Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:527-72-0
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:527-72-0
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiryGood price Good quality Appearance:powder Storage:dry condition Package:According to the demand of customer Application:intermediate Transportation:By sea or by air Port:Shanghai Port
Cas:527-72-0
Min.Order:1000 Kilogram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Cas:527-72-0
Min.Order:1 Kilogram
FOB Price: $5.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:527-72-0
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:527-72-0
Min.Order:1 Kilogram
FOB Price: $100.0 / 150.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:527-72-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:527-72-0
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:527-72-0
Min.Order:1 Kilogram
FOB Price: $50.0 / 100.0
Type:Trading Company
inquiry1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea
Cas:527-72-0
Min.Order:1 Gram
FOB Price: $5.0
Type:Lab/Research institutions
inquiry1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
Cas:527-72-0
Min.Order:0 Metric Ton
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Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:527-72-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: 2-Thiophenecarboxylic acid Synonyms: 2-Thenoic Acid 2-Thiophenic Acid Thiophene-2-carboxylic acid;LABOTEST-BB LT02016392;AKOS B022791;AKOS BBS-00003739;ALPHA-THENOIC ACID;2-THENOIC ACID;2-THIOPHENIC ACID;2-THIOPHENECARBOXYLIC ACID
Cas:527-72-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:527-72-0
Min.Order:1 Kilogram
FOB Price: $68.0 / 75.0
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:527-72-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:527-72-0
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:527-72-0
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:527-72-0
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:527-72-0
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryEstablished in 2010, located in Hangzhou Qinglan science park, lingruichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. In our R&D centre, we have a staff of skilled and experie
Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
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Cas:527-72-0
Min.Order:10 Gram
FOB Price: $5.0 / 7.0
Type:Trading Company
inquiryShandong Baimao Chemical Co., Ltd is a private joint-stock fine chemical enterprises, with a sound management system. Long-term commitment to chemical products research and development, production and marketing. Our products include organic chemical
Cas:527-72-0
Min.Order:1 Kilogram
FOB Price: $40.0 / 50.0
Type:Trading Company
inquirySuperior quality, moderate price & quick delivery. Appearance:white to light yellow crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum;200kg/drum as per your request Application:Used
Cas:527-72-0
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryProduct name: Thiophene-2-carboxylic Acid CAS No.: 527-72-0 Molecule Formula:C5H3O2S Molecule Weight:127.14 Purity: 98.0% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise Standard
Cas:527-72-0
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:527-72-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:527-72-0
Min.Order:1 Milligram
Negotiable
Type:Trading Company
