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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-Thiophenecarboxylicacid, methyl ester Manufacturer/High quality/Best price/In stock

Cas:5380-42-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Thiophenecarboxylic acid methyl ester

Cas:5380-42-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 5380-42-7 with best quality

Cas:5380-42-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Thiophenecarboxylicacid, methyl ester 5380-42-7

Cas:5380-42-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

METHYL THIOPHENE-2-CARBOXYLATE CAS: 5380-42-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality or

METHYL THIOPHENE-2-CARBOXYLATE CAS: 5380-42-7

Cas:5380-42-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Thiophenecarboxylicacid, methyl ester

Cas:5380-42-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Thiophenecarboxylicacid, methyl ester

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Thiophene-2-carboxylic acid methy lester

Cas:5380-42-7

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Thiophenecarboxylicacid, methyl ester

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-Thiophenecarboxylicacid, methyl ester

Cas:5380-42-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

2-Thiophenecarboxylicacid, methyl ester Methyl thiophene-2-carboxylate; METHYL THIOPHENE-2-CARBOXYLATE; Methylthiophene-2-carboxylate; CAS No.: 5380-42-7 Molecular formula: C6H6O2S Molecular weight: 142.17600 Exact quality: 142.00900 PSA: 5

5380-42-7

Cas:5380-42-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Methyl thiophene-2-carboxylate

Cas:5380-42-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

Methylthiophene-2-carboxylate

Cas:5380-42-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Methyl thiophene-2-carboxylate

Cas:5380-42-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Methyl thiophene-2-carboxylate

Cas:5380-42-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

5380-42-7

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Methyl thiophene-2-carboxylate

Cas:5380-42-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Methyl thiophene-2-carboxylate

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Thiophene-2-carboxylic acid methy lester

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

Methylthiophene-2-carboxylate

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Methyl 2-Thiophenecarboxylate

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

METHYL THIOPHENE-2-CARBOXYLATE

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

METHYL THIOPHENE-2-CARBOXYLATE

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2-Thiophenecarboxylicacid, methyl ester

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Methyl thiophene-2-carboxylate Application:Methyl thiophene-2-carboxylate

Methyl thiophene-2-carboxylate

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Other

inquiry

DB BIOTECH CO., LTD

best seller Application:API

METHYL THIOPHENE-2-CARBOXYLATE

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

2-Thiophenecarboxylicacid, methyl ester cas 5380-42-7Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

2-Thiophenecarboxylicacid, methyl ester cas 5380-42-7

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

Thiophene-2-carboxylicacidmethylester

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

METHYL THIOPHENE-2-CARBOXYLATE

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

5380-42-7 Application:intermediate

2-Thiophenecarboxylic acid, methyl ester

Cas:5380-42-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

dimethyl sulfate
77-78-1

dimethyl sulfate

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran for 0.5h; Methylation; esterification; Heating;100%
2-thienyl chloride
96-43-5

2-thienyl chloride

methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate; methyl chloroacetate; dicobalt octacarbonyl at 60℃;98%
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

methanol
67-56-1

methanol

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: methanol With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-dimethyl-1,2,4-triazolium iodide In tetrahydrofuran for 0.0833333h; Inert atmosphere;
Stage #2: thiophene-2-carbaldehyde With 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;
97%
With FeMo6O24(9-)*3H3N*9H(1+); potassium chloride; dihydrogen peroxide at 65℃; for 24h; Schlenk technique;89%
With sodium hydrogen sulfate; iodine; potassium hydroxide at 0℃; for 2h;89%
2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

methyl iodide
74-88-4

methyl iodide

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: 2-thiophenylcarboxylic acid With sodium t-butanolate In dimethyl sulfoxide for 0.166667h; Inert atmosphere;
Stage #2: methyl iodide In dimethyl sulfoxide at 0 - 20℃; for 18h;
97%
With sodium carbonate In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere;78%
methanol
67-56-1

methanol

2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With thionyl chloride at 0 - 20℃; for 3h;96%
With iron(III) sulfate; sulfuric acid for 1h; Heating;95%
With thionyl chloride for 36h; Inert atmosphere; Schlenk technique; Reflux;93%
methanol
67-56-1

methanol

2-thiophenemethanol
636-72-6

2-thiophenemethanol

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With dihydrogen peroxide for 3h; Irradiation;96%
With oxygen at 20℃; for 12h; Irradiation;93%
With iodine; potassium carbonate for 39h; Heating;91%
2-Iodothiophene
3437-95-4

