dihydroxy-propylamino}phenyl]morpholin-3-one
1447919-65-4

4-[4-{(R)-2,3-dihydroxy-propylamino}phenyl]morpholin-3-one

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: methanol / 48 h / 30 °C
1.2: 2 h / Reflux
2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C
3.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C
4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: methanol / 48 h / 30 °C
1.2: 2 h / Reflux
2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C
3.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / chloroform / 1 h / -5 °C
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 10 h / 80 °C
3: sodium azide / water; N,N-dimethyl-formamide / 10 h / 0 - 40 °C
4: 5%-palladium/activated carbon; hydrogen / ethanol / 24 h / 40 °C
View Scheme
butyric acid-2(R)-2-hydroxy-3-[4-(3-oxo-morpholin-4-yl)phenylamino]-propyl ester
1446022-14-5

butyric acid-2(R)-2-hydroxy-3-[4-(3-oxo-morpholin-4-yl)phenylamino]-propyl ester

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: methanol / 48 h / 30 °C
1.2: 2 h / Reflux
2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C
3.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C
4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: methanol / 48 h / 30 °C
1.2: 2 h / Reflux
2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C
3.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr
View Scheme
Multi-step reaction with 5 steps
1: dichloromethane / 48 h / 30 °C
2: sodium methylate; methanol / 1 h / 30 °C
3: triethylamine / dichloromethane / 18 h / 0 - 20 °C
4: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C
5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: dichloromethane / 48 h / 30 °C
2: sodium methylate; methanol / 1 h / 30 °C
3: triethylamine / dichloromethane / 18 h / 0 - 20 °C
4: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C
5: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr
View Scheme
butyric acid-2-oxo-5(R)-3-[4-(3-oxomorpholin-4-yl)-phenyl]oxazolidin-5-yl-methyl ester
1446022-15-6

butyric acid-2-oxo-5(R)-3-[4-(3-oxomorpholin-4-yl)-phenyl]oxazolidin-5-yl-methyl ester

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium methylate; methanol / 1 h / 30 °C
2: triethylamine / dichloromethane / 18 h / 0 - 20 °C
3: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C
4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: sodium methylate; methanol / 1 h / 30 °C
2: triethylamine / dichloromethane / 18 h / 0 - 20 °C
3: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C
4: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr
View Scheme
4-(4-((R)-5-benzyloxymethyl-2-oxo-oxazolidin-3-yl)phenyl)morpholin-3-one
1117893-59-0

4-(4-((R)-5-benzyloxymethyl-2-oxo-oxazolidin-3-yl)phenyl)morpholin-3-one

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave
2: triethylamine / dichloromethane / 18 h / 0 - 20 °C
3: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C
4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave
2: triethylamine / dichloromethane / 18 h / 0 - 20 °C
3: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C
4: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr
View Scheme
4-(4-(R)-3-benzyloxy-2-hydroxy-propylamino)phenyl-morpholin-3-one
1117893-58-9

4-(4-(R)-3-benzyloxy-2-hydroxy-propylamino)phenyl-morpholin-3-one

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: dichloromethane / 44 h / 30 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave
3: triethylamine / dichloromethane / 18 h / 0 - 20 °C
4: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C
5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: dichloromethane / 44 h / 30 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave
3: triethylamine / dichloromethane / 18 h / 0 - 20 °C
4: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C
5: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr
View Scheme
acetic acid-1-benzyloxymethyl-2-[(R)-4-(3-oxo-morpholin-4-yl)phenylamino]-ethylester
1447919-68-7

acetic acid-1-benzyloxymethyl-2-[(R)-4-(3-oxo-morpholin-4-yl)phenylamino]-ethylester

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: chloroform / 2 h / 50 °C
2: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 °C
3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave
4: triethylamine / dichloromethane / 18 h / 0 - 20 °C
5: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C
6: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1: chloroform / 2 h / 50 °C
2: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 °C
3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave
4: triethylamine / dichloromethane / 18 h / 0 - 20 °C
5: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C
6: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr
View Scheme
acetic acid-1-benzyloxymethyl-2-{[(R)-(3-oxo-morpholin-4-yl)-phenyl]-chlorocarbonyl-amino} ethyl ester
1447919-69-8

acetic acid-1-benzyloxymethyl-2-{[(R)-(3-oxo-morpholin-4-yl)-phenyl]-chlorocarbonyl-amino} ethyl ester