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:527-72-0
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryConditions | Yield |
---|---|
With sodium; diphenyldisulfane In 1-methyl-pyrrolidin-2-one at 90℃; for 0.25h; | 100% |
With hydrogenchloride In 1,4-dioxane for 1h; Heating; | 97% |
With potassium carbonate; thiophenol In 1-methyl-pyrrolidin-2-one at 190℃; for 0.166667h; Substitution; | 75% |
Conditions | Yield |
---|---|
Stage #1: thiophene; acetic anhydride at 30℃; for 0.333333h; Stage #2: With oxygen; manganese (II) acetate tetrahydrate; cobalt(II) diacetate tetrahydrate; acetic acid; sodium bromide at 90 - 125℃; under 1654.92 Torr; for 4.75h; Reagent/catalyst; | 100% |
Conditions | Yield |
---|---|
With copper acetylacetonate; oxygen; sodium hydroxide; 1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene In water at 50℃; under 760.051 Torr; for 12h; Sealed tube; | 99% |
With 4H3N*4H(1+)*CuMo6O18(OH)6(4-); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 12h; | 99% |
With C20H25N2(1+)*Cl(1-); water; oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 3.5h; Schlenk technique; | 96% |
toluene
A
2-thiophenylcarboxylic acid
B
1-methyl-3-(phenylmethyl)-benzene
C
1-methyl-4-(phenylmethyl)benzene
D
2-benzyltoluene
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate; water at 80℃; for 2h; regioselective reaction; | A 99% B n/a C n/a D n/a |
Conditions | Yield |
---|---|
With oxygen; sodium hydrogencarbonate In acetonitrile for 4h; Molecular sieve; Irradiation; | 99% |
thiophene-2-carbaldehyde
A
2-thiophenylcarboxylic acid
B
2-thiophenemethanol
Conditions | Yield |
---|---|
Stage #1: thiophene-2-carbaldehyde With potassium hydroxide for 0.0833333h; Cannizzaro Reaction; Milling; Inert atmosphere; Sealed tube; Green chemistry; Stage #2: With hydrogenchloride In water for 0.0833333h; Green chemistry; | A 98% B 98% |
With aluminum oxide; water; sodium hydroxide at 100℃; for 0.0333333h; Cannizzaro Reaction; Microwave irradiation; | A 47% B 47% |
With aluminum oxide; sodium hydroxide; water for 0.00416667h; Irradiation; Yield given; Yields of byproduct given; |
4,4-dimethyl-2-(2-thienyl)oxazoline
2-thiophenylcarboxylic acid
Conditions | Yield |
---|---|
With potassium hydroxide; sodium hypochlorite; tetra-tert-butylammonium hydrogen sulfate 1.) ethyl acetate, water, 20 deg C, 12 h; 2.) MeOH, water, 12 h, 20 deg C; | 97% |
With potassium hydroxide; sodium hypochlorite; tetra-tert-butylammonium hydrogen sulfate Product distribution; multistep.: 1.) ethyl acetate-water, 20 deg C, 12 h; 2.) MeOH-water, 20 deg C, 12 h; transformation of oxazoline derivatives into carboxylic functions; | 97% |
Multi-step reaction with 3 steps 1: 85 percent / CH2Cl2 / 0.25 h / 0 °C 2: 98 percent / diethyl ether / Ambient temperature 3: 92 percent / 2.0M KOH / dimethylsulfoxide-d6 / 4 h / 110 °C View Scheme |
Conditions | Yield |
---|---|
With sodium hydroxide; cobalt(II) acetate In ethanol at 30℃; under 1520 Torr; for 20h; Irradiation; | 96.9% |
With sodium hydroxide; tetra-(n-butyl)ammonium iodide; bis(benzonitrile)palladium(II) dichloride; triphenylphosphine In xylene at 90℃; for 4h; Carbonylation; | 18% |
(thiophen-2-yl)methyl acetate
A
thiophene-2-carbaldehyde
B
2-thiophenylcarboxylic acid
Conditions | Yield |
---|---|
With oxygen; cobalt(II) acetate; sodium bromide In acetic acid at 100℃; for 1.66667h; Product distribution; Rate constant; dependence on temperatures and concentrations of reagent and catalysts; | A n/a B 96.5% |