2-Iodothiophene

methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With triethylamine at 100℃; for 1.5h; Inert atmosphere;96%
With palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In N,N-dimethyl-formamide; toluene at 100℃; under 5250.53 Torr; continuous flow reactor;71%
With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In N,N-dimethyl-formamide; toluene at 100℃; under 5250.53 Torr; Flow reactor;71%
2-bromothiophene
1003-09-4

2-bromothiophene

methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate; methyl chloroacetate; dicobalt octacarbonyl at 60℃;95%
2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With triethylamine at 160℃; for 3h; Autoclave; Green chemistry;95%
With diiron nonacarbonyl at 180℃; for 1h; Sealed tube;95%
With tributyl-amine In N,N-dimethyl-formamide at 285℃; under 112511 Torr; for 0.05h;81%
2-Iodothiophene
3437-95-4

2-Iodothiophene

Methyl formate
107-31-3

Methyl formate

sodium methylate
124-41-4

sodium methylate

A

thiophene
188290-36-0

thiophene

B

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
bis-triphenylphosphine-palladium(II) chloride In dichloromethane at 80℃; under 11250.9 Torr; for 0.75h;A 7%
B 93%
2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

Methyl trichloroacetate
598-99-2

Methyl trichloroacetate

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With 18-crown-6 ether; potassium carbonate at 90 - 150℃; for 2h;93%
Methyl 3-aminothiophene-2-carboxylate
22288-78-4

Methyl 3-aminothiophene-2-carboxylate

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; sodium nitrite In N,N-dimethyl-formamide at 20℃; for 1h;92%
With tetrahydrofuran; tert.-butylnitrite; salicylic acid at 20℃; for 3h; Schlenk technique; Inert atmosphere;50%
With hydrogenchloride; sodium tetrafluoroborate; diazonium fluoroborate; sodium nitrite Multistep reaction;
Multi-step reaction with 2 steps
1: 97 percent / i-pentyl nitrite; HCOOH / 0 - 5 °C
2: 10 percent / Pd(OAc)2 / ethanol / 0.25 h / 70 °C
View Scheme
Stage #1: Methyl 3-aminothiophene-2-carboxylate With tetrafluoroboric acid; acetic acid; isopentyl nitrite In water at 20℃; for 0.0833333h;
Stage #2: With eosin B disodium salt In N,N-dimethyl-formamide at 18℃; for 0.5h; Inert atmosphere; Irradiation;
76 %Chromat.
methanol
67-56-1

methanol

(thiophen-2-yl)methyl thiophene-2-carboxylate

(thiophen-2-yl)methyl thiophene-2-carboxylate

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With diethylamine; lithium bromide at 20℃; for 24h; neat (no solvent);92%
potassium methanolate
865-33-8

potassium methanolate

2-thiophenemethanol
636-72-6

2-thiophenemethanol

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With tellurium; bismuth (III) nitrate pentahydrate; 5%-palladium/activated carbon; oxygen In methanol at 60℃; under 760.051 Torr; for 8h; Catalytic behavior; Temperature; Reagent/catalyst;92%
2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

1-methoxy-2,2,6,6-tetramethylpiperidine
34672-84-9

1-methoxy-2,2,6,6-tetramethylpiperidine

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With 2,6-di-tert-butyl-pyridine In acetonitrile at 21 - 25℃; for 18h; Electrochemical reaction;92%
2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

1,2-dichloro-ethane
107-06-2

1,2-dichloro-ethane

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With sulfuric acid In methanol90%
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

tert.-butylhydroperoxide
75-91-2

tert.-butylhydroperoxide

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With copper (II)-fluoride In water; dimethyl sulfoxide at 120℃; for 12h; Schlenk technique; Inert atmosphere; Green chemistry;90%
With copper quinolate; tetra-(n-butyl)ammonium iodide In water; dimethyl sulfoxide at 120℃; for 24h;65%
methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

2-thienylphenyliodonium tosylate
91228-44-3

2-thienylphenyliodonium tosylate

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
palladium diacetate In N,N-dimethyl-formamide under 760 Torr; for 0.5h; Ambient temperature;89%
methanol
67-56-1

methanol

3-(thiophene-2-carbonyl)oxazolidin-2-one

3-(thiophene-2-carbonyl)oxazolidin-2-one

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0) In toluene at 25℃; for 12h; Sealed tube; Inert atmosphere; Green chemistry; chemoselective reaction;89%
5-bromo-2-thiophenecarboxylic acid methyl ester
62224-19-5