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave
3: triethylamine / dichloromethane / 18 h / 0 - 20 °C
4: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C
5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: lithium tert-butoxide; methanol / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 °C
2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 3000.3 - 3750.38 Torr / Autoclave
3: triethylamine / dichloromethane / 18 h / 0 - 20 °C
4: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C
5: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr
View Scheme
4-(4-((R)-5-((phenyloxycarbonyloxy)methyl)-2-oxo-oxazolidin-3-yl)phenyl)-morpholin-3-one
1447919-71-2

4-(4-((R)-5-((phenyloxycarbonyloxy)methyl)-2-oxo-oxazolidin-3-yl)phenyl)-morpholin-3-one

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium methylate; methanol / 4 h / 30 °C
2: triethylamine / dichloromethane / 18 h / 0 - 20 °C
3: sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C
4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: sodium methylate; methanol / 4 h / 30 °C
2: triethylamine / dichloromethane / 18 h / 0 - 20 °C
3: sodium azide / N,N-dimethyl-formamide / 4 h / 80 - 85 °C
4: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 1500.15 - 3000.3 Torr
View Scheme
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

5-chlorothiophene-2-carbonyl chloride
42518-98-9

5-chlorothiophene-2-carbonyl chloride

Rivaroxaban
366789-02-8

Rivaroxaban

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 3h; Product distribution / selectivity;100%
With triethylamine In tetrahydrofuran at 20℃; for 3h; Reagent/catalyst; Solvent; Time; Concentration; Temperature;100%
With sodium carbonate In water; acetone; toluene at 8 - 53℃; for 0.5h;98.7%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

formic acid
64-18-6

formic acid

N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)formamide
1616563-62-2

N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)formamide

Conditions
ConditionsYield
In toluene at 110 - 120℃; Solvent;96%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

Conditions
ConditionsYield
With 4-methyl-morpholine In water; acetonitrile at -5 - 20℃; for 2.5h; Reagent/catalyst;96%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

5-Chlorothiophene-2-carboxylic acid
24065-33-6

5-Chlorothiophene-2-carboxylic acid

Rivaroxaban
366789-02-8

Rivaroxaban

Conditions
ConditionsYield
With 4-methyl-morpholine; hydrogenchloride In water; N,N-dimethyl-formamide at 20℃; for 2.83333h;95.2%
With ortho-iodophenylboronic acid In dichloromethane at 30℃; for 48h; Reagent/catalyst; Time; Concentration; Temperature; Solvent; Dean-Stark;85%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h;68.9%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

N-(Benzyloxycarbonyl)sarcosine
39608-31-6

N-(Benzyloxycarbonyl)sarcosine

C25H28N4O7
947181-22-8

C25H28N4O7

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h;92%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

C11H6ClN3O2S

C11H6ClN3O2S

Rivaroxaban
366789-02-8

Rivaroxaban

Conditions
ConditionsYield
With triethylamine at 10 - 25℃;90.3%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

4-chloro-N-{2-oxo-3-[4-(3-oxo-morpholin-4-yl)-phenyl]-oxazolidin-5-ylmethyl}-benzamide

4-chloro-N-{2-oxo-3-[4-(3-oxo-morpholin-4-yl)-phenyl]-oxazolidin-5-ylmethyl}-benzamide

Conditions
ConditionsYield
With pyridine; aminomethylpolystyrol resin at 20℃; for 3.5h;89%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

O-acetylsalicyloyl chloride
5538-51-2

O-acetylsalicyloyl chloride

C23H23N3O7

C23H23N3O7

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;73%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

2-(methylcarbamoyl)benzoic acid.
6843-36-3

2-(methylcarbamoyl)benzoic acid.