Conditions | Yield |
---|---|
Stage #1: carbon dioxide; 2-thienylmagnesium chloride In tetrahydrofuran at 20℃; under 3000.3 Torr; gas-liquid flow reactor assembly; Stage #2: With polymer-supported sulfonic acid In tetrahydrofuran | 95% |
In tetrahydrofuran at 1℃; for 0.0833333h; | 82% |
Conditions | Yield |
---|---|
With C32H25Cl2N6O2Rh2(1+)*Cl(1-); sodium hydroxide In water at 100℃; for 12h; Sealed tube; Green chemistry; | 94% |
With C30H24AgBr4N8(1+)*AgBr2(1-); potassium hydroxide In 1,2-dimethoxyethane at 60℃; for 24h; Molecular sieve; Schlenk technique; | 92% |
With tert-butyldimethylsilyl chloride In methanol; water at 20℃; for 1h; Green chemistry; | 92% |
Thiophene-2-carboxylic acid 2-methyl-2-(methyl-trifluoromethanesulfonyl-amino)-propyl ester
2-thiophenylcarboxylic acid
Conditions | Yield |
---|---|
With potassium hydroxide In dimethylsulfoxide-d6 at 110℃; for 4h; | 92% |
Conditions | Yield |
---|---|
With sodium hydroxide; dihydrogen peroxide In methanol; water at 20℃; for 0.0833333h; | 92% |
2-Iodothiophene
diphenylmethylsilanecarboxylic acid
2-thiophenylcarboxylic acid
Conditions | Yield |
---|---|
With potassium trimethylsilonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium(0) In toluene at 40℃; for 0.333333h; | 92% |
Conditions | Yield |
---|---|
With water; palladium diacetate; potassium carbonate at 20℃; under 760.051 Torr; for 6h; | 91% |
With potassium carbonate; palladium diacetate In water; N,N-dimethyl-formamide at 25℃; under 760 Torr; for 10h; | 85% |
Conditions | Yield |
---|---|
With copper(l) iodide; hydroxylamine hydrochloride; oxygen In dimethyl sulfoxide at 100℃; for 12h; | 90% |
With hydroxylamine hydrochloride; iodine In dimethyl sulfoxide at 100℃; for 5h; | 89% |
Stage #1: 2-Acetylthiophene With iodine; dimethyl sulfoxide In chlorobenzene at 110℃; for 3h; Stage #2: With tert.-butylhydroperoxide In chlorobenzene at 20 - 110℃; for 8h; | 72% |
Conditions | Yield |
---|---|
Stage #1: thiophene With n-chlorooctane; sodium In toluene at 20℃; Stage #2: carbon dioxide In toluene at 20℃; | 90% |
Stage #1: thiophene With lithium diisopropyl amide In tetrahydrofuran at 20℃; for 0.000833333h; Flow reactor; Stage #2: carbon dioxide In tetrahydrofuran at 20℃; for 0.000138889h; Flow reactor; Stage #3: With water; acetic acid In tetrahydrofuran at 20℃; under 7500.75 Torr; Flow reactor; | 79% |
With ethylaluminum dichloride In hexane; toluene at 100℃; under 22502.3 Torr; for 3h; Autoclave; Inert atmosphere; regioselective reaction; | 30% |
With n-butyllithium; water Multistep reaction; |
(thiophen-2-yl)methyl acetate
2-thiophenylcarboxylic acid
Conditions | Yield |
---|---|
With oxygen; cobalt(II) acetate; sodium bromide In acetic acid at 95℃; for 0.5h; | 90% |
C15H16O2S
A
2-thiophenylcarboxylic acid
B
[2-(4-methoxy-phenyl)-cyclopropyl]-thiophen-2-yl-methanone
C
4-methoxybenzoic acid
Conditions | Yield |
---|---|
Stage #1: C15H16O2S With oxygen; sodium hydride In tetrahydrofuran at 0 - 20℃; for 11h; Stage #2: With hydrogenchloride In water | A 10% B 90% C 10% |
Conditions | Yield |
---|---|
With [PhCOPd(PtBu3)I]; dtbpf In 2-methyltetrahydrofuran at 80℃; for 18h; Inert atmosphere; | 89% |
Conditions | Yield |
---|---|
With tetrakis[tris(dimethylamino)phosphoranylideneamino]phosphonium chloride; cesium fluoride In o-xylene at 100℃; under 760.051 Torr; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; | 89% |