5-bromo-2-thiophenecarboxylic acid methyl ester

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; palladium diacetate; triphenylphosphine In tetrahydrofuran at 20℃; for 2h; Reagent/catalyst; Time; Inert atmosphere; chemoselective reaction;88%
With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; palladium diacetate; triphenylphosphine In tetrahydrofuran at 25℃; for 3h; Inert atmosphere; regioselective reaction;88%
3-thiophene carboxaldehyde
498-62-4

3-thiophene carboxaldehyde

methanol
67-56-1

methanol

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With tert.-butylhydroperoxide In decane at 25℃; for 10h; Inert atmosphere;88%
Trimethyl orthoacetate
1445-45-0

Trimethyl orthoacetate

2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
microwave irradiation;85%
2-bromothiophene
1003-09-4

2-bromothiophene

methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

A

2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

B

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With CoCRACO; sodium tert-pentoxide; sodium hydride In tetrahydrofuran for 14h; Irradiation;A 2%
B 83%
With CoCRACO; sodium tert-pentoxide; sodium hydride In tetrahydrofuran for 13h; Irradiation;A 2%
B 83%
With tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 13h; Irradiation;A 2%
B 83%
2-bromothiophene
1003-09-4

2-bromothiophene

carbon monoxide
201230-82-2

carbon monoxide

A

2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

B

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With methanol; tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 13h; Irradiation;A 2%
B 83%
methanol
67-56-1

methanol

2,2'-thenil
7333-07-5

2,2'-thenil

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With sodium cyanide; potassium iodide at 15℃; Electrochemical reaction;83%
2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

methyl salicylate
119-36-8

methyl salicylate

A

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

B

salicylic acid
69-72-7

salicylic acid

Conditions
ConditionsYield
Stage #1: 2-thiophenylcarboxylic acid With potassium carbonate In N,N-dimethyl acetamide at 110℃; for 0.5h;
Stage #2: methyl salicylate at 110℃; for 24h;
A 83%
B n/a
methanol
67-56-1

methanol

2,5-dimethyl-1H-pyrrol-1-yl(thiophen-2-yl)methanone

2,5-dimethyl-1H-pyrrol-1-yl(thiophen-2-yl)methanone

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0) In toluene at 20℃; for 1h; Sealed tube; chemoselective reaction;83%
2-thienyl chloride
96-43-5

2-thienyl chloride

methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

A

2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

B

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 15h; Irradiation;A 7%
B 81%
With CoCRACO; sodium tert-pentoxide; sodium hydride In tetrahydrofuran for 40h; Irradiation;A 8.5%
B 78.5%
2-thienyl chloride
96-43-5

2-thienyl chloride

carbon monoxide
201230-82-2

carbon monoxide

A

2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

B

thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With methanol; tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 15h; Irradiation;A 7%
B 81%
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

Conditions
ConditionsYield
With sodium; diphenyldisulfane In 1-methyl-pyrrolidin-2-one at 90℃; for 0.25h;100%
With hydrogenchloride In 1,4-dioxane for 1h; Heating;97%
With potassium carbonate; thiophenol In 1-methyl-pyrrolidin-2-one at 190℃; for 0.166667h; Substitution;75%
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

1-octadecanol
112-92-5

1-octadecanol

octadecyl thiophene-2-carboxylate

octadecyl thiophene-2-carboxylate

Conditions
ConditionsYield
Stage #1: thiophene-2-carboxylic acid methyl ester; 1-octadecanol In xylene for 0.5h; Heating;
Stage #2: With TiO(acac)2 In xylene for 13h; Heating;
99%
With iron(III)-acetylacetonate; sodium carbonate In n-heptane at 105℃; for 5h; Inert atmosphere;96%
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

O-methyl thiophene-2-carbothioate
127918-67-6

O-methyl thiophene-2-carbothioate

Conditions
ConditionsYield
With Lawessons reagent In 5,5-dimethyl-1,3-cyclohexadiene at 150℃; for 3h;99%
With Lawessons reagent In 5,5-dimethyl-1,3-cyclohexadiene Lawesson Thiocarbonylation; Inert atmosphere; Reflux;
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

tris(allyl)aluminum
18854-66-5

tris(allyl)aluminum

C11H14OS

C11H14OS

Conditions
ConditionsYield
In diethyl ether at 20℃; for 0.5h;98%
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
25015-63-8