(S)-N1-methyl-N2-((2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)oxazolidin-5-yl)methyl)phthalamide

(S)-N1-methyl-N2-((2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)oxazolidin-5-yl)methyl)phthalamide

Conditions
ConditionsYield
Stage #1: 2-(methylcarbamoyl)benzoic acid. With sodium hydrogencarbonate In N,N-dimethyl-formamide for 0.5h;
Stage #2: With isobutyl chloroformate In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #3: 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one In N,N-dimethyl-formamide for 8h;
65%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

(S)-2-(((2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)oxazolidin-5-yl)methyl)carbamoyl)benzoic acid
1365267-37-3

(S)-2-(((2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)oxazolidin-5-yl)methyl)carbamoyl)benzoic acid

N,N'-bis[{(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl]benzene-1,2-diamide
1365267-36-2

N,N'-bis[{(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl]benzene-1,2-diamide

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In ethyl acetate; acetonitrile at 5℃; for 2.16667h; pH=8;62.8%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

4-nitrophenyl 5-chlorothiophene-2-carboxylate
1450877-56-1

4-nitrophenyl 5-chlorothiophene-2-carboxylate

Rivaroxaban
366789-02-8

Rivaroxaban

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 25 - 30℃;55.5%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

2-[2-({4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}amino)ethoxy]acetohydrazide

2-[2-({4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}amino)ethoxy]acetohydrazide

Conditions
ConditionsYield
With hydrazine hydrate In methanol at 80℃; for 12h; Temperature; Solvent;49.5%
With hydrazine hydrate In methanol at 80℃; for 12h;49.5%
With hydrazine hydrate In methanol at 90℃; for 12h;49.5%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

Conditions
ConditionsYield
Stage #1: 2-thiophenylcarboxylic acid With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2h; Inert atmosphere;
Stage #2: 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one In dichloromethane at 20℃; for 6h; Inert atmosphere;
48%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

(S)-4-(4-(((2-oxooxazolidin-5-yl)methyl)amino)phenyl)morpholin-3-one

(S)-4-(4-(((2-oxooxazolidin-5-yl)methyl)amino)phenyl)morpholin-3-one

Conditions
ConditionsYield
In water at 130℃; for 12h; Temperature; Time; Solvent; Autoclave;46%
With water at 130℃; for 12h; Sealed tube;46%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

5-chlorothien-2-ylsulfonyl chloride
2766-74-7

5-chlorothien-2-ylsulfonyl chloride

5-Chloro-thiophene-2-sulfonic acid {(R)-2-oxo-3-[4-(3-oxo-morpholin-4-yl)-phenyl]-oxazolidin-5-ylmethyl}-amide

5-Chloro-thiophene-2-sulfonic acid {(R)-2-oxo-3-[4-(3-oxo-morpholin-4-yl)-phenyl]-oxazolidin-5-ylmethyl}-amide

Conditions
ConditionsYield
With pyridine In tetrahydrofuran at 20℃; for 4h;43%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

N,N'-bis[{(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl]urea
1365267-35-1

N,N'-bis[{(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl]urea

Conditions
ConditionsYield
Stage #1: 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one; bis(trichloromethyl) carbonate With triethylamine In tetrahydrofuran at 20℃; Cooling;
Stage #2: With sodium carbonate In tetrahydrofuran
38.8%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

5-bromothiophene-2-carboxylic acid
7311-63-9

5-bromothiophene-2-carboxylic acid

5-bromo-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

5-bromo-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide

Conditions
ConditionsYield
Stage #1: 5-bromothiophene-2-carboxylic acid With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2h; Inert atmosphere;
Stage #2: 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one In dichloromethane at 20℃; for 6h; Inert atmosphere;
37%
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

(5-fluorothiophen-2-yl)formyl chloride

(5-fluorothiophen-2-yl)formyl chloride

(S)-5-fluoro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide

(S)-5-fluoro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide

Conditions
ConditionsYield
With pyridine at 0 - 23℃; for 1h; Inert atmosphere;37%
4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one
446292-10-0

4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one

6-chloropicolinic acid
4684-94-0

6-chloropicolinic acid

6-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)pyridine-2-carboxamide

6-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)pyridine-2-carboxamide

Conditions
ConditionsYield
Stage #1: 6-chloropicolinic acid With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2h; Inert atmosphere;
Stage #2: 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one In dichloromethane at 20℃; for 6h; Inert atmosphere;
27%

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