Conditions | Yield |
---|---|
Stage #1: 2-thienyl chloride With bis(cyclopentadienyl)titanium dichloride; butyl magnesium bromide In tetrahydrofuran at 40℃; for 6h; Inert atmosphere; Schlenk technique; Stage #2: carbon dioxide In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Schlenk technique; | 88% |
Stage #1: 2-thienyl chloride With magnesium In tetrahydrofuran for 2h; Inert atmosphere; Reflux; Stage #2: carbon dioxide In tetrahydrofuran at -78 - 20℃; | 82% |
In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide at 5℃; electrochemical oxidation; | 80% |
Stage #1: 2-thienyl chloride; carbon dioxide With manganese; bis(triphenylphosphine)nickel(II) chloride; tetraethylammonium iodide; triphenylphosphine In 1,3-dimethyl-2-imidazolidinone at 35℃; under 760.051 Torr; for 30h; Stage #2: With hydrogenchloride; water In diethyl ether at 20℃; for 0.166667h; | 52% |
With manganese; 2,9-dibutyl-4,7-dimethyl-1,10-phenanthroline; tetraethylammonium iodide; lithium acetate; cobalt(II) bromide In N,N-dimethyl acetamide at 100℃; under 760.051 Torr; for 12h; Inert atmosphere; Schlenk technique; | 35% |
Conditions | Yield |
---|---|
With 3,4-benzo-1,1,2,2-tetraethyl-1,2-disilacyclobut-3-ene; cesium fluoride In N,N-dimethyl-formamide at 0 - 20℃; under 760.051 Torr; for 2h; | 88% |
With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; diethylzinc In dimethyl sulfoxide at 25℃; under 760.051 Torr; | 63% |
carbon dioxide
thiophen-2-yl magnesium bromide
2-thiophenylcarboxylic acid
Conditions | Yield |
---|---|
In tetrahydrofuran at 1℃; for 0.0833333h; | 87% |
3% |
Conditions | Yield |
---|---|
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; 2-(diphenylphosphino)-2’(3-(dimethylamino)-3-oxopropyl)-6’-(3-(icosyloxy)-3-oxopropyl)biphenyl; water; palladium diacetate; N-ethyl-N,N-diisopropylamine In toluene under 760.051 Torr; for 16h; Inert atmosphere; Schlenk technique; Irradiation; | 87% |
Stage #1: 2-bromothiophene With magnesium In tetrahydrofuran for 0.75h; Inert atmosphere; Reflux; Stage #2: carbon dioxide In tetrahydrofuran at -78 - 20℃; | 86% |
With diethylzinc; palladium diacetate; tert-butyl XPhos In hexanes; N,N-dimethyl acetamide at 40℃; under 7600.51 Torr; Automated synthesizer; | 62% |
Conditions | Yield |
---|---|
With phosphate buffer at 30℃; for 48h; rhodococcus rhodocrous AJ270, pH 7.0; | 86% |
With potassium phosphate buffer at 30℃; for 48h; Rhodococcus sp. AJ270 cells; | 85.8% |
Conditions | Yield |
---|---|
With niobium(V) oxide; water In neat (no solvent) for 20h; Reflux; Inert atmosphere; | 85% |
With potassium hydroxide; water | |
With sodium hydroxide; water | |
With hydrogenchloride In dibutyl ether at 100℃; for 7h; |
carbon dioxide
5,5-dimethyl-2-(thiophen-2-yl)-1,3,2-dioxaborinane
2-thiophenylcarboxylic acid
Conditions | Yield |
---|---|
Stage #1: carbon dioxide; 5,5-dimethyl-2-(thiophen-2-yl)-1,3,2-dioxaborinane With potassium tert-butylate; silver(I) acetate; triphenylphosphine In tetrahydrofuran at 70℃; under 15201 Torr; for 16h; Inert atmosphere; Autoclave; Stage #2: With hydrogenchloride In tetrahydrofuran; water Inert atmosphere; | 84% |
With potassium tert-butylate; copper(l) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 70℃; under 760.051 Torr; for 24h; | 83% |
Conditions | Yield |
---|---|