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylic acid methyl ester
916138-13-1

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 70℃; for 16h; Inert atmosphere;97%
With 4,4'-di(tert-butyl)-2,2'-dipyridyl; [Ir(μ2-OMe)(1,4-cyclooctadiene)]2 In hexane at 20℃; for 0.5h;94%
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In hexane at 25℃; for 0.5h; regioselective reaction;95 %Chromat.
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

hexan-1-ol
111-27-3

hexan-1-ol

hexyl thiophene-2-carboxylate
91968-83-1

hexyl thiophene-2-carboxylate

Conditions
ConditionsYield
With tetrabutylammonium acetate; oxiranyl-methanol In hexane for 6h; Reflux;97%
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

ethanolamine
141-43-5

ethanolamine

N-(2-Hydroxyethyl)amide of thiophen-2-carboxylic acid
93448-78-3

N-(2-Hydroxyethyl)amide of thiophen-2-carboxylic acid

Conditions
ConditionsYield
96%
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

ethanolamine
141-43-5

ethanolamine

2-(thiophen-2-yl)-4,5-dihydrooxazole
60705-32-0

2-(thiophen-2-yl)-4,5-dihydrooxazole

Conditions
ConditionsYield
96%
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

benzyl alcohol
100-51-6

benzyl alcohol

thiophene-2-carboxylic acid benzyl ester

thiophene-2-carboxylic acid benzyl ester

Conditions
ConditionsYield
With N,N'-biscyclohexyl-imidazol-2-ylidene; 4 A molecular sieve In tetrahydrofuran at 20℃; for 0.25h;96%
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

tris(methylthio)methane
5418-86-0

tris(methylthio)methane

A

tetrathioorthocarbonic acid tetramethyl ester
6156-25-8

tetrathioorthocarbonic acid tetramethyl ester

B

2,2-Bis-methylsulfanyl-1-thiophen-2-yl-ethanone

2,2-Bis-methylsulfanyl-1-thiophen-2-yl-ethanone

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane 1.) -95 deg C, 2 h, 2.) -78 deg C, 30 min;A n/a
B 95%
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

benzyl-methyl-amine
103-67-3

benzyl-methyl-amine

N-benzyl-N-methylthiophene-2-carboxamide
349404-48-4

N-benzyl-N-methylthiophene-2-carboxamide

Conditions
ConditionsYield
Stage #1: thiophene-2-carboxylic acid methyl ester With potassium phosphate; 2,2,2-trifluoroethanol In 1,4-dioxane at 125℃; for 0.5h; Sealed tube; Schlenk technique; Inert atmosphere;
Stage #2: benzyl-methyl-amine In 1,4-dioxane at 125℃; for 22h; Sealed tube; Schlenk technique; Inert atmosphere;
95%
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

4,5-Bis-chloromethyl-thiophene-2-carboxylic acid methyl ester
7353-89-1

4,5-Bis-chloromethyl-thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With titanium tetrachloride for 5h; Inert atmosphere; Cooling with ice;93.2%
With titanium tetrachloride at 0℃; for 1h;87%
With zinc(II) chloride at 20 - 60℃; for 3.25h; Inert atmosphere;61%
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

Pentafluorobenzene
363-72-4

Pentafluorobenzene

methyl 5-(perfluorophenyl)thiophene-2-carboxylate
1244039-08-4

methyl 5-(perfluorophenyl)thiophene-2-carboxylate

Conditions
ConditionsYield
With oxygen; palladium diacetate; silver(l) oxide; Trimethylacetic acid In dimethyl sulfoxide; N,N-dimethyl-formamide at 120℃; under 760.051 Torr; for 9h; Autoclave;92%
With palladium diacetate; acetic acid; silver carbonate In dimethyl sulfoxide; N,N-dimethyl-formamide at 120℃; for 7h; Inert atmosphere; regioselective reaction;91%
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

2-[diethyl(methyl)silyl]phenyl trifluoromethanesulfonate

2-[diethyl(methyl)silyl]phenyl trifluoromethanesulfonate

methyl 5-[2-{[(trifluoromethyl)sulfonyl]oxy}phenyl]thiophene-2-carboxylate

methyl 5-[2-{[(trifluoromethyl)sulfonyl]oxy}phenyl]thiophene-2-carboxylate

Conditions
ConditionsYield
With (Ph3P)Au(I)(OTs); [bis(acetoxy)iodo]benzene In methanol; chloroform at 70℃; for 24h;92%

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