With 1,3-bis(dicyclohexylphosphino)propane bis(tetrafluoroborate) salt; water; palladium diacetate; potassium carbonate In dimethyl sulfoxide at 100℃; under 760.051 Torr; for 15h; | 84% |
carbon dioxide
2-thiopheneboronic acid pinacol ester
2-thiophenylcarboxylic acid
Conditions | Yield |
---|---|
With copper(l) iodide; cesium fluoride; sodium t-butanolate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In 2-methyltetrahydrofuran at 120℃; for 24h; Solvent; Sealed tube; | 84% |
2-thiophenylcarboxylic acid
dimethyl sulfate
thiophene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With lithium hydroxide In tetrahydrofuran for 0.5h; Methylation; esterification; Heating; | 100% |
Conditions | Yield |
---|---|
Stage #1: 2-thiophenylcarboxylic acid With trifluoroacetic anhydride; indium(III) chloride at 20℃; for 0.5h; Stage #2: β-naphthol at 20℃; for 0.166667h; | 100% |
2-thiophenylcarboxylic acid
2-hydroxy-1-(2-hydroxy-4,6-dimethoxyphenyl)ethan-1-one
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 8h; | 100% |
2-thiophenylcarboxylic acid
Conditions | Yield |
---|---|
In toluene Inert atmosphere; Reflux; enantioselective reaction; | 100% |
2-thiophenylcarboxylic acid
4-nitro-2-thiophenecarbonyl chloride
Conditions | Yield |
---|---|
Stage #1: 2-thiophenylcarboxylic acid With sulfuric acid; nitric acid at 10 - 20℃; Stage #2: With thionyl chloride Reagent/catalyst; Reflux; | 100% |
Stage #1: 2-thiophenylcarboxylic acid With sulfuric acid; nitric acid at 10 - 20℃; Stage #2: With thionyl chloride Reflux; |
2-thiophenylcarboxylic acid
N-(2-aminoethyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; | 100% |
2-thiophenylcarboxylic acid
thiophen-2-carboxylic anhydride
Conditions | Yield |
---|---|
Stage #1: 2-thiophenylcarboxylic acid With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0℃; Stage #2: With bis(trichloromethyl) carbonate In tetrahydrofuran at 0 - 20℃; | 99% |
With methanesulfonyl chloride; triethylamine In tetrahydrofuran at 0℃; for 1h; Inert atmosphere; | 99% |
With triethylamine; trichloroacetonitrile; triphenylphosphine In dichloromethane at 20℃; for 2h; | 82% |
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In neat (no solvent) at 80℃; Microwave irradiation; | 99% |
With potassium carbonate In dimethyl sulfoxide at 130℃; for 5h; | 99% |
Conditions | Yield |
---|---|
Stage #1: 2-thiophenylcarboxylic acid With dirhodium tetraacetate In tetrahydrofuran at 30℃; for 0.5h; Stage #2: C11H11FN2O2 In diethyl ether at -10℃; for 1h; enantioselective reaction; | 99% |
Conditions | Yield |
---|---|
Stage #1: 2-thiophenylcarboxylic acid With dirhodium tetraacetate; C28H44N4O In tetrahydrofuran at 30℃; for 0.5h; Stage #2: C11H11FN2O2 In diethyl ether at -10℃; for 1h; Temperature; Reagent/catalyst; enantioselective reaction; | 99% |
2-thiophenylcarboxylic acid
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
Conditions | Yield |
---|---|
In neat (no solvent) at 30℃; Inert atmosphere; Schlenk technique; Glovebox; chemoselective reaction; | 99% |
With (4-Me)Triaz(NHPiPr2)2Mn(CO)2Br In toluene at 25℃; for 6h; Catalytic behavior; Inert atmosphere; chemoselective reaction; | > 99 %Spectr. |
methanol
2-thiophenylcarboxylic acid
Dimethyl thiophene-2,5-dicarboxylate
Conditions | Yield |
---|---|
With cobalt(II) chloride In 1,1,2,2-tetrachloroethane at 150℃; for 2h; Temperature; Reagent/catalyst; | 99% |
2-thiophenylcarboxylic acid
N-methylaniline
N-methyl-N-(thiophen-2-ylmethyl)aniline
Conditions | Yield |
---|---|
With potassium phosphate; 18-crown-6 ether; phenylsilane In tetrahydrofuran at 80℃; for 12h; Glovebox; Molecular sieve; Schlenk technique; | 99% |
Conditions | Yield |
---|---|
With trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,2-dichloro-ethane at 100℃; for 24h; Schlenk technique; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
Stage #1: 2-thiophenylcarboxylic acid With trimethylamine In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere; Sealed tube; Stage #2: isopropyl chloroformate With triethylamine In tetrahydrofuran; toluene at 0 - 20℃; for 1.66667h; Inert atmosphere; Sealed tube; | 98% |
2-thiophenylcarboxylic acid
Conditions | Yield |
---|---|
Stage #1: 2-thiophenylcarboxylic acid With 2,4,6-trichlorobenzoyl chloride; triethylamine In tetrahydrofuran at 0 - 20℃; for 2h; Yamaguchi Lactonization; Stage #2: (4S,10S,12R,E)-4-hydroxy-10-(methoxymethoxy)-12-methyloxacyclododec-5-ene-2,8-dione With dmap In toluene at 0℃; Yamaguchi Lactonization; | 98% |
2-thiophenylcarboxylic acid
Conditions | Yield |
---|---|
Stage #1: 2-thiophenylcarboxylic acid With 2,4,6-trichlorobenzoyl chloride; triethylamine In tetrahydrofuran at 0 - 20℃; for 2h; Yamaguchi Lactonization; Stage #2: (4S,10R,12R,E)-4-hydroxy-10-(methoxymethoxy)-12-methyloxacyclododec-5-ene-2,8-dione With dmap In toluene at 0℃; Yamaguchi Lactonization; | 98% |
Conditions | Yield |
---|---|
Stage #1: 2-thiophenylcarboxylic acid With dirhodium tetraacetate; C28H44N4O In tetrahydrofuran at 30℃; for 0.5h; Stage #2: C11H9FN2O In diethyl ether at -30℃; for 3h; enantioselective reaction; | 98% |
Conditions | Yield |
---|---|
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h; | 98% |
Stage #1: 2-thiophenylcarboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Stage #2: aniline In N,N-dimethyl-formamide at 20℃; for 24h; | |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; Schlenk technique; |
2-thiophenylcarboxylic acid
Conditions | Yield |
---|---|
Stage #1: 2-thiophenylcarboxylic acid With thionyl chloride; N,N-dimethyl-formamide In dichloromethane Reflux; Stage #2: 4-isopropyl-1-methylcyclohex-3-en-1-amine With triethylamine In dichloromethane; N,N-dimethyl-formamide Reflux; | 97.27% |
Conditions | Yield |
---|---|
97% | |
With thionyl chloride for 2h; Heating; | 82% |
With thionyl chloride; N,N-dimethyl-formamide; sodium hydroxide In ethyl acetate at 58 - 65℃; for 2.5h; Inert atmosphere; | 81% |
2-thiophenylcarboxylic acid
1,2,3-Benzotriazole
(1H-benzo[d][1,2,3]triazol-1-yl)(thiophen-2-yl)methanone
Conditions | Yield |
---|---|
With thionyl chloride In dichloromethane at 25℃; for 2h; | 97% |
With thionyl chloride In dichloromethane at 20℃; | 93% |
Stage #1: 1,2,3-Benzotriazole With thionyl chloride In tetrahydrofuran at 20℃; for 0.5h; Stage #2: 2-thiophenylcarboxylic acid In tetrahydrofuran at 20℃; for 2h; | 90% |
1,4-dioxane
2-thiophenylcarboxylic acid
thiophene-2-carboxylic acid [1,4]dioxan-2-yl ester
Conditions | Yield |
---|---|
With iron(III)-acetylacetonate; di-tert-butyl peroxide at 120℃; for 24h; Schlenk technique; | 97% |
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In water; ethyl acetate at 80℃; for 12h; | 95% |
With di-tert-butyl peroxide; Fe3O(1,4-benzenedicarboxylate)3 at 120℃; for 3h; High pressure; | 68% |